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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19745

FusionGeneSummary for LIMS1_RNF185

check button Fusion gene summary
Fusion gene informationFusion gene name: LIMS1_RNF185
Fusion gene ID: 19745
HgeneTgene
Gene symbol

LIMS1

RNF185

Gene ID

3987

91445

Gene nameLIM zinc finger domain containing 1ring finger protein 185
SynonymsPINCH|PINCH-1|PINCH1-
Cytomap

2q12.3

22q12.2

Type of geneprotein-codingprotein-coding
DescriptionLIM and senescent cell antigen-like-containing domain protein 1LIM and senescent cell antigen-like domains 1LIM-type zinc finger domains 1particularly interesting new Cys-His protein 1renal carcinoma antigen NY-REN-48senescent cell antigenE3 ubiquitin-protein ligase RNF185BSK65-MONO1BSK65-MONO2BSK65-PANC1BSK65-PANC2BSK65-TEST1BSK65-TEST2BSK65-TEST3RING-type E3 ubiquitin transferase RNF185
Modification date2018052220180523
UniProtAcc

P48059

Q96GF1

Ensembl transtripts involved in fusion geneENST00000544547, ENST00000332345, 
ENST00000393310, ENST00000410093, 
ENST00000409441, ENST00000338045, 
ENST00000462817, ENST00000542845, 
ENST00000393314, 
ENST00000426256, 
ENST00000326132, ENST00000266252, 
Fusion gene scores* DoF score4 X 2 X 3=243 X 3 X 1=9
# samples 43
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LIMS1 [Title/Abstract] AND RNF185 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLIMS1

GO:0045892

negative regulation of transcription, DNA-templated

21390327

TgeneRNF185

GO:0051865

protein autoubiquitination

24019521


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX644470LIMS1chr2

109205075

+RNF185chr22

31562886

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000544547ENST00000426256LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000544547ENST00000326132LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000544547ENST00000266252LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000332345ENST00000426256LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000332345ENST00000326132LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000332345ENST00000266252LIMS1chr2

109205075

+RNF185chr22

31562886

+
5UTR-intronENST00000393310ENST00000426256LIMS1chr2

109205075

+RNF185chr22

31562886

+
5UTR-intronENST00000393310ENST00000326132LIMS1chr2

109205075

+RNF185chr22

31562886

+
5UTR-intronENST00000393310ENST00000266252LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000410093ENST00000426256LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000410093ENST00000326132LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000410093ENST00000266252LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000409441ENST00000426256LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000409441ENST00000326132LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000409441ENST00000266252LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000338045ENST00000426256LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000338045ENST00000326132LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000338045ENST00000266252LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000462817ENST00000426256LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000462817ENST00000326132LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000462817ENST00000266252LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000542845ENST00000426256LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000542845ENST00000326132LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000542845ENST00000266252LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000393314ENST00000426256LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000393314ENST00000326132LIMS1chr2

109205075

+RNF185chr22

31562886

+
intron-intronENST00000393314ENST00000266252LIMS1chr2

109205075

+RNF185chr22

31562886

+

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FusionProtFeatures for LIMS1_RNF185


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LIMS1

P48059

RNF185

Q96GF1

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cellsurface receptor tyrosine kinases and growth factor receptors.Involved in the regulation of cell survival, cell proliferationand cell differentiation. E3 ubiquitin-protein ligase that regulates selectivemitochondrial autophagy by mediating 'Lys-63'-linkedpolyubiquitination of BNIP1 (PubMed:21931693). Acts in theendoplasmic reticulum (ER)-associated degradation (ERAD) pathway,which targets misfolded proteins that accumulate in theendoplasmic reticulum (ER) for ubiquitination and subsequentproteasome-mediated degradation (PubMed:27485036). Protects cellsfrom ER stress-induced apoptosis (PubMed:27485036). Responsiblefor the cotranslational ubiquitination and degradation of CFTR inthe ERAD pathway (PubMed:24019521). Preferentially associates withthe E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521).{ECO:0000269|PubMed:21931693, ECO:0000269|PubMed:24019521,ECO:0000269|PubMed:27485036}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LIMS1_RNF185


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LIMS1_RNF185


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LIMS1_RNF185


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LIMS1_RNF185


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource