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Fusion gene ID: 19745 |
FusionGeneSummary for LIMS1_RNF185 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LIMS1_RNF185 | Fusion gene ID: 19745 | Hgene | Tgene | Gene symbol | LIMS1 | RNF185 | Gene ID | 3987 | 91445 |
| Gene name | LIM zinc finger domain containing 1 | ring finger protein 185 | |
| Synonyms | PINCH|PINCH-1|PINCH1 | - | |
| Cytomap | 2q12.3 | 22q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | LIM and senescent cell antigen-like-containing domain protein 1LIM and senescent cell antigen-like domains 1LIM-type zinc finger domains 1particularly interesting new Cys-His protein 1renal carcinoma antigen NY-REN-48senescent cell antigen | E3 ubiquitin-protein ligase RNF185BSK65-MONO1BSK65-MONO2BSK65-PANC1BSK65-PANC2BSK65-TEST1BSK65-TEST2BSK65-TEST3RING-type E3 ubiquitin transferase RNF185 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P48059 | Q96GF1 | |
| Ensembl transtripts involved in fusion gene | ENST00000544547, ENST00000332345, ENST00000393310, ENST00000410093, ENST00000409441, ENST00000338045, ENST00000462817, ENST00000542845, ENST00000393314, | ENST00000426256, ENST00000326132, ENST00000266252, | |
| Fusion gene scores | * DoF score | 4 X 2 X 3=24 | 3 X 3 X 1=9 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LIMS1 [Title/Abstract] AND RNF185 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LIMS1 | GO:0045892 | negative regulation of transcription, DNA-templated | 21390327 |
| Tgene | RNF185 | GO:0051865 | protein autoubiquitination | 24019521 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BX644470 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000544547 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000544547 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000544547 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000332345 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000332345 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000332345 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| 5UTR-intron | ENST00000393310 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| 5UTR-intron | ENST00000393310 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| 5UTR-intron | ENST00000393310 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000410093 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000410093 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000410093 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000409441 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000409441 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000409441 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000338045 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000338045 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000338045 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000462817 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000462817 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000462817 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000542845 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000542845 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000542845 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000393314 | ENST00000426256 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000393314 | ENST00000326132 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
| intron-intron | ENST00000393314 | ENST00000266252 | LIMS1 | chr2 | 109205075 | + | RNF185 | chr22 | 31562886 | + |
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FusionProtFeatures for LIMS1_RNF185 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LIMS1 | RNF185 |
| Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cellsurface receptor tyrosine kinases and growth factor receptors.Involved in the regulation of cell survival, cell proliferationand cell differentiation. | E3 ubiquitin-protein ligase that regulates selectivemitochondrial autophagy by mediating 'Lys-63'-linkedpolyubiquitination of BNIP1 (PubMed:21931693). Acts in theendoplasmic reticulum (ER)-associated degradation (ERAD) pathway,which targets misfolded proteins that accumulate in theendoplasmic reticulum (ER) for ubiquitination and subsequentproteasome-mediated degradation (PubMed:27485036). Protects cellsfrom ER stress-induced apoptosis (PubMed:27485036). Responsiblefor the cotranslational ubiquitination and degradation of CFTR inthe ERAD pathway (PubMed:24019521). Preferentially associates withthe E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521).{ECO:0000269|PubMed:21931693, ECO:0000269|PubMed:24019521,ECO:0000269|PubMed:27485036}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LIMS1_RNF185 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LIMS1_RNF185 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LIMS1_RNF185 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LIMS1_RNF185 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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