	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 19729

FusionGeneSummary for LIMCH1_RUNX1T1

Fusion gene summary

Fusion gene information	Fusion gene name: LIMCH1_RUNX1T1
	Fusion gene ID: 19729
		Hgene	Tgene
	Gene symbol	LIMCH1	RUNX1T1
	Gene ID	22998	862
	Gene name	LIM and calponin homology domains 1	RUNX1 translocation partner 1
	Synonyms	LIMCH1A\|LMO7B	AML1-MTG8\|AML1T1\|CBFA2T1\|CDR\|ETO\|MTG8\|ZMYND2
	Cytomap	4p13	8q21.3
	Type of gene	protein-coding	protein-coding
	Description	LIM and calponin homology domains-containing protein 1	protein CBFA2T1acute myelogenous leukemia 1 translocation 1, cyclin-D relatedcore-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-relatedeight twenty one proteinmyeloid translocation gene on 8q22runt related transcription f
	Modification date	20180519	20180523
	UniProtAcc	Q9UPQ0	Q06455
	Ensembl transtripts involved in fusion gene	ENST00000513024, ENST00000509638, ENST00000508501, ENST00000512946, ENST00000313860, ENST00000512632, ENST00000512820, ENST00000503057, ENST00000511496, ENST00000514096, ENST00000509277, ENST00000396595, ENST00000381753, ENST00000509454, ENST00000515785,	ENST00000523629, ENST00000396218, ENST00000265814, ENST00000360348, ENST00000436581, ENST00000520724, ENST00000518844, ENST00000522163, ENST00000422361, ENST00000521553,
Fusion gene scores	* DoF score	10 X 8 X 6=480	6 X 19 X 2=228
	# samples	13	30
	** MAII score	log2(13/480*10)=-1.88452278258006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(30/228*10)=0.395928676331139 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: LIMCH1 [Title/Abstract] AND RUNX1T1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RUNX1T1	GO:0045892	negative regulation of transcription, DNA-templated	23251453

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			DQ177301	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-intron	ENST00000513024	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000513024	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000513024	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000513024	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000513024	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000513024	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000513024	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000513024	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000513024	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000513024	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509638	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509638	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509638	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509638	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509638	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509638	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509638	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509638	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509638	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509638	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000508501	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000508501	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000508501	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000508501	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000508501	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000508501	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000508501	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000508501	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000508501	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000508501	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512946	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512946	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512946	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512946	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512946	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512946	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512946	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512946	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512946	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512946	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000313860	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000313860	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000313860	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000313860	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000313860	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000313860	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000313860	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000313860	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000313860	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000313860	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512632	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512632	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512632	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512632	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512632	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512632	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512632	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512632	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512632	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512632	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512820	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512820	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512820	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512820	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512820	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512820	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512820	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512820	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512820	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000512820	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000503057	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000503057	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000503057	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000503057	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000503057	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000503057	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000503057	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000503057	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000503057	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000503057	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000511496	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000511496	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000511496	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000511496	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000511496	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000511496	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000511496	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000511496	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000511496	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000511496	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000514096	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000514096	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000514096	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000514096	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000514096	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000514096	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000514096	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000514096	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000514096	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000514096	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509277	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509277	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509277	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509277	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509277	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509277	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509277	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509277	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509277	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509277	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000396595	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000396595	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000396595	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000396595	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000396595	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000396595	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000396595	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000396595	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000396595	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000396595	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000381753	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000381753	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000381753	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000381753	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000381753	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000381753	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000381753	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000381753	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000381753	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
3UTR-intron	ENST00000381753	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509454	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509454	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509454	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509454	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509454	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509454	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509454	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509454	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509454	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000509454	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000515785	ENST00000523629	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000515785	ENST00000396218	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000515785	ENST00000265814	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000515785	ENST00000360348	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000515785	ENST00000436581	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000515785	ENST00000520724	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000515785	ENST00000518844	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000515785	ENST00000522163	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000515785	ENST00000422361	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-
intron-intron	ENST00000515785	ENST00000521553	LIMCH1	chr4	41700527	+	RUNX1T1	chr8	93081521	-

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FusionProtFeatures for LIMCH1_RUNX1T1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LIMCH1 Q9UPQ0	RUNX1T1 Q06455

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for LIMCH1_RUNX1T1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LIMCH1_RUNX1T1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for LIMCH1_RUNX1T1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for LIMCH1_RUNX1T1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	LIMCH1	C0236969	Substance-Related Disorders	1	CTD_human
Hgene	LIMCH1	C0345967	Malignant mesothelioma	1	CTD_human
Tgene	RUNX1T1	C0023467	Leukemia, Myelocytic, Acute	2	CTD_human
Tgene	RUNX1T1	C0149925	Small cell carcinoma of lung	1	CTD_human

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Fusion gene ID: 19729

FusionGeneSummary for LIMCH1_RUNX1T1

FusionProtFeatures for LIMCH1_RUNX1T1

FusionGeneSequence for LIMCH1_RUNX1T1

FusionGenePPI for LIMCH1_RUNX1T1

RelatedDrugs for LIMCH1_RUNX1T1

RelatedDiseases for LIMCH1_RUNX1T1