	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
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Fusion gene ID: 19898

FusionGeneSummary for LMNA_LMNA

Fusion gene summary

Fusion gene information	Fusion gene name: LMNA_LMNA
	Fusion gene ID: 19898
		Hgene	Tgene
	Gene symbol	LMNA	LMNA
	Gene ID	4000	4000
	Gene name	lamin A/C	lamin A/C
	Synonyms	CDCD1\|CDDC\|CMD1A\|CMT2B1\|EMD2\|FPL\|FPLD\|FPLD2\|HGPS\|IDC\|LDP1\|LFP\|LGMD1B\|LMN1\|LMNC\|LMNL1\|MADA\|PRO1	CDCD1\|CDDC\|CMD1A\|CMT2B1\|EMD2\|FPL\|FPLD\|FPLD2\|HGPS\|IDC\|LDP1\|LFP\|LGMD1B\|LMN1\|LMNC\|LMNL1\|MADA\|PRO1
	Cytomap	1q22	1q22
	Type of gene	protein-coding	protein-coding
	Description	lamin70 kDa laminlamin A/C-like 1mandibuloacral dysplasia type Aprelamin-A/Crenal carcinoma antigen NY-REN-32	lamin70 kDa laminlamin A/C-like 1mandibuloacral dysplasia type Aprelamin-A/Crenal carcinoma antigen NY-REN-32
	Modification date	20180523	20180523
	UniProtAcc	P02545	P02545
	Ensembl transtripts involved in fusion gene	ENST00000368301, ENST00000361308, ENST00000347559, ENST00000368300, ENST00000368299, ENST00000448611, ENST00000368297, ENST00000473598, ENST00000392353, ENST00000496738,	ENST00000368301, ENST00000361308, ENST00000347559, ENST00000368300, ENST00000368299, ENST00000448611, ENST00000368297, ENST00000473598, ENST00000392353, ENST00000496738,
Fusion gene scores	* DoF score	11 X 12 X 6=792	9 X 11 X 3=297
	# samples	14	11
	** MAII score	log2(14/792*10)=-2.50007360313464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/297*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LMNA [Title/Abstract] AND LMNA [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Transcription factor involved fusion gene, inframe and retained DNA-binding domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LMNA	GO:0090343	positive regulation of cell aging	20458013
Tgene	LMNA	GO:0090343	positive regulation of cell aging	20458013

