FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1973

FusionGeneSummary for ANTXR2_RNF111

check button Fusion gene summary
Fusion gene informationFusion gene name: ANTXR2_RNF111
Fusion gene ID: 1973
HgeneTgene
Gene symbol

ANTXR2

RNF111

Gene ID

118429

54778

Gene nameANTXR cell adhesion molecule 2ring finger protein 111
SynonymsCMG-2|CMG2|HFS|ISH|JHFARK|hRNF111
Cytomap

4q21.21

15q22.1-q22.2

Type of geneprotein-codingprotein-coding
Descriptionanthrax toxin receptor 2capillary morphogenesis gene 2 proteincapillary morphogenesis protein 2E3 ubiquitin-protein ligase ArkadiaArkadiaRING-type E3 ubiquitin transferase Arkadia
Modification date2018052320180523
UniProtAcc

P58335

Q6ZNA4

Ensembl transtripts involved in fusion geneENST00000403729, ENST00000482406, 
ENST00000404191, ENST00000346652, 
ENST00000307333, ENST00000295465, 
ENST00000348370, ENST00000434298, 
ENST00000559209, ENST00000557998, 
ENST00000561186, ENST00000560080, 
Fusion gene scores* DoF score5 X 6 X 3=907 X 6 X 5=210
# samples 87
** MAII scorelog2(8/90*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANTXR2 [Title/Abstract] AND RNF111 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF329240ANTXR2chr4

80901389

-RNF111chr15

59359150

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000403729ENST00000348370ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000403729ENST00000434298ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000403729ENST00000559209ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000403729ENST00000557998ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000403729ENST00000561186ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-intronENST00000403729ENST00000560080ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000482406ENST00000348370ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000482406ENST00000434298ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000482406ENST00000559209ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000482406ENST00000557998ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000482406ENST00000561186ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-intronENST00000482406ENST00000560080ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000404191ENST00000348370ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000404191ENST00000434298ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000404191ENST00000559209ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000404191ENST00000557998ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000404191ENST00000561186ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-intronENST00000404191ENST00000560080ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000346652ENST00000348370ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000346652ENST00000434298ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000346652ENST00000559209ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000346652ENST00000557998ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000346652ENST00000561186ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-intronENST00000346652ENST00000560080ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000307333ENST00000348370ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000307333ENST00000434298ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000307333ENST00000559209ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000307333ENST00000557998ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000307333ENST00000561186ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-intronENST00000307333ENST00000560080ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000295465ENST00000348370ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000295465ENST00000434298ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000295465ENST00000559209ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000295465ENST00000557998ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-3CDSENST00000295465ENST00000561186ANTXR2chr4

80901389

-RNF111chr15

59359150

-
intron-intronENST00000295465ENST00000560080ANTXR2chr4

80901389

-RNF111chr15

59359150

-

Top

FusionProtFeatures for ANTXR2_RNF111


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANTXR2

P58335

RNF111

Q6ZNA4

Necessary for cellular interactions with laminin and theextracellular matrix. {ECO:0000269|PubMed:11683410,ECO:0000269|PubMed:12973667}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ANTXR2_RNF111


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ANTXR2_RNF111


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ANTXR2_RNF111


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ANTXR2_RNF111


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANTXR2C0009917Contracture2CTD_human
HgeneANTXR2C0016045fibroma2CTD_human
HgeneANTXR2C0017567Gingival Hypertrophy2CTD_human
HgeneANTXR2C0038013Ankylosing spondylitis2CTD_human
HgeneANTXR2C2745948Hyalinosis, Systemic2CTD_human;ORPHANET;UNIPROT
HgeneANTXR2C0029456Osteoporosis1CTD_human
HgeneANTXR2C0221204Lytic lesion1CTD_human