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Fusion gene ID: 19750 |
FusionGeneSummary for LIN54_GDE1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LIN54_GDE1 | Fusion gene ID: 19750 | Hgene | Tgene | Gene symbol | LIN54 | GDE1 | Gene ID | 132660 | 51573 |
| Gene name | lin-54 DREAM MuvB core complex component | glycerophosphodiester phosphodiesterase 1 | |
| Synonyms | CXCDC1|JC8.6|MIP120|TCX1 | 363E6.2|MIR16 | |
| Cytomap | 4q21.22 | 16p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein lin-54 homologCXC domain-containing protein 1lin-54 homolog | glycerophosphodiester phosphodiesterase 1RGS16-interacting membrane proteinmembrane interacting protein of RGS16 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q6MZP7 | Q9NZC3 | |
| Ensembl transtripts involved in fusion gene | ENST00000395282, ENST00000395283, ENST00000340417, ENST00000442461, ENST00000446851, ENST00000510557, ENST00000506560, ENST00000505397, ENST00000505905, | ENST00000353258, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 3 X 1=12 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LIN54 [Title/Abstract] AND GDE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW881269 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000395282 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000395283 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000340417 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000442461 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000446851 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000510557 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000506560 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000505397 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000505905 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
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FusionProtFeatures for LIN54_GDE1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LIN54 | GDE1 |
| Component of the DREAM complex, a multiprotein complexthat can both act as a transcription activator or repressordepending on the context (PubMed:17671431, PubMed:17531812). In G0phase, the complex binds to more than 800 promoters and isrequired for repression of E2F target genes (PubMed:17671431,PubMed:17531812). In S phase, the complex selectively binds to thepromoters of G2/M genes whose products are required for mitosisand participates in their cell cycle dependent activation(PubMed:17671431, PubMed:17531812). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes theconsensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258).{ECO:0000269|PubMed:17531812, ECO:0000269|PubMed:17671431,ECO:0000269|PubMed:19725879, ECO:0000269|PubMed:27465258}. | Has glycerophosphoinositol phosphodiesterase activity.Hydrolyzes lysoglycerophospholipids to produce lysophosphatidicacid (LPA) and the corresponding amines. Has little or no activitytowards glycerophosphocholine. GDE1 activity can be modulated byG-protein signaling pathways (By similarity).{ECO:0000250|UniProtKB:Q9JL55, ECO:0000250|UniProtKB:Q9JL56}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LIN54_GDE1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LIN54_GDE1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LIN54_GDE1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LIN54_GDE1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | GDE1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | GDE1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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