FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 19824

FusionGeneSummary for LIPI_LIPI

check button Fusion gene summary
Fusion gene informationFusion gene name: LIPI_LIPI
Fusion gene ID: 19824
HgeneTgene
Gene symbol

LIPI

LIPI

Gene ID

149998

149998

Gene namelipase Ilipase I
SynonymsCT17|LPDL|PLA1C|PRED5|mPA-PLA1 betaCT17|LPDL|PLA1C|PRED5|mPA-PLA1 beta
Cytomap

21q11.2

21q11.2

Type of geneprotein-codingprotein-coding
Descriptionlipase member ILPD lipasecancer/testis antigen 17lipase, member Imembrane-associated phosphatidic acid-selective phospholipase A1-betalipase member ILPD lipasecancer/testis antigen 17lipase, member Imembrane-associated phosphatidic acid-selective phospholipase A1-beta
Modification date2018042120180421
UniProtAcc

Q6XZB0

Q6XZB0

Ensembl transtripts involved in fusion geneENST00000344577, ENST00000536861, 
ENST00000344577, ENST00000536861, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: LIPI [Title/Abstract] AND LIPI [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLIPI

GO:0016042

lipid catabolic process

12963729

TgeneLIPI

GO:0016042

lipid catabolic process

12963729


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA483957LIPIchr21

15561521

-LIPIchr21

15561461

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000344577ENST00000344577LIPIchr21

15561521

-LIPIchr21

15561461

+
intron-3CDSENST00000344577ENST00000536861LIPIchr21

15561521

-LIPIchr21

15561461

+
intron-3CDSENST00000536861ENST00000344577LIPIchr21

15561521

-LIPIchr21

15561461

+
intron-3CDSENST00000536861ENST00000536861LIPIchr21

15561521

-LIPIchr21

15561461

+

Top

FusionProtFeatures for LIPI_LIPI


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LIPI

Q6XZB0

LIPI

Q6XZB0

Hydrolyzes specifically phosphatidic acid (PA) toproduce 2-acyl lysophosphatidic acid (LPA; a potent bioactivelipid mediator) and fatty acid. Does not hydrolyze otherphospholipids, like phosphatidylserine (PS), phosphatidylcholine(PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).{ECO:0000269|PubMed:12963729}. Hydrolyzes specifically phosphatidic acid (PA) toproduce 2-acyl lysophosphatidic acid (LPA; a potent bioactivelipid mediator) and fatty acid. Does not hydrolyze otherphospholipids, like phosphatidylserine (PS), phosphatidylcholine(PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).{ECO:0000269|PubMed:12963729}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for LIPI_LIPI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LIPI_LIPI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LIPI_LIPI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for LIPI_LIPI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLIPIC0020480Hyperlipoproteinemia Type IV1CTD_human;UNIPROT
TgeneLIPIC0020480Hyperlipoproteinemia Type IV1CTD_human;UNIPROT