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Fusion gene ID: 1971 |
FusionGeneSummary for ANTXR2_IGFBP3 |
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Fusion gene information | Fusion gene name: ANTXR2_IGFBP3 | Fusion gene ID: 1971 | Hgene | Tgene | Gene symbol | ANTXR2 | IGFBP3 | Gene ID | 118429 | 3486 |
Gene name | ANTXR cell adhesion molecule 2 | insulin like growth factor binding protein 3 | |
Synonyms | CMG-2|CMG2|HFS|ISH|JHF | BP-53|IBP3 | |
Cytomap | 4q21.21 | 7p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | anthrax toxin receptor 2capillary morphogenesis gene 2 proteincapillary morphogenesis protein 2 | insulin-like growth factor-binding protein 3IBP-3IGF-binding protein 3IGFBP-3acid stable subunit of the 140 K IGF complexbinding protein 29binding protein 53growth hormone-dependent binding protein | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | P58335 | P17936 | |
Ensembl transtripts involved in fusion gene | ENST00000403729, ENST00000482406, ENST00000404191, ENST00000346652, ENST00000307333, ENST00000295465, | ENST00000381086, ENST00000275521, ENST00000381083, ENST00000465642, | |
Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 5 X 5 X 1=25 |
# samples | 8 | 6 | |
** MAII score | log2(8/90*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/25*10)=1.26303440583379 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ANTXR2 [Title/Abstract] AND IGFBP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | IGFBP3 | GO:0001933 | negative regulation of protein phosphorylation | 17591901 |
Tgene | IGFBP3 | GO:0006468 | protein phosphorylation | 17434920 |
Tgene | IGFBP3 | GO:0014912 | negative regulation of smooth muscle cell migration | 10766744 |
Tgene | IGFBP3 | GO:0045663 | positive regulation of myoblast differentiation | 12599210 |
Tgene | IGFBP3 | GO:0048662 | negative regulation of smooth muscle cell proliferation | 10766744 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AK091721 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - | ||
ChiTaRS3.1 | AX747144 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000403729 | ENST00000381086 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000403729 | ENST00000275521 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000403729 | ENST00000381083 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000403729 | ENST00000465642 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-3UTR | ENST00000482406 | ENST00000381086 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000482406 | ENST00000275521 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000482406 | ENST00000381083 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000482406 | ENST00000465642 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-3UTR | ENST00000404191 | ENST00000381086 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000404191 | ENST00000275521 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000404191 | ENST00000381083 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000404191 | ENST00000465642 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-3UTR | ENST00000346652 | ENST00000381086 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000346652 | ENST00000275521 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000346652 | ENST00000381083 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000346652 | ENST00000465642 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-3UTR | ENST00000307333 | ENST00000381086 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000307333 | ENST00000275521 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000307333 | ENST00000381083 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000307333 | ENST00000465642 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-3UTR | ENST00000295465 | ENST00000381086 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000295465 | ENST00000275521 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000295465 | ENST00000381083 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
intron-intron | ENST00000295465 | ENST00000465642 | ANTXR2 | chr4 | 80828557 | - | IGFBP3 | chr7 | 45952180 | - |
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FusionProtFeatures for ANTXR2_IGFBP3 |
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Hgene | Tgene |
ANTXR2 | IGFBP3 |
Necessary for cellular interactions with laminin and theextracellular matrix. {ECO:0000269|PubMed:11683410,ECO:0000269|PubMed:12973667}. | IGF-binding proteins prolong the half-life of the IGFsand have been shown to either inhibit or stimulate the growthpromoting effects of the IGFs on cell culture. They alter theinteraction of IGFs with their cell surface receptors. Alsoexhibits IGF-independent antiproliferative and apoptotic effectsmediated by its receptor TMEM219/IGFBP-3R.{ECO:0000269|PubMed:20353938}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ANTXR2_IGFBP3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ANTXR2_IGFBP3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANTXR2_IGFBP3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | IGFBP3 | P17936 | DB00523 | Alitretinoin | Insulin-like growth factor-binding protein 3 | small molecule | approved|investigational |
Tgene | IGFBP3 | P17936 | DB01277 | Mecasermin | Insulin-like growth factor-binding protein 3 | biotech | approved|investigational |
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RelatedDiseases for ANTXR2_IGFBP3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ANTXR2 | C0009917 | Contracture | 2 | CTD_human |
Hgene | ANTXR2 | C0016045 | fibroma | 2 | CTD_human |
Hgene | ANTXR2 | C0017567 | Gingival Hypertrophy | 2 | CTD_human |
Hgene | ANTXR2 | C0038013 | Ankylosing spondylitis | 2 | CTD_human |
Hgene | ANTXR2 | C2745948 | Hyalinosis, Systemic | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | ANTXR2 | C0029456 | Osteoporosis | 1 | CTD_human |
Hgene | ANTXR2 | C0221204 | Lytic lesion | 1 | CTD_human |
Tgene | IGFBP3 | C0033578 | Prostatic Neoplasms | 3 | CTD_human |
Tgene | IGFBP3 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Tgene | IGFBP3 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Tgene | IGFBP3 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | IGFBP3 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Tgene | IGFBP3 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
Tgene | IGFBP3 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | IGFBP3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | IGFBP3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | IGFBP3 | C0151744 | Myocardial Ischemia | 1 | CTD_human |