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Fusion gene ID: 19917 |
FusionGeneSummary for LMO7_MUC4 |
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Fusion gene information | Fusion gene name: LMO7_MUC4 | Fusion gene ID: 19917 | Hgene | Tgene | Gene symbol | LMO7 | MUC4 | Gene ID | 4008 | 4585 |
Gene name | LIM domain 7 | mucin 4, cell surface associated | |
Synonyms | FBX20|FBXO20|LMO7b|LOMP | ASGP|HSA276359|MUC-4 | |
Cytomap | 13q22.2 | 3q29 | |
Type of gene | protein-coding | protein-coding | |
Description | LIM domain only protein 7F-box only protein 20F-box protein Fbx20LIM domain only 7 proteinLMO-7zinc-finger domain-containing protein | mucin-4ascites sialoglycoproteinmucin 4, tracheobronchialpancreatic adenocarcinoma mucintestis mucintracheobronchial mucin | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | Q8WWI1 | Q99102 | |
Ensembl transtripts involved in fusion gene | ENST00000341547, ENST00000357063, ENST00000377534, ENST00000321797, ENST00000526202, ENST00000465261, ENST00000605961, | ENST00000346145, ENST00000349607, ENST00000463781, ENST00000475231, ENST00000478685, | |
Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 5 X 5 X 1=25 |
# samples | 9 | 6 | |
** MAII score | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/25*10)=1.26303440583379 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: LMO7 [Title/Abstract] AND MUC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LMO7 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17067998 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW391858 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + | ||
ChiTaRS3.1 | AW391853 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000341547 | ENST00000346145 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000341547 | ENST00000349607 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000341547 | ENST00000463781 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000341547 | ENST00000475231 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000341547 | ENST00000478685 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000357063 | ENST00000346145 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000357063 | ENST00000349607 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000357063 | ENST00000463781 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000357063 | ENST00000475231 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000357063 | ENST00000478685 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
intron-intron | ENST00000377534 | ENST00000346145 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
intron-intron | ENST00000377534 | ENST00000349607 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
intron-intron | ENST00000377534 | ENST00000463781 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
intron-intron | ENST00000377534 | ENST00000475231 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
intron-intron | ENST00000377534 | ENST00000478685 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000321797 | ENST00000346145 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000321797 | ENST00000349607 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000321797 | ENST00000463781 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000321797 | ENST00000475231 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000321797 | ENST00000478685 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000526202 | ENST00000346145 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000526202 | ENST00000349607 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000526202 | ENST00000463781 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000526202 | ENST00000475231 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000526202 | ENST00000478685 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000465261 | ENST00000346145 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000465261 | ENST00000349607 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000465261 | ENST00000463781 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000465261 | ENST00000475231 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
5CDS-intron | ENST00000465261 | ENST00000478685 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
intron-intron | ENST00000605961 | ENST00000346145 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
intron-intron | ENST00000605961 | ENST00000349607 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
intron-intron | ENST00000605961 | ENST00000463781 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
intron-intron | ENST00000605961 | ENST00000475231 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
intron-intron | ENST00000605961 | ENST00000478685 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
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FusionProtFeatures for LMO7_MUC4 |
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Hgene | Tgene |
LMO7 | MUC4 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LMO7_MUC4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LMO7_MUC4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LMO7_MUC4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LMO7_MUC4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MUC4 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Tgene | MUC4 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | MUC4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |