FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 19813

FusionGeneSummary for LIPC_UGDH-AS1

check button Fusion gene summary
Fusion gene informationFusion gene name: LIPC_UGDH-AS1
Fusion gene ID: 19813
HgeneTgene
Gene symbol

LIPC

UGDH-AS1

Gene ID

3990

100885776

Gene namelipase C, hepatic typeUGDH antisense RNA 1
SynonymsHDLCQ12|HL|HTGL|LIPH-
Cytomap

15q21.3

4p14

Type of geneprotein-codingncRNA
Descriptionhepatic triacylglycerol lipaseTriacylglycerol lipasehepatic lipaselipase member Clipase, hepaticUGDH antisense RNA 1 (non-protein coding)
Modification date2018051920180329
UniProtAcc

P11150

Ensembl transtripts involved in fusion geneENST00000356113, ENST00000414170, 
ENST00000299022, ENST00000433326, 
ENST00000504032, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 1=4
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: LIPC [Title/Abstract] AND UGDH-AS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLIPC

GO:0006633

fatty acid biosynthetic process

182536

HgeneLIPC

GO:0019433

triglyceride catabolic process

182536|2839510|8640403

HgeneLIPC

GO:0034372

very-low-density lipoprotein particle remodeling

8640403


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI114700LIPCchr15

58860913

-UGDH-AS1chr4

39594408

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000356113ENST00000504032LIPCchr15

58860913

-UGDH-AS1chr4

39594408

-
intron-3UTRENST00000414170ENST00000504032LIPCchr15

58860913

-UGDH-AS1chr4

39594408

-
intron-3UTRENST00000299022ENST00000504032LIPCchr15

58860913

-UGDH-AS1chr4

39594408

-
intron-3UTRENST00000433326ENST00000504032LIPCchr15

58860913

-UGDH-AS1chr4

39594408

-

Top

FusionProtFeatures for LIPC_UGDH-AS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LIPC

P11150

UGDH-AS1

Hepatic lipase has the capacity to catalyze hydrolysisof phospholipids, mono-, di-, and triglycerides, and acyl-CoAthioesters. It is an important enzyme in HDL metabolism. Hepaticlipase binds heparin. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for LIPC_UGDH-AS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LIPC_UGDH-AS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LIPC_UGDH-AS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for LIPC_UGDH-AS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLIPCC0023772Lipid Metabolism, Inborn Errors3CTD_human
HgeneLIPCC0011860Diabetes Mellitus, Non-Insulin-Dependent2CTD_human
HgeneLIPCC3151466HEPATIC LIPASE DEFICIENCY (disorder)2ORPHANET;UNIPROT
HgeneLIPCC0020445Hypercholesterolemia, Familial1CTD_human
HgeneLIPCC0020452Hyperemia1CTD_human
HgeneLIPCC0020473Hyperlipidemia1CTD_human
HgeneLIPCC0020476Hyperlipoproteinemias1CTD_human
HgeneLIPCC0021655Insulin Resistance1CTD_human