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA852769	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
ChiTaRS3.1			AW793883	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
ChiTaRS3.1			AI184403	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000368301	ENST00000368301	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368301	ENST00000361308	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368301	ENST00000347559	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368301	ENST00000368300	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368301	ENST00000368299	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368301	ENST00000448611	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368301	ENST00000368297	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368301	ENST00000473598	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368301	ENST00000392353	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
5CDS-3UTR	ENST00000368301	ENST00000496738	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000361308	ENST00000368301	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000361308	ENST00000361308	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000361308	ENST00000347559	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000361308	ENST00000368300	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000361308	ENST00000368299	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000361308	ENST00000448611	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000361308	ENST00000368297	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000361308	ENST00000473598	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000361308	ENST00000392353	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
5CDS-3UTR	ENST00000361308	ENST00000496738	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000347559	ENST00000368301	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000347559	ENST00000361308	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000347559	ENST00000347559	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000347559	ENST00000368300	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000347559	ENST00000368299	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000347559	ENST00000448611	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000347559	ENST00000368297	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000347559	ENST00000473598	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000347559	ENST00000392353	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
5CDS-3UTR	ENST00000347559	ENST00000496738	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368300	ENST00000368301	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368300	ENST00000361308	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368300	ENST00000347559	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368300	ENST00000368300	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368300	ENST00000368299	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368300	ENST00000448611	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368300	ENST00000368297	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368300	ENST00000473598	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368300	ENST00000392353	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
5CDS-3UTR	ENST00000368300	ENST00000496738	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368299	ENST00000368301	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368299	ENST00000361308	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368299	ENST00000347559	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368299	ENST00000368300	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368299	ENST00000368299	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368299	ENST00000448611	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368299	ENST00000368297	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368299	ENST00000473598	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368299	ENST00000392353	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
5CDS-3UTR	ENST00000368299	ENST00000496738	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000448611	ENST00000368301	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000448611	ENST00000361308	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000448611	ENST00000347559	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000448611	ENST00000368300	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000448611	ENST00000368299	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000448611	ENST00000448611	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000448611	ENST00000368297	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000448611	ENST00000473598	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000448611	ENST00000392353	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
5CDS-3UTR	ENST00000448611	ENST00000496738	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368297	ENST00000368301	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368297	ENST00000361308	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368297	ENST00000347559	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368297	ENST00000368300	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368297	ENST00000368299	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368297	ENST00000448611	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368297	ENST00000368297	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368297	ENST00000473598	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000368297	ENST00000392353	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
5CDS-3UTR	ENST00000368297	ENST00000496738	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000473598	ENST00000368301	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000473598	ENST00000361308	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000473598	ENST00000347559	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000473598	ENST00000368300	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000473598	ENST00000368299	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000473598	ENST00000448611	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000473598	ENST00000368297	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000473598	ENST00000473598	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000473598	ENST00000392353	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
5CDS-3UTR	ENST00000473598	ENST00000496738	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000392353	ENST00000368301	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000392353	ENST00000361308	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000392353	ENST00000347559	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000392353	ENST00000368300	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000392353	ENST00000368299	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000392353	ENST00000448611	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000392353	ENST00000368297	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000392353	ENST00000473598	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
In-frame	ENST00000392353	ENST00000392353	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
5CDS-3UTR	ENST00000392353	ENST00000496738	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
3UTR-3CDS	ENST00000496738	ENST00000368301	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
3UTR-3CDS	ENST00000496738	ENST00000361308	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
3UTR-3CDS	ENST00000496738	ENST00000347559	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
3UTR-3CDS	ENST00000496738	ENST00000368300	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
3UTR-3CDS	ENST00000496738	ENST00000368299	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
3UTR-3CDS	ENST00000496738	ENST00000448611	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
3UTR-3CDS	ENST00000496738	ENST00000368297	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
3UTR-3CDS	ENST00000496738	ENST00000473598	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
3UTR-3CDS	ENST00000496738	ENST00000392353	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
3UTR-3UTR	ENST00000496738	ENST00000496738	LMNA	chr1	156104673	-	LMNA	chr1	156105753	+
intron-intron	ENST00000368301	ENST00000368301	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368301	ENST00000361308	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368301	ENST00000347559	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368301	ENST00000368300	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368301	ENST00000368299	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368301	ENST00000448611	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368301	ENST00000368297	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368301	ENST00000473598	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368301	ENST00000392353	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368301	ENST00000496738	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000361308	ENST00000368301	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000361308	ENST00000361308	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000361308	ENST00000347559	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000361308	ENST00000368300	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000361308	ENST00000368299	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000361308	ENST00000448611	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000361308	ENST00000368297	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000361308	ENST00000473598	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000361308	ENST00000392353	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000361308	ENST00000496738	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000347559	ENST00000368301	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000347559	ENST00000361308	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000347559	ENST00000347559	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000347559	ENST00000368300	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000347559	ENST00000368299	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000347559	ENST00000448611	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000347559	ENST00000368297	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000347559	ENST00000473598	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000347559	ENST00000392353	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000347559	ENST00000496738	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368300	ENST00000368301	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368300	ENST00000361308	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368300	ENST00000347559	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368300	ENST00000368300	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368300	ENST00000368299	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368300	ENST00000448611	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368300	ENST00000368297	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368300	ENST00000473598	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368300	ENST00000392353	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368300	ENST00000496738	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368299	ENST00000368301	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368299	ENST00000361308	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368299	ENST00000347559	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368299	ENST00000368300	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368299	ENST00000368299	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368299	ENST00000448611	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368299	ENST00000368297	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368299	ENST00000473598	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368299	ENST00000392353	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368299	ENST00000496738	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000448611	ENST00000368301	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000448611	ENST00000361308	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000448611	ENST00000347559	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000448611	ENST00000368300	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000448611	ENST00000368299	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000448611	ENST00000448611	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000448611	ENST00000368297	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000448611	ENST00000473598	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000448611	ENST00000392353	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000448611	ENST00000496738	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368297	ENST00000368301	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368297	ENST00000361308	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368297	ENST00000347559	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368297	ENST00000368300	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368297	ENST00000368299	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368297	ENST00000448611	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368297	ENST00000368297	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368297	ENST00000473598	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368297	ENST00000392353	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368297	ENST00000496738	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000473598	ENST00000368301	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000473598	ENST00000361308	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000473598	ENST00000347559	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000473598	ENST00000368300	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000473598	ENST00000368299	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000473598	ENST00000448611	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000473598	ENST00000368297	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000473598	ENST00000473598	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000473598	ENST00000392353	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000473598	ENST00000496738	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000392353	ENST00000368301	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000392353	ENST00000361308	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000392353	ENST00000347559	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000392353	ENST00000368300	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000392353	ENST00000368299	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000392353	ENST00000448611	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000392353	ENST00000368297	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000392353	ENST00000473598	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000392353	ENST00000392353	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000392353	ENST00000496738	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000496738	ENST00000368301	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000496738	ENST00000361308	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000496738	ENST00000347559	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000496738	ENST00000368300	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000496738	ENST00000368299	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000496738	ENST00000448611	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000496738	ENST00000368297	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000496738	ENST00000473598	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000496738	ENST00000392353	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000496738	ENST00000496738	LMNA	chr1	156099550	-	LMNA	chr1	156099391	+
intron-intron	ENST00000368301	ENST00000368301	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368301	ENST00000361308	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-3UTR	ENST00000368301	ENST00000347559	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-3UTR	ENST00000368301	ENST00000368300	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368301	ENST00000368299	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368301	ENST00000448611	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368301	ENST00000368297	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368301	ENST00000473598	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368301	ENST00000392353	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368301	ENST00000496738	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000361308	ENST00000368301	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000361308	ENST00000361308	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-3UTR	ENST00000361308	ENST00000347559	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-3UTR	ENST00000361308	ENST00000368300	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000361308	ENST00000368299	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000361308	ENST00000448611	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000361308	ENST00000368297	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000361308	ENST00000473598	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000361308	ENST00000392353	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000361308	ENST00000496738	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000347559	ENST00000368301	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000347559	ENST00000361308	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-3UTR	ENST00000347559	ENST00000347559	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-3UTR	ENST00000347559	ENST00000368300	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000347559	ENST00000368299	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000347559	ENST00000448611	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000347559	ENST00000368297	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000347559	ENST00000473598	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000347559	ENST00000392353	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000347559	ENST00000496738	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368300	ENST00000368301	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368300	ENST00000361308	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-3UTR	ENST00000368300	ENST00000347559	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-3UTR	ENST00000368300	ENST00000368300	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368300	ENST00000368299	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368300	ENST00000448611	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368300	ENST00000368297	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368300	ENST00000473598	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368300	ENST00000392353	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368300	ENST00000496738	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368299	ENST00000368301	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368299	ENST00000361308	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-3UTR	ENST00000368299	ENST00000347559	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-3UTR	ENST00000368299	ENST00000368300	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368299	ENST00000368299	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368299	ENST00000448611	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368299	ENST00000368297	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368299	ENST00000473598	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368299	ENST00000392353	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000368299	ENST00000496738	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000448611	ENST00000368301	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000448611	ENST00000361308	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-3UTR	ENST00000448611	ENST00000347559	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-3UTR	ENST00000448611	ENST00000368300	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000448611	ENST00000368299	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000448611	ENST00000448611	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000448611	ENST00000368297	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000448611	ENST00000473598	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000448611	ENST00000392353	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000448611	ENST00000496738	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368297	ENST00000368301	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368297	ENST00000361308	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-3UTR	ENST00000368297	ENST00000347559	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-3UTR	ENST00000368297	ENST00000368300	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368297	ENST00000368299	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368297	ENST00000448611	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368297	ENST00000368297	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368297	ENST00000473598	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368297	ENST00000392353	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000368297	ENST00000496738	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000473598	ENST00000368301	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000473598	ENST00000361308	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-3UTR	ENST00000473598	ENST00000347559	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-3UTR	ENST00000473598	ENST00000368300	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000473598	ENST00000368299	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000473598	ENST00000448611	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000473598	ENST00000368297	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000473598	ENST00000473598	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000473598	ENST00000392353	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000473598	ENST00000496738	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000392353	ENST00000368301	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000392353	ENST00000361308	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-3UTR	ENST00000392353	ENST00000347559	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-3UTR	ENST00000392353	ENST00000368300	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000392353	ENST00000368299	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000392353	ENST00000448611	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000392353	ENST00000368297	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000392353	ENST00000473598	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000392353	ENST00000392353	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
intron-intron	ENST00000392353	ENST00000496738	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000496738	ENST00000368301	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000496738	ENST00000361308	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-3UTR	ENST00000496738	ENST00000347559	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-3UTR	ENST00000496738	ENST00000368300	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000496738	ENST00000368299	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000496738	ENST00000448611	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000496738	ENST00000368297	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000496738	ENST00000473598	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000496738	ENST00000392353	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-
3UTR-intron	ENST00000496738	ENST00000496738	LMNA	chr1	156108918	-	LMNA	chr1	156109572	-

Top

FusionProtFeatures for LMNA_LMNA

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LMNA P02545	LMNA P02545

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

31_387

-83

635

Domain

IF rod

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

428_545

-83

635

Domain

LTD

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

31_387

-83

573

Domain

IF rod

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

428_545

-83

573

Domain

LTD

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

31_387

-71

665

Domain

IF rod

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

428_545

-71

665

Domain

LTD

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

31_387

-214

573

Domain

IF rod

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

428_545

-214

573

Domain

LTD

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

31_387

-15

575

Domain

IF rod

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

428_545

-15

575

Domain

LTD

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

417_422

-83

635

Motif

Nuclear localization signal

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

417_422

-83

573

Motif

Nuclear localization signal

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

417_422

-71

665

Motif

Nuclear localization signal

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

417_422

-214

573

Motif

Nuclear localization signal

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

417_422

-15

575

Motif

Nuclear localization signal

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

1_33

-83

635

Region

Note=Head

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

219_242

-83

635

Region

Note=Linker 2

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

243_383

-83

635

Region

Note=Coil 2

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

34_70

-83

635

Region

Note=Coil 1A

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

384_664

-83

635

Region

Note=Tail

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

71_80

-83

635

Region

Note=Linker 1

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

81_218

-83

635

Region

Note=Coil 1B

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

1_33

-83

573

Region

Note=Head

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

219_242

-83

573

Region

Note=Linker 2

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

243_383

-83

573

Region

Note=Coil 2

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

34_70

-83

573

Region

Note=Coil 1A

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

384_664

-83

573

Region

Note=Tail

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

71_80

-83

573

Region

Note=Linker 1

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

81_218

-83

573

Region

Note=Coil 1B

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

1_33

-71

665

Region

Note=Head

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

219_242

-71

665

Region

Note=Linker 2

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

243_383

-71

665

Region

Note=Coil 2

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

34_70

-71

665

Region

Note=Coil 1A

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

384_664

-71

665

Region

Note=Tail

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

71_80

-71

665

Region

Note=Linker 1

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

81_218

-71

665

Region

Note=Coil 1B

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

1_33

-214

573

Region

Note=Head

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

219_242

-214

573

Region

Note=Linker 2

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

243_383

-214

573

Region

Note=Coil 2

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

34_70

-214

573

Region

Note=Coil 1A

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

384_664

-214

573

Region

Note=Tail

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

71_80

-214

573

Region

Note=Linker 1

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

81_218

-214

573

Region

Note=Coil 1B

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

1_33

-15

575

Region

Note=Head

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

219_242

-15

575

Region

Note=Linker 2

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

243_383

-15

575

Region

Note=Coil 2

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

34_70

-15

575

Region

Note=Coil 1A

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

384_664

-15

575

Region

Note=Tail

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

71_80

-15

575

Region

Note=Linker 1

Tgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

81_218

-15

575

Region

Note=Coil 1B

- In-frame and not-retained protein feature among the 13 regional features.

>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

31_387

-83

635

Domain

IF rod

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

428_545

-83

635

Domain

LTD

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

31_387

-83

573

Domain

IF rod

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

428_545

-83

573

Domain

LTD

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

31_387

-71

665

Domain

IF rod

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

428_545

-71

665

Domain

LTD

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

31_387

-214

573

Domain

IF rod

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

428_545

-214

573

Domain

LTD

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

31_387

-15

575

Domain

IF rod

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

428_545

-15

575

Domain

LTD

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

417_422

-83

635

Motif

Nuclear localization signal

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

417_422

-83

573

Motif

Nuclear localization signal

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

417_422

-71

665

Motif

Nuclear localization signal

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

417_422

-214

573

Motif

Nuclear localization signal

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

417_422

-15

575

Motif

Nuclear localization signal

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

1_33

-83

635

Region

Note=Head

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

219_242

-83

635

Region

Note=Linker 2

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

243_383

-83

635

Region

Note=Coil 2

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

34_70

-83

635

Region

Note=Coil 1A

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

384_664

-83

635

Region

Note=Tail

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

71_80

-83

635

Region

Note=Linker 1

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000347559

81_218

-83

635

Region

Note=Coil 1B

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

1_33

-83

573

Region

Note=Head

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

219_242

-83

573

Region

Note=Linker 2

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

243_383

-83

573

Region

Note=Coil 2

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

34_70

-83

573

Region

Note=Coil 1A

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

384_664

-83

573

Region

Note=Tail

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

71_80

-83

573

Region

Note=Linker 1

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000361308

81_218

-83

573

Region

Note=Coil 1B

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

1_33

-71

665

Region

Note=Head

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

219_242

-71

665

Region

Note=Linker 2

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

243_383

-71

665

Region

Note=Coil 2

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

34_70

-71

665

Region

Note=Coil 1A

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

384_664

-71

665

Region

Note=Tail

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

71_80

-71

665

Region

Note=Linker 1

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368300

81_218

-71

665

Region

Note=Coil 1B

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

1_33

-214

573

Region

Note=Head

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

219_242

-214

573

Region

Note=Linker 2

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

243_383

-214

573

Region

Note=Coil 2

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

34_70

-214

573

Region

Note=Coil 1A

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

384_664

-214

573

Region

Note=Tail

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

71_80

-214

573

Region

Note=Linker 1

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000368301

81_218

-214

573

Region

Note=Coil 1B

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

1_33

-15

575

Region

Note=Head

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

219_242

-15

575

Region

Note=Linker 2

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

243_383

-15

575

Region

Note=Coil 2

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

34_70

-15

575

Region

Note=Coil 1A

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

384_664

-15

575

Region

Note=Tail

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

71_80

-15

575

Region

Note=Linker 1

Hgene

LMNA

chr1:156104673

chr1:156105753

ENST00000448611

81_218

-15

575

Region

Note=Coil 1B

Top

FusionGeneSequence for LMNA_LMNA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LMNA_LMNA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	LMNA	chr1:156104673	chr1:156105753	ENST00000347559	+	0	11	1_130	-83	635	MLIP
Tgene	LMNA	chr1:156104673	chr1:156105753	ENST00000361308	+	0	10	1_130	-83	573	MLIP
Tgene	LMNA	chr1:156104673	chr1:156105753	ENST00000368300	+	0	12	1_130	-71	665	MLIP
Tgene	LMNA	chr1:156104673	chr1:156105753	ENST00000368301	+	0	13	1_130	-214	573	MLIP
Tgene	LMNA	chr1:156104673	chr1:156105753	ENST00000448611	+	0	13	1_130	-15	575	MLIP

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	LMNA	chr1:156104673	chr1:156105753	ENST00000347559	+	1	11	1_130	-83	635	MLIP
Hgene	LMNA	chr1:156104673	chr1:156105753	ENST00000361308	+	1	10	1_130	-83	573	MLIP
Hgene	LMNA	chr1:156104673	chr1:156105753	ENST00000368300	+	1	12	1_130	-71	665	MLIP
Hgene	LMNA	chr1:156104673	chr1:156105753	ENST00000368301	+	1	13	1_130	-214	573	MLIP
Hgene	LMNA	chr1:156104673	chr1:156105753	ENST00000448611	+	1	13	1_130	-15	575	MLIP

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for LMNA_LMNA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for LMNA_LMNA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	LMNA	C0410190	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	19	ORPHANET;UNIPROT
Hgene	LMNA	C1449563	Cardiomyopathy, Familial Idiopathic	17	ORPHANET;UNIPROT
Hgene	LMNA	C0033300	Progeria	14	CTD_human;ORPHANET;UNIPROT
Hgene	LMNA	C1720860	Familial Partial Lipodystrophy, Type 2	10	ORPHANET;UNIPROT
Hgene	LMNA	C1834653	MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1B (disorder)	7	CTD_human;ORPHANET;UNIPROT
Hgene	LMNA	C0432291	Mandibuloacral dysostosis	5	CTD_human;ORPHANET;UNIPROT
Hgene	LMNA	C0271694	Familial partial lipodystrophy	4	CTD_human
Hgene	LMNA	C0007193	Cardiomyopathy, Dilated	3	CTD_human;HPO
Hgene	LMNA	C0796031	Malouf syndrome	3	ORPHANET;UNIPROT
Hgene	LMNA	C2750035	Emery-Dreifuss Muscular Dystrophy 3	2	UNIPROT
Hgene	LMNA	C2750785	MUSCULAR DYSTROPHY, CONGENITAL, LMNA-RELATED (disorder)	2	CTD_human;ORPHANET;UNIPROT
Hgene	LMNA	C0016508	Congenital Foot Deformity	1	CTD_human
Hgene	LMNA	C0018566	Congenital Hand Deformities	1	CTD_human
Hgene	LMNA	C0018794	Heart Block	1	CTD_human
Hgene	LMNA	C0032460	Polycystic Ovary Syndrome	1	CTD_human;HPO
Hgene	LMNA	C0036420	Localized scleroderma	1	CTD_human
Hgene	LMNA	C0037188	Sinoatrial Block	1	CTD_human
Hgene	LMNA	C0042514	Tachycardia, Ventricular	1	CTD_human
Hgene	LMNA	C0085298	Sudden Cardiac Death	1	CTD_human;HPO
Hgene	LMNA	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Hgene	LMNA	C0376634	Craniofacial Abnormalities	1	CTD_human
Hgene	LMNA	C0410189	Muscular Dystrophy, Emery-Dreifuss	1	CTD_human
Hgene	LMNA	C0686353	Muscular Dystrophies, Limb-Girdle	1	CTD_human;HPO
Hgene	LMNA	C1136321	HIV-Associated Lipodystrophy Syndrome	1	CTD_human
Hgene	LMNA	C1854154	Charcot-Marie-Tooth disease, Type 2B1	1	CTD_human;ORPHANET;UNIPROT
Tgene	LMNA	C0410190	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	19	ORPHANET;UNIPROT
Tgene	LMNA	C1449563	Cardiomyopathy, Familial Idiopathic	17	ORPHANET;UNIPROT
Tgene	LMNA	C0033300	Progeria	14	CTD_human;ORPHANET;UNIPROT
Tgene	LMNA	C1720860	Familial Partial Lipodystrophy, Type 2	10	ORPHANET;UNIPROT
Tgene	LMNA	C1834653	MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1B (disorder)	7	CTD_human;ORPHANET;UNIPROT
Tgene	LMNA	C0432291	Mandibuloacral dysostosis	5	CTD_human;ORPHANET;UNIPROT
Tgene	LMNA	C0271694	Familial partial lipodystrophy	4	CTD_human
Tgene	LMNA	C0007193	Cardiomyopathy, Dilated	3	CTD_human;HPO
Tgene	LMNA	C0796031	Malouf syndrome	3	ORPHANET;UNIPROT
Tgene	LMNA	C2750035	Emery-Dreifuss Muscular Dystrophy 3	2	UNIPROT
Tgene	LMNA	C2750785	MUSCULAR DYSTROPHY, CONGENITAL, LMNA-RELATED (disorder)	2	CTD_human;ORPHANET;UNIPROT
Tgene	LMNA	C0016508	Congenital Foot Deformity	1	CTD_human
Tgene	LMNA	C0018566	Congenital Hand Deformities	1	CTD_human
Tgene	LMNA	C0018794	Heart Block	1	CTD_human
Tgene	LMNA	C0032460	Polycystic Ovary Syndrome	1	CTD_human;HPO
Tgene	LMNA	C0036420	Localized scleroderma	1	CTD_human
Tgene	LMNA	C0037188	Sinoatrial Block	1	CTD_human
Tgene	LMNA	C0042514	Tachycardia, Ventricular	1	CTD_human
Tgene	LMNA	C0085298	Sudden Cardiac Death	1	CTD_human;HPO
Tgene	LMNA	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Tgene	LMNA	C0376634	Craniofacial Abnormalities	1	CTD_human
Tgene	LMNA	C0410189	Muscular Dystrophy, Emery-Dreifuss	1	CTD_human
Tgene	LMNA	C0686353	Muscular Dystrophies, Limb-Girdle	1	CTD_human;HPO
Tgene	LMNA	C1136321	HIV-Associated Lipodystrophy Syndrome	1	CTD_human
Tgene	LMNA	C1854154	Charcot-Marie-Tooth disease, Type 2B1	1	CTD_human;ORPHANET;UNIPROT

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Fusion gene ID: 19898

FusionGeneSummary for LMNA_LMNA

FusionProtFeatures for LMNA_LMNA

FusionGeneSequence for LMNA_LMNA

FusionGenePPI for LMNA_LMNA

RelatedDrugs for LMNA_LMNA

RelatedDiseases for LMNA_LMNA