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Fusion gene ID: 1986 |
FusionGeneSummary for ANXA2_SLC51A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANXA2_SLC51A | Fusion gene ID: 1986 | Hgene | Tgene | Gene symbol | ANXA2 | SLC51A | Gene ID | 302 | 200931 |
| Gene name | annexin A2 | solute carrier family 51 alpha subunit | |
| Synonyms | ANX2|ANX2L4|CAL1H|HEL-S-270|LIP2|LPC2|LPC2D|P36|PAP-IV | OSTA|OSTalpha | |
| Cytomap | 15q22.2 | 3q29 | |
| Type of gene | protein-coding | protein-coding | |
| Description | annexin A2annexin IIannexin-2calpactin I heavy chaincalpactin I heavy polypeptidecalpactin-1 heavy chainchromobindin 8epididymis secretory protein Li 270lipocortin IIplacental anticoagulant protein IVprotein I | organic solute transporter subunit alphaOST-alphaorganic solute transporter alphaorganic solute transporter, alpha subunitsolute carrier family 51 subunit alpha | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P07355 | Q86UW1 | |
| Ensembl transtripts involved in fusion gene | ENST00000396024, ENST00000451270, ENST00000332680, ENST00000421017, ENST00000557937, | ENST00000296327, ENST00000479732, | |
| Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ANXA2 [Title/Abstract] AND SLC51A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ANXA2 | GO:0001921 | positive regulation of receptor recycling | 22848640 |
| Hgene | ANXA2 | GO:0031340 | positive regulation of vesicle fusion | 2138016 |
| Hgene | ANXA2 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process | 22848640 |
| Hgene | ANXA2 | GO:0036035 | osteoclast development | 7961821 |
| Hgene | ANXA2 | GO:0051290 | protein heterotetramerization | 23091277|23861394 |
| Hgene | ANXA2 | GO:1905581 | positive regulation of low-density lipoprotein particle clearance | 22848640 |
| Hgene | ANXA2 | GO:1905597 | positive regulation of low-density lipoprotein particle receptor binding | 22848640 |
| Hgene | ANXA2 | GO:1905602 | positive regulation of receptor-mediated endocytosis involved in cholesterol transport | 22848640 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-CG-4437-01A | ANXA2 | chr15 | 60653140 | - | SLC51A | chr3 | 195959290 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000396024 | ENST00000296327 | ANXA2 | chr15 | 60653140 | - | SLC51A | chr3 | 195959290 | + |
| 5CDS-intron | ENST00000396024 | ENST00000479732 | ANXA2 | chr15 | 60653140 | - | SLC51A | chr3 | 195959290 | + |
| In-frame | ENST00000451270 | ENST00000296327 | ANXA2 | chr15 | 60653140 | - | SLC51A | chr3 | 195959290 | + |
| 5CDS-intron | ENST00000451270 | ENST00000479732 | ANXA2 | chr15 | 60653140 | - | SLC51A | chr3 | 195959290 | + |
| In-frame | ENST00000332680 | ENST00000296327 | ANXA2 | chr15 | 60653140 | - | SLC51A | chr3 | 195959290 | + |
| 5CDS-intron | ENST00000332680 | ENST00000479732 | ANXA2 | chr15 | 60653140 | - | SLC51A | chr3 | 195959290 | + |
| In-frame | ENST00000421017 | ENST00000296327 | ANXA2 | chr15 | 60653140 | - | SLC51A | chr3 | 195959290 | + |
| 5CDS-intron | ENST00000421017 | ENST00000479732 | ANXA2 | chr15 | 60653140 | - | SLC51A | chr3 | 195959290 | + |
| intron-3CDS | ENST00000557937 | ENST00000296327 | ANXA2 | chr15 | 60653140 | - | SLC51A | chr3 | 195959290 | + |
| intron-intron | ENST00000557937 | ENST00000479732 | ANXA2 | chr15 | 60653140 | - | SLC51A | chr3 | 195959290 | + |
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FusionProtFeatures for ANXA2_SLC51A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANXA2 | SLC51A |
| Calcium-regulated membrane-binding protein whoseaffinity for calcium is greatly enhanced by anionic phospholipids.It binds two calcium ions with high affinity. May be involved inheat-stress response. Inhibits PCSK9-enhanced LDLR degradation,probably reduces PCSK9 protein levels via a translationalmechanism but also competes with LDLR for binding with PCSK9(PubMed:18799458, PubMed:24808179, PubMed:22848640).{ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640,ECO:0000269|PubMed:24808179}. | Essential component of the Ost-alpha/Ost-beta complex, aheterodimer that acts as the intestinal basolateral transporterresponsible for bile acid export from enterocytes into portalblood. Efficiently transports the major species of bile acids.{ECO:0000269|PubMed:16317684}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000332680 | - | 5 | 13 | 2_24 | 137 | 358 | Region | S100A10-binding site |
| Hgene | ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000396024 | - | 6 | 14 | 2_24 | 119 | 340 | Region | S100A10-binding site |
| Hgene | ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000421017 | - | 6 | 14 | 2_24 | 119 | 340 | Region | S100A10-binding site |
| Hgene | ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000451270 | - | 5 | 13 | 2_24 | 119 | 340 | Region | S100A10-binding site |
| Hgene | ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000332680 | - | 5 | 13 | 42_102 | 137 | 358 | Repeat | Note=Annexin 1 |
| Hgene | ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000396024 | - | 6 | 14 | 42_102 | 119 | 340 | Repeat | Note=Annexin 1 |
| Hgene | ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000421017 | - | 6 | 14 | 42_102 | 119 | 340 | Repeat | Note=Annexin 1 |
| Hgene | ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000451270 | - | 5 | 13 | 42_102 | 119 | 340 | Repeat | Note=Annexin 1 |
| Tgene | >SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 277_294 | 260 | 341 | Topological domain | Extracellular |
| Tgene | >SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 318_340 | 260 | 341 | Topological domain | Cytoplasmic |
| Tgene | >SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 295_317 | 260 | 341 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000332680 | - | 5 | 13 | 114_174 | 137 | 358 | Repeat | Note=Annexin 2 |
| Hgene | >ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000332680 | - | 5 | 13 | 199_259 | 137 | 358 | Repeat | Note=Annexin 3 |
| Hgene | >ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000332680 | - | 5 | 13 | 274_334 | 137 | 358 | Repeat | Note=Annexin 4 |
| Hgene | >ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000396024 | - | 6 | 14 | 114_174 | 119 | 340 | Repeat | Note=Annexin 2 |
| Hgene | >ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000396024 | - | 6 | 14 | 199_259 | 119 | 340 | Repeat | Note=Annexin 3 |
| Hgene | >ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000396024 | - | 6 | 14 | 274_334 | 119 | 340 | Repeat | Note=Annexin 4 |
| Hgene | >ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000421017 | - | 6 | 14 | 114_174 | 119 | 340 | Repeat | Note=Annexin 2 |
| Hgene | >ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000421017 | - | 6 | 14 | 199_259 | 119 | 340 | Repeat | Note=Annexin 3 |
| Hgene | >ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000421017 | - | 6 | 14 | 274_334 | 119 | 340 | Repeat | Note=Annexin 4 |
| Hgene | >ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000451270 | - | 5 | 13 | 114_174 | 119 | 340 | Repeat | Note=Annexin 2 |
| Hgene | >ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000451270 | - | 5 | 13 | 199_259 | 119 | 340 | Repeat | Note=Annexin 3 |
| Hgene | >ANXA2 | chr15:60653140 | chr3:195959290 | ENST00000451270 | - | 5 | 13 | 274_334 | 119 | 340 | Repeat | Note=Annexin 4 |
| Tgene | SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 160_167 | 260 | 341 | Compositional bias | Note=Poly-Cys |
| Tgene | SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 109_118 | 260 | 341 | Topological domain | Extracellular |
| Tgene | SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 140_181 | 260 | 341 | Topological domain | Cytoplasmic |
| Tgene | SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 1_48 | 260 | 341 | Topological domain | Extracellular |
| Tgene | SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 203_218 | 260 | 341 | Topological domain | Extracellular |
| Tgene | SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 240_255 | 260 | 341 | Topological domain | Cytoplasmic |
| Tgene | SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 70_87 | 260 | 341 | Topological domain | Cytoplasmic |
| Tgene | SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 119_139 | 260 | 341 | Transmembrane | Helical |
| Tgene | SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 182_202 | 260 | 341 | Transmembrane | Helical |
| Tgene | SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 219_239 | 260 | 341 | Transmembrane | Helical |
| Tgene | SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 256_276 | 260 | 341 | Transmembrane | Helical |
| Tgene | SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 49_69 | 260 | 341 | Transmembrane | Helical |
| Tgene | SLC51A | chr15:60653140 | chr3:195959290 | ENST00000296327 | + | 6 | 9 | 88_108 | 260 | 341 | Transmembrane | Helical |
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FusionGeneSequence for ANXA2_SLC51A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ANXA2_ENST00000396024_chr15_60653140_-_SLC51A_ENST00000296327_chr3_195959290_+_200aa MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKVLLILTALQPSIFSVLANGGQIACSPPYSSKTRSQVMNCHLLILETFLMTVLTRMYYRRKD >In-frame_ANXA2_ENST00000451270_chr15_60653140_-_SLC51A_ENST00000296327_chr3_195959290_+_200aa MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKVLLILTALQPSIFSVLANGGQIACSPPYSSKTRSQVMNCHLLILETFLMTVLTRMYYRRKD >In-frame_ANXA2_ENST00000332680_chr15_60653140_-_SLC51A_ENST00000296327_chr3_195959290_+_218aa MGRQLAGCGDAGKKASFKMSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIA FAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKVLLILTALQPSIFSVLANGGQIACSPPYSSKTRSQVMNCHLLI >In-frame_ANXA2_ENST00000421017_chr15_60653140_-_SLC51A_ENST00000296327_chr3_195959290_+_200aa MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKVLLILTALQPSIFSVLANGGQIACSPPYSSKTRSQVMNCHLLILETFLMTVLTRMYYRRKD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ANXA2_ENST00000396024_chr15_60653140_-_SLC51A_ENST00000296327_chr3_195959290_+_600nt ATGTCTACTGTTCACGAAATCCTGTGCAAGCTCAGCTTGGAGGGTGATCACTCTACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTAT ACTAACTTTGATGCTGAGCGGGATGCTTTGAACATTGAAACAGCCATCAAGACCAAAGGTGTGGATGAGGTCACCATTGTCAACATTTTG ACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCC TTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGTT CTCCTCATCCTGACTGCCCTACAGCCCTCCATCTTCTCAGTCTTGGCCAACGGTGGGCAGATTGCTTGTTCGCCTCCCTATTCCTCTAAA ACCAGGTCTCAAGTGATGAATTGCCACCTCCTCATACTGGAGACTTTTCTAATGACTGTGCTGACACGAATGTACTACCGAAGGAAAGAC >In-frame_ANXA2_ENST00000451270_chr15_60653140_-_SLC51A_ENST00000296327_chr3_195959290_+_600nt ATGTCTACTGTTCACGAAATCCTGTGCAAGCTCAGCTTGGAGGGTGATCACTCTACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTAT ACTAACTTTGATGCTGAGCGGGATGCTTTGAACATTGAAACAGCCATCAAGACCAAAGGTGTGGATGAGGTCACCATTGTCAACATTTTG ACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCC TTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGTT CTCCTCATCCTGACTGCCCTACAGCCCTCCATCTTCTCAGTCTTGGCCAACGGTGGGCAGATTGCTTGTTCGCCTCCCTATTCCTCTAAA ACCAGGTCTCAAGTGATGAATTGCCACCTCCTCATACTGGAGACTTTTCTAATGACTGTGCTGACACGAATGTACTACCGAAGGAAAGAC >In-frame_ANXA2_ENST00000332680_chr15_60653140_-_SLC51A_ENST00000296327_chr3_195959290_+_654nt ATGGGCCGCCAGCTAGCGGGGTGTGGAGACGCTGGGAAGAAGGCTTCCTTCAAAATGTCTACTGTTCACGAAATCCTGTGCAAGCTCAGC TTGGAGGGTGATCACTCTACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTATACTAACTTTGATGCTGAGCGGGATGCTTTGAACATT GAAACAGCCATCAAGACCAAAGGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCC TTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTA TTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGTTCTCCTCATCCTGACTGCCCTACAGCCCTCCATCTTC TCAGTCTTGGCCAACGGTGGGCAGATTGCTTGTTCGCCTCCCTATTCCTCTAAAACCAGGTCTCAAGTGATGAATTGCCACCTCCTCATA CTGGAGACTTTTCTAATGACTGTGCTGACACGAATGTACTACCGAAGGAAAGACCACAAGGTTGGGTATGAAACTTTCTCTTCTCCAGAC >In-frame_ANXA2_ENST00000421017_chr15_60653140_-_SLC51A_ENST00000296327_chr3_195959290_+_600nt ATGTCTACTGTTCACGAAATCCTGTGCAAGCTCAGCTTGGAGGGTGATCACTCTACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTAT ACTAACTTTGATGCTGAGCGGGATGCTTTGAACATTGAAACAGCCATCAAGACCAAAGGTGTGGATGAGGTCACCATTGTCAACATTTTG ACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCC TTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGTT CTCCTCATCCTGACTGCCCTACAGCCCTCCATCTTCTCAGTCTTGGCCAACGGTGGGCAGATTGCTTGTTCGCCTCCCTATTCCTCTAAA ACCAGGTCTCAAGTGATGAATTGCCACCTCCTCATACTGGAGACTTTTCTAATGACTGTGCTGACACGAATGTACTACCGAAGGAAAGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ANXA2_ENST00000396024_chr15_60653140_-_SLC51A_ENST00000296327_chr3_195959290_+_991nt GCTCAGCATTTGGGGACGCTCTCAGCTCTCGGCGCACGGCCCAGGGTGAAAATGTTTGCCATTAAACTCACATGAAGTAGGAAATATTTA TATGGATACAAAAGGCACCTGCATGGGATAATGTCAAATTTCATAGATACTGCTTTGTGCTTCCTTCAAAATGTCTACTGTTCACGAAAT CCTGTGCAAGCTCAGCTTGGAGGGTGATCACTCTACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTATACTAACTTTGATGCTGAGCG GGATGCTTTGAACATTGAAACAGCCATCAAGACCAAAGGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACA GAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGAC GGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGTTCTCCTCATCCTGACTGCCCT ACAGCCCTCCATCTTCTCAGTCTTGGCCAACGGTGGGCAGATTGCTTGTTCGCCTCCCTATTCCTCTAAAACCAGGTCTCAAGTGATGAA TTGCCACCTCCTCATACTGGAGACTTTTCTAATGACTGTGCTGACACGAATGTACTACCGAAGGAAAGACCACAAGGTTGGGTATGAAAC TTTCTCTTCTCCAGACCTGGACTTGAACCTCAAAGCCTAAGGTGGATGGCTTGGACAATGAAAGGATGCTGTACTCATTAGAATACAAGA TTCCTTTACTGTCCCTCAACCTTGACCAAATGGGAAGCATTCCCCCTTGTCAACACAAGCTGGCAGATACATTTGACTCTACAGATGAAG GTGAACAATGTTAGAATAAAATTGCTTTGGATCTTGCCTGGAAGGTGTTTTAAGTTTTGTAATAAACAAGATGATGTCTGAAAATGTGTA >In-frame_ANXA2_ENST00000451270_chr15_60653140_-_SLC51A_ENST00000296327_chr3_195959290_+_943nt GCCTCGCCTAGGGAGGATGTGGCGGGTATAAAAGCCCCACCCAGGCCAGCCGGCTCTGCTCAGCATTTGGGGACGCTCTCAGCTCTCGGC GCACGGCCCAGCTTCCTTCAAAATGTCTACTGTTCACGAAATCCTGTGCAAGCTCAGCTTGGAGGGTGATCACTCTACACCCCCAAGTGC ATATGGGTCTGTCAAAGCCTATACTAACTTTGATGCTGAGCGGGATGCTTTGAACATTGAAACAGCCATCAAGACCAAAGGTGTGGATGA GGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACT TGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGA GCTAAAAGCTTCCATGAAGGTTCTCCTCATCCTGACTGCCCTACAGCCCTCCATCTTCTCAGTCTTGGCCAACGGTGGGCAGATTGCTTG TTCGCCTCCCTATTCCTCTAAAACCAGGTCTCAAGTGATGAATTGCCACCTCCTCATACTGGAGACTTTTCTAATGACTGTGCTGACACG AATGTACTACCGAAGGAAAGACCACAAGGTTGGGTATGAAACTTTCTCTTCTCCAGACCTGGACTTGAACCTCAAAGCCTAAGGTGGATG GCTTGGACAATGAAAGGATGCTGTACTCATTAGAATACAAGATTCCTTTACTGTCCCTCAACCTTGACCAAATGGGAAGCATTCCCCCTT GTCAACACAAGCTGGCAGATACATTTGACTCTACAGATGAAGGTGAACAATGTTAGAATAAAATTGCTTTGGATCTTGCCTGGAAGGTGT >In-frame_ANXA2_ENST00000332680_chr15_60653140_-_SLC51A_ENST00000296327_chr3_195959290_+_957nt CTCAGCATTTGGGGACGCTCTCAGCTCTCGGCGCACGGCCCAGGTAAGCGGGGCGCGCCCTGCCCGCCCGCGATGGGCCGCCAGCTAGCG GGGTGTGGAGACGCTGGGAAGAAGGCTTCCTTCAAAATGTCTACTGTTCACGAAATCCTGTGCAAGCTCAGCTTGGAGGGTGATCACTCT ACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTATACTAACTTTGATGCTGAGCGGGATGCTTTGAACATTGAAACAGCCATCAAGACC AAAGGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGG ACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAG TATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGTTCTCCTCATCCTGACTGCCCTACAGCCCTCCATCTTCTCAGTCTTGGCCAACGGT GGGCAGATTGCTTGTTCGCCTCCCTATTCCTCTAAAACCAGGTCTCAAGTGATGAATTGCCACCTCCTCATACTGGAGACTTTTCTAATG ACTGTGCTGACACGAATGTACTACCGAAGGAAAGACCACAAGGTTGGGTATGAAACTTTCTCTTCTCCAGACCTGGACTTGAACCTCAAA GCCTAAGGTGGATGGCTTGGACAATGAAAGGATGCTGTACTCATTAGAATACAAGATTCCTTTACTGTCCCTCAACCTTGACCAAATGGG AAGCATTCCCCCTTGTCAACACAAGCTGGCAGATACATTTGACTCTACAGATGAAGGTGAACAATGTTAGAATAAAATTGCTTTGGATCT >In-frame_ANXA2_ENST00000421017_chr15_60653140_-_SLC51A_ENST00000296327_chr3_195959290_+_967nt GCTCAGCATTTGGGGACGCTCTCAGCTCTCGGCGCACGGCCCAGGTTATCTTGTAGCATAGCAACTTCGGATTTCACTCTACCCGGAGAG TTTCCCGCTTGGTTGAACACATTGGCCTCAGGAAGCTTCCTTCAAAATGTCTACTGTTCACGAAATCCTGTGCAAGCTCAGCTTGGAGGG TGATCACTCTACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTATACTAACTTTGATGCTGAGCGGGATGCTTTGAACATTGAAACAGC CATCAAGACCAAAGGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTA CCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGAC ACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGTTCTCCTCATCCTGACTGCCCTACAGCCCTCCATCTTCTCAGTCTT GGCCAACGGTGGGCAGATTGCTTGTTCGCCTCCCTATTCCTCTAAAACCAGGTCTCAAGTGATGAATTGCCACCTCCTCATACTGGAGAC TTTTCTAATGACTGTGCTGACACGAATGTACTACCGAAGGAAAGACCACAAGGTTGGGTATGAAACTTTCTCTTCTCCAGACCTGGACTT GAACCTCAAAGCCTAAGGTGGATGGCTTGGACAATGAAAGGATGCTGTACTCATTAGAATACAAGATTCCTTTACTGTCCCTCAACCTTG ACCAAATGGGAAGCATTCCCCCTTGTCAACACAAGCTGGCAGATACATTTGACTCTACAGATGAAGGTGAACAATGTTAGAATAAAATTG |
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FusionGenePPI for ANXA2_SLC51A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ANXA2 | PPM1B, CEACAM1, TRPV5, PHB, CTSB, PLAT, SOS1, GRB2, PCNA, S100A10, APOH, STAT6, MGMT, H2AFX, CD4, CDK7, NCOA3, EP300, UBE3A, ARRB1, ARRB2, SP1, ISG15, TERF1, POT1, CUL2, CDK2, PPP2R1A, MID1, CD99, MYOC, CDK9, SHC1, APP, GNB2L1, RPS13, RPL11, ESR1, HNF1A, VCP, MYC, FN1, VCAM1, IQCB1, MLH1, ITGA4, TP53, NPM1, HMGA1, TERT, BAG3, ATP4A, YWHAQ, PARK2, DNAJC8, LOC100128588, RPA3, RPA2, RPA1, WWOX, ASB9, SPRTN, PLA2G4A, CUL7, OBSL1, CCDC8, SIRT6, ANXA13, MAP1S, RPS6KB2, HNRNPA1, ANXA11, CACYBP, FUBP1, LGALS1, NCKAP1L, PRDX2, RAB7A, EWSR1, PCBP2, PDCD6, NTRK1, PTEN, DBN1, FLNA, MYH9, PPP1CB, IQGAP1, SYNPO, LIMA1, MYO19, MYO18A, FBXL12, MCM2, MCM5, ERBB3, ERRFI1, ESRRB, U2AF2, RAB14, CDC73, CDH1, AHNAK2, KLHL42, CYLD, DLST, HSD17B10, PDHA1, SOAT1, STAT3, TRIM25, UBE2A, RSC1A1, DCAF4L2 | SLC51A | ATXN1, ANO6, TMEM63A, UBB, FAM8A1, KIAA1715 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANXA2_SLC51A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ANXA2 | P07355 | DB00031 | Tenecteplase | Annexin A2 | biotech | approved |
| Hgene | ANXA2 | P07355 | DB11638 | Artenimol | Annexin A2 | small molecule | approved|investigational |
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RelatedDiseases for ANXA2_SLC51A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ANXA2 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | ANXA2 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Hgene | ANXA2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | ANXA2 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | ANXA2 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | ANXA2 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | ANXA2 | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| Hgene | ANXA2 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | ANXA2 | C0029456 | Osteoporosis | 1 | CTD_human |
| Hgene | ANXA2 | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | ANXA2 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Hgene | ANXA2 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Tgene | SLC51A | C0008370 | Cholestasis | 2 | CTD_human |
| Tgene | SLC51A | C0023892 | Biliary cirrhosis | 1 | CTD_human |
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