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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19699

FusionGeneSummary for LIFR_C9

check button Fusion gene summary
Fusion gene informationFusion gene name: LIFR_C9
Fusion gene ID: 19699
HgeneTgene
Gene symbol

LIFR

C9

Gene ID

3977

1645

Gene nameLIF receptor alphaaldo-keto reductase family 1 member C1
SynonymsCD118|LIF-R|SJS2|STWS|SWS2-ALPHA-HSD|20-ALPHA-HSD|C9|DD1|DD1/DD2|DDH|DDH1|H-37|HAKRC|HBAB|MBAB
Cytomap

5p13.1

10p15.1

Type of geneprotein-codingprotein-coding
Descriptionleukemia inhibitory factor receptorCD118 antigenLIF receptorleukemia inhibitory factor receptor alphaaldo-keto reductase family 1 member C120 alpha-hydroxysteroid dehydrogenasealdo-keto reductase Cchlordecone reductase homolog HAKRCdihydrodiol dehydrogenase 1dihydrodiol dehydrogenase 1/2dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid
Modification date2018052320180523
UniProtAcc

P42702

P02748

Ensembl transtripts involved in fusion geneENST00000263409, ENST00000453190, 
ENST00000503088, 		ENST00000263408, 
ENST00000509186, 
Fusion gene scores* DoF score5 X 5 X 5=1255 X 4 X 3=60
# samples 55
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LIFR [Title/Abstract] AND C9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLIFR

GO:0008284

positive regulation of cell proliferation

7957045|8999038

HgeneLIFR

GO:0019221

cytokine-mediated signaling pathway

7957045

HgeneLIFR

GO:0034097

response to cytokine

8999038

HgeneLIFR

GO:0048861

leukemia inhibitory factor signaling pathway

8999038|12643274

HgeneLIFR

GO:0070120

ciliary neurotrophic factor-mediated signaling pathway

12643274

TgeneC9

GO:0007586

digestion

8486699

TgeneC9

GO:0008206

bile acid metabolic process

8486699

TgeneC9

GO:0030855

epithelial cell differentiation

21492153

TgeneC9

GO:0042448

progesterone metabolic process

21232532

TgeneC9

GO:0042574

retinal metabolic process

21851338

TgeneC9

GO:0051260

protein homooligomerization

8486699

TgeneC9

GO:0055114

oxidation-reduction process

8486699|19442656|21232532

TgeneC9

GO:0071395

cellular response to jasmonic acid stimulus

19487289


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A7-A26G-01ALIFRchr5

38493708

-C9chr5

39316131

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000263409ENST00000263408LIFRchr5

38493708

-C9chr5

39316131

-
5CDS-5UTRENST00000263409ENST00000509186LIFRchr5

38493708

-C9chr5

39316131

-
Frame-shiftENST00000453190ENST00000263408LIFRchr5

38493708

-C9chr5

39316131

-
5CDS-5UTRENST00000453190ENST00000509186LIFRchr5

38493708

-C9chr5

39316131

-
5UTR-3CDSENST00000503088ENST00000263408LIFRchr5

38493708

-C9chr5

39316131

-
5UTR-5UTRENST00000503088ENST00000509186LIFRchr5

38493708

-C9chr5

39316131

-

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FusionProtFeatures for LIFR_C9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LIFR

P42702

C9

P02748

Signal-transducing molecule. May have a common pathwaywith IL6ST. The soluble form inhibits the biological activity ofLIF by blocking its binding to receptors on target cells. Constituent of the membrane attack complex (MAC) thatplays a key role in the innate and adaptive immune response byforming pores in the plasma membrane of target cells(PubMed:9634479, PubMed:9212048, PubMed:26841934). C9 is the pore-forming subunit of the MAC (PubMed:4055801, PubMed:26841934).{ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:4055801,ECO:0000269|PubMed:9212048, ECO:0000269|PubMed:9634479}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420335_4346881098DomainFibronectin type-III 2
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420435_5346881098DomainFibronectin type-III 3
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-142049_1386881098DomainFibronectin type-III 1
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420538_6296881098DomainFibronectin type-III 4
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420335_4346881098DomainFibronectin type-III 2
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420435_5346881098DomainFibronectin type-III 3
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-142049_1386881098DomainFibronectin type-III 1
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420538_6296881098DomainFibronectin type-III 4
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420519_5236881098MotifNote=WSXWS motif
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420519_5236881098MotifNote=WSXWS motif
TgeneC9chr5:38493708chr5:39316131ENST00000263408-411510_540205560DomainNote=EGF-like
TgeneC9chr5:38493708chr5:39316131ENST00000263408-411314_330205560TransmembraneBeta stranded
TgeneC9chr5:38493708chr5:39316131ENST00000263408-411335_354205560TransmembraneBeta stranded

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420627_7196881098DomainFibronectin type-III 5
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420724_8336881098DomainFibronectin type-III 6
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420627_7196881098DomainFibronectin type-III 5
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420724_8336881098DomainFibronectin type-III 6
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420869_8776881098MotifNote=Box 1 motif
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420869_8776881098MotifNote=Box 1 motif
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-142045_8336881098Topological domainExtracellular
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420859_10976881098Topological domainCytoplasmic
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-142045_8336881098Topological domainExtracellular
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420859_10976881098Topological domainCytoplasmic
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420834_8586881098TransmembraneHelical
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420834_8586881098TransmembraneHelical
TgeneC9chr5:38493708chr5:39316131ENST00000263408-411138_509205560DomainMACPF
TgeneC9chr5:38493708chr5:39316131ENST00000263408-41142_95205560DomainTSP type-1
TgeneC9chr5:38493708chr5:39316131ENST00000263408-41199_136205560DomainLDL-receptor class A


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FusionGeneSequence for LIFR_C9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_LIFR_ENST00000263409_chr5_38493708_-_C9_ENST00000263408_chr5_39316131_-_1043aa
MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSC
YQLEKTSIKIPALSHGDYEITINSLHDFGSSTSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE
SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFC
CVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA
LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVK
LSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD
TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDD
LKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDQRREKFQNRTLRRTNXSIXKYHPREDIKFXC
SYISKIYTHXNKXSXTMLXGNSLLNFFTWQGXFSVFIFQKXNLPTIFVIFFKEGKNVSACERRNSSGKICNEKSRCCAHNNFCGXYKSFA
NYLXKGRIFCLFGNLWNSLQXLWVSRRTLXTNICFGXSFHEAERCXTKRHKEMPWVSSGCISGFLXNLCWSXIXXRXLCKEGRGXSCKHH
QXKPHRXCCFTHKRWNQKICIXTERKASPRNRDXCDXLCQLGLFHKXCSCSHXSKTVSYIXSGSSENEKCTPKETKLGKSHXRLYQXIXC


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_LIFR_ENST00000263409_chr5_38493708_-_C9_ENST00000263408_chr5_39316131_-_3130nt
ATGATGGATATTTACGTATGTTTGAAACGACCATCCTGGATGGTGGACAATAAAAGAATGAGGACTGCTTCAAATTTCCAGTGGCTGTTA
TCAACATTTATTCTTCTATATCTAATGAATCAAGTAAATAGCCAGAAAAAGGGGGCTCCTCATGATTTGAAGTGTGTAACTAACAATTTG
CAAGTGTGGAACTGTTCTTGGAAAGCACCCTCTGGAACAGGCCGTGGTACTGATTATGAAGTTTGCATTGAAAACAGGTCCCGTTCTTGT
TATCAGTTGGAGAAAACCAGTATTAAAATTCCAGCTCTTTCACATGGTGATTATGAAATAACAATAAATTCTCTACATGATTTTGGAAGT
TCTACAAGTAAATTCACACTAAATGAACAAAACGTTTCCTTAATTCCAGATACTCCAGAGATCTTGAATTTGTCTGCTGATTTCTCAACC
TCTACATTATACCTAAAGTGGAACGACAGGGGTTCAGTTTTTCCACACCGCTCAAATGTTATCTGGGAAATTAAAGTTCTACGTAAAGAG
AGTATGGAGCTCGTAAAATTAGTGACCCACAACACAACTCTGAATGGCAAAGATACACTTCATCACTGGAGTTGGGCCTCAGATATGCCC
TTGGAATGTGCCATTCATTTTGTGGAAATTAGATGCTACATTGACAATCTTCATTTTTCTGGTCTCGAAGAGTGGAGTGACTGGAGCCCT
GTGAAGAACATTTCTTGGATACCTGATTCTCAGACTAAGGTTTTTCCTCAAGATAAAGTGATACTTGTAGGCTCAGACATAACATTTTGT
TGTGTGAGTCAAGAAAAAGTGTTATCAGCACTGATTGGCCATACAAACTGCCCCTTGATCCATCTTGATGGGGAAAATGTTGCAATCAAG
ATTCGTAATATTTCTGTTTCTGCAAGTAGTGGAACAAATGTAGTTTTTACAACCGAAGATAACATATTTGGAACCGTTATTTTTGCTGGA
TATCCACCAGATACTCCTCAACAACTGAATTGTGAGACACATGATTTAAAAGAAATTATATGTAGTTGGAATCCAGGAAGGGTGACAGCG
TTGGTGGGCCCACGTGCTACAAGCTACACTTTAGTTGAAAGTTTTTCAGGAAAATATGTTAGACTTAAAAGAGCTGAAGCACCTACAAAC
GAAAGCTATCAATTATTATTTCAAATGCTTCCAAATCAAGAAATATATAATTTTACTTTGAATGCTCACAATCCGCTGGGTCGATCACAA
TCAACAATTTTAGTTAATATAACTGAAAAAGTTTATCCCCATACTCCTACTTCATTCAAAGTGAAGGATATTAATTCAACAGCTGTTAAA
CTTTCTTGGCATTTACCAGGCAACTTTGCAAAGATTAATTTTTTATGTGAAATTGAAATTAAGAAATCTAATTCAGTACAAGAGCAGCGG
AATGTCACAATCAAAGGAGTAGAAAATTCAAGTTATCTTGTTGCTCTGGACAAGTTAAATCCATACACTCTATATACTTTTCGGATTCGT
TGTTCTACTGAAACTTTCTGGAAATGGAGCAAATGGAGCAATAAAAAACAACATTTAACAACAGAAGCCAGTCCTTCAAAGGGGCCTGAT
ACTTGGAGAGAGTGGAGTTCTGATGGAAAAAATTTAATAATCTATTGGAAGCCTTTACCCATTAATGAAGCTAATGGAAAAATACTTTCC
TACAATGTATCGTGTTCATCAGATGAGGAAACACAGTCCCTTTCTGAAATCCCTGATCCTCAGCACAAAGCAGAGATACGACTTGATAAG
AATGACTACATCATCAGCGTAGTGGCTAAAAATTCTGTGGGCTCATCACCACCTTCCAAAATAGCGAGTATGGAAATTCCAAATGATGAT
CTCAAAATAGAACAAGTTGTTGGGATGGGAAAGGGGATTCTCCTCACCTGGCATTACGACCCCAACATGACTTGCGACTACGTCATTAAG
TGGTGTAACTCGTCTCGGTCGGAACCATGCCTTATGGACTGGAGAAAAGTTCCCTCAAACAGCACTGAAACTGTAATAGAATCTGACCAA
AGGCGAGAAAAATTTCAGAACCGAACATTACGAAGAACAAATTGAAGCATTTAAAAGTATCATCCAAGAGAAGACATCAAATTTTAATGC
AGCTATATCTCTAAAATTTACACCCACTGAAACAAATAAAGCTGAACAATGTTGTGAGGAAACAGCCTCCTCAATTTCTTTACATGGCAA
GGGTAGTTTTCGGTTTTCATATTCCAAAAATGAAACTTACCAACTATTTTTGTCATATTCTTCAAAGAAGGAAAAAATGTTTCTGCATGT
GAAAGGAGAAATTCATCTGGGAAGATTTGTAATGAGAAATCGCGATGTTGTGCTCACAACAACTTTTGTGGATGATATAAAAGCTTTGCC
AACTACCTATGAAAAGGGAGAATATTTTGCCTTTTTGGAAACCTATGGAACTCACTACAGTAGCTCTGGGTCTCTAGGAGGACTCTATGA
ACTAATATATGTTTTGGATAAAGCTTCCATGAAGCGGAAAGGTGTTGAACTAAAAGACATAAAGAGATGCCTTGGGTATCATCTGGATGT
ATCTCTGGCTTTCTCTGAAATCTCTGTTGGAGCTGAATTTAATAAAGATGATTGTGTAAAGAGGGGAGAGGGTAGAGCTGTAAACATCAC
CAGTGAAAACCTCATAGATGATGTTGTTTCACTCATAAGAGGTGGAACCAGAAAATATGCATTTGAACTGAAAGAAAAGCTTCTCCGAGG
AACCGTGATTGATGTGACTGACTTTGTCAACTGGGCCTCTTCCATAAATGATGCTCCTGTTCTCATTAGTCAAAAACTGTCTCCTATATA
TAATCTGGTTCCAGTGAAAATGAAAAATGCACACCTAAAGAAACAAAACTTGGAAAGAGCCATTGAAGACTATATCAATGAATTTAGTGT
AAGAAAATGCCACACATGCCAAAATGGAGGTACAGTGATTCTAATGGATGGAAAGTGTTTGTGTGCCTGCCCATTCAAATTTGAGGGAAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_LIFR_ENST00000263409_chr5_38493708_-_C9_ENST00000263408_chr5_39316131_-_4230nt
AATCCTAACCCTCTCTCCCAGAACGTGTCTCTGCTGCAAGGCACCGGGCCCTTTCGCTCTGCAGAACTGCACTTGCAAGACCATTATCAA
CTCCTAATCCCAGCTCAGAAAGGGAGCCTCTGCGACTCATTCATCGCCCTCCAGGACTGACTGCATTGCACAGATGATGGATATTTACGT
ATGTTTGAAACGACCATCCTGGATGGTGGACAATAAAAGAATGAGGACTGCTTCAAATTTCCAGTGGCTGTTATCAACATTTATTCTTCT
ATATCTAATGAATCAAGTAAATAGCCAGAAAAAGGGGGCTCCTCATGATTTGAAGTGTGTAACTAACAATTTGCAAGTGTGGAACTGTTC
TTGGAAAGCACCCTCTGGAACAGGCCGTGGTACTGATTATGAAGTTTGCATTGAAAACAGGTCCCGTTCTTGTTATCAGTTGGAGAAAAC
CAGTATTAAAATTCCAGCTCTTTCACATGGTGATTATGAAATAACAATAAATTCTCTACATGATTTTGGAAGTTCTACAAGTAAATTCAC
ACTAAATGAACAAAACGTTTCCTTAATTCCAGATACTCCAGAGATCTTGAATTTGTCTGCTGATTTCTCAACCTCTACATTATACCTAAA
GTGGAACGACAGGGGTTCAGTTTTTCCACACCGCTCAAATGTTATCTGGGAAATTAAAGTTCTACGTAAAGAGAGTATGGAGCTCGTAAA
ATTAGTGACCCACAACACAACTCTGAATGGCAAAGATACACTTCATCACTGGAGTTGGGCCTCAGATATGCCCTTGGAATGTGCCATTCA
TTTTGTGGAAATTAGATGCTACATTGACAATCTTCATTTTTCTGGTCTCGAAGAGTGGAGTGACTGGAGCCCTGTGAAGAACATTTCTTG
GATACCTGATTCTCAGACTAAGGTTTTTCCTCAAGATAAAGTGATACTTGTAGGCTCAGACATAACATTTTGTTGTGTGAGTCAAGAAAA
AGTGTTATCAGCACTGATTGGCCATACAAACTGCCCCTTGATCCATCTTGATGGGGAAAATGTTGCAATCAAGATTCGTAATATTTCTGT
TTCTGCAAGTAGTGGAACAAATGTAGTTTTTACAACCGAAGATAACATATTTGGAACCGTTATTTTTGCTGGATATCCACCAGATACTCC
TCAACAACTGAATTGTGAGACACATGATTTAAAAGAAATTATATGTAGTTGGAATCCAGGAAGGGTGACAGCGTTGGTGGGCCCACGTGC
TACAAGCTACACTTTAGTTGAAAGTTTTTCAGGAAAATATGTTAGACTTAAAAGAGCTGAAGCACCTACAAACGAAAGCTATCAATTATT
ATTTCAAATGCTTCCAAATCAAGAAATATATAATTTTACTTTGAATGCTCACAATCCGCTGGGTCGATCACAATCAACAATTTTAGTTAA
TATAACTGAAAAAGTTTATCCCCATACTCCTACTTCATTCAAAGTGAAGGATATTAATTCAACAGCTGTTAAACTTTCTTGGCATTTACC
AGGCAACTTTGCAAAGATTAATTTTTTATGTGAAATTGAAATTAAGAAATCTAATTCAGTACAAGAGCAGCGGAATGTCACAATCAAAGG
AGTAGAAAATTCAAGTTATCTTGTTGCTCTGGACAAGTTAAATCCATACACTCTATATACTTTTCGGATTCGTTGTTCTACTGAAACTTT
CTGGAAATGGAGCAAATGGAGCAATAAAAAACAACATTTAACAACAGAAGCCAGTCCTTCAAAGGGGCCTGATACTTGGAGAGAGTGGAG
TTCTGATGGAAAAAATTTAATAATCTATTGGAAGCCTTTACCCATTAATGAAGCTAATGGAAAAATACTTTCCTACAATGTATCGTGTTC
ATCAGATGAGGAAACACAGTCCCTTTCTGAAATCCCTGATCCTCAGCACAAAGCAGAGATACGACTTGATAAGAATGACTACATCATCAG
CGTAGTGGCTAAAAATTCTGTGGGCTCATCACCACCTTCCAAAATAGCGAGTATGGAAATTCCAAATGATGATCTCAAAATAGAACAAGT
TGTTGGGATGGGAAAGGGGATTCTCCTCACCTGGCATTACGACCCCAACATGACTTGCGACTACGTCATTAAGTGGTGTAACTCGTCTCG
GTCGGAACCATGCCTTATGGACTGGAGAAAAGTTCCCTCAAACAGCACTGAAACTGTAATAGAATCTGACCAAAGGCGAGAAAAATTTCA
GAACCGAACATTACGAAGAACAAATTGAAGCATTTAAAAGTATCATCCAAGAGAAGACATCAAATTTTAATGCAGCTATATCTCTAAAAT
TTACACCCACTGAAACAAATAAAGCTGAACAATGTTGTGAGGAAACAGCCTCCTCAATTTCTTTACATGGCAAGGGTAGTTTTCGGTTTT
CATATTCCAAAAATGAAACTTACCAACTATTTTTGTCATATTCTTCAAAGAAGGAAAAAATGTTTCTGCATGTGAAAGGAGAAATTCATC
TGGGAAGATTTGTAATGAGAAATCGCGATGTTGTGCTCACAACAACTTTTGTGGATGATATAAAAGCTTTGCCAACTACCTATGAAAAGG
GAGAATATTTTGCCTTTTTGGAAACCTATGGAACTCACTACAGTAGCTCTGGGTCTCTAGGAGGACTCTATGAACTAATATATGTTTTGG
ATAAAGCTTCCATGAAGCGGAAAGGTGTTGAACTAAAAGACATAAAGAGATGCCTTGGGTATCATCTGGATGTATCTCTGGCTTTCTCTG
AAATCTCTGTTGGAGCTGAATTTAATAAAGATGATTGTGTAAAGAGGGGAGAGGGTAGAGCTGTAAACATCACCAGTGAAAACCTCATAG
ATGATGTTGTTTCACTCATAAGAGGTGGAACCAGAAAATATGCATTTGAACTGAAAGAAAAGCTTCTCCGAGGAACCGTGATTGATGTGA
CTGACTTTGTCAACTGGGCCTCTTCCATAAATGATGCTCCTGTTCTCATTAGTCAAAAACTGTCTCCTATATATAATCTGGTTCCAGTGA
AAATGAAAAATGCACACCTAAAGAAACAAAACTTGGAAAGAGCCATTGAAGACTATATCAATGAATTTAGTGTAAGAAAATGCCACACAT
GCCAAAATGGAGGTACAGTGATTCTAATGGATGGAAAGTGTTTGTGTGCCTGCCCATTCAAATTTGAGGGAATTGCCTGTGAAATCAGTA
AACAAAAAATTTCTGAAGGATTGCCAGCCCTAGAGTTCCCCAATGAAAAATAGAGCTGTTGGCTTCTCTGAGCTCCAGTGGAAGAAGAAA
ACACTAGTACCTTCAGATCCTACCCCTGAAGATAATCTTAGCTGCCAAGTAAATAGCAACATGCTTCATGAAAATCCTACCAACCTCTGA
AGTCTCTTCTCTCTTAGGTCTATAATTTTTTTTTAAATTTTTCTTCCTTAAACTCCTGTGATGTTTCCATTTTTTGTTCCCTAATGAGAA
GTCAACAGTGAAATACGCCAGAACTGCTTTATCCCACGGAAAATGCCAATCTCTTCTAAAAAAAAACAAAATTAAATTAAAAACAGAATG
TTGGTTTAAAAAACTTCAAAGTAATTTTCAAACGGCTTTGTATGGTTAACATATTCTGCCAGGTCCATGACCACACGTCTGTACCATGCA
ATTTAACTCTTATTTACATTGTTATGTTTAGTTTGGTTATTTGCTTAGGTGTGCATACATTCATTCAGCAAATGCTGAGCACCAGCCACG
TGCACAGCAGTTGCTTTTACTAGTCTTAGCTCTACGATTTAAATCCATGTGTCCAAGGGGGAAAACATATTATATTTGTAACCAAAAACT
ACTAGTTTACCAGAGGACTGAAGGGAGATAAAGAGGAGTTGGTTAATGGGTACAAAAATCCAGTTAGATGAAAGGAATAATATAGATAGT
GTTCAGTAGCAGAATAGAATGAACATAAACTATTAGTTTAAATTATGTGAAATTCCTTCTATTTGATCATATTTTACAAGAAAAAACATC
AATTTTATATAGTCCAACTTAATACCTAGCCTTATGAGTTGTATAAGGTAAGGTTACCTACCTGAGAAGCTGATTAACATTGGTTGTACA
ATCTTATTCATTAGAGAACATGGTGCTTAGGGTCTGAGACCTTTTGAAAGGTCTGAGAACTCTTTAAAAAAAGGAAAGAAAGAAAGAAAA


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FusionGenePPI for LIFR_C9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LIFRCNTFR, LIF, OSM, IL6ST, PTPN6, FBXO6, PRPF4, BAG3, GOLT1B, SCGB1D1, DEFA1, FAM19A4, SLAMF1, TRIM25C9CLU, CD59, FN1, LAMTOR5, APOE, CST6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LIFR_C9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LIFR_C9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLIFRC0796176STUVE-WIEDEMANN SYNDROME2CTD_human;ORPHANET;UNIPROT
HgeneLIFRC0032460Polycystic Ovary Syndrome1CTD_human
HgeneLIFRC0033578Prostatic Neoplasms1CTD_human
HgeneLIFRC0036341Schizophrenia1PSYGENET
HgeneLIFRC0349398Paranoid delusion1PSYGENET
TgeneC9C0021051Immunologic Deficiency Syndromes2CTD_human
TgeneC9C0011633Dermatomyositis1CTD_human
TgeneC9C0015456Facial Dermatoses1CTD_human
TgeneC9C0025294Meningococcal meningitis1CTD_human
TgeneC9C0027412Opioid-Related Disorders1CTD_human
TgeneC9C0041834Erythema1CTD_human
TgeneC9C0242383Age related macular degeneration1CTD_human
TgeneC9C0345967Malignant mesothelioma1CTD_human
TgeneC9C2239176Liver carcinoma1CTD_human
TgeneC9C3151189C9 Deficiency1UNIPROT
TgeneC9C3810042MACULAR DEGENERATION, AGE-RELATED, 151UNIPROT