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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19721

FusionGeneSummary for LIMCH1_APBB2

check button Fusion gene summary
Fusion gene informationFusion gene name: LIMCH1_APBB2
Fusion gene ID: 19721
HgeneTgene
Gene symbol

LIMCH1

APBB2

Gene ID

22998

323

Gene nameLIM and calponin homology domains 1amyloid beta precursor protein binding family B member 2
SynonymsLIMCH1A|LMO7BFE65L|FE65L1
Cytomap

4p13

4p14-p13

Type of geneprotein-codingprotein-coding
DescriptionLIM and calponin homology domains-containing protein 1amyloid-beta A4 precursor protein-binding family B member 2Fe65-like 1protein Fe65-like 1
Modification date2018051920180523
UniProtAcc

Q9UPQ0

Q92870

Ensembl transtripts involved in fusion geneENST00000513024, ENST00000509638, 
ENST00000508501, ENST00000512946, 
ENST00000313860, ENST00000512632, 
ENST00000512820, ENST00000503057, 
ENST00000511496, ENST00000514096, 
ENST00000509277, ENST00000396595, 
ENST00000381753, ENST00000509454, 
ENST00000515785, 		ENST00000295974, 
ENST00000513140, ENST00000508593, 
ENST00000506352, ENST00000511572, 
ENST00000543538, ENST00000502841, 
ENST00000504305, 
Fusion gene scores* DoF score10 X 8 X 6=4805 X 5 X 6=150
# samples 138
** MAII scorelog2(13/480*10)=-1.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LIMCH1 [Title/Abstract] AND APBB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-D8-A1X5-01ALIMCH1chr4

41526495

+APBB2chr4

41102767

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000513024ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-5UTRENST00000513024ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-5UTRENST00000513024ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-5UTRENST00000513024ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-5UTRENST00000513024ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-intronENST00000513024ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-intronENST00000513024ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-intronENST00000513024ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-5UTRENST00000509638ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-5UTRENST00000509638ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-5UTRENST00000509638ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-5UTRENST00000509638ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-5UTRENST00000509638ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-intronENST00000509638ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-intronENST00000509638ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5UTR-intronENST00000509638ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000508501ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000508501ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000508501ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000508501ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000508501ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000508501ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000508501ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000508501ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512946ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512946ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512946ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512946ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512946ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000512946ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000512946ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000512946ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000313860ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000313860ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000313860ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000313860ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000313860ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000313860ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000313860ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000313860ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512632ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512632ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512632ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512632ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512632ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000512632ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000512632ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000512632ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512820ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512820ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512820ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512820ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-5UTRENST00000512820ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000512820ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000512820ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
5CDS-intronENST00000512820ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000503057ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000503057ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000503057ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000503057ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000503057ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000503057ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000503057ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000503057ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000511496ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000511496ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000511496ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000511496ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000511496ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000511496ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000511496ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000511496ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000514096ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000514096ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000514096ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000514096ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000514096ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000514096ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000514096ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000514096ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000509277ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000509277ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000509277ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000509277ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000509277ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000509277ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000509277ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000509277ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000396595ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000396595ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000396595ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000396595ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000396595ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000396595ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000396595ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000396595ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000381753ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000381753ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000381753ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000381753ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000381753ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000381753ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000381753ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000381753ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000509454ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000509454ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000509454ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000509454ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000509454ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000509454ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000509454ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000509454ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000515785ENST00000295974LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000515785ENST00000513140LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000515785ENST00000508593LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000515785ENST00000506352LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-5UTRENST00000515785ENST00000511572LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000515785ENST00000543538LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000515785ENST00000502841LIMCH1chr4

41526495

+APBB2chr4

41102767

-
intron-intronENST00000515785ENST00000504305LIMCH1chr4

41526495

+APBB2chr4

41102767

-

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FusionProtFeatures for LIMCH1_APBB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LIMCH1

Q9UPQ0

APBB2

Q92870

May modulate the internalization of amyloid-betaprecursor protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LIMCH1_APBB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LIMCH1_APBB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LIMCH1ELAVL1, SH3KBP1, APP, HUWE1, CUTC, DIABLO, GABPA, KPNA1, NPM1, TRMT61A, RPA3, RPA2, RPA1, OTUD6B, KLHL15, RFC2, YES1, NAGK, GNB4, UNK, NTRK1, CEP120, ODF2, XPO1, CAPZA2, CDK2, MYH9, PPP1CB, IQGAP1, ANLN, MYO19, MYO18A, CDH1, TRIM25APBB2APP, EGFR, HSPA8, TBC1D4, OSBPL2, APLP2, APBB1, AKAP1, GOPC, TUBA1A, APLP1, CBWD1, APOL2, RAP1GDS1, SYDE2, ATP7A, WDR41, TBC1D2B, FMN2, QTRT1, LDHAL6B, WISP3, NCK1, SORT1, SYNCRIP, MRPL1, GAN, TMEM30B, ADCYAP1, VAV1, HGFAC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LIMCH1_APBB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LIMCH1_APBB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLIMCH1C0236969Substance-Related Disorders1CTD_human
HgeneLIMCH1C0345967Malignant mesothelioma1CTD_human
TgeneAPBB2C0043094Weight Gain1CTD_human