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Fusion gene ID: 19813 |
FusionGeneSummary for LIPC_UGDH-AS1 |
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Fusion gene information | Fusion gene name: LIPC_UGDH-AS1 | Fusion gene ID: 19813 | Hgene | Tgene | Gene symbol | LIPC | UGDH-AS1 | Gene ID | 3990 | 100885776 |
Gene name | lipase C, hepatic type | UGDH antisense RNA 1 | |
Synonyms | HDLCQ12|HL|HTGL|LIPH | - | |
Cytomap | 15q21.3 | 4p14 | |
Type of gene | protein-coding | ncRNA | |
Description | hepatic triacylglycerol lipaseTriacylglycerol lipasehepatic lipaselipase member Clipase, hepatic | UGDH antisense RNA 1 (non-protein coding) | |
Modification date | 20180519 | 20180329 | |
UniProtAcc | P11150 | ||
Ensembl transtripts involved in fusion gene | ENST00000356113, ENST00000414170, ENST00000299022, ENST00000433326, | ENST00000504032, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 1=4 |
# samples | 3 | 2 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: LIPC [Title/Abstract] AND UGDH-AS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LIPC | GO:0006633 | fatty acid biosynthetic process | 182536 |
Hgene | LIPC | GO:0019433 | triglyceride catabolic process | 182536|2839510|8640403 |
Hgene | LIPC | GO:0034372 | very-low-density lipoprotein particle remodeling | 8640403 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI114700 | LIPC | chr15 | 58860913 | - | UGDH-AS1 | chr4 | 39594408 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000356113 | ENST00000504032 | LIPC | chr15 | 58860913 | - | UGDH-AS1 | chr4 | 39594408 | - |
intron-3UTR | ENST00000414170 | ENST00000504032 | LIPC | chr15 | 58860913 | - | UGDH-AS1 | chr4 | 39594408 | - |
intron-3UTR | ENST00000299022 | ENST00000504032 | LIPC | chr15 | 58860913 | - | UGDH-AS1 | chr4 | 39594408 | - |
intron-3UTR | ENST00000433326 | ENST00000504032 | LIPC | chr15 | 58860913 | - | UGDH-AS1 | chr4 | 39594408 | - |
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FusionProtFeatures for LIPC_UGDH-AS1 |
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Hgene | Tgene |
LIPC | UGDH-AS1 |
Hepatic lipase has the capacity to catalyze hydrolysisof phospholipids, mono-, di-, and triglycerides, and acyl-CoAthioesters. It is an important enzyme in HDL metabolism. Hepaticlipase binds heparin. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LIPC_UGDH-AS1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LIPC_UGDH-AS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LIPC_UGDH-AS1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LIPC_UGDH-AS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LIPC | C0023772 | Lipid Metabolism, Inborn Errors | 3 | CTD_human |
Hgene | LIPC | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | CTD_human |
Hgene | LIPC | C3151466 | HEPATIC LIPASE DEFICIENCY (disorder) | 2 | ORPHANET;UNIPROT |
Hgene | LIPC | C0020445 | Hypercholesterolemia, Familial | 1 | CTD_human |
Hgene | LIPC | C0020452 | Hyperemia | 1 | CTD_human |
Hgene | LIPC | C0020473 | Hyperlipidemia | 1 | CTD_human |
Hgene | LIPC | C0020476 | Hyperlipoproteinemias | 1 | CTD_human |
Hgene | LIPC | C0021655 | Insulin Resistance | 1 | CTD_human |