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Fusion gene ID: 1985 |
FusionGeneSummary for ANXA2_RNF114 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANXA2_RNF114 | Fusion gene ID: 1985 | Hgene | Tgene | Gene symbol | ANXA2 | RNF114 | Gene ID | 302 | 55905 |
| Gene name | annexin A2 | ring finger protein 114 | |
| Synonyms | ANX2|ANX2L4|CAL1H|HEL-S-270|LIP2|LPC2|LPC2D|P36|PAP-IV | PSORS12|ZNF313 | |
| Cytomap | 15q22.2 | 20q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | annexin A2annexin IIannexin-2calpactin I heavy chaincalpactin I heavy polypeptidecalpactin-1 heavy chainchromobindin 8epididymis secretory protein Li 270lipocortin IIplacental anticoagulant protein IVprotein I | E3 ubiquitin-protein ligase RNF114RING-type E3 ubiquitin transferase RNF114zinc finger protein 228zinc finger protein 313 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P07355 | Q9Y508 | |
| Ensembl transtripts involved in fusion gene | ENST00000396024, ENST00000451270, ENST00000332680, ENST00000421017, ENST00000557937, | ENST00000244061, | |
| Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 6 X 4 X 4=96 |
| # samples | 8 | 6 | |
| ** MAII score | log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ANXA2 [Title/Abstract] AND RNF114 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ANXA2 | GO:0001921 | positive regulation of receptor recycling | 22848640 |
| Hgene | ANXA2 | GO:0031340 | positive regulation of vesicle fusion | 2138016 |
| Hgene | ANXA2 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process | 22848640 |
| Hgene | ANXA2 | GO:0036035 | osteoclast development | 7961821 |
| Hgene | ANXA2 | GO:0051290 | protein heterotetramerization | 23091277|23861394 |
| Hgene | ANXA2 | GO:1905581 | positive regulation of low-density lipoprotein particle clearance | 22848640 |
| Hgene | ANXA2 | GO:1905597 | positive regulation of low-density lipoprotein particle receptor binding | 22848640 |
| Hgene | ANXA2 | GO:1905602 | positive regulation of receptor-mediated endocytosis involved in cholesterol transport | 22848640 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-C8-A12P-01A | ANXA2 | chr15 | 60643392 | - | RNF114 | chr20 | 48565785 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000396024 | ENST00000244061 | ANXA2 | chr15 | 60643392 | - | RNF114 | chr20 | 48565785 | + |
| In-frame | ENST00000451270 | ENST00000244061 | ANXA2 | chr15 | 60643392 | - | RNF114 | chr20 | 48565785 | + |
| In-frame | ENST00000332680 | ENST00000244061 | ANXA2 | chr15 | 60643392 | - | RNF114 | chr20 | 48565785 | + |
| In-frame | ENST00000421017 | ENST00000244061 | ANXA2 | chr15 | 60643392 | - | RNF114 | chr20 | 48565785 | + |
| intron-3CDS | ENST00000557937 | ENST00000244061 | ANXA2 | chr15 | 60643392 | - | RNF114 | chr20 | 48565785 | + |
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FusionProtFeatures for ANXA2_RNF114 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANXA2 | RNF114 |
| Calcium-regulated membrane-binding protein whoseaffinity for calcium is greatly enhanced by anionic phospholipids.It binds two calcium ions with high affinity. May be involved inheat-stress response. Inhibits PCSK9-enhanced LDLR degradation,probably reduces PCSK9 protein levels via a translationalmechanism but also competes with LDLR for binding with PCSK9(PubMed:18799458, PubMed:24808179, PubMed:22848640).{ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640,ECO:0000269|PubMed:24808179}. | E3 ubiquitin-protein ligase promoting the ubiquitinationand degradation of the CDK inhibitor CDKN1A and probably alsoCDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-Sphase transition and suppress cellular senescence. May play a rolein spermatogenesis. {ECO:0000269|PubMed:23645206}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000332680 | - | 11 | 13 | 2_24 | 297 | 358 | Region | S100A10-binding site |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000396024 | - | 12 | 14 | 2_24 | 279 | 340 | Region | S100A10-binding site |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000421017 | - | 12 | 14 | 2_24 | 279 | 340 | Region | S100A10-binding site |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000451270 | - | 11 | 13 | 2_24 | 279 | 340 | Region | S100A10-binding site |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000332680 | - | 11 | 13 | 114_174 | 297 | 358 | Repeat | Note=Annexin 2 |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000332680 | - | 11 | 13 | 199_259 | 297 | 358 | Repeat | Note=Annexin 3 |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000332680 | - | 11 | 13 | 42_102 | 297 | 358 | Repeat | Note=Annexin 1 |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000396024 | - | 12 | 14 | 114_174 | 279 | 340 | Repeat | Note=Annexin 2 |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000396024 | - | 12 | 14 | 199_259 | 279 | 340 | Repeat | Note=Annexin 3 |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000396024 | - | 12 | 14 | 42_102 | 279 | 340 | Repeat | Note=Annexin 1 |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000421017 | - | 12 | 14 | 114_174 | 279 | 340 | Repeat | Note=Annexin 2 |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000421017 | - | 12 | 14 | 199_259 | 279 | 340 | Repeat | Note=Annexin 3 |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000421017 | - | 12 | 14 | 42_102 | 279 | 340 | Repeat | Note=Annexin 1 |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000451270 | - | 11 | 13 | 114_174 | 279 | 340 | Repeat | Note=Annexin 2 |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000451270 | - | 11 | 13 | 199_259 | 279 | 340 | Repeat | Note=Annexin 3 |
| Hgene | ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000451270 | - | 11 | 13 | 42_102 | 279 | 340 | Repeat | Note=Annexin 1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000332680 | - | 11 | 13 | 274_334 | 297 | 358 | Repeat | Note=Annexin 4 |
| Hgene | >ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000396024 | - | 12 | 14 | 274_334 | 279 | 340 | Repeat | Note=Annexin 4 |
| Hgene | >ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000421017 | - | 12 | 14 | 274_334 | 279 | 340 | Repeat | Note=Annexin 4 |
| Hgene | >ANXA2 | chr15:60643392 | chr20:48565785 | ENST00000451270 | - | 11 | 13 | 274_334 | 279 | 340 | Repeat | Note=Annexin 4 |
| Tgene | RNF114 | chr15:60643392 | chr20:48565785 | ENST00000244061 | + | 3 | 6 | 29_68 | 171 | 229 | Zinc finger | RING-type |
| Tgene | RNF114 | chr15:60643392 | chr20:48565785 | ENST00000244061 | + | 3 | 6 | 91_110 | 171 | 229 | Zinc finger | C2HC RNF-type |
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FusionGeneSequence for ANXA2_RNF114 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ANXA2_ENST00000396024_chr15_60643392_-_RNF114_ENST00000244061_chr20_48565785_+_58aa >In-frame_ANXA2_ENST00000451270_chr15_60643392_-_RNF114_ENST00000244061_chr20_48565785_+_337aa MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRA EDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYF >In-frame_ANXA2_ENST00000332680_chr15_60643392_-_RNF114_ENST00000244061_chr20_48565785_+_355aa MGRQLAGCGDAGKKASFKMSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIA FAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISD TSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDL >In-frame_ANXA2_ENST00000421017_chr15_60643392_-_RNF114_ENST00000244061_chr20_48565785_+_58aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ANXA2_ENST00000396024_chr15_60643392_-_RNF114_ENST00000244061_chr20_48565785_+_174nt GTTTGTCCGATATGTGCCTCGATGCCCTGGGGAGACCCCAACTACCGCAGCGCCAACTTCAGAGAGCACATCCAGCGCCGGCACCGGTTT >In-frame_ANXA2_ENST00000451270_chr15_60643392_-_RNF114_ENST00000244061_chr20_48565785_+_1011nt ATGTCTACTGTTCACGAAATCCTGTGCAAGCTCAGCTTGGAGGGTGATCACTCTACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTAT ACTAACTTTGATGCTGAGCGGGATGCTTTGAACATTGAAACAGCCATCAAGACCAAAGGTGTGGATGAGGTCACCATTGTCAACATTTTG ACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCC TTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGGG CTGGGAACCGACGAGGACTCTCTCATTGAGATCATCTGCTCCAGAACCAACCAGGAGCTGCAGGAAATTAACAGAGTCTACAAGGAAATG TACAAGACTGATCTGGAGAAGGACATTATTTCGGACACATCTGGTGACTTCCGCAAGCTGATGGTTGCCCTGGCAAAGGGTAGAAGAGCA GAGGATGGCTCTGTCATTGATTATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAAGAGGAAAGGAACTGATGTT CCCAAGTGGATCAGCATCATGACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAGTTACAGCCCTTATGACATG TTGGAAAGCATCAGGAAAGAGGTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCAGAACAAGCCCCTGTATTTT GCTGATCGGCTGTATGACTCCATGAAGGTTTGTCCGATATGTGCCTCGATGCCCTGGGGAGACCCCAACTACCGCAGCGCCAACTTCAGA GAGCACATCCAGCGCCGGCACCGGTTTTCTTATGACACTTTTGTGGATTATGATGTTGATGAAGAGGACATGATGAATCAGGTGTTGCAG >In-frame_ANXA2_ENST00000332680_chr15_60643392_-_RNF114_ENST00000244061_chr20_48565785_+_1065nt ATGGGCCGCCAGCTAGCGGGGTGTGGAGACGCTGGGAAGAAGGCTTCCTTCAAAATGTCTACTGTTCACGAAATCCTGTGCAAGCTCAGC TTGGAGGGTGATCACTCTACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTATACTAACTTTGATGCTGAGCGGGATGCTTTGAACATT GAAACAGCCATCAAGACCAAAGGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCC TTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTA TTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGGGCTGGGAACCGACGAGGACTCTCTCATTGAGATCATC TGCTCCAGAACCAACCAGGAGCTGCAGGAAATTAACAGAGTCTACAAGGAAATGTACAAGACTGATCTGGAGAAGGACATTATTTCGGAC ACATCTGGTGACTTCCGCAAGCTGATGGTTGCCCTGGCAAAGGGTAGAAGAGCAGAGGATGGCTCTGTCATTGATTATGAACTGATTGAC CAAGATGCTCGGGATCTCTATGACGCTGGAGTGAAGAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCATGACCGAGCGGAGCGTG CCCCACCTCCAGAAAGTATTTGATAGGTACAAGAGTTACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGAGGTTAAAGGAGACCTG GAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCAGAACAAGCCCCTGTATTTTGCTGATCGGCTGTATGACTCCATGAAGGTTTGTCCG ATATGTGCCTCGATGCCCTGGGGAGACCCCAACTACCGCAGCGCCAACTTCAGAGAGCACATCCAGCGCCGGCACCGGTTTTCTTATGAC >In-frame_ANXA2_ENST00000421017_chr15_60643392_-_RNF114_ENST00000244061_chr20_48565785_+_174nt GTTTGTCCGATATGTGCCTCGATGCCCTGGGGAGACCCCAACTACCGCAGCGCCAACTTCAGAGAGCACATCCAGCGCCGGCACCGGTTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ANXA2_ENST00000396024_chr15_60643392_-_RNF114_ENST00000244061_chr20_48565785_+_2922nt GCTCAGCATTTGGGGACGCTCTCAGCTCTCGGCGCACGGCCCAGGGTGAAAATGTTTGCCATTAAACTCACATGAAGTAGGAAATATTTA TATGGATACAAAAGGCACCTGCATGGGATAATGTCAAATTTCATAGATACTGCTTTGTGCTTCCTTCAAAATGTCTACTGTTCACGAAAT CCTGTGCAAGCTCAGCTTGGAGGGTGATCACTCTACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTATACTAACTTTGATGCTGAGCG GGATGCTTTGAACATTGAAACAGCCATCAAGACCAAAGGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACA GAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGAC GGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGGGCTGGGAACCGACGAGGACTC TCTCATTGAGATCATCTGCTCCAGAACCAACCAGGAGCTGCAGGAAATTAACAGAGTCTACAAGGAAATGTACAAGACTGATCTGGAGAA GGACATTATTTCGGACACATCTGGTGACTTCCGCAAGCTGATGGTTGCCCTGGCAAAGGGTAGAAGAGCAGAGGATGGCTCTGTCATTGA TTATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAAGAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCAT GACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAGTTACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGA GGTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCAGAACAAGCCCCTGTATTTTGCTGATCGGCTGTATGACTC CATGAAGGTTTGTCCGATATGTGCCTCGATGCCCTGGGGAGACCCCAACTACCGCAGCGCCAACTTCAGAGAGCACATCCAGCGCCGGCA CCGGTTTTCTTATGACACTTTTGTGGATTATGATGTTGATGAAGAGGACATGATGAATCAGGTGTTGCAGCGCTCCATCATCGACCAGTG AGCAGAGTCCGTGCTTGCTATCTGTCTCATGTTACAGAGCTTCCATTACATATTAAACGTGAAATCTATGACTCCTGTACCTTACCTGTT CAACAGACCTGAAAATGAGCCATGGCATTGGGACAGGGTCACTTCTGACAGGGGAAGTGGGTCCCCAGGTCAGCCCTTCTCTTCCCTTTG GGCTCTTGCCAAAGCTGTCTTCCCCTACTGTTAACCTTGTTTGTCACACGGTCGAGTTCGTATTGGTTCTCGGCTACTTCCTGGAGCTTC TGCCGCCTCCTGTGGAAGATAATCTAGCTTCTCCACCTCTTGTTTCACACTCATTCCTCCCATCCAGTGTTTGTCTCTCGGGTCCTTCAA GCCAGCCAGGACCTTTTCTGGGTCATGAATAGCACAATGAAGCAAGTGTCTCCTTTCCTTGTCCCCAAGGTGTGCAGACTTTGGCAGCCG TGCACCTGACCAGAGCTGAAGCTCCCGCTGGGCTGTGGGGTTGCCAGAAGCTGGGGTTGCCATCCCGGGGTACATGTCACCAGTCCTCTT GGGGTTTTGTACCATCTGATGCTGGAAGTTTTGATTAGTGATATTTTCTACTACTACATATTTAGAGTTCACTGGTTCAGTCTTAAATGC CTGCATGGTGCCTTTTTAGGATAAGGTATAACCATACATTTTTGGTGGAAGTGTTTCTGGGTTAGGGAAGTTAAAGTCTGTTTATCCGTA AGTGGGGAGGAGGGTCAGCTAAGAGAAGTGGGAGGGCCAGAGCTTTTTGGTTCTGATTTACAAATTAATGAAGTAGTTTCAAACAACGCG GTCATGTTTACCTCTCCATTTGGGAGCCTGCCTACATTCTTGTTCTAGAAGCACAAAAAATCCTCAGATGAATTAGAAGAAAGAGGTTTG GGGACTCAGCGGATACTAGTTCTTTTACCTTCTGCTTGGTAACTTAGATTAAACTGAGCATTGTTTTTCTGTCACAAATGTTTTCCTTAT GACACTGGTTTCGACATGTAAAATGTGTTTGAAAACCTGCTTTGTAGATGCAGAGAGAAGCTATAGGAAACCCAGTACCACCCCTGGTCT GTTCTGACGAGACATCGTTCATAAGGCACAGCACATCGCAAGATGAACAGTTGTTAATAAAAGCTGTTGCTGGAAACTTGCTTTAGGAAC AGCTCAAGAACCTTGGAGTTCATATTTCACAAATATTAATAAATATAAGTCCAAGAGCTGTCAGCCTAATCTGTAGGAGCAGAACCTCTG ATTGACCAAAAGGCATATGGGTTTAGGTTGGTTTTTTGATGTCATATGTCTCTGATGGGGCTGCAAGTGCTACCTCGCGCTTGTACACTG CTGCTGTGGGGCTCCGCGCCTGCCGGTGAAGAGCTGCAGATGCCGAGAAGCCAGCAAACACAGGGCCCACTGGAAAAAAATAGTTTTTTC ATTAGTATTTCTCGGGAGGACCCAAAAGTTAAGGTCAGCTTGTTCACTGTAATTTCTGGAAGAAGTTCACTCAGACCTTCCTGAATTCAG ATCATCTCAGAAGTCTGGAGGGAAATCTGGCGAAACCTTCGTTTGAGGGACTGATGTGAGTGTATGTCCACCTCACTGGTGGCACCGAGA AACTTACTTCCTTGTATTAAGTGCACTTCTTGTATTTCTAATAAGATGACTTTCCAGAAAGTGAGATTTGTTATGTTCTGGCTTTTAAAA >In-frame_ANXA2_ENST00000451270_chr15_60643392_-_RNF114_ENST00000244061_chr20_48565785_+_2874nt GCCTCGCCTAGGGAGGATGTGGCGGGTATAAAAGCCCCACCCAGGCCAGCCGGCTCTGCTCAGCATTTGGGGACGCTCTCAGCTCTCGGC GCACGGCCCAGCTTCCTTCAAAATGTCTACTGTTCACGAAATCCTGTGCAAGCTCAGCTTGGAGGGTGATCACTCTACACCCCCAAGTGC ATATGGGTCTGTCAAAGCCTATACTAACTTTGATGCTGAGCGGGATGCTTTGAACATTGAAACAGCCATCAAGACCAAAGGTGTGGATGA GGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACT TGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGA GCTAAAAGCTTCCATGAAGGGGCTGGGAACCGACGAGGACTCTCTCATTGAGATCATCTGCTCCAGAACCAACCAGGAGCTGCAGGAAAT TAACAGAGTCTACAAGGAAATGTACAAGACTGATCTGGAGAAGGACATTATTTCGGACACATCTGGTGACTTCCGCAAGCTGATGGTTGC CCTGGCAAAGGGTAGAAGAGCAGAGGATGGCTCTGTCATTGATTATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGT GAAGAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCATGACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAA GAGTTACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGAGGTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCAT TCAGAACAAGCCCCTGTATTTTGCTGATCGGCTGTATGACTCCATGAAGGTTTGTCCGATATGTGCCTCGATGCCCTGGGGAGACCCCAA CTACCGCAGCGCCAACTTCAGAGAGCACATCCAGCGCCGGCACCGGTTTTCTTATGACACTTTTGTGGATTATGATGTTGATGAAGAGGA CATGATGAATCAGGTGTTGCAGCGCTCCATCATCGACCAGTGAGCAGAGTCCGTGCTTGCTATCTGTCTCATGTTACAGAGCTTCCATTA CATATTAAACGTGAAATCTATGACTCCTGTACCTTACCTGTTCAACAGACCTGAAAATGAGCCATGGCATTGGGACAGGGTCACTTCTGA CAGGGGAAGTGGGTCCCCAGGTCAGCCCTTCTCTTCCCTTTGGGCTCTTGCCAAAGCTGTCTTCCCCTACTGTTAACCTTGTTTGTCACA CGGTCGAGTTCGTATTGGTTCTCGGCTACTTCCTGGAGCTTCTGCCGCCTCCTGTGGAAGATAATCTAGCTTCTCCACCTCTTGTTTCAC ACTCATTCCTCCCATCCAGTGTTTGTCTCTCGGGTCCTTCAAGCCAGCCAGGACCTTTTCTGGGTCATGAATAGCACAATGAAGCAAGTG TCTCCTTTCCTTGTCCCCAAGGTGTGCAGACTTTGGCAGCCGTGCACCTGACCAGAGCTGAAGCTCCCGCTGGGCTGTGGGGTTGCCAGA AGCTGGGGTTGCCATCCCGGGGTACATGTCACCAGTCCTCTTGGGGTTTTGTACCATCTGATGCTGGAAGTTTTGATTAGTGATATTTTC TACTACTACATATTTAGAGTTCACTGGTTCAGTCTTAAATGCCTGCATGGTGCCTTTTTAGGATAAGGTATAACCATACATTTTTGGTGG AAGTGTTTCTGGGTTAGGGAAGTTAAAGTCTGTTTATCCGTAAGTGGGGAGGAGGGTCAGCTAAGAGAAGTGGGAGGGCCAGAGCTTTTT GGTTCTGATTTACAAATTAATGAAGTAGTTTCAAACAACGCGGTCATGTTTACCTCTCCATTTGGGAGCCTGCCTACATTCTTGTTCTAG AAGCACAAAAAATCCTCAGATGAATTAGAAGAAAGAGGTTTGGGGACTCAGCGGATACTAGTTCTTTTACCTTCTGCTTGGTAACTTAGA TTAAACTGAGCATTGTTTTTCTGTCACAAATGTTTTCCTTATGACACTGGTTTCGACATGTAAAATGTGTTTGAAAACCTGCTTTGTAGA TGCAGAGAGAAGCTATAGGAAACCCAGTACCACCCCTGGTCTGTTCTGACGAGACATCGTTCATAAGGCACAGCACATCGCAAGATGAAC AGTTGTTAATAAAAGCTGTTGCTGGAAACTTGCTTTAGGAACAGCTCAAGAACCTTGGAGTTCATATTTCACAAATATTAATAAATATAA GTCCAAGAGCTGTCAGCCTAATCTGTAGGAGCAGAACCTCTGATTGACCAAAAGGCATATGGGTTTAGGTTGGTTTTTTGATGTCATATG TCTCTGATGGGGCTGCAAGTGCTACCTCGCGCTTGTACACTGCTGCTGTGGGGCTCCGCGCCTGCCGGTGAAGAGCTGCAGATGCCGAGA AGCCAGCAAACACAGGGCCCACTGGAAAAAAATAGTTTTTTCATTAGTATTTCTCGGGAGGACCCAAAAGTTAAGGTCAGCTTGTTCACT GTAATTTCTGGAAGAAGTTCACTCAGACCTTCCTGAATTCAGATCATCTCAGAAGTCTGGAGGGAAATCTGGCGAAACCTTCGTTTGAGG GACTGATGTGAGTGTATGTCCACCTCACTGGTGGCACCGAGAAACTTACTTCCTTGTATTAAGTGCACTTCTTGTATTTCTAATAAGATG >In-frame_ANXA2_ENST00000332680_chr15_60643392_-_RNF114_ENST00000244061_chr20_48565785_+_2888nt CTCAGCATTTGGGGACGCTCTCAGCTCTCGGCGCACGGCCCAGGTAAGCGGGGCGCGCCCTGCCCGCCCGCGATGGGCCGCCAGCTAGCG GGGTGTGGAGACGCTGGGAAGAAGGCTTCCTTCAAAATGTCTACTGTTCACGAAATCCTGTGCAAGCTCAGCTTGGAGGGTGATCACTCT ACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTATACTAACTTTGATGCTGAGCGGGATGCTTTGAACATTGAAACAGCCATCAAGACC AAAGGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGG ACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAG TATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGGGCTGGGAACCGACGAGGACTCTCTCATTGAGATCATCTGCTCCAGAACCAACCAG GAGCTGCAGGAAATTAACAGAGTCTACAAGGAAATGTACAAGACTGATCTGGAGAAGGACATTATTTCGGACACATCTGGTGACTTCCGC AAGCTGATGGTTGCCCTGGCAAAGGGTAGAAGAGCAGAGGATGGCTCTGTCATTGATTATGAACTGATTGACCAAGATGCTCGGGATCTC TATGACGCTGGAGTGAAGAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCATGACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTA TTTGATAGGTACAAGAGTTACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGAGGTTAAAGGAGACCTGGAAAATGCTTTCCTGAAC CTGGTTCAGTGCATTCAGAACAAGCCCCTGTATTTTGCTGATCGGCTGTATGACTCCATGAAGGTTTGTCCGATATGTGCCTCGATGCCC TGGGGAGACCCCAACTACCGCAGCGCCAACTTCAGAGAGCACATCCAGCGCCGGCACCGGTTTTCTTATGACACTTTTGTGGATTATGAT GTTGATGAAGAGGACATGATGAATCAGGTGTTGCAGCGCTCCATCATCGACCAGTGAGCAGAGTCCGTGCTTGCTATCTGTCTCATGTTA CAGAGCTTCCATTACATATTAAACGTGAAATCTATGACTCCTGTACCTTACCTGTTCAACAGACCTGAAAATGAGCCATGGCATTGGGAC AGGGTCACTTCTGACAGGGGAAGTGGGTCCCCAGGTCAGCCCTTCTCTTCCCTTTGGGCTCTTGCCAAAGCTGTCTTCCCCTACTGTTAA CCTTGTTTGTCACACGGTCGAGTTCGTATTGGTTCTCGGCTACTTCCTGGAGCTTCTGCCGCCTCCTGTGGAAGATAATCTAGCTTCTCC ACCTCTTGTTTCACACTCATTCCTCCCATCCAGTGTTTGTCTCTCGGGTCCTTCAAGCCAGCCAGGACCTTTTCTGGGTCATGAATAGCA CAATGAAGCAAGTGTCTCCTTTCCTTGTCCCCAAGGTGTGCAGACTTTGGCAGCCGTGCACCTGACCAGAGCTGAAGCTCCCGCTGGGCT GTGGGGTTGCCAGAAGCTGGGGTTGCCATCCCGGGGTACATGTCACCAGTCCTCTTGGGGTTTTGTACCATCTGATGCTGGAAGTTTTGA TTAGTGATATTTTCTACTACTACATATTTAGAGTTCACTGGTTCAGTCTTAAATGCCTGCATGGTGCCTTTTTAGGATAAGGTATAACCA TACATTTTTGGTGGAAGTGTTTCTGGGTTAGGGAAGTTAAAGTCTGTTTATCCGTAAGTGGGGAGGAGGGTCAGCTAAGAGAAGTGGGAG GGCCAGAGCTTTTTGGTTCTGATTTACAAATTAATGAAGTAGTTTCAAACAACGCGGTCATGTTTACCTCTCCATTTGGGAGCCTGCCTA CATTCTTGTTCTAGAAGCACAAAAAATCCTCAGATGAATTAGAAGAAAGAGGTTTGGGGACTCAGCGGATACTAGTTCTTTTACCTTCTG CTTGGTAACTTAGATTAAACTGAGCATTGTTTTTCTGTCACAAATGTTTTCCTTATGACACTGGTTTCGACATGTAAAATGTGTTTGAAA ACCTGCTTTGTAGATGCAGAGAGAAGCTATAGGAAACCCAGTACCACCCCTGGTCTGTTCTGACGAGACATCGTTCATAAGGCACAGCAC ATCGCAAGATGAACAGTTGTTAATAAAAGCTGTTGCTGGAAACTTGCTTTAGGAACAGCTCAAGAACCTTGGAGTTCATATTTCACAAAT ATTAATAAATATAAGTCCAAGAGCTGTCAGCCTAATCTGTAGGAGCAGAACCTCTGATTGACCAAAAGGCATATGGGTTTAGGTTGGTTT TTTGATGTCATATGTCTCTGATGGGGCTGCAAGTGCTACCTCGCGCTTGTACACTGCTGCTGTGGGGCTCCGCGCCTGCCGGTGAAGAGC TGCAGATGCCGAGAAGCCAGCAAACACAGGGCCCACTGGAAAAAAATAGTTTTTTCATTAGTATTTCTCGGGAGGACCCAAAAGTTAAGG TCAGCTTGTTCACTGTAATTTCTGGAAGAAGTTCACTCAGACCTTCCTGAATTCAGATCATCTCAGAAGTCTGGAGGGAAATCTGGCGAA ACCTTCGTTTGAGGGACTGATGTGAGTGTATGTCCACCTCACTGGTGGCACCGAGAAACTTACTTCCTTGTATTAAGTGCACTTCTTGTA TTTCTAATAAGATGACTTTCCAGAAAGTGAGATTTGTTATGTTCTGGCTTTTAAAAGGTAAAATATAAATAAATTTCATAACTTAATCTA >In-frame_ANXA2_ENST00000421017_chr15_60643392_-_RNF114_ENST00000244061_chr20_48565785_+_2898nt GCTCAGCATTTGGGGACGCTCTCAGCTCTCGGCGCACGGCCCAGGTTATCTTGTAGCATAGCAACTTCGGATTTCACTCTACCCGGAGAG TTTCCCGCTTGGTTGAACACATTGGCCTCAGGAAGCTTCCTTCAAAATGTCTACTGTTCACGAAATCCTGTGCAAGCTCAGCTTGGAGGG TGATCACTCTACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTATACTAACTTTGATGCTGAGCGGGATGCTTTGAACATTGAAACAGC CATCAAGACCAAAGGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTA CCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGAC ACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGGGCTGGGAACCGACGAGGACTCTCTCATTGAGATCATCTGCTCCAG AACCAACCAGGAGCTGCAGGAAATTAACAGAGTCTACAAGGAAATGTACAAGACTGATCTGGAGAAGGACATTATTTCGGACACATCTGG TGACTTCCGCAAGCTGATGGTTGCCCTGGCAAAGGGTAGAAGAGCAGAGGATGGCTCTGTCATTGATTATGAACTGATTGACCAAGATGC TCGGGATCTCTATGACGCTGGAGTGAAGAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCATGACCGAGCGGAGCGTGCCCCACCT CCAGAAAGTATTTGATAGGTACAAGAGTTACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGAGGTTAAAGGAGACCTGGAAAATGC TTTCCTGAACCTGGTTCAGTGCATTCAGAACAAGCCCCTGTATTTTGCTGATCGGCTGTATGACTCCATGAAGGTTTGTCCGATATGTGC CTCGATGCCCTGGGGAGACCCCAACTACCGCAGCGCCAACTTCAGAGAGCACATCCAGCGCCGGCACCGGTTTTCTTATGACACTTTTGT GGATTATGATGTTGATGAAGAGGACATGATGAATCAGGTGTTGCAGCGCTCCATCATCGACCAGTGAGCAGAGTCCGTGCTTGCTATCTG TCTCATGTTACAGAGCTTCCATTACATATTAAACGTGAAATCTATGACTCCTGTACCTTACCTGTTCAACAGACCTGAAAATGAGCCATG GCATTGGGACAGGGTCACTTCTGACAGGGGAAGTGGGTCCCCAGGTCAGCCCTTCTCTTCCCTTTGGGCTCTTGCCAAAGCTGTCTTCCC CTACTGTTAACCTTGTTTGTCACACGGTCGAGTTCGTATTGGTTCTCGGCTACTTCCTGGAGCTTCTGCCGCCTCCTGTGGAAGATAATC TAGCTTCTCCACCTCTTGTTTCACACTCATTCCTCCCATCCAGTGTTTGTCTCTCGGGTCCTTCAAGCCAGCCAGGACCTTTTCTGGGTC ATGAATAGCACAATGAAGCAAGTGTCTCCTTTCCTTGTCCCCAAGGTGTGCAGACTTTGGCAGCCGTGCACCTGACCAGAGCTGAAGCTC CCGCTGGGCTGTGGGGTTGCCAGAAGCTGGGGTTGCCATCCCGGGGTACATGTCACCAGTCCTCTTGGGGTTTTGTACCATCTGATGCTG GAAGTTTTGATTAGTGATATTTTCTACTACTACATATTTAGAGTTCACTGGTTCAGTCTTAAATGCCTGCATGGTGCCTTTTTAGGATAA GGTATAACCATACATTTTTGGTGGAAGTGTTTCTGGGTTAGGGAAGTTAAAGTCTGTTTATCCGTAAGTGGGGAGGAGGGTCAGCTAAGA GAAGTGGGAGGGCCAGAGCTTTTTGGTTCTGATTTACAAATTAATGAAGTAGTTTCAAACAACGCGGTCATGTTTACCTCTCCATTTGGG AGCCTGCCTACATTCTTGTTCTAGAAGCACAAAAAATCCTCAGATGAATTAGAAGAAAGAGGTTTGGGGACTCAGCGGATACTAGTTCTT TTACCTTCTGCTTGGTAACTTAGATTAAACTGAGCATTGTTTTTCTGTCACAAATGTTTTCCTTATGACACTGGTTTCGACATGTAAAAT GTGTTTGAAAACCTGCTTTGTAGATGCAGAGAGAAGCTATAGGAAACCCAGTACCACCCCTGGTCTGTTCTGACGAGACATCGTTCATAA GGCACAGCACATCGCAAGATGAACAGTTGTTAATAAAAGCTGTTGCTGGAAACTTGCTTTAGGAACAGCTCAAGAACCTTGGAGTTCATA TTTCACAAATATTAATAAATATAAGTCCAAGAGCTGTCAGCCTAATCTGTAGGAGCAGAACCTCTGATTGACCAAAAGGCATATGGGTTT AGGTTGGTTTTTTGATGTCATATGTCTCTGATGGGGCTGCAAGTGCTACCTCGCGCTTGTACACTGCTGCTGTGGGGCTCCGCGCCTGCC GGTGAAGAGCTGCAGATGCCGAGAAGCCAGCAAACACAGGGCCCACTGGAAAAAAATAGTTTTTTCATTAGTATTTCTCGGGAGGACCCA AAAGTTAAGGTCAGCTTGTTCACTGTAATTTCTGGAAGAAGTTCACTCAGACCTTCCTGAATTCAGATCATCTCAGAAGTCTGGAGGGAA ATCTGGCGAAACCTTCGTTTGAGGGACTGATGTGAGTGTATGTCCACCTCACTGGTGGCACCGAGAAACTTACTTCCTTGTATTAAGTGC ACTTCTTGTATTTCTAATAAGATGACTTTCCAGAAAGTGAGATTTGTTATGTTCTGGCTTTTAAAAGGTAAAATATAAATAAATTTCATA |
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FusionGenePPI for ANXA2_RNF114 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ANXA2 | PPM1B, CEACAM1, TRPV5, PHB, CTSB, PLAT, SOS1, GRB2, PCNA, S100A10, APOH, STAT6, MGMT, H2AFX, CD4, CDK7, NCOA3, EP300, UBE3A, ARRB1, ARRB2, SP1, ISG15, TERF1, POT1, CUL2, CDK2, PPP2R1A, MID1, CD99, MYOC, CDK9, SHC1, APP, GNB2L1, RPS13, RPL11, ESR1, HNF1A, VCP, MYC, FN1, VCAM1, IQCB1, MLH1, ITGA4, TP53, NPM1, HMGA1, TERT, BAG3, ATP4A, YWHAQ, PARK2, DNAJC8, LOC100128588, RPA3, RPA2, RPA1, WWOX, ASB9, SPRTN, PLA2G4A, CUL7, OBSL1, CCDC8, SIRT6, ANXA13, MAP1S, RPS6KB2, HNRNPA1, ANXA11, CACYBP, FUBP1, LGALS1, NCKAP1L, PRDX2, RAB7A, EWSR1, PCBP2, PDCD6, NTRK1, PTEN, DBN1, FLNA, MYH9, PPP1CB, IQGAP1, SYNPO, LIMA1, MYO19, MYO18A, FBXL12, MCM2, MCM5, ERBB3, ERRFI1, ESRRB, U2AF2, RAB14, CDC73, CDH1, AHNAK2, KLHL42, CYLD, DLST, HSD17B10, PDHA1, SOAT1, STAT3, TRIM25, UBE2A, RSC1A1, DCAF4L2 | RNF114 | AK5, PARP11, UBE2U, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E3, UBE2E2, UEVLD, UBE2DNL, UBE2E1, UBE2H, UBE2K, UBE2W, UBC, MAPK3, HSP90AA1, CPLX1, LAGE3, NUDCD2, DSTN, HSPB1, XAF1, CDKN1A, RNF114, TRIM52, RNF38, BMI1, TRIM55, TRAF6, TRAF4, TRAIP, EVI2A, RPSA, TNFAIP3, SUZ12, RNF2, MAP3K1, USO1, IDI2, AUP1, DTX3, EWSR1, SMURF1, PARP12, CD93, LTBR, PLP1, LACRT, RNF166, APC, MAVS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANXA2_RNF114 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ANXA2 | P07355 | DB00031 | Tenecteplase | Annexin A2 | biotech | approved |
| Hgene | ANXA2 | P07355 | DB11638 | Artenimol | Annexin A2 | small molecule | approved|investigational |
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RelatedDiseases for ANXA2_RNF114 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ANXA2 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | ANXA2 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Hgene | ANXA2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | ANXA2 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | ANXA2 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | ANXA2 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | ANXA2 | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| Hgene | ANXA2 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | ANXA2 | C0029456 | Osteoporosis | 1 | CTD_human |
| Hgene | ANXA2 | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | ANXA2 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Hgene | ANXA2 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Tgene | RNF114 | C0033860 | Psoriasis | 1 | CTD_human |
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