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Fusion gene ID: 19693 |
FusionGeneSummary for LHPP_TANGO6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LHPP_TANGO6 | Fusion gene ID: 19693 | Hgene | Tgene | Gene symbol | LHPP | TANGO6 | Gene ID | 64077 | 79613 |
| Gene name | phospholysine phosphohistidine inorganic pyrophosphate phosphatase | transport and golgi organization 6 homolog | |
| Synonyms | HDHD2B | TMCO7 | |
| Cytomap | 10q26.13 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phospholysine phosphohistidine inorganic pyrophosphate phosphatasehLHPP | transport and Golgi organization protein 6 homologtransmembrane and coiled-coil domain-containing protein 7transmembrane and coiled-coil domains 7 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9H008 | Q9C0B7 | |
| Ensembl transtripts involved in fusion gene | ENST00000368842, ENST00000368839, ENST00000392757, ENST00000482963, | ENST00000261778, ENST00000561931, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 4 X 6=120 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LHPP [Title/Abstract] AND TANGO6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LHPP | GO:0006796 | phosphate-containing compound metabolic process | 12801912 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-CV-6948-01A | LHPP | chr10 | 126172895 | + | TANGO6 | chr16 | 69056731 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000368842 | ENST00000261778 | LHPP | chr10 | 126172895 | + | TANGO6 | chr16 | 69056731 | + |
| 5CDS-intron | ENST00000368842 | ENST00000561931 | LHPP | chr10 | 126172895 | + | TANGO6 | chr16 | 69056731 | + |
| In-frame | ENST00000368839 | ENST00000261778 | LHPP | chr10 | 126172895 | + | TANGO6 | chr16 | 69056731 | + |
| 5CDS-intron | ENST00000368839 | ENST00000561931 | LHPP | chr10 | 126172895 | + | TANGO6 | chr16 | 69056731 | + |
| In-frame | ENST00000392757 | ENST00000261778 | LHPP | chr10 | 126172895 | + | TANGO6 | chr16 | 69056731 | + |
| 5CDS-intron | ENST00000392757 | ENST00000561931 | LHPP | chr10 | 126172895 | + | TANGO6 | chr16 | 69056731 | + |
| intron-3CDS | ENST00000482963 | ENST00000261778 | LHPP | chr10 | 126172895 | + | TANGO6 | chr16 | 69056731 | + |
| intron-intron | ENST00000482963 | ENST00000561931 | LHPP | chr10 | 126172895 | + | TANGO6 | chr16 | 69056731 | + |
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FusionProtFeatures for LHPP_TANGO6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LHPP | TANGO6 |
| Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substratespecificity and can also hydrolyze inorganic diphosphate, but withlower efficiency (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LHPP | chr10:126172895 | chr16:69056731 | ENST00000368839 | + | 2 | 6 | 17_19 | 104 | 211 | Region | Note=Substrate binding |
| Hgene | LHPP | chr10:126172895 | chr16:69056731 | ENST00000368839 | + | 2 | 6 | 54_55 | 104 | 211 | Region | Note=Substrate binding |
| Hgene | LHPP | chr10:126172895 | chr16:69056731 | ENST00000368842 | + | 2 | 7 | 17_19 | 104 | 271 | Region | Note=Substrate binding |
| Hgene | LHPP | chr10:126172895 | chr16:69056731 | ENST00000368842 | + | 2 | 7 | 54_55 | 104 | 271 | Region | Note=Substrate binding |
| Tgene | >TANGO6 | chr10:126172895 | chr16:69056731 | ENST00000261778 | + | 14 | 18 | 952_988 | 947 | 1095 | Repeat | Note=HEAT 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | TANGO6 | chr10:126172895 | chr16:69056731 | ENST00000261778 | + | 14 | 18 | 873_909 | 947 | 1095 | Repeat | Note=HEAT 1 |
| Tgene | TANGO6 | chr10:126172895 | chr16:69056731 | ENST00000261778 | + | 14 | 18 | 468_488 | 947 | 1095 | Transmembrane | Helical |
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FusionGeneSequence for LHPP_TANGO6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LHPP_ENST00000368842_chr10_126172895_+_TANGO6_ENST00000261778_chr16_69056731_+_252aa MAPWGKRLAGVRGVLLDISGVLYDSGAGGGTAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFDISEQEVTAPAPAACQI LKEQGLRPYLLIHDGDMVSKYREPLIHTFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVVHEVTACLIAVAKTDGEVQVRRAAIHVV >In-frame_LHPP_ENST00000368839_chr10_126172895_+_TANGO6_ENST00000261778_chr16_69056731_+_252aa MAPWGKRLAGVRGVLLDISGVLYDSGAGGGTAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFDISEQEVTAPAPAACQI LKEQGLRPYLLIHDGDMVSKYREPLIHTFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVVHEVTACLIAVAKTDGEVQVRRAAIHVV >In-frame_LHPP_ENST00000392757_chr10_126172895_+_TANGO6_ENST00000261778_chr16_69056731_+_252aa MAPWGKRLAGVRGVLLDISGVLYDSGAGGGTAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFDISEQEVTAPAPAACQI LKEQGLRPYLLIHDGDMVSKYREPLIHTFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVVHEVTACLIAVAKTDGEVQVRRAAIHVV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LHPP_ENST00000368842_chr10_126172895_+_TANGO6_ENST00000261778_chr16_69056731_+_756nt ATGGCACCGTGGGGCAAGCGGCTGGCTGGCGTGCGCGGGGTGCTGCTTGACATCTCGGGCGTGCTGTACGACAGCGGCGCGGGCGGCGGC ACGGCCATCGCCGGCTCGGTGGAGGCGGTGGCCAGACTGAAGCGTTCCCGGCTGAAGGTGAGGTTCTGCACCAACGAGTCGCAGAAGTCC CGGGCAGAGCTGGTGGGGCAGCTTCAGAGGCTGGGATTTGACATCTCTGAGCAGGAGGTGACCGCCCCGGCACCAGCTGCCTGCCAGATC CTGAAGGAGCAAGGCCTGCGACCATACCTGCTCATCCATGACGGAGACATGGTCTCAAAGTACCGAGAACCTTTGATCCATACCTTCCTG AGGGGAGTGAGAGATCCTGATGGTGCTCACAGGGCCAGCAGCTTGGCCAACCTTGGGGAGCTGTGCCAGAGGCTGGACTTTCTGCTGGGC TCCGTGGTCCATGAGGTAACAGCTTGCCTGATTGCTGTGGCCAAAACAGATGGTGAAGTTCAAGTACGCAGAGCTGCCATACATGTGGTT GTGCTGCTGCTTCGGGGACTCAGCCAGAAAGCTACTGAGGTGCTGAGCGCCGTCCTCAAGGATCTCTACCACCTGCTGAAGCACGTAGTG TGTCTGGAGCCCGATGACGTGGCCAAGCTCCATGCCCAGTTGGCCCTAGAAGAGCTGGATGACATCATGAAAAACTTCCTGTTCCCTCCA >In-frame_LHPP_ENST00000368839_chr10_126172895_+_TANGO6_ENST00000261778_chr16_69056731_+_756nt ATGGCACCGTGGGGCAAGCGGCTGGCTGGCGTGCGCGGGGTGCTGCTTGACATCTCGGGCGTGCTGTACGACAGCGGCGCGGGCGGCGGC ACGGCCATCGCCGGCTCGGTGGAGGCGGTGGCCAGACTGAAGCGTTCCCGGCTGAAGGTGAGGTTCTGCACCAACGAGTCGCAGAAGTCC CGGGCAGAGCTGGTGGGGCAGCTTCAGAGGCTGGGATTTGACATCTCTGAGCAGGAGGTGACCGCCCCGGCACCAGCTGCCTGCCAGATC CTGAAGGAGCAAGGCCTGCGACCATACCTGCTCATCCATGACGGAGACATGGTCTCAAAGTACCGAGAACCTTTGATCCATACCTTCCTG AGGGGAGTGAGAGATCCTGATGGTGCTCACAGGGCCAGCAGCTTGGCCAACCTTGGGGAGCTGTGCCAGAGGCTGGACTTTCTGCTGGGC TCCGTGGTCCATGAGGTAACAGCTTGCCTGATTGCTGTGGCCAAAACAGATGGTGAAGTTCAAGTACGCAGAGCTGCCATACATGTGGTT GTGCTGCTGCTTCGGGGACTCAGCCAGAAAGCTACTGAGGTGCTGAGCGCCGTCCTCAAGGATCTCTACCACCTGCTGAAGCACGTAGTG TGTCTGGAGCCCGATGACGTGGCCAAGCTCCATGCCCAGTTGGCCCTAGAAGAGCTGGATGACATCATGAAAAACTTCCTGTTCCCTCCA >In-frame_LHPP_ENST00000392757_chr10_126172895_+_TANGO6_ENST00000261778_chr16_69056731_+_756nt ATGGCACCGTGGGGCAAGCGGCTGGCTGGCGTGCGCGGGGTGCTGCTTGACATCTCGGGCGTGCTGTACGACAGCGGCGCGGGCGGCGGC ACGGCCATCGCCGGCTCGGTGGAGGCGGTGGCCAGACTGAAGCGTTCCCGGCTGAAGGTGAGGTTCTGCACCAACGAGTCGCAGAAGTCC CGGGCAGAGCTGGTGGGGCAGCTTCAGAGGCTGGGATTTGACATCTCTGAGCAGGAGGTGACCGCCCCGGCACCAGCTGCCTGCCAGATC CTGAAGGAGCAAGGCCTGCGACCATACCTGCTCATCCATGACGGAGACATGGTCTCAAAGTACCGAGAACCTTTGATCCATACCTTCCTG AGGGGAGTGAGAGATCCTGATGGTGCTCACAGGGCCAGCAGCTTGGCCAACCTTGGGGAGCTGTGCCAGAGGCTGGACTTTCTGCTGGGC TCCGTGGTCCATGAGGTAACAGCTTGCCTGATTGCTGTGGCCAAAACAGATGGTGAAGTTCAAGTACGCAGAGCTGCCATACATGTGGTT GTGCTGCTGCTTCGGGGACTCAGCCAGAAAGCTACTGAGGTGCTGAGCGCCGTCCTCAAGGATCTCTACCACCTGCTGAAGCACGTAGTG TGTCTGGAGCCCGATGACGTGGCCAAGCTCCATGCCCAGTTGGCCCTAGAAGAGCTGGATGACATCATGAAAAACTTCCTGTTCCCTCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LHPP_ENST00000368842_chr10_126172895_+_TANGO6_ENST00000261778_chr16_69056731_+_2303nt