![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 19916 |
FusionGeneSummary for LMO7_MED4 |
![]() |
Fusion gene information | Fusion gene name: LMO7_MED4 | Fusion gene ID: 19916 | Hgene | Tgene | Gene symbol | LMO7 | MED4 | Gene ID | 4008 | 29079 |
Gene name | LIM domain 7 | mediator complex subunit 4 | |
Synonyms | FBX20|FBXO20|LMO7b|LOMP | ARC36|DRIP36|HSPC126|TRAP36|VDRIP | |
Cytomap | 13q22.2 | 13q14.2 | |
Type of gene | protein-coding | protein-coding | |
Description | LIM domain only protein 7F-box only protein 20F-box protein Fbx20LIM domain only 7 proteinLMO-7zinc-finger domain-containing protein | mediator of RNA polymerase II transcription subunit 4TRAP/SMCC/PC2 subunit p36activator-recruited cofactor 36 kDa componentmediator, 34-kD subunit, homologvitamin D receptor-interacting protein, 36-kDvitamin D3 receptor-interacting protein complex 36 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q8WWI1 | Q9NPJ6 | |
Ensembl transtripts involved in fusion gene | ENST00000341547, ENST00000357063, ENST00000377534, ENST00000321797, ENST00000526202, ENST00000465261, ENST00000605961, | ENST00000495013, ENST00000258648, ENST00000378586, | |
Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 6 X 2 X 5=60 |
# samples | 9 | 7 | |
** MAII score | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/60*10)=0.222392421336448 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: LMO7 [Title/Abstract] AND MED4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LMO7 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17067998 |
Tgene | MED4 | GO:0006366 | transcription by RNA polymerase II | 10882111 |
Tgene | MED4 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 12218053 |
Tgene | MED4 | GO:0030518 | intracellular steroid hormone receptor signaling pathway | 11867769 |
Tgene | MED4 | GO:0030521 | androgen receptor signaling pathway | 12218053 |
Tgene | MED4 | GO:0045893 | positive regulation of transcription, DNA-templated | 10198638 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-73-4658-01A | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000341547 | ENST00000495013 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-intron | ENST00000341547 | ENST00000258648 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-5UTR | ENST00000341547 | ENST00000378586 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-intron | ENST00000357063 | ENST00000495013 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-intron | ENST00000357063 | ENST00000258648 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-5UTR | ENST00000357063 | ENST00000378586 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-intron | ENST00000377534 | ENST00000495013 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-intron | ENST00000377534 | ENST00000258648 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-5UTR | ENST00000377534 | ENST00000378586 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-intron | ENST00000321797 | ENST00000495013 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-intron | ENST00000321797 | ENST00000258648 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-5UTR | ENST00000321797 | ENST00000378586 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-intron | ENST00000526202 | ENST00000495013 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-intron | ENST00000526202 | ENST00000258648 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-5UTR | ENST00000526202 | ENST00000378586 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-intron | ENST00000465261 | ENST00000495013 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-intron | ENST00000465261 | ENST00000258648 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
5CDS-5UTR | ENST00000465261 | ENST00000378586 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
intron-intron | ENST00000605961 | ENST00000495013 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
intron-intron | ENST00000605961 | ENST00000258648 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
intron-5UTR | ENST00000605961 | ENST00000378586 | LMO7 | chr13 | 76398009 | + | MED4 | chr13 | 48664554 | - |
Top |
FusionProtFeatures for LMO7_MED4 |
![]() |
Hgene | Tgene |
LMO7 | MED4 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for LMO7_MED4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for LMO7_MED4 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LMO7 | SFN, EMD, CALM1, SP1, HNRNPR, ILF3, FMNL1, YWHAE, CFTR, MDM2, PKM, YWHAQ, YWHAB, RPA1, RPA2, RPA3, CCDC8, RNF2, SFPQ, SRPK2, CEP128, CEP135, CNTRL, NINL, ODF2, CAPZA2, CDK2, DBN1, MYH9, PPP1CB, RNH1, IQGAP1, SYNPO, ANLN, MYO19, MYO18A, RHOU, CDC5L, CDH1, KCTD3, CBY1, RAB3IP, TES | MED4 | TNFAIP8, AP2M1, MCRS1, MED10, MED9, MED29, MED19, MED28, MED26, MED30, MED1, RPAP2, PCBD2, MED18, EMD, MED12, ZC3H13, TRIP4, OBFC1, QKI, TADA2A, VDR, CTDP1, PUM2, MED13, WDTC1, FOXJ3, ELAVL1, COPS2, MED6, MED8, MED14, MED16, MED24, MED11, MED27, MED21, MED22, NIFK, FBXW7, EPAS1, ESR2, CDK8, CDK19, RPA3, RPA2, RPA1, NDE1, AES, KIFC3, SDCBP, SMARCD1, SMARCE1, LRRFIP1, SSX3, NDC80, FTCD, CCHCR1, CTNNBL1, CCDC146, USHBP1, IFT20, CCDC101, HAUS1, FRMD6, MAB21L3, C1orf216, AMOT, TXLNA, FAM13C, NXF1, MED7, CCNC, SEC13, NR1I3, TCL1B, MED17, HUWE1, MED15, MED20, PPM1G, PCM1, CEP131, OFD1, CCDC138, HAUS6, PCNT, AHNAK, PIBF1, CCDC14, KIAA0753, HAUS5, HAUS3, CD2AP, CEP170, MIB1, GIT1, CCDC18, KIF7, HAUS4, CEP350, NBN, FLNB, CEP290, KIF3A, MED13L, SQSTM1, KIF5B, CKAP5, TBC1D31, CEP72, DVL2, SSX2IP, HAUS8, MYCBP2, CEP55, POLR2A, XRN1, ERC1, EXOC4, LUZP1, ARHGEF7, ANKRD26, DCTN2, KIF11, CSPP1, GIT2, ACTR1A, EPB41L3, SRP68, CCDC61, CEP162, NSFL1C, ADSL, TLN1, EDRF1, SLK, SPAG5, MAP1B, HAUS2, MPHOSPH9, CCDC77, NIN, CEP152, DBT, DLG5, RAI14, KIF5A, TBK1, PSMD7, ODF2, PAICS, IFT74, TP53BP2, ECD, HAUS7, TXLNG, MAP7D3, CCP110, MED31, SPICE1, TTLL5, IFIT5, ATG2B, EPS15L1, SPAG9, CCDC66, CLINT1, KEAP1, MICAL3, ODF2L, UBE2O, CAMSAP1, EDC4, IFT81, SDCCAG3, PSMA2, TRIM25, ALMS1, SKA3, CCDC22, WRAP73, SPC24, BUB1B, CNOT10, LRBA, PDLIM5, UTRN, WDR90, CNOT1, CNTROB, KIAA1598, CNOT11, EIF3M, EPB41, WNK1, TTC28, C2CD3, CYLD, DCTN3, DPYSL3, ERBB2IP, FAM101B, KANK2, KIAA1524, LSM12, PSMB1, RBM11, SH3GLB2, SNX1, USP15, ZFYVE16, ZYX, PDIA6, CEP135, CPSF3, FAM111B, FAM91A1, KIF14, SCRIB, SNAP29, DENND4C, DST, FGFR1OP, NAV1, NEK9, TCHP, MED23, ATP5F1, PDCD6, AMD1, DHX40, LARP7, MOGS, NUFIP2, SCO1, ZC3H15, DNAJB1, RRP1, SRSF5, TNRC6B, ATP5H, SDE2, EEF1E1, FIP1L1, GLYR1, GNAO1, HBB, MESDC2, MRPS17, NOP2, PIP4K2A, RAB5A, RANBP9, SEC61A1, TAX1BP1, TXNDC9, WDR33, BAG6, CSNK2A2, ATPIF1, LRRC47, CRIPT, AP2A1, ATP6V1B2, HBA2, MRRF, ZMAT2, MED25, NCAPG, GTF2F1, FAM50A, CAP2, SRRM1, ARRB2, BRIX1, EXOC1, NOP56, PMAIP1, CYCS, MANF, EXOSC8, SPTAN1, CDK11A, F5, RBM27, SUPT16H, XRCC4, CP, HADHB, A2M, SERF1A, ZNF638, CORO1C, THOC2, GLUD2, RSL1D1, SSNA1, KARS, ARHGEF6, MOB2, PIP5K1A, FLII, SKA1, TCEA1, SNRPG, ALB, HPX, DZIP3, ERCC3, RBM14, HOMER1, RNPS1, RSRC2, ATP5C1, CPSF7, HSPBP1, PIP4K2B, POLR2B, PI4KA, C3, PIP4K2C, QPCT, MRFAP1, MAP3K7, GTF2B, HADHA, PSME3, PDAP1, UBAP2L, THRAP3, BCLAF1, ACAP2, RAE1, RIOK1, CCAR1, EWSR1, AHI1, CEP120, CEP128, CEP63, CEP89, CNTRL, POC5, LCA5, SASS6, KRAS, MYH11, POLR2G, KIF21B, PTPN22, TPTE2, TXLNB, PSMC5, BIRC5, LRRCC1, TRIP11, CHPF |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for LMO7_MED4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for LMO7_MED4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MED4 | C0014175 | Endometriosis | 1 | CTD_human |