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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19918

FusionGeneSummary for LMO7_TGFBI

check button Fusion gene summary
Fusion gene informationFusion gene name: LMO7_TGFBI
Fusion gene ID: 19918
HgeneTgene
Gene symbol

LMO7

TGFBI

Gene ID

4008

7045

Gene nameLIM domain 7transforming growth factor beta induced
SynonymsFBX20|FBXO20|LMO7b|LOMPBIGH3|CDB1|CDG2|CDGG1|CSD|CSD1|CSD2|CSD3|EBMD|LCD1
Cytomap

13q22.2

5q31.1

Type of geneprotein-codingprotein-coding
DescriptionLIM domain only protein 7F-box only protein 20F-box protein Fbx20LIM domain only 7 proteinLMO-7zinc-finger domain-containing proteintransforming growth factor-beta-induced protein ig-h3RGD-CAPRGD-containing collagen-associated proteinbeta ig-h3betaig-h3kerato-epithelintransforming growth factor beta-induced 68kDatransforming growth factor, beta-induced, 68kD
Modification date2018052220180527
UniProtAcc

Q8WWI1

Q15582

Ensembl transtripts involved in fusion geneENST00000341547, ENST00000357063, 
ENST00000377534, ENST00000321797, 
ENST00000526202, ENST00000465261, 
ENST00000605961, 
ENST00000442011, 
ENST00000305126, ENST00000508076, 
ENST00000504185, 
Fusion gene scores* DoF score7 X 6 X 4=1686 X 7 X 2=84
# samples 98
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/84*10)=-0.070389327891398
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LMO7 [Title/Abstract] AND TGFBI [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLMO7

GO:0045944

positive regulation of transcription by RNA polymerase II

17067998


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE736691LMO7chr13

76335180

+TGFBIchr5

135382540

+
ChiTaRS3.1BE616343LMO7chr13

76335180

+TGFBIchr5

135382540

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000341547ENST00000442011LMO7chr13

76335180

+TGFBIchr5

135382540

+
Frame-shitENST00000341547ENST00000305126LMO7chr13

76335180

+TGFBIchr5

135382540

+
5CDS-intronENST00000341547ENST00000508076LMO7chr13

76335180

+TGFBIchr5

135382540

+
5CDS-intronENST00000341547ENST00000504185LMO7chr13

76335180

+TGFBIchr5

135382540

+
Frame-shitENST00000357063ENST00000442011LMO7chr13

76335180

+TGFBIchr5

135382540

+
Frame-shitENST00000357063ENST00000305126LMO7chr13

76335180

+TGFBIchr5

135382540

+
5CDS-intronENST00000357063ENST00000508076LMO7chr13

76335180

+TGFBIchr5

135382540

+
5CDS-intronENST00000357063ENST00000504185LMO7chr13

76335180

+TGFBIchr5

135382540

+
Frame-shitENST00000377534ENST00000442011LMO7chr13

76335180

+TGFBIchr5

135382540

+
Frame-shitENST00000377534ENST00000305126LMO7chr13

76335180

+TGFBIchr5

135382540

+
5CDS-intronENST00000377534ENST00000508076LMO7chr13

76335180

+TGFBIchr5

135382540

+
5CDS-intronENST00000377534ENST00000504185LMO7chr13

76335180

+TGFBIchr5

135382540

+
5UTR-3CDSENST00000321797ENST00000442011LMO7chr13

76335180

+TGFBIchr5

135382540

+
5UTR-3CDSENST00000321797ENST00000305126LMO7chr13

76335180

+TGFBIchr5

135382540

+
5UTR-intronENST00000321797ENST00000508076LMO7chr13

76335180

+TGFBIchr5

135382540

+
5UTR-intronENST00000321797ENST00000504185LMO7chr13

76335180

+TGFBIchr5

135382540

+
Frame-shitENST00000526202ENST00000442011LMO7chr13

76335180

+TGFBIchr5

135382540

+
Frame-shitENST00000526202ENST00000305126LMO7chr13

76335180

+TGFBIchr5

135382540

+
5CDS-intronENST00000526202ENST00000508076LMO7chr13

76335180

+TGFBIchr5

135382540

+
5CDS-intronENST00000526202ENST00000504185LMO7chr13

76335180

+TGFBIchr5

135382540

+
5UTR-3CDSENST00000465261ENST00000442011LMO7chr13

76335180

+TGFBIchr5

135382540

+
5UTR-3CDSENST00000465261ENST00000305126LMO7chr13

76335180

+TGFBIchr5

135382540

+
5UTR-intronENST00000465261ENST00000508076LMO7chr13

76335180

+TGFBIchr5

135382540

+
5UTR-intronENST00000465261ENST00000504185LMO7chr13

76335180

+TGFBIchr5

135382540

+
intron-3CDSENST00000605961ENST00000442011LMO7chr13

76335180

+TGFBIchr5

135382540

+
intron-3CDSENST00000605961ENST00000305126LMO7chr13

76335180

+TGFBIchr5

135382540

+
intron-intronENST00000605961ENST00000508076LMO7chr13

76335180

+TGFBIchr5

135382540

+
intron-intronENST00000605961ENST00000504185LMO7chr13

76335180

+TGFBIchr5

135382540

+

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FusionProtFeatures for LMO7_TGFBI


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMO7

Q8WWI1

TGFBI

Q15582


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LMO7_TGFBI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LMO7_TGFBI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LMO7_TGFBI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LMO7_TGFBI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTGFBIC1690006Lattice corneal dystrophy Type I12CTD_human;ORPHANET;UNIPROT
TgeneTGFBIC1641846Groenouw corneal dystrophy type I (disorder)7CTD_human;ORPHANET;UNIPROT
TgeneTGFBIC1275685Avellino corneal dystrophy6CTD_human;ORPHANET;UNIPROT
TgeneTGFBIC0339278Reis-Bucklers' corneal dystrophy5CTD_human;ORPHANET;UNIPROT
TgeneTGFBIC1837974Corneal Dystrophy, Lattice Type IIIA5CTD_human;UNIPROT
TgeneTGFBIC1562894Thiel-Behnke corneal dystrophy4CTD_human;ORPHANET;UNIPROT
TgeneTGFBIC0000786Spontaneous abortion1CTD_human
TgeneTGFBIC0011881Diabetic Nephropathy1CTD_human
TgeneTGFBIC0521723Corneal dystrophy, epithelial basement membrane1CTD_human;ORPHANET;UNIPROT