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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1989

FusionGeneSummary for ANXA3_BMP2K

check button Fusion gene summary
Fusion gene informationFusion gene name: ANXA3_BMP2K
Fusion gene ID: 1989
HgeneTgene
Gene symbol

ANXA3

BMP2K

Gene ID

306

55589

Gene nameannexin A3BMP2 inducible kinase
SynonymsANX3BIKE|HRIHFB2017
Cytomap

4q21.21

4q21.21

Type of geneprotein-codingprotein-coding
Descriptionannexin A335-alpha calcimedinAnnexin III (lipocortin III)PAP-IIIannexin III (lipocortin III, 1,2-cyclic-inositol-phosphate phosphodiesterase, placental anticoagulant protein III, calcimedin 35-alpha)annexin-3calcimedin 35-alphainositol 1,2-cyclic pBMP-2-inducible protein kinase
Modification date2018051920180523
UniProtAcc

P12429

Q9NSY1

Ensembl transtripts involved in fusion geneENST00000264908, ENST00000512884, 
ENST00000503570, 
ENST00000335016, 
ENST00000502871, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANXA3 [Title/Abstract] AND BMP2K [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANXA3

GO:0006909

phagocytosis

9497492

HgeneANXA3

GO:0010595

positive regulation of endothelial cell migration

16236264

HgeneANXA3

GO:0042742

defense response to bacterium

9497492

HgeneANXA3

GO:0043312

neutrophil degranulation

9550422

HgeneANXA3

GO:0045766

positive regulation of angiogenesis

16236264

HgeneANXA3

GO:0051091

positive regulation of DNA binding transcription factor activity

16236264


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A1JA-01AANXA3chr4

79475642

+BMP2Kchr4

79831764

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000264908ENST00000335016ANXA3chr4

79475642

+BMP2Kchr4

79831764

+
5CDS-intronENST00000264908ENST00000502871ANXA3chr4

79475642

+BMP2Kchr4

79831764

+
5UTR-3CDSENST00000512884ENST00000335016ANXA3chr4

79475642

+BMP2Kchr4

79831764

+
5UTR-intronENST00000512884ENST00000502871ANXA3chr4

79475642

+BMP2Kchr4

79831764

+
5UTR-3CDSENST00000503570ENST00000335016ANXA3chr4

79475642

+BMP2Kchr4

79831764

+
5UTR-intronENST00000503570ENST00000502871ANXA3chr4

79475642

+BMP2Kchr4

79831764

+

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FusionProtFeatures for ANXA3_BMP2K


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANXA3

P12429

BMP2K

Q9NSY1

Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol1,2-cyclic phosphate to form inositol 1-phosphate. May be involved in osteoblast differentiation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANXA3_BMP2K


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANXA3_BMP2K


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANXA3IGSF21, TP53, UBR1, UNC119, ISG15, STX4, ANXA11, STXBP2, ANXA4, SNAP23, ATF2, PPP2R4, SSNA1, TESBMP2KKDM5B, TERF1, TERF2, ABL1, EPS15, AP2M1, FN1, SLC25A41, LIMS1, XPO1, CAPZA2, CDK2, CLTB, CLTC, DBN1, FLNA, GAK, GBA, MYH9, PPP1CB, PICALM, IQGAP1, PDLIM7, SEC16A, SYNPO, LIMA1, GTSE1, ANLN, MYO19, MYO18A, AP2S1, CLINT1, REPS1, STAMBP, STAMBPL1, RALBP1, INTS4, RUNDC3A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANXA3_BMP2K


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneANXA3P12429DB09095DifluocortoloneAnnexin A3small moleculeapproved|investigational|withdrawn

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RelatedDiseases for ANXA3_BMP2K


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANXA3C0003873Rheumatoid Arthritis1CTD_human
HgeneANXA3C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneANXA3C0024141Lupus Erythematosus, Systemic1CTD_human
HgeneANXA3C0033578Prostatic Neoplasms1CTD_human
HgeneANXA3C0919267ovarian neoplasm1CTD_human