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Fusion gene ID: 19745 |
FusionGeneSummary for LIMS1_RNF185 |
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Fusion gene information | Fusion gene name: LIMS1_RNF185 | Fusion gene ID: 19745 | Hgene | Tgene | Gene symbol | LIMS1 | RNF185 | Gene ID | 3987 | 91445 |
Gene name | LIM zinc finger domain containing 1 | ring finger protein 185 | |
Synonyms | PINCH|PINCH-1|PINCH1 | - | |
Cytomap | 2q12.3 | 22q12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | LIM and senescent cell antigen-like-containing domain protein 1LIM and senescent cell antigen-like domains 1LIM-type zinc finger domains 1particularly interesting new Cys-His protein 1renal carcinoma antigen NY-REN-48senescent cell antigen | E3 ubiquitin-protein ligase RNF185BSK65-MONO1BSK65-MONO2BSK65-PANC1BSK65-PANC2BSK65-TEST1BSK65-TEST2BSK65-TEST3RING-type E3 ubiquitin transferase RNF185 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P48059 | Q96GF1 | |
Ensembl transtripts involved in fusion gene | ENST00000544547, ENST00000332345, ENST00000393310, ENST00000410093, ENST00000409441, ENST00000338045, ENST00000462817, ENST00000542845, ENST00000393314, | ENST00000426256, ENST00000326132, ENST00000266252, | |
Fusion gene scores | * DoF score | 4 X 2 X 3=24 | 3 X 3 X 1=9 |
# samples | 4 | 3 | |
** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: LIMS1 [Title/Abstract] AND RNF185 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LIMS1 | GO:0045892 | negative regulation of transcription, DNA-templated | 21390327 |
Tgene | RNF185 | GO:0051865 | protein autoubiquitination | 24019521 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BX644470 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000544547 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000544547 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000544547 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000332345 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000332345 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000332345 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
5UTR-intron | ENST00000393310 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
5UTR-intron | ENST00000393310 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
5UTR-intron | ENST00000393310 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000410093 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000410093 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000410093 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000409441 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000409441 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000409441 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000338045 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000338045 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000338045 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000462817 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000462817 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000462817 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000542845 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000542845 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000542845 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000393314 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000393314 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
intron-intron | ENST00000393314 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
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FusionProtFeatures for LIMS1_RNF185 |
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Hgene | Tgene |
LIMS1 | RNF185 |
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cellsurface receptor tyrosine kinases and growth factor receptors.Involved in the regulation of cell survival, cell proliferationand cell differentiation. | E3 ubiquitin-protein ligase that regulates selectivemitochondrial autophagy by mediating 'Lys-63'-linkedpolyubiquitination of BNIP1 (PubMed:21931693). Acts in theendoplasmic reticulum (ER)-associated degradation (ERAD) pathway,which targets misfolded proteins that accumulate in theendoplasmic reticulum (ER) for ubiquitination and subsequentproteasome-mediated degradation (PubMed:27485036). Protects cellsfrom ER stress-induced apoptosis (PubMed:27485036). Responsiblefor the cotranslational ubiquitination and degradation of CFTR inthe ERAD pathway (PubMed:24019521). Preferentially associates withthe E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521).{ECO:0000269|PubMed:21931693, ECO:0000269|PubMed:24019521,ECO:0000269|PubMed:27485036}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LIMS1_RNF185 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LIMS1_RNF185 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LIMS1_RNF185 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LIMS1_RNF185 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |