	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
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Fusion gene ID: 19724

FusionGeneSummary for LIMCH1_DNM1L

Fusion gene summary

Fusion gene information	Fusion gene name: LIMCH1_DNM1L
	Fusion gene ID: 19724
		Hgene	Tgene
	Gene symbol	LIMCH1	DNM1L
	Gene ID	22998	10059
	Gene name	LIM and calponin homology domains 1	dynamin 1 like
	Synonyms	LIMCH1A\|LMO7B	DLP1\|DRP1\|DVLP\|DYMPLE\|EMPF\|EMPF1\|HDYNIV\|OPA5
	Cytomap	4p13	12p11.21
	Type of gene	protein-coding	protein-coding
	Description	LIM and calponin homology domains-containing protein 1	dynamin-1-like proteinDnm1p/Vps1p-like proteindynamin family member proline-rich carboxyl-terminal domain lessdynamin-like protein 4dynamin-like protein IVdynamin-related protein 1
	Modification date	20180519	20180523
	UniProtAcc	Q9UPQ0	O00429
	Ensembl transtripts involved in fusion gene	ENST00000513024, ENST00000509638, ENST00000508501, ENST00000512946, ENST00000313860, ENST00000512632, ENST00000512820, ENST00000503057, ENST00000511496, ENST00000514096, ENST00000509277, ENST00000396595, ENST00000381753, ENST00000509454, ENST00000515785,	ENST00000452533, ENST00000553257, ENST00000549701, ENST00000358214, ENST00000548671, ENST00000266481, ENST00000547312, ENST00000414834, ENST00000381000,
Fusion gene scores	* DoF score	10 X 8 X 6=480	7 X 6 X 7=294
	# samples	13	8
	** MAII score	log2(13/480*10)=-1.88452278258006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/294*10)=-1.877744249949 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LIMCH1 [Title/Abstract] AND DNM1L [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DNM1L	GO:0000266	mitochondrial fission	23530241
Tgene	DNM1L	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	11514614\|23530241
Tgene	DNM1L	GO:0016559	peroxisome fission	12618434
Tgene	DNM1L	GO:0032459	regulation of protein oligomerization	20850011
Tgene	DNM1L	GO:0050714	positive regulation of protein secretion	9570752
Tgene	DNM1L	GO:0051289	protein homotetramerization	18353969
Tgene	DNM1L	GO:0061025	membrane fusion	20850011
Tgene	DNM1L	GO:0090149	mitochondrial membrane fission	11514614

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	PRAD	TCGA-EJ-7793-01A	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
TCGA	LD	PRAD	TCGA-EJ-7793-01A	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000513024	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000513024	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000513024	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000513024	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000513024	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000513024	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000513024	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000513024	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000513024	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509638	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509638	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509638	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509638	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509638	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509638	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509638	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509638	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509638	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000508501	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000508501	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000508501	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000508501	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000508501	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000508501	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000508501	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000508501	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000508501	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512946	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512946	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512946	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512946	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512946	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512946	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512946	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512946	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512946	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000313860	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000313860	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000313860	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000313860	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000313860	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000313860	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000313860	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000313860	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000313860	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512632	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512632	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512632	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512632	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512632	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512632	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512632	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512632	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512632	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512820	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512820	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512820	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512820	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512820	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512820	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512820	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512820	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000512820	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000503057	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000503057	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000503057	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000503057	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000503057	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000503057	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000503057	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000503057	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000503057	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000511496	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000511496	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000511496	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000511496	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000511496	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000511496	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000511496	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000511496	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000511496	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000514096	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000514096	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000514096	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000514096	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000514096	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000514096	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000514096	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000514096	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000514096	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509277	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509277	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509277	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509277	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509277	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509277	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509277	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509277	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509277	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000396595	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000396595	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000396595	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000396595	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000396595	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000396595	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000396595	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000396595	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000396595	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000381753	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000381753	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000381753	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000381753	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000381753	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000381753	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000381753	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000381753	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
5CDS-intron	ENST00000381753	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509454	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509454	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509454	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509454	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509454	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509454	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509454	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509454	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000509454	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000515785	ENST00000452533	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000515785	ENST00000553257	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000515785	ENST00000549701	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000515785	ENST00000358214	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000515785	ENST00000548671	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000515785	ENST00000266481	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000515785	ENST00000547312	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000515785	ENST00000414834	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-intron	ENST00000515785	ENST00000381000	LIMCH1	chr4	41702059	+	DNM1L	chr12	32905677	+
intron-3CDS	ENST00000513024	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000513024	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000513024	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000513024	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000513024	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000513024	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000513024	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000513024	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000513024	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5UTR-3CDS	ENST00000509638	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5UTR-3CDS	ENST00000509638	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5UTR-3CDS	ENST00000509638	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5UTR-3CDS	ENST00000509638	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5UTR-intron	ENST00000509638	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5UTR-intron	ENST00000509638	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5UTR-intron	ENST00000509638	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5UTR-intron	ENST00000509638	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5UTR-intron	ENST00000509638	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000508501	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000508501	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000508501	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000508501	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000508501	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000508501	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000508501	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000508501	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000508501	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000512946	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000512946	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000512946	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000512946	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512946	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512946	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512946	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512946	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512946	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000313860	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000313860	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000313860	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000313860	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000313860	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000313860	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000313860	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000313860	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000313860	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000512632	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000512632	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000512632	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000512632	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512632	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512632	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512632	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512632	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512632	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000512820	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000512820	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000512820	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
Frame-shift	ENST00000512820	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512820	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512820	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512820	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512820	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
5CDS-intron	ENST00000512820	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000503057	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000503057	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000503057	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000503057	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000503057	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000503057	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000503057	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000503057	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000503057	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000511496	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000511496	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000511496	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000511496	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000511496	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000511496	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000511496	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000511496	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000511496	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000514096	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000514096	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000514096	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000514096	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000514096	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000514096	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000514096	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000514096	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000514096	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000509277	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000509277	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000509277	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000509277	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000509277	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000509277	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000509277	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000509277	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000509277	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000396595	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000396595	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000396595	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000396595	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000396595	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000396595	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000396595	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000396595	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000396595	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000381753	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000381753	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000381753	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000381753	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000381753	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000381753	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000381753	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000381753	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000381753	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000509454	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000509454	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000509454	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000509454	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000509454	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000509454	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000509454	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000509454	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000509454	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000515785	ENST00000452533	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000515785	ENST00000553257	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000515785	ENST00000549701	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-3CDS	ENST00000515785	ENST00000358214	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000515785	ENST00000548671	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000515785	ENST00000266481	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000515785	ENST00000547312	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000515785	ENST00000414834	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+
intron-intron	ENST00000515785	ENST00000381000	LIMCH1	chr4	41362953	+	DNM1L	chr12	32875361	+

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FusionProtFeatures for LIMCH1_DNM1L

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LIMCH1 Q9UPQ0	DNM1L O00429

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for LIMCH1_DNM1L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LIMCH1_DNM1L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
LIMCH1	ELAVL1, SH3KBP1, APP, HUWE1, CUTC, DIABLO, GABPA, KPNA1, NPM1, TRMT61A, RPA3, RPA2, RPA1, OTUD6B, KLHL15, RFC2, YES1, NAGK, GNB4, UNK, NTRK1, CEP120, ODF2, XPO1, CAPZA2, CDK2, MYH9, PPP1CB, IQGAP1, ANLN, MYO19, MYO18A, CDH1, TRIM25	DNM1L	GSK3B, FIS1, PEX11A, PEX11B, PEX11G, PARK2, GABRR1, MUL1, COPS5, LRRK2, MIEF1, PEX14, MARCH5, DNM1L, MFF, MIEF2, SOX2, APEH, CYHR1, CARS, ARFIP1, ATP6V1C1, TBC1D15, FAM129B, JMJD6, PSMG3, SEC24A, SSB, VPS26A, EGFR, MAGEA1, MAGEA3, RRM2, SCG3, SH3GL1, ZBTB24, FZR1, HAX1, NUFIP1, DGUOK, DNAAF2, FGL1, UNK, ATIC, TES, NTRK1, PINK1, LLGL2, PPIA, CDCA5, SNW1, CDC5L, CPNE2, CA14, DUSP23, MYL12A, PFN1, LDHB, RPL30, DBN1, NME1, CKB, TPI1, ALDOA, SAP18, CCT8, RPL12, TXN, EEF2, YWHAE, YWHAZ, YWHAB, HPRT1, CCT2, ARF1, LDHA, EIF5A, RPL27, MDH2, PRDX6, PSMC5, HNRNPA1L2, EEF1B2, PRDX2, RUVBL2, PSMC3, UBA1, EEF1G, TIMM13, VCP, RUVBL1, SF3B6, ACTN4, TPM1, SUB1, XRCC6, HSD17B10, HNRNPAB, PABPC1, HSPA4, HNRNPDL, ILF2, C14orf166, EEF1D, PAICS, YWHAQ, AHCY, PDIA6, STIP1, HSP90B1, IMPDH2, RNPS1, TAGLN2, ACLY, KPNB1, PGAM1, CDC37, PCMT1, NAP1L1, RPL28, ACTR1A, SUMO2, CCT7, TKT, EIF3F, ERH, SERBP1, RBBP4, PARK7, DCD, PSMC6, RANBP1, RARS, PTBP1, UBE2L3, EIF4A3, PDHB, PSMA4, RPA3, PLS3, GFAP, PSMC2, NACA, KCTD12, PSMC1, TRIM28, DNAJA1, HSPH1, HNRNPH3, DCTN2, RBM8A, SAE1, PRMT1, MTHFD1, PSMD2, RBMXL2, EIF2S1, EIF3D, ACTN1, SKP1, FASN, XRCC5, EZR, EIF3B, PFDN2, AHSA1, DDX21, DARS, PNN, BUB3, ACIN1, MYH11, RCC1, EIF3A, DDX39B, PSMC4, DYNC1H1, CDK1, LARS, MAT2A, TLN1, ABCE1, GANAB, CAPRIN1, IQGAP1, SAFB, SOD1, HIST1H2AE, HIST1H2AB, CKMT1B, CKMT1A, CALM1, CALM2, CALM3

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for LIMCH1_DNM1L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for LIMCH1_DNM1L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	LIMCH1	C0236969	Substance-Related Disorders	1	CTD_human
Hgene	LIMCH1	C0345967	Malignant mesothelioma	1	CTD_human
Tgene	DNM1L	C3280660	ENCEPHALOPATHY, LETHAL, DUE TO DEFECTIVE MITOCHONDRIAL AND PEROXISOMAL FISSION	2	ORPHANET;UNIPROT
Tgene	DNM1L	C0001125	Acidosis, Lactic	1	CTD_human;HPO
Tgene	DNM1L	C0025958	Microcephaly	1	CTD_human
Tgene	DNM1L	C0029124	Optic Atrophy	1	CTD_human;HPO
Tgene	DNM1L	C0151744	Myocardial Ischemia	1	CTD_human
Tgene	DNM1L	C0162666	Mitochondrial Encephalomyopathies	1	CTD_human

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Fusion gene ID: 19724

FusionGeneSummary for LIMCH1_DNM1L

FusionProtFeatures for LIMCH1_DNM1L

FusionGeneSequence for LIMCH1_DNM1L

FusionGenePPI for LIMCH1_DNM1L

RelatedDrugs for LIMCH1_DNM1L

RelatedDiseases for LIMCH1_DNM1L