![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 1991 |
FusionGeneSummary for ANXA4_BCAR4 |
![]() |
Fusion gene information | Fusion gene name: ANXA4_BCAR4 | Fusion gene ID: 1991 | Hgene | Tgene | Gene symbol | ANXA4 | BCAR4 | Gene ID | 307 | 400500 |
Gene name | annexin A4 | breast cancer anti-estrogen resistance 4 | |
Synonyms | ANX4|HEL-S-274|P32.5|PAP-II|PIG28|PP4-X|ZAP36 | - | |
Cytomap | 2p13.3 | 16p13.13 | |
Type of gene | protein-coding | ncRNA | |
Description | annexin A435-beta calcimedinannexin IV (placental anticoagulant protein II)annexin-4carbohydrate-binding protein p33/p41chromobindin-4endonexin Iepididymis secretory protein Li 274lipocortin IVplacental anticoagulant protein IIproliferation-indu | breast cancer anti-estrogen resistance 4 (non-protein coding)breast cancer antiestrogen resistance 4 protein | |
Modification date | 20180519 | 20180517 | |
UniProtAcc | P09525 | ||
Ensembl transtripts involved in fusion gene | ENST00000418066, ENST00000409920, ENST00000394295, ENST00000536030, | ENST00000573319, | |
Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 15 X 4 X 8=480 |
# samples | 5 | 15 | |
** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/480*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ANXA4 [Title/Abstract] AND BCAR4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ANXA4 | GO:0006357 | regulation of transcription by RNA polymerase II | 20237821 |
Hgene | ANXA4 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 20237821 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCEC | TCGA-AJ-A6NU-01A | ANXA4 | chr2 | 69969307 | + | BCAR4 | chr16 | 11914154 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000418066 | ENST00000573319 | ANXA4 | chr2 | 69969307 | + | BCAR4 | chr16 | 11914154 | - |
5UTR-5UTR | ENST00000409920 | ENST00000573319 | ANXA4 | chr2 | 69969307 | + | BCAR4 | chr16 | 11914154 | - |
5UTR-5UTR | ENST00000394295 | ENST00000573319 | ANXA4 | chr2 | 69969307 | + | BCAR4 | chr16 | 11914154 | - |
5UTR-5UTR | ENST00000536030 | ENST00000573319 | ANXA4 | chr2 | 69969307 | + | BCAR4 | chr16 | 11914154 | - |
Top |
FusionProtFeatures for ANXA4_BCAR4 |
![]() |
Hgene | Tgene |
ANXA4 | BCAR4 |
Calcium/phospholipid-binding protein which promotesmembrane fusion and is involved in exocytosis. {ECO:0000250}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ANXA4_BCAR4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ANXA4_BCAR4 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ANXA4 | NFKB1, H2AFX, UCHL5, SMPD1, NMT2, TINF2, POT1, DNAJB11, ANXA7, MPST, ANXA3, ANXA1, PADI4, EZH2, RAB8A, RHOU, CDH1, SF3A3 | BCAR4 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ANXA4_BCAR4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ANXA4_BCAR4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ANXA4 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | ANXA4 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | ANXA4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | ANXA4 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | ANXA4 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | ANXA4 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | ANXA4 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | ANXA4 | C0032927 | Precancerous Conditions | 1 | CTD_human |
Hgene | ANXA4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | ANXA4 | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | BCAR4 | C1458155 | Mammary Neoplasms | 2 | CTD_human |