GCGGAGCTGAGGAGCAGGGCCGGGCGCCATGGCACCGTGGGGCAAGCGGCTGGCTGGCGTGCGCGGGGTGCTGCTTGACATCTCGGGCGT GCTGTACGACAGCGGCGCGGGCGGCGGCACGGCCATCGCCGGCTCGGTGGAGGCGGTGGCCAGACTGAAGCGTTCCCGGCTGAAGGTGAG GTTCTGCACCAACGAGTCGCAGAAGTCCCGGGCAGAGCTGGTGGGGCAGCTTCAGAGGCTGGGATTTGACATCTCTGAGCAGGAGGTGAC CGCCCCGGCACCAGCTGCCTGCCAGATCCTGAAGGAGCAAGGCCTGCGACCATACCTGCTCATCCATGACGGAGACATGGTCTCAAAGTA CCGAGAACCTTTGATCCATACCTTCCTGAGGGGAGTGAGAGATCCTGATGGTGCTCACAGGGCCAGCAGCTTGGCCAACCTTGGGGAGCT GTGCCAGAGGCTGGACTTTCTGCTGGGCTCCGTGGTCCATGAGGTAACAGCTTGCCTGATTGCTGTGGCCAAAACAGATGGTGAAGTTCA AGTACGCAGAGCTGCCATACATGTGGTTGTGCTGCTGCTTCGGGGACTCAGCCAGAAAGCTACTGAGGTGCTGAGCGCCGTCCTCAAGGA TCTCTACCACCTGCTGAAGCACGTAGTGTGTCTGGAGCCCGATGACGTGGCCAAGCTCCATGCCCAGTTGGCCCTAGAAGAGCTGGATGA CATCATGAAAAACTTCCTGTTCCCTCCACAGAAGCTGGAGAAGAAGATCATGGTCCTGCCGTAGACCTGGCTCCAAGGACGTGGAGGAGG CAGGCAGGGCCAGGCACCCAGAGCCGTGCCCAGGTCTTCCAGCAGGTGGCCCTGCTGCCTCTTGAGTGCTGGCAGCATGGCTGACCCTCG GGGTGGTTTTATGGTGCAGGTCACTTGGGTCTTCAGGGTCCCTTCCGAGGGCATGTGTTCAGCACTCCCGCGTTCAGCCTGAGGGGTGTA CAGTTAAGAGAAGACAGTTACAGATCTCATTAATCTACATTTTTCACTGTCCTCTAGCATTGAAAGAAGGATGTCTACCTGGTGAAAGTA TATTTTAACATGACTGATGGAATTTCACTAATTGCCCACTCTCTTGGAACTTGAGGAGAAGCGGTTGGCCACCCATATGTCACCTAGCTC TATATTCTTTCAGGCTGAGATTCTTCTTCAGGAAAATGAGGAGCAGAACTGGCCACCCTTGGCTGCTCAAGAGGCATTTCAGAGTAGGAG ATGCAGTTGGAGGTGGGGAGGGGAAGGAAATAGTTATCAAATAATGCAAAATGGAATAAAGTTATCTTGGATGGAAAGAACAGGGCTAAA TCTGGTCCTCTGGTGTCGAGATGGAAAACTGTGGAGTTGAAGAGGCTCTGATGCCCAGAAAGGACAATCAAGCTGGTTGACTCTTCCAGA GAAGAAGGGTAAGCCCTGTATTTATCCTCCCAGGCCATTCTTCTTCACTCCTGCTGCTGTTTGCAGAGAGTTGCCCTGATTATCAGGAGA AAAGAACCACGAGCATCCAGAGAGTTTACATCCTGCCTTCTGTCCTCTGCTCCTTCAGAAAGATGAATGCCTAGACAATGGGTTCACACT GAATGCAGGCTGGAAAGAATGCATGCTGGTGGCCTAATGCCAGGGCTGTTGAAACAATTTCAGATATAGCACTGTGGTCTCCACTTTATT TCTTTATATGTTTTGGCCGCTGCATTTTGATTGCAGCTAAAAGAGATAACAGAAAGGAGATACTGGCTGGCTGCTTCATATTAGCCCTCT CTGTTGTCAACACCTTGATGAGGCCAACCCAGAGATGCTTGATCAGTCCTCAGCTTTGCAGGGCTAGGTACAGAATTTTATCACAGGATT TTATCACGCTCTCTGGGGTGACTAGATCCACAGGAACCAAAACGCAGTTTCCAAAAGCTCGAGTGACTGAAGGATCTATACACAAACATG GCTATTTGCTAGTTAACAACAGGATATTTCTCTCTGGCCAGATCACAGACATGGTTCTGAGTCAGATCTTCCTTGGTGGCATCCCTTTAA AGAGGCCATCTTATGAACAGGATCACAAGTGAGCTTAGTGAGCAGAGAGTTAGAACAAATCTAGCTAGGTGTGTTTAAGGAATATTTCCA TTCAGCTAGTGTAGCTGGATTAATTTCTATTCTCCAAATCAAGGATGTCTAGAAAATGGGCATTGTGGCTTTCAAATCTAAGAAGAATCT >In-frame_LHPP_ENST00000368839_chr10_126172895_+_TANGO6_ENST00000261778_chr16_69056731_+_2295nt GAGGAGCAGGGCCGGGCGCCATGGCACCGTGGGