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Fusion gene ID: 19787 |
FusionGeneSummary for LINC00877_SH3RF3 |
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Fusion gene information | Fusion gene name: LINC00877_SH3RF3 | Fusion gene ID: 19787 | Hgene | Tgene | Gene symbol | LINC00877 | SH3RF3 | Gene ID | 285286 | 344558 |
Gene name | long intergenic non-protein coding RNA 877 | SH3 domain containing ring finger 3 | |
Synonyms | - | POSH2|SH3MD4 | |
Cytomap | 3p13 | 2q13 | |
Type of gene | ncRNA | protein-coding | |
Description | - | SH3 domain-containing RING finger protein 3SH3 multiple domains 4plenty of SH3s-2 | |
Modification date | 20180329 | 20180519 | |
UniProtAcc | Q8TEJ3 | ||
Ensembl transtripts involved in fusion gene | ENST00000468646, | ENST00000309415, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 2=32 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: LINC00877 [Title/Abstract] AND SH3RF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DB027763 | LINC00877 | chr3 | 72108840 | - | SH3RF3 | chr2 | 110007525 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-intron | ENST00000468646 | ENST00000309415 | LINC00877 | chr3 | 72108840 | - | SH3RF3 | chr2 | 110007525 | - |
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FusionProtFeatures for LINC00877_SH3RF3 |
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Hgene | Tgene |
LINC00877 | SH3RF3 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Has E3 ubiquitin-protein ligase activity.{ECO:0000269|PubMed:20696164}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LINC00877_SH3RF3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LINC00877_SH3RF3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LINC00877_SH3RF3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LINC00877_SH3RF3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SH3RF3 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |