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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19780

FusionGeneSummary for LINC00668_SLC9B1

check button Fusion gene summary
Fusion gene informationFusion gene name: LINC00668_SLC9B1
Fusion gene ID: 19780
HgeneTgene
Gene symbol

LINC00668

SLC9B1

Gene ID

400643

150159

Gene namelong intergenic non-protein coding RNA 668solute carrier family 9 member B1
Synonyms-NHA1|NHEDC1
Cytomap

18p11.31

4q24

Type of genencRNAprotein-coding
Description-sodium/hydrogen exchanger 9B1NHE domain-containing protein 1Na(+)/H(+) exchanger-like domain-containing protein 1sodium/hydrogen exchanger-like domain-containing protein 1solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member
Modification date2018032920180523
UniProtAcc

Q4ZJI4

Ensembl transtripts involved in fusion geneENST00000580197, ENST00000394789, 
ENST00000296422, ENST00000512651, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 22
** MAII scorelog2(2/1*10)=4.32192809488736log2(2/1*10)=4.32192809488736
Context

PubMed: LINC00668 [Title/Abstract] AND SLC9B1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI970491LINC00668chr18

6925664

+SLC9B1chr4

103936016

+
ChiTaRS3.1BE464457LINC00668chr18

6925664

+SLC9B1chr4

103936016

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000580197ENST00000394789LINC00668chr18

6925664

+SLC9B1chr4

103936016

+
intron-intronENST00000580197ENST00000296422LINC00668chr18

6925664

+SLC9B1chr4

103936016

+
intron-intronENST00000580197ENST00000512651LINC00668chr18

6925664

+SLC9B1chr4

103936016

+

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FusionProtFeatures for LINC00668_SLC9B1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LINC00668

SLC9B1

Q4ZJI4

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Sperm-specific Na(+)/H(+) exchanger involved inintracellular pH regulation of spermatozoa. Involved in spermmotility and fertility. {ECO:0000250|UniProtKB:Q8C0X2}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LINC00668_SLC9B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LINC00668_SLC9B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LINC00668_SLC9B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LINC00668_SLC9B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource