![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 19919 |
FusionGeneSummary for LMO7_UCHL3 |
![]() |
Fusion gene information | Fusion gene name: LMO7_UCHL3 | Fusion gene ID: 19919 | Hgene | Tgene | Gene symbol | LMO7 | UCHL3 | Gene ID | 4008 | 7347 |
Gene name | LIM domain 7 | ubiquitin C-terminal hydrolase L3 | |
Synonyms | FBX20|FBXO20|LMO7b|LOMP | UCH-L3 | |
Cytomap | 13q22.2 | 13q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | LIM domain only protein 7F-box only protein 20F-box protein Fbx20LIM domain only 7 proteinLMO-7zinc-finger domain-containing protein | ubiquitin carboxyl-terminal hydrolase isozyme L3testicular tissue protein Li 221ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)ubiquitin thioesterase L3ubiquitin thiolesterase | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q8WWI1 | P15374 | |
Ensembl transtripts involved in fusion gene | ENST00000341547, ENST00000357063, ENST00000377534, ENST00000321797, ENST00000526202, ENST00000465261, ENST00000605961, | ENST00000377595, ENST00000606347, | |
Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 5 X 3 X 5=75 |
# samples | 9 | 5 | |
** MAII score | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LMO7 [Title/Abstract] AND UCHL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LMO7 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17067998 |
Tgene | UCHL3 | GO:0016579 | protein deubiquitination | 9521656 |
Tgene | UCHL3 | GO:0030163 | protein catabolic process | 21762696 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-LL-A8F5-01A | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000341547 | ENST00000377595 | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
intron-intron | ENST00000341547 | ENST00000606347 | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
intron-3CDS | ENST00000357063 | ENST00000377595 | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
intron-intron | ENST00000357063 | ENST00000606347 | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
intron-3CDS | ENST00000377534 | ENST00000377595 | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
intron-intron | ENST00000377534 | ENST00000606347 | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
intron-3CDS | ENST00000321797 | ENST00000377595 | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
intron-intron | ENST00000321797 | ENST00000606347 | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
intron-3CDS | ENST00000526202 | ENST00000377595 | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
intron-intron | ENST00000526202 | ENST00000606347 | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
intron-3CDS | ENST00000465261 | ENST00000377595 | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
intron-intron | ENST00000465261 | ENST00000606347 | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
intron-3CDS | ENST00000605961 | ENST00000377595 | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
intron-intron | ENST00000605961 | ENST00000606347 | LMO7 | chr13 | 76210862 | + | UCHL3 | chr13 | 76140831 | + |
Top |
FusionProtFeatures for LMO7_UCHL3 |
![]() |
Hgene | Tgene |
LMO7 | UCHL3 |
Deubiquitinating enzyme (DUB) that controls levels ofcellular ubiquitin through processing of ubiquitin precursors andubiquitinated proteins. Thiol protease that recognizes andhydrolyzes a peptide bond at the C-terminal glycine of eitherubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys atposition P3", and exhibits a preference towards 'Lys-48'-linkedubiquitin chains. Deubiquitinates ENAC in apical compartments,thereby regulating apical membrane recycling. Indirectly increasesthe phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. Maybe involved in working memory. Can hydrolyze UBB(+1), a mutatedform of ubiquitin which is not effectively degraded by theproteasome and is associated with neurogenerative disorders.{ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696,ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630,ECO:0000269|PubMed:9790970}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for LMO7_UCHL3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for LMO7_UCHL3 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LMO7 | SFN, EMD, CALM1, SP1, HNRNPR, ILF3, FMNL1, YWHAE, CFTR, MDM2, PKM, YWHAQ, YWHAB, RPA1, RPA2, RPA3, CCDC8, RNF2, SFPQ, SRPK2, CEP128, CEP135, CNTRL, NINL, ODF2, CAPZA2, CDK2, DBN1, MYH9, PPP1CB, RNH1, IQGAP1, SYNPO, ANLN, MYO19, MYO18A, RHOU, CDC5L, CDH1, KCTD3, CBY1, RAB3IP, TES | UCHL3 | NEDD8, COPS5, COPS6, USP20, CLPB, SMAD1, HMP19, POGK, UBC, UBE2S, UCHL3, ATXN7L3, PJA1, TRIM63, TRIM55, TRIM54, USP21, USP15, USP28, TSN, ZFYVE19, AHCYL1, UBA6, ZNF593, USP48, USP9X, SSSCA1, USP34, USP5, UBE2V1, UBQLN1, CSE1L, UBE2A, XIAP, UBXN7, UBR1, UNK, ZYX, SNRPD1, UBE2L3, ZRANB2, ATP6V1F, PCMT1, TTC9C, SULT1A1, YAP1, UBE4B, TTC1, VPS33B, PBX1, NT5DC1, UBL7, LONRF1, TRIM27, BAG3, CDH1, PLA2G2A, ZMYM6, ACAA2, ARHGDIA, GDI1, GPX4, HINT1, IMPDH2, MAPRE1, PEBP1, PGD, STIP1, DLD, ENO1, ENO2, EZR, HSD17B10, ISYNA1, MSN, NUP93, P4HB, PPIB, RDX, SMS, SOD2, SUMO3, TAGLN, TAGLN2, TPD52, TPD52L1, UBA1, RAD51, ATM, ZEB1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for LMO7_UCHL3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for LMO7_UCHL3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | UCHL3 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |