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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19913

FusionGeneSummary for LMO7_HLTF

check button Fusion gene summary
Fusion gene informationFusion gene name: LMO7_HLTF
Fusion gene ID: 19913
HgeneTgene
Gene symbol

LMO7

HLTF

Gene ID

4008

6596

Gene nameLIM domain 7helicase like transcription factor
SynonymsFBX20|FBXO20|LMO7b|LOMPHIP116|HIP116A|HLTF1|RNF80|SMARCA3|SNF2L3|ZBU1
Cytomap

13q22.2

3q24

Type of geneprotein-codingprotein-coding
DescriptionLIM domain only protein 7F-box only protein 20F-box protein Fbx20LIM domain only 7 proteinLMO-7zinc-finger domain-containing proteinhelicase-like transcription factorDNA-binding protein/plasminogen activator inhibitor-1 regulatorRING finger protein 80RING-type E3 ubiquitin transferase HLTFSNF2-like 3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfa
Modification date2018052220180519
UniProtAcc

Q8WWI1

Q14527

Ensembl transtripts involved in fusion geneENST00000341547, ENST00000357063, 
ENST00000377534, ENST00000321797, 
ENST00000526202, ENST00000465261, 
ENST00000605961, 
ENST00000465259, 
ENST00000310053, ENST00000392912, 
ENST00000494055, ENST00000481663, 
Fusion gene scores* DoF score7 X 6 X 4=1683 X 3 X 3=27
# samples 93
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LMO7 [Title/Abstract] AND HLTF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLMO7

GO:0045944

positive regulation of transcription by RNA polymerase II

17067998


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1Z46606LMO7chr13

76423309

-HLTFchr3

148804317

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000341547ENST00000465259LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000341547ENST00000310053LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000341547ENST00000392912LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-5UTRENST00000341547ENST00000494055LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000341547ENST00000481663LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000357063ENST00000465259LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000357063ENST00000310053LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000357063ENST00000392912LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-5UTRENST00000357063ENST00000494055LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000357063ENST00000481663LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000377534ENST00000465259LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000377534ENST00000310053LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000377534ENST00000392912LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-5UTRENST00000377534ENST00000494055LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000377534ENST00000481663LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000321797ENST00000465259LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000321797ENST00000310053LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000321797ENST00000392912LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-5UTRENST00000321797ENST00000494055LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000321797ENST00000481663LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000526202ENST00000465259LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000526202ENST00000310053LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000526202ENST00000392912LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-5UTRENST00000526202ENST00000494055LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000526202ENST00000481663LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000465261ENST00000465259LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000465261ENST00000310053LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000465261ENST00000392912LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-5UTRENST00000465261ENST00000494055LMO7chr13

76423309

-HLTFchr3

148804317

-
5CDS-intronENST00000465261ENST00000481663LMO7chr13

76423309

-HLTFchr3

148804317

-
intron-intronENST00000605961ENST00000465259LMO7chr13

76423309

-HLTFchr3

148804317

-
intron-intronENST00000605961ENST00000310053LMO7chr13

76423309

-HLTFchr3

148804317

-
intron-intronENST00000605961ENST00000392912LMO7chr13

76423309

-HLTFchr3

148804317

-
intron-5UTRENST00000605961ENST00000494055LMO7chr13

76423309

-HLTFchr3

148804317

-
intron-intronENST00000605961ENST00000481663LMO7chr13

76423309

-HLTFchr3

148804317

-

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FusionProtFeatures for LMO7_HLTF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMO7

Q8WWI1

HLTF

Q14527

Has both helicase and E3 ubiquitin ligase activities.Possesses intrinsic ATP-dependent nucleosome-remodeling activity;This activity may be required for transcriptional activation orrepression of specific target promoters (By similarity). These mayinclude the SERPINE1 and HIV-1 promoters and the SV40 enhancer, towhich this protein can bind directly. Plays a role in error-freepostreplication repair (PRR) of damaged DNA and maintains genomicstability through acting as a ubiquitin ligase for 'Lys-63'-linkedpolyubiquitination of chromatin-bound PCNA. {ECO:0000250,ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:18316726,ECO:0000269|PubMed:18719106, ECO:0000269|PubMed:7876228,ECO:0000269|PubMed:8672239, ECO:0000269|PubMed:9126292}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LMO7_HLTF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LMO7_HLTF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LMO7_HLTF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LMO7_HLTF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHLTFC0022665Kidney Neoplasm1CTD_human