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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19917

FusionGeneSummary for LMO7_MUC4

check button Fusion gene summary
Fusion gene informationFusion gene name: LMO7_MUC4
Fusion gene ID: 19917
HgeneTgene
Gene symbol

LMO7

MUC4

Gene ID

4008

4585

Gene nameLIM domain 7mucin 4, cell surface associated
SynonymsFBX20|FBXO20|LMO7b|LOMPASGP|HSA276359|MUC-4
Cytomap

13q22.2

3q29

Type of geneprotein-codingprotein-coding
DescriptionLIM domain only protein 7F-box only protein 20F-box protein Fbx20LIM domain only 7 proteinLMO-7zinc-finger domain-containing proteinmucin-4ascites sialoglycoproteinmucin 4, tracheobronchialpancreatic adenocarcinoma mucintestis mucintracheobronchial mucin
Modification date2018052220180522
UniProtAcc

Q8WWI1

Q99102

Ensembl transtripts involved in fusion geneENST00000341547, ENST00000357063, 
ENST00000377534, ENST00000321797, 
ENST00000526202, ENST00000465261, 
ENST00000605961, 
ENST00000346145, 
ENST00000349607, ENST00000463781, 
ENST00000475231, ENST00000478685, 
Fusion gene scores* DoF score7 X 6 X 4=1685 X 5 X 1=25
# samples 96
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/25*10)=1.26303440583379
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LMO7 [Title/Abstract] AND MUC4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLMO7

GO:0045944

positive regulation of transcription by RNA polymerase II

17067998


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW391858LMO7chr13

76430648

-MUC4chr3

195530516

+
ChiTaRS3.1AW391853LMO7chr13

76430648

-MUC4chr3

195530516

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000341547ENST00000346145LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000341547ENST00000349607LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000341547ENST00000463781LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000341547ENST00000475231LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000341547ENST00000478685LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000357063ENST00000346145LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000357063ENST00000349607LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000357063ENST00000463781LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000357063ENST00000475231LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000357063ENST00000478685LMO7chr13

76430648

-MUC4chr3

195530516

+
intron-intronENST00000377534ENST00000346145LMO7chr13

76430648

-MUC4chr3

195530516

+
intron-intronENST00000377534ENST00000349607LMO7chr13

76430648

-MUC4chr3

195530516

+
intron-intronENST00000377534ENST00000463781LMO7chr13

76430648

-MUC4chr3

195530516

+
intron-intronENST00000377534ENST00000475231LMO7chr13

76430648

-MUC4chr3

195530516

+
intron-intronENST00000377534ENST00000478685LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000321797ENST00000346145LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000321797ENST00000349607LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000321797ENST00000463781LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000321797ENST00000475231LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000321797ENST00000478685LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000526202ENST00000346145LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000526202ENST00000349607LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000526202ENST00000463781LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000526202ENST00000475231LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000526202ENST00000478685LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000465261ENST00000346145LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000465261ENST00000349607LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000465261ENST00000463781LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000465261ENST00000475231LMO7chr13

76430648

-MUC4chr3

195530516

+
5CDS-intronENST00000465261ENST00000478685LMO7chr13

76430648

-MUC4chr3

195530516

+
intron-intronENST00000605961ENST00000346145LMO7chr13

76430648

-MUC4chr3

195530516

+
intron-intronENST00000605961ENST00000349607LMO7chr13

76430648

-MUC4chr3

195530516

+
intron-intronENST00000605961ENST00000463781LMO7chr13

76430648

-MUC4chr3

195530516

+
intron-intronENST00000605961ENST00000475231LMO7chr13

76430648

-MUC4chr3

195530516

+
intron-intronENST00000605961ENST00000478685LMO7chr13

76430648

-MUC4chr3

195530516

+

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FusionProtFeatures for LMO7_MUC4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMO7

Q8WWI1

MUC4

Q99102


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LMO7_MUC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LMO7_MUC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LMO7_MUC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LMO7_MUC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMUC4C0000786Spontaneous abortion1CTD_human
TgeneMUC4C0007134Renal Cell Carcinoma1CTD_human
TgeneMUC4C0033578Prostatic Neoplasms1CTD_human