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Fusion gene ID: 19751 |
FusionGeneSummary for LIN54_PLAC8 |
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Fusion gene information | Fusion gene name: LIN54_PLAC8 | Fusion gene ID: 19751 | Hgene | Tgene | Gene symbol | LIN54 | PLAC8 | Gene ID | 132660 | 51316 |
Gene name | lin-54 DREAM MuvB core complex component | placenta specific 8 | |
Synonyms | CXCDC1|JC8.6|MIP120|TCX1 | C15|DGIC|PNAS-144|onzin | |
Cytomap | 4q21.22 | 4q21.22 | |
Type of gene | protein-coding | protein-coding | |
Description | protein lin-54 homologCXC domain-containing protein 1lin-54 homolog | placenta-specific gene 8 proteindown-regulated in gastrointestinal cancer protein | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q6MZP7 | Q9NZF1 | |
Ensembl transtripts involved in fusion gene | ENST00000395282, ENST00000395283, ENST00000340417, ENST00000442461, ENST00000446851, ENST00000510557, ENST00000506560, ENST00000505397, ENST00000505905, | ENST00000311507, ENST00000411416, ENST00000515389, ENST00000509973, ENST00000505406, ENST00000426923, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 2 X 3=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: LIN54 [Title/Abstract] AND PLAC8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-BR-6454-01A | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000395282 | ENST00000311507 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000395282 | ENST00000411416 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000395282 | ENST00000515389 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000395282 | ENST00000509973 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-5UTR | ENST00000395282 | ENST00000505406 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000395282 | ENST00000426923 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000395283 | ENST00000311507 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000395283 | ENST00000411416 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000395283 | ENST00000515389 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000395283 | ENST00000509973 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-5UTR | ENST00000395283 | ENST00000505406 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000395283 | ENST00000426923 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000340417 | ENST00000311507 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000340417 | ENST00000411416 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000340417 | ENST00000515389 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000340417 | ENST00000509973 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-5UTR | ENST00000340417 | ENST00000505406 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000340417 | ENST00000426923 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000442461 | ENST00000311507 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000442461 | ENST00000411416 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000442461 | ENST00000515389 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000442461 | ENST00000509973 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-5UTR | ENST00000442461 | ENST00000505406 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000442461 | ENST00000426923 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000446851 | ENST00000311507 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000446851 | ENST00000411416 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000446851 | ENST00000515389 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000446851 | ENST00000509973 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-5UTR | ENST00000446851 | ENST00000505406 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000446851 | ENST00000426923 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
5UTR-intron | ENST00000510557 | ENST00000311507 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
5UTR-intron | ENST00000510557 | ENST00000411416 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
5UTR-intron | ENST00000510557 | ENST00000515389 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
5UTR-intron | ENST00000510557 | ENST00000509973 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
5UTR-5UTR | ENST00000510557 | ENST00000505406 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
5UTR-intron | ENST00000510557 | ENST00000426923 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000506560 | ENST00000311507 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000506560 | ENST00000411416 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000506560 | ENST00000515389 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000506560 | ENST00000509973 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-5UTR | ENST00000506560 | ENST00000505406 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000506560 | ENST00000426923 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
5UTR-intron | ENST00000505397 | ENST00000311507 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
5UTR-intron | ENST00000505397 | ENST00000411416 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
5UTR-intron | ENST00000505397 | ENST00000515389 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
5UTR-intron | ENST00000505397 | ENST00000509973 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
5UTR-5UTR | ENST00000505397 | ENST00000505406 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
5UTR-intron | ENST00000505397 | ENST00000426923 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000505905 | ENST00000311507 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000505905 | ENST00000411416 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000505905 | ENST00000515389 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000505905 | ENST00000509973 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-5UTR | ENST00000505905 | ENST00000505406 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
intron-intron | ENST00000505905 | ENST00000426923 | LIN54 | chr4 | 83933945 | - | PLAC8 | chr4 | 84039124 | - |
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FusionProtFeatures for LIN54_PLAC8 |
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Hgene | Tgene |
LIN54 | PLAC8 |
Component of the DREAM complex, a multiprotein complexthat can both act as a transcription activator or repressordepending on the context (PubMed:17671431, PubMed:17531812). In G0phase, the complex binds to more than 800 promoters and isrequired for repression of E2F target genes (PubMed:17671431,PubMed:17531812). In S phase, the complex selectively binds to thepromoters of G2/M genes whose products are required for mitosisand participates in their cell cycle dependent activation(PubMed:17671431, PubMed:17531812). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes theconsensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258).{ECO:0000269|PubMed:17531812, ECO:0000269|PubMed:17671431,ECO:0000269|PubMed:19725879, ECO:0000269|PubMed:27465258}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LIN54_PLAC8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LIN54_PLAC8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LIN54 | RB1, LIN9, LIN37, LIN52, MYBL2, E2F4, RBL2, TFDP1, TFDP2, RBBP4, MYBL1, RBL1, ELAVL1, SPINT2, PSMC3, B9D2, DYNLT1, FOXJ2, FOXM1, RPN2, L3MBTL2, TUSC3, IKZF5, CAMK2D | PLAC8 | TRIP13, COPS5, ELAVL1, RBPMS, TP53 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LIN54_PLAC8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LIN54_PLAC8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PLAC8 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |