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Fusion gene ID: 19821 |
FusionGeneSummary for LIPG_UCMA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LIPG_UCMA | Fusion gene ID: 19821 | Hgene | Tgene | Gene symbol | LIPG | UCMA | Gene ID | 9388 | 221044 |
| Gene name | lipase G, endothelial type | upper zone of growth plate and cartilage matrix associated | |
| Synonyms | EDL|EL|PRO719 | C10orf49|GRP|GRP/UCMA | |
| Cytomap | 18q21.1 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | endothelial lipaseendothelial cell-derived lipaselipase, endotheliallipoprotein lipase H | unique cartilage matrix-associated proteinGla-rich protein | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9Y5X9 | Q8WVF2 | |
| Ensembl transtripts involved in fusion gene | ENST00000577628, ENST00000261292, ENST00000427224, ENST00000580036, | ENST00000378681, ENST00000463405, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: LIPG [Title/Abstract] AND UCMA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LIPG | GO:0032376 | positive regulation of cholesterol transport | 19136670 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-ZF-AA4T-01A | LIPG | chr18 | 47095918 | + | UCMA | chr10 | 13275800 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000577628 | ENST00000378681 | LIPG | chr18 | 47095918 | + | UCMA | chr10 | 13275800 | - |
| 5CDS-intron | ENST00000577628 | ENST00000463405 | LIPG | chr18 | 47095918 | + | UCMA | chr10 | 13275800 | - |
| In-frame | ENST00000261292 | ENST00000378681 | LIPG | chr18 | 47095918 | + | UCMA | chr10 | 13275800 | - |
| 5CDS-intron | ENST00000261292 | ENST00000463405 | LIPG | chr18 | 47095918 | + | UCMA | chr10 | 13275800 | - |
| In-frame | ENST00000427224 | ENST00000378681 | LIPG | chr18 | 47095918 | + | UCMA | chr10 | 13275800 | - |
| 5CDS-intron | ENST00000427224 | ENST00000463405 | LIPG | chr18 | 47095918 | + | UCMA | chr10 | 13275800 | - |
| In-frame | ENST00000580036 | ENST00000378681 | LIPG | chr18 | 47095918 | + | UCMA | chr10 | 13275800 | - |
| 5CDS-intron | ENST00000580036 | ENST00000463405 | LIPG | chr18 | 47095918 | + | UCMA | chr10 | 13275800 | - |
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FusionProtFeatures for LIPG_UCMA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LIPG | UCMA |
| Has phospholipase and triglyceride lipase activities.Hydrolyzes high density lipoproteins (HDL) more efficiently thanother lipoproteins. Binds heparin. | May be involved in the negative control of osteogenicdifferentiation of osteochondrogenic precursor cells in peripheralzones of fetal cartilage and at the cartilage-bone interface.{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LIPG | chr18:47095918 | chr10:13275800 | ENST00000261292 | + | 4 | 10 | 118_121 | 190 | 501 | Compositional bias | Note=Poly-Val |
| Hgene | LIPG | chr18:47095918 | chr10:13275800 | ENST00000580036 | + | 4 | 6 | 118_121 | 190 | 355 | Compositional bias | Note=Poly-Val |
| Tgene | >UCMA | chr18:47095918 | chr10:13275800 | ENST00000378681 | - | 0 | 5 | 90_122 | 19 | 139 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LIPG | chr18:47095918 | chr10:13275800 | ENST00000261292 | + | 4 | 10 | 347_482 | 190 | 501 | Domain | PLAT |
| Hgene | >LIPG | chr18:47095918 | chr10:13275800 | ENST00000580036 | + | 4 | 6 | 347_482 | 190 | 355 | Domain | PLAT |
| Hgene | >LIPG | chr18:47095918 | chr10:13275800 | ENST00000261292 | + | 4 | 10 | 325_337 | 190 | 501 | Region | Heparin-binding |
| Hgene | >LIPG | chr18:47095918 | chr10:13275800 | ENST00000580036 | + | 4 | 6 | 325_337 | 190 | 355 | Region | Heparin-binding |
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FusionGeneSequence for LIPG_UCMA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LIPG_ENST00000577628_chr18_47095918_+_UCMA_ENST00000378681_chr10_13275800_-_346aa MLSFSRDRLPSGRRVSGKCPPPPLGMAVGRGGSGCPEEGSGRKLELLESQLPAERAREEAGPSVRRPRDKLHKPKATQTEVKPSVRFNLR TSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHS IARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGTAGNFVKGTVGRITVLREGTSVSVGTMQMAGEEASEDAKQKIFMQESDASNFLKRRGK >In-frame_LIPG_ENST00000261292_chr18_47095918_+_UCMA_ENST00000378681_chr10_13275800_-_310aa MSNSVPLLCFWSLCTCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIH GWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGTAGN FVKGTVGRITVLREGTSVSVGTMQMAGEEASEDAKQKIFMQESDASNFLKRRGKRSPKSRDEVNVENRQKLRVDELRRETYEEQRNEFEN >In-frame_LIPG_ENST00000427224_chr18_47095918_+_UCMA_ENST00000378681_chr10_13275800_-_310aa MSNSVPLLCFWSLCTCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIH GWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGTAGN FVKGTVGRITVLREGTSVSVGTMQMAGEEASEDAKQKIFMQESDASNFLKRRGKRSPKSRDEVNVENRQKLRVDELRRETYEEQRNEFEN >In-frame_LIPG_ENST00000580036_chr18_47095918_+_UCMA_ENST00000378681_chr10_13275800_-_310aa MSNSVPLLCFWSLCTCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIH GWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGTAGN FVKGTVGRITVLREGTSVSVGTMQMAGEEASEDAKQKIFMQESDASNFLKRRGKRSPKSRDEVNVENRQKLRVDELRRETYEEQRNEFEN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LIPG_ENST00000577628_chr18_47095918_+_UCMA_ENST00000378681_chr10_13275800_-_1038nt ATGCTCTCCTTCTCCAGGGATCGCCTCCCCAGCGGACGCAGAGTTTCAGGGAAATGTCCGCCTCCGCCACTTGGGATGGCAGTGGGGAGA GGAGGATCTGGGTGTCCGGAGGAGGGCAGTGGGAGAAAGCTGGAGCTGCTGGAGTCGCAGCTGCCTGCGGAGCGGGCCCGGGAGGAAGCG GGGCCGAGCGTGCGGCGTCCACGCGATAAGCTCCACAAACCCAAAGCTACACAGACTGAGGTCAAACCATCTGTGAGGTTTAACCTCCGC ACCTCCAAGGACCCAGAGCATGAAGGATGCTACCTCTCCGTCGGCCACAGCCAGCCCTTAGAAGACTGCAGTTTCAACATGACAGCTAAA ACCTTTTTCATCATTCACGGATGGACGATGAGCGGTATCTTTGAAAACTGGCTGCACAAACTCGTGTCAGCCCTGCACACAAGAGAGAAA GACGCCAATGTAGTTGTGGTTGACTGGCTCCCCCTGGCCCACCAGCTTTACACGGATGCGGTCAATAATACCAGGGTGGTGGGACACAGC ATTGCCAGGATGCTCGACTGGCTGCAGGAGAAGGACGATTTTTCTCTCGGGAATGTCCACTTGATCGGCTACAGCCTCGGAGCGCACGTG GCCGGGTATGCAGGCAACTTCGTGAAAGGAACGGTGGGCCGAATCACAGTGCTGAGAGAGGGAACCAGTGTATCTGTGGGCACCATGCAG ATGGCGGGAGAAGAGGCGAGTGAAGATGCAAAACAGAAGATTTTCATGCAGGAATCAGATGCCTCGAATTTCCTCAAGAGGCGCGGCAAG CGGTCCCCCAAGTCCAGAGATGAGGTCAATGTGGAAAACAGGCAGAAGCTTCGGGTTGATGAGCTGCGGAGAGAATATTACGAGGAACAA AGGAATGAATTTGAGAACTTCGTGGAGGAACAAAACGATGAGCAGGAAGAGAGGAGCCGGGAGGCTGTGGAGCAGTGGCGCCAGTGGCAC >In-frame_LIPG_ENST00000261292_chr18_47095918_+_UCMA_ENST00000378681_chr10_13275800_-_930nt ATGAGCAACTCCGTTCCTCTGCTCTGTTTCTGGAGCCTCTGCTATTGCTTTGCTGCGGGGAGCCCCGTACCTTTTGGTCCAGAGGGACGG CTGGAAGATAAGCTCCACAAACCCAAAGCTACACAGACTGAGGTCAAACCATCTGTGAGGTTTAACCTCCGCACCTCCAAGGACCCAGAG CATGAAGGATGCTACCTCTCCGTCGGCCACAGCCAGCCCTTAGAAGACTGCAGTTTCAACATGACAGCTAAAACCTTTTTCATCATTCAC GGATGGACGATGAGCGGTATCTTTGAAAACTGGCTGCACAAACTCGTGTCAGCCCTGCACACAAGAGAGAAAGACGCCAATGTAGTTGTG GTTGACTGGCTCCCCCTGGCCCACCAGCTTTACACGGATGCGGTCAATAATACCAGGGTGGTGGGACACAGCATTGCCAGGATGCTCGAC TGGCTGCAGGAGAAGGACGATTTTTCTCTCGGGAATGTCCACTTGATCGGCTACAGCCTCGGAGCGCACGTGGCCGGGTATGCAGGCAAC TTCGTGAAAGGAACGGTGGGCCGAATCACAGTGCTGAGAGAGGGAACCAGTGTATCTGTGGGCACCATGCAGATGGCGGGAGAAGAGGCG AGTGAAGATGCAAAACAGAAGATTTTCATGCAGGAATCAGATGCCTCGAATTTCCTCAAGAGGCGCGGCAAGCGGTCCCCCAAGTCCAGA GATGAGGTCAATGTGGAAAACAGGCAGAAGCTTCGGGTTGATGAGCTGCGGAGAGAATATTACGAGGAACAAAGGAATGAATTTGAGAAC TTCGTGGAGGAACAAAACGATGAGCAGGAAGAGAGGAGCCGGGAGGCTGTGGAGCAGTGGCGCCAGTGGCACTATGACGGCCTGCACCCA >In-frame_LIPG_ENST00000427224_chr18_47095918_+_UCMA_ENST00000378681_chr10_13275800_-_930nt ATGAGCAACTCCGTTCCTCTGCTCTGTTTCTGGAGCCTCTGCTATTGCTTTGCTGCGGGGAGCCCCGTACCTTTTGGTCCAGAGGGACGG CTGGAAGATAAGCTCCACAAACCCAAAGCTACACAGACTGAGGTCAAACCATCTGTGAGGTTTAACCTCCGCACCTCCAAGGACCCAGAG CATGAAGGATGCTACCTCTCCGTCGGCCACAGCCAGCCCTTAGAAGACTGCAGTTTCAACATGACAGCTAAAACCTTTTTCATCATTCAC GGATGGACGATGAGCGGTATCTTTGAAAACTGGCTGCACAAACTCGTGTCAGCCCTGCACACAAGAGAGAAAGACGCCAATGTAGTTGTG GTTGACTGGCTCCCCCTGGCCCACCAGCTTTACACGGATGCGGTCAATAATACCAGGGTGGTGGGACACAGCATTGCCAGGATGCTCGAC TGGCTGCAGGAGAAGGACGATTTTTCTCTCGGGAATGTCCACTTGATCGGCTACAGCCTCGGAGCGCACGTGGCCGGGTATGCAGGCAAC TTCGTGAAAGGAACGGTGGGCCGAATCACAGTGCTGAGAGAGGGAACCAGTGTATCTGTGGGCACCATGCAGATGGCGGGAGAAGAGGCG AGTGAAGATGCAAAACAGAAGATTTTCATGCAGGAATCAGATGCCTCGAATTTCCTCAAGAGGCGCGGCAAGCGGTCCCCCAAGTCCAGA GATGAGGTCAATGTGGAAAACAGGCAGAAGCTTCGGGTTGATGAGCTGCGGAGAGAATATTACGAGGAACAAAGGAATGAATTTGAGAAC TTCGTGGAGGAACAAAACGATGAGCAGGAAGAGAGGAGCCGGGAGGCTGTGGAGCAGTGGCGCCAGTGGCACTATGACGGCCTGCACCCA >In-frame_LIPG_ENST00000580036_chr18_47095918_+_UCMA_ENST00000378681_chr10_13275800_-_930nt ATGAGCAACTCCGTTCCTCTGCTCTGTTTCTGGAGCCTCTGCTATTGCTTTGCTGCGGGGAGCCCCGTACCTTTTGGTCCAGAGGGACGG CTGGAAGATAAGCTCCACAAACCCAAAGCTACACAGACTGAGGTCAAACCATCTGTGAGGTTTAACCTCCGCACCTCCAAGGACCCAGAG CATGAAGGATGCTACCTCTCCGTCGGCCACAGCCAGCCCTTAGAAGACTGCAGTTTCAACATGACAGCTAAAACCTTTTTCATCATTCAC GGATGGACGATGAGCGGTATCTTTGAAAACTGGCTGCACAAACTCGTGTCAGCCCTGCACACAAGAGAGAAAGACGCCAATGTAGTTGTG GTTGACTGGCTCCCCCTGGCCCACCAGCTTTACACGGATGCGGTCAATAATACCAGGGTGGTGGGACACAGCATTGCCAGGATGCTCGAC TGGCTGCAGGAGAAGGACGATTTTTCTCTCGGGAATGTCCACTTGATCGGCTACAGCCTCGGAGCGCACGTGGCCGGGTATGCAGGCAAC TTCGTGAAAGGAACGGTGGGCCGAATCACAGTGCTGAGAGAGGGAACCAGTGTATCTGTGGGCACCATGCAGATGGCGGGAGAAGAGGCG AGTGAAGATGCAAAACAGAAGATTTTCATGCAGGAATCAGATGCCTCGAATTTCCTCAAGAGGCGCGGCAAGCGGTCCCCCAAGTCCAGA GATGAGGTCAATGTGGAAAACAGGCAGAAGCTTCGGGTTGATGAGCTGCGGAGAGAATATTACGAGGAACAAAGGAATGAATTTGAGAAC TTCGTGGAGGAACAAAACGATGAGCAGGAAGAGAGGAGCCGGGAGGCTGTGGAGCAGTGGCGCCAGTGGCACTATGACGGCCTGCACCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LIPG_ENST00000577628_chr18_47095918_+_UCMA_ENST00000378681_chr10_13275800_-_2361nt AATGAGGCGAGGTCGGAACAGGATCTGCTGGCTCCGGCTCGGTTTCCTCGCACAGGTCTCTCCAGCTGGATCCTCGACGCTAGGGAGGAA GGGGCGCGGGACTGCTGTGGGGGTTTTCCCTCCCCAGGCAGGGGCAGGACCTGTTCCGGGCGACTGCAGGGTTAAGGGTATCGTCTTAAA GAGCCGGATCCTCCCGGCTGGAGCGAGGCTGGATGGCGGGACGCAGCCTCTCAGCCTCTCGTACCCGCCCTGCGTCCGCAGTGGTTGTTG GCGCAGCCGCCCCGTCGGTGTTCCGGGCTCAGTCCCCGCTCCCCAGCGCCAGACGCAGACTCCGGGCCAAGTTCTCCCTCCGCTCGCTGC TTTCTGCCGCAGGACCCGGATCAATAAAGGGAAGGAGAGCCGGGAGGAAATGATGGAGAACAGAGAGAAAGGAGATGCTTGATTTCACTC GCCAAGGAGTGAGTGCTCATCGGCAGACACTGGGCTCTGGCCACGCGTCTTAGACTCCAAATCTCGGCTCACTGGTCCCTTTGAGGAGGT CGCCTGGTGTTCCCGTAGCCCTCCACCCCACCGTAGGAGAGCGCCTGCCACGAGCTCCGCGCCTCGCTAAGTGCTTTGCTACGTGAACTC TTAGTTTTCCCAACATCCCTAAGCCGCCGATACATTATCACCCACGTATTGCGGACGAGAGAACCGCCTCGGAGAAGCTGGCTGGCTCGC TTGGAGTTTTGCAGCTAGTGGCGGAGCGAGCATTCCGAGCAGGTACTGTGCGATCCTCCAGCGCCGGCCGCAGCTCACAGCCCCTTAGCT CCGCCGGGTTATTGTGCGGCCGCGCCTTCTGCACCTGTTGCGGCCCTCGCTAGGCGGGAAGGGAGGGAGAAGAGGAGGACAAAGGGGATG ACCAGGTGGCTCTCCCCCGACGGACTCCCGGCCCAGGGAGCGGATAGACCACTCCCAGAGAGAGTGTGGCTTTGAGCCTTGGAGAGGATG CTCTCCTTCTCCAGGGATCGCCTCCCCAGCGGACGCAGAGTTTCAGGGAAATGTCCGCCTCCGCCACTTGGGATGGCAGTGGGGAGAGGA GGATCTGGGTGTCCGGAGGAGGGCAGTGGGAGAAAGCTGGAGCTGCTGGAGTCGCAGCTGCCTGCGGAGCGGGCCCGGGAGGAAGCGGGG CCGAGCGTGCGGCGTCCACGCGATAAGCTCCACAAACCCAAAGCTACACAGACTGAGGTCAAACCATCTGTGAGGTTTAACCTCCGCACC TCCAAGGACCCAGAGCATGAAGGATGCTACCTCTCCGTCGGCCACAGCCAGCCCTTAGAAGACTGCAGTTTCAACATGACAGCTAAAACC TTTTTCATCATTCACGGATGGACGATGAGCGGTATCTTTGAAAACTGGCTGCACAAACTCGTGTCAGCCCTGCACACAAGAGAGAAAGAC GCCAATGTAGTTGTGGTTGACTGGCTCCCCCTGGCCCACCAGCTTTACACGGATGCGGTCAATAATACCAGGGTGGTGGGACACAGCATT GCCAGGATGCTCGACTGGCTGCAGGAGAAGGACGATTTTTCTCTCGGGAATGTCCACTTGATCGGCTACAGCCTCGGAGCGCACGTGGCC GGGTATGCAGGCAACTTCGTGAAAGGAACGGTGGGCCGAATCACAGTGCTGAGAGAGGGAACCAGTGTATCTGTGGGCACCATGCAGATG GCGGGAGAAGAGGCGAGTGAAGATGCAAAACAGAAGATTTTCATGCAGGAATCAGATGCCTCGAATTTCCTCAAGAGGCGCGGCAAGCGG TCCCCCAAGTCCAGAGATGAGGTCAATGTGGAAAACAGGCAGAAGCTTCGGGTTGATGAGCTGCGGAGAGAATATTACGAGGAACAAAGG AATGAATTTGAGAACTTCGTGGAGGAACAAAACGATGAGCAGGAAGAGAGGAGCCGGGAGGCTGTGGAGCAGTGGCGCCAGTGGCACTAT GACGGCCTGCACCCATCCTATCTCTACAACCGCCACCACACCTGATCCCATCCTGAAGCCGGCCAAGAAGACAAAGCTTGTAGCACCATT GGCATCCCCGTGTTCCAGCAATCTTTCCCATGCAAACCGGCCCTTCAGAGGGTCTCAGCTTGGGGTCTGCAGTGGCCAGCAGCTCTTGAA AAGACGCATGCCTTTCCTTCCAGTGTGTGAAAGTGTCCTGACTTTCACCTCTTTGCAGACCATCTTCTGAGGTGAGCAACTGCCTGCAGG GCCTCCTAGTACCAAACCTACAGTGGCTTCCCCTGGCTTCGTTCCCAAGCAAAAGAATCAGTCAAGAATCACATGTTTGCTTATGGCTTA >In-frame_LIPG_ENST00000261292_chr18_47095918_+_UCMA_ENST00000378681_chr10_13275800_-_1544nt AAAAACTACCTCTATAGGAGCGTGACAGCAGCGAGTCCTTGCCTCCCGGCGGCTCAGGACGAGGGCAGATCTCGTTCTGGGGCAAGCCGT TGACACTCGCTCCCTGCCACCGCCCGGGCTCCGTGCCGCCAAGTTTTCATTTTCCACCTTCTCTGCCTCCAGTCCCCCAGCCCCTGGCCG AGAGAAGGGTCTTACCGGCCGGGATTGCTGGAAACACCAAGAGGTGGTTTTTGTTTTTTAAAACTTCTGTTTCTTGGGAGGGGGTGTGGC GGGGCAGGATGAGCAACTCCGTTCCTCTGCTCTGTTTCTGGAGCCTCTGCTATTGCTTTGCTGCGGGGAGCCCCGTACCTTTTGGTCCAG AGGGACGGCTGGAAGATAAGCTCCACAAACCCAAAGCTACACAGACTGAGGTCAAACCATCTGTGAGGTTTAACCTCCGCACCTCCAAGG ACCCAGAGCATGAAGGATGCTACCTCTCCGTCGGCCACAGCCAGCCCTTAGAAGACTGCAGTTTCAACATGACAGCTAAAACCTTTTTCA TCATTCACGGATGGACGATGAGCGGTATCTTTGAAAACTGGCTGCACAAACTCGTGTCAGCCCTGCACACAAGAGAGAAAGACGCCAATG TAGTTGTGGTTGACTGGCTCCCCCTGGCCCACCAGCTTTACACGGATGCGGTCAATAATACCAGGGTGGTGGGACACAGCATTGCCAGGA TGCTCGACTGGCTGCAGGAGAAGGACGATTTTTCTCTCGGGAATGTCCACTTGATCGGCTACAGCCTCGGAGCGCACGTGGCCGGGTATG CAGGCAACTTCGTGAAAGGAACGGTGGGCCGAATCACAGTGCTGAGAGAGGGAACCAGTGTATCTGTGGGCACCATGCAGATGGCGGGAG AAGAGGCGAGTGAAGATGCAAAACAGAAGATTTTCATGCAGGAATCAGATGCCTCGAATTTCCTCAAGAGGCGCGGCAAGCGGTCCCCCA AGTCCAGAGATGAGGTCAATGTGGAAAACAGGCAGAAGCTTCGGGTTGATGAGCTGCGGAGAGAATATTACGAGGAACAAAGGAATGAAT TTGAGAACTTCGTGGAGGAACAAAACGATGAGCAGGAAGAGAGGAGCCGGGAGGCTGTGGAGCAGTGGCGCCAGTGGCACTATGACGGCC TGCACCCATCCTATCTCTACAACCGCCACCACACCTGATCCCATCCTGAAGCCGGCCAAGAAGACAAAGCTTGTAGCACCATTGGCATCC CCGTGTTCCAGCAATCTTTCCCATGCAAACCGGCCCTTCAGAGGGTCTCAGCTTGGGGTCTGCAGTGGCCAGCAGCTCTTGAAAAGACGC ATGCCTTTCCTTCCAGTGTGTGAAAGTGTCCTGACTTTCACCTCTTTGCAGACCATCTTCTGAGGTGAGCAACTGCCTGCAGGGCCTCCT AGTACCAAACCTACAGTGGCTTCCCCTGGCTTCGTTCCCAAGCAAAAGAATCAGTCAAGAATCACATGTTTGCTTATGGCTTACAAATAA >In-frame_LIPG_ENST00000427224_chr18_47095918_+_UCMA_ENST00000378681_chr10_13275800_-_1515nt AGCGAGTCCTTGCCTCCCGGCGGCTCAGGACGAGGGCAGATCTCGTTCTGGGGCAAGCCGTTGACACTCGCTCCCTGCCACCGCCCGGGC TCCGTGCCGCCAAGTTTTCATTTTCCACCTTCTCTGCCTCCAGTCCCCCAGCCCCTGGCCGAGAGAAGGGTCTTACCGGCCGGGATTGCT GGAAACACCAAGAGGTGGTTTTTGTTTTTTAAAACTTCTGTTTCTTGGGAGGGGGTGTGGCGGGGCAGGATGAGCAACTCCGTTCCTCTG CTCTGTTTCTGGAGCCTCTGCTATTGCTTTGCTGCGGGGAGCCCCGTACCTTTTGGTCCAGAGGGACGGCTGGAAGATAAGCTCCACAAA CCCAAAGCTACACAGACTGAGGTCAAACCATCTGTGAGGTTTAACCTCCGCACCTCCAAGGACCCAGAGCATGAAGGATGCTACCTCTCC GTCGGCCACAGCCAGCCCTTAGAAGACTGCAGTTTCAACATGACAGCTAAAACCTTTTTCATCATTCACGGATGGACGATGAGCGGTATC TTTGAAAACTGGCTGCACAAACTCGTGTCAGCCCTGCACACAAGAGAGAAAGACGCCAATGTAGTTGTGGTTGACTGGCTCCCCCTGGCC CACCAGCTTTACACGGATGCGGTCAATAATACCAGGGTGGTGGGACACAGCATTGCCAGGATGCTCGACTGGCTGCAGGAGAAGGACGAT TTTTCTCTCGGGAATGTCCACTTGATCGGCTACAGCCTCGGAGCGCACGTGGCCGGGTATGCAGGCAACTTCGTGAAAGGAACGGTGGGC CGAATCACAGTGCTGAGAGAGGGAACCAGTGTATCTGTGGGCACCATGCAGATGGCGGGAGAAGAGGCGAGTGAAGATGCAAAACAGAAG ATTTTCATGCAGGAATCAGATGCCTCGAATTTCCTCAAGAGGCGCGGCAAGCGGTCCCCCAAGTCCAGAGATGAGGTCAATGTGGAAAAC AGGCAGAAGCTTCGGGTTGATGAGCTGCGGAGAGAATATTACGAGGAACAAAGGAATGAATTTGAGAACTTCGTGGAGGAACAAAACGAT GAGCAGGAAGAGAGGAGCCGGGAGGCTGTGGAGCAGTGGCGCCAGTGGCACTATGACGGCCTGCACCCATCCTATCTCTACAACCGCCAC CACACCTGATCCCATCCTGAAGCCGGCCAAGAAGACAAAGCTTGTAGCACCATTGGCATCCCCGTGTTCCAGCAATCTTTCCCATGCAAA CCGGCCCTTCAGAGGGTCTCAGCTTGGGGTCTGCAGTGGCCAGCAGCTCTTGAAAAGACGCATGCCTTTCCTTCCAGTGTGTGAAAGTGT CCTGACTTTCACCTCTTTGCAGACCATCTTCTGAGGTGAGCAACTGCCTGCAGGGCCTCCTAGTACCAAACCTACAGTGGCTTCCCCTGG >In-frame_LIPG_ENST00000580036_chr18_47095918_+_UCMA_ENST00000378681_chr10_13275800_-_1488nt GGACGAGGGCAGATCTCGTTCTGGGGCAAGCCGTTGACACTCGCTCCCTGCCACCGCCCGGGCTCCGTGCCGCCAAGTTTTCATTTTCCA CCTTCTCTGCCTCCAGTCCCCCAGCCCCTGGCCGAGAGAAGGGTCTTACCGGCCGGGATTGCTGGAAACACCAAGAGGTGGTTTTTGTTT TTTAAAACTTCTGTTTCTTGGGAGGGGGTGTGGCGGGGCAGGATGAGCAACTCCGTTCCTCTGCTCTGTTTCTGGAGCCTCTGCTATTGC TTTGCTGCGGGGAGCCCCGTACCTTTTGGTCCAGAGGGACGGCTGGAAGATAAGCTCCACAAACCCAAAGCTACACAGACTGAGGTCAAA CCATCTGTGAGGTTTAACCTCCGCACCTCCAAGGACCCAGAGCATGAAGGATGCTACCTCTCCGTCGGCCACAGCCAGCCCTTAGAAGAC TGCAGTTTCAACATGACAGCTAAAACCTTTTTCATCATTCACGGATGGACGATGAGCGGTATCTTTGAAAACTGGCTGCACAAACTCGTG TCAGCCCTGCACACAAGAGAGAAAGACGCCAATGTAGTTGTGGTTGACTGGCTCCCCCTGGCCCACCAGCTTTACACGGATGCGGTCAAT AATACCAGGGTGGTGGGACACAGCATTGCCAGGATGCTCGACTGGCTGCAGGAGAAGGACGATTTTTCTCTCGGGAATGTCCACTTGATC GGCTACAGCCTCGGAGCGCACGTGGCCGGGTATGCAGGCAACTTCGTGAAAGGAACGGTGGGCCGAATCACAGTGCTGAGAGAGGGAACC AGTGTATCTGTGGGCACCATGCAGATGGCGGGAGAAGAGGCGAGTGAAGATGCAAAACAGAAGATTTTCATGCAGGAATCAGATGCCTCG AATTTCCTCAAGAGGCGCGGCAAGCGGTCCCCCAAGTCCAGAGATGAGGTCAATGTGGAAAACAGGCAGAAGCTTCGGGTTGATGAGCTG CGGAGAGAATATTACGAGGAACAAAGGAATGAATTTGAGAACTTCGTGGAGGAACAAAACGATGAGCAGGAAGAGAGGAGCCGGGAGGCT GTGGAGCAGTGGCGCCAGTGGCACTATGACGGCCTGCACCCATCCTATCTCTACAACCGCCACCACACCTGATCCCATCCTGAAGCCGGC CAAGAAGACAAAGCTTGTAGCACCATTGGCATCCCCGTGTTCCAGCAATCTTTCCCATGCAAACCGGCCCTTCAGAGGGTCTCAGCTTGG GGTCTGCAGTGGCCAGCAGCTCTTGAAAAGACGCATGCCTTTCCTTCCAGTGTGTGAAAGTGTCCTGACTTTCACCTCTTTGCAGACCAT CTTCTGAGGTGAGCAACTGCCTGCAGGGCCTCCTAGTACCAAACCTACAGTGGCTTCCCCTGGCTTCGTTCCCAAGCAAAAGAATCAGTC |
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FusionGenePPI for LIPG_UCMA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LIPG | FANCA, EXOSC5, LIPG, DNAJC13, TMED4, TUBB1, TMED9, TMED5, TRMT1, PLS1, PTPRS, NRP1, TMED10, TMED2, CANX, ITIH2, SDC2, HLA-C, MAPK14, ARL8A, ABHD14A, GPC3 | UCMA | KRT40 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LIPG_UCMA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LIPG_UCMA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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