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Fusion gene ID: 19744 |
FusionGeneSummary for LIMS1_PTP4A2 |
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Fusion gene information | Fusion gene name: LIMS1_PTP4A2 | Fusion gene ID: 19744 | Hgene | Tgene | Gene symbol | LIMS1 | PTP4A2 | Gene ID | 3987 | 8073 |
Gene name | LIM zinc finger domain containing 1 | protein tyrosine phosphatase type IVA, member 2 | |
Synonyms | PINCH|PINCH-1|PINCH1 | HH13|HH7-2|HU-PP-1|OV-1|PRL-2|PRL2|PTP4A|PTPCAAX2|ptp-IV1a|ptp-IV1b | |
Cytomap | 2q12.3 | 1p35.2 | |
Type of gene | protein-coding | protein-coding | |
Description | LIM and senescent cell antigen-like-containing domain protein 1LIM and senescent cell antigen-like domains 1LIM-type zinc finger domains 1particularly interesting new Cys-His protein 1renal carcinoma antigen NY-REN-48senescent cell antigen | protein tyrosine phosphatase type IVA 2PTP(CAAXII)phosphatase of regenerating liver 2protein tyrosine phosphatase IVAprotein tyrosine phosphatase IVA2protein-tyrosine phosphatase 4a2protein-tyrosine phosphatase of regenerating liver 2 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P48059 | Q12974 | |
Ensembl transtripts involved in fusion gene | ENST00000544547, ENST00000332345, ENST00000393310, ENST00000410093, ENST00000409441, ENST00000338045, ENST00000462817, ENST00000542845, ENST00000393314, | ENST00000602725, ENST00000344035, ENST00000356536, ENST00000457805, ENST00000470404, ENST00000526960, | |
Fusion gene scores | * DoF score | 4 X 2 X 3=24 | 3 X 2 X 3=18 |
# samples | 4 | 3 | |
** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: LIMS1 [Title/Abstract] AND PTP4A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LIMS1 | GO:0045892 | negative regulation of transcription, DNA-templated | 21390327 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-55-7995-01A | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000544547 | ENST00000602725 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
5CDS-5UTR | ENST00000544547 | ENST00000344035 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
5CDS-5UTR | ENST00000544547 | ENST00000356536 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
5CDS-intron | ENST00000544547 | ENST00000457805 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
5CDS-intron | ENST00000544547 | ENST00000470404 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
5CDS-5UTR | ENST00000544547 | ENST00000526960 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000332345 | ENST00000602725 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000332345 | ENST00000344035 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000332345 | ENST00000356536 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000332345 | ENST00000457805 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000332345 | ENST00000470404 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000332345 | ENST00000526960 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000393310 | ENST00000602725 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000393310 | ENST00000344035 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000393310 | ENST00000356536 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000393310 | ENST00000457805 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000393310 | ENST00000470404 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000393310 | ENST00000526960 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000410093 | ENST00000602725 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000410093 | ENST00000344035 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000410093 | ENST00000356536 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000410093 | ENST00000457805 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000410093 | ENST00000470404 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000410093 | ENST00000526960 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000409441 | ENST00000602725 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000409441 | ENST00000344035 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000409441 | ENST00000356536 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000409441 | ENST00000457805 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000409441 | ENST00000470404 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000409441 | ENST00000526960 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000338045 | ENST00000602725 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000338045 | ENST00000344035 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000338045 | ENST00000356536 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000338045 | ENST00000457805 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000338045 | ENST00000470404 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000338045 | ENST00000526960 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000462817 | ENST00000602725 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000462817 | ENST00000344035 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000462817 | ENST00000356536 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000462817 | ENST00000457805 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000462817 | ENST00000470404 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000462817 | ENST00000526960 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000542845 | ENST00000602725 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000542845 | ENST00000344035 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000542845 | ENST00000356536 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000542845 | ENST00000457805 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000542845 | ENST00000470404 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000542845 | ENST00000526960 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000393314 | ENST00000602725 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000393314 | ENST00000344035 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000393314 | ENST00000356536 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000393314 | ENST00000457805 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-intron | ENST00000393314 | ENST00000470404 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
intron-5UTR | ENST00000393314 | ENST00000526960 | LIMS1 | chr2 | 109151050 | + | PTP4A2 | chr1 | 32385259 | - |
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FusionProtFeatures for LIMS1_PTP4A2 |
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Hgene | Tgene |
LIMS1 | PTP4A2 |
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cellsurface receptor tyrosine kinases and growth factor receptors.Involved in the regulation of cell survival, cell proliferationand cell differentiation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LIMS1_PTP4A2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LIMS1_PTP4A2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LIMS1 | ILK, RBBP8, LPXN, EHMT2, ACP6, NCK2, STK11, HNRNPU, MBIP, MAPT, STUB1, RSU1, TYMS, MYO18A, PARVA, PARVB, CMAS, SRRT, RABGAP1, REPS1, MYH7, PXN, TRIP6, BMP2K, PARVG, KIF22, XRCC5, TMEM132A, SGOL1, ASPM, SNW1, CDC5L, MYH4 | PTP4A2 | CNNM3, TNFAIP8, CNNM4, FNTA, FNTB, PTP4A1, USF2, RABGGTB, MYC, PON2, UNK, GNB4, SPTAN1, SPTBN1, CNNM1, EFTUD1, CNNM2, PCDHB5, FMN2, GPAA1, CYP8B1, PTP4A3, PTP4A2, FHL3, ATXN7L3B, TARBP2, PRDX4, GADD45GIP1, PRDX3, RPS19BP1, RPL22L1, RPL18A, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LIMS1_PTP4A2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LIMS1_PTP4A2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |