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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19919

FusionGeneSummary for LMO7_UCHL3

check button Fusion gene summary
Fusion gene informationFusion gene name: LMO7_UCHL3
Fusion gene ID: 19919
HgeneTgene
Gene symbol

LMO7

UCHL3

Gene ID

4008

7347

Gene nameLIM domain 7ubiquitin C-terminal hydrolase L3
SynonymsFBX20|FBXO20|LMO7b|LOMPUCH-L3
Cytomap

13q22.2

13q22.2

Type of geneprotein-codingprotein-coding
DescriptionLIM domain only protein 7F-box only protein 20F-box protein Fbx20LIM domain only 7 proteinLMO-7zinc-finger domain-containing proteinubiquitin carboxyl-terminal hydrolase isozyme L3testicular tissue protein Li 221ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)ubiquitin thioesterase L3ubiquitin thiolesterase
Modification date2018052220180523
UniProtAcc

Q8WWI1

P15374

Ensembl transtripts involved in fusion geneENST00000341547, ENST00000357063, 
ENST00000377534, ENST00000321797, 
ENST00000526202, ENST00000465261, 
ENST00000605961, 
ENST00000377595, 
ENST00000606347, 
Fusion gene scores* DoF score7 X 6 X 4=1685 X 3 X 5=75
# samples 95
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LMO7 [Title/Abstract] AND UCHL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLMO7

GO:0045944

positive regulation of transcription by RNA polymerase II

17067998

TgeneUCHL3

GO:0016579

protein deubiquitination

9521656

TgeneUCHL3

GO:0030163

protein catabolic process

21762696


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-LL-A8F5-01ALMO7chr13

76210862

+UCHL3chr13

76140831

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000341547ENST00000377595LMO7chr13

76210862

+UCHL3chr13

76140831

+
intron-intronENST00000341547ENST00000606347LMO7chr13

76210862

+UCHL3chr13

76140831

+
intron-3CDSENST00000357063ENST00000377595LMO7chr13

76210862

+UCHL3chr13

76140831

+
intron-intronENST00000357063ENST00000606347LMO7chr13

76210862

+UCHL3chr13

76140831

+
intron-3CDSENST00000377534ENST00000377595LMO7chr13

76210862

+UCHL3chr13

76140831

+
intron-intronENST00000377534ENST00000606347LMO7chr13

76210862

+UCHL3chr13

76140831

+
intron-3CDSENST00000321797ENST00000377595LMO7chr13

76210862

+UCHL3chr13

76140831

+
intron-intronENST00000321797ENST00000606347LMO7chr13

76210862

+UCHL3chr13

76140831

+
intron-3CDSENST00000526202ENST00000377595LMO7chr13

76210862

+UCHL3chr13

76140831

+
intron-intronENST00000526202ENST00000606347LMO7chr13

76210862

+UCHL3chr13

76140831

+
intron-3CDSENST00000465261ENST00000377595LMO7chr13

76210862

+UCHL3chr13

76140831

+
intron-intronENST00000465261ENST00000606347LMO7chr13

76210862

+UCHL3chr13

76140831

+
intron-3CDSENST00000605961ENST00000377595LMO7chr13

76210862

+UCHL3chr13

76140831

+
intron-intronENST00000605961ENST00000606347LMO7chr13

76210862

+UCHL3chr13

76140831

+

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FusionProtFeatures for LMO7_UCHL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMO7

Q8WWI1

UCHL3

P15374

Deubiquitinating enzyme (DUB) that controls levels ofcellular ubiquitin through processing of ubiquitin precursors andubiquitinated proteins. Thiol protease that recognizes andhydrolyzes a peptide bond at the C-terminal glycine of eitherubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys atposition P3", and exhibits a preference towards 'Lys-48'-linkedubiquitin chains. Deubiquitinates ENAC in apical compartments,thereby regulating apical membrane recycling. Indirectly increasesthe phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. Maybe involved in working memory. Can hydrolyze UBB(+1), a mutatedform of ubiquitin which is not effectively degraded by theproteasome and is associated with neurogenerative disorders.{ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696,ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630,ECO:0000269|PubMed:9790970}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LMO7_UCHL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LMO7_UCHL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LMO7SFN, EMD, CALM1, SP1, HNRNPR, ILF3, FMNL1, YWHAE, CFTR, MDM2, PKM, YWHAQ, YWHAB, RPA1, RPA2, RPA3, CCDC8, RNF2, SFPQ, SRPK2, CEP128, CEP135, CNTRL, NINL, ODF2, CAPZA2, CDK2, DBN1, MYH9, PPP1CB, RNH1, IQGAP1, SYNPO, ANLN, MYO19, MYO18A, RHOU, CDC5L, CDH1, KCTD3, CBY1, RAB3IP, TESUCHL3NEDD8, COPS5, COPS6, USP20, CLPB, SMAD1, HMP19, POGK, UBC, UBE2S, UCHL3, ATXN7L3, PJA1, TRIM63, TRIM55, TRIM54, USP21, USP15, USP28, TSN, ZFYVE19, AHCYL1, UBA6, ZNF593, USP48, USP9X, SSSCA1, USP34, USP5, UBE2V1, UBQLN1, CSE1L, UBE2A, XIAP, UBXN7, UBR1, UNK, ZYX, SNRPD1, UBE2L3, ZRANB2, ATP6V1F, PCMT1, TTC9C, SULT1A1, YAP1, UBE4B, TTC1, VPS33B, PBX1, NT5DC1, UBL7, LONRF1, TRIM27, BAG3, CDH1, PLA2G2A, ZMYM6, ACAA2, ARHGDIA, GDI1, GPX4, HINT1, IMPDH2, MAPRE1, PEBP1, PGD, STIP1, DLD, ENO1, ENO2, EZR, HSD17B10, ISYNA1, MSN, NUP93, P4HB, PPIB, RDX, SMS, SOD2, SUMO3, TAGLN, TAGLN2, TPD52, TPD52L1, UBA1, RAD51, ATM, ZEB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LMO7_UCHL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LMO7_UCHL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneUCHL3C0027627Neoplasm Metastasis1CTD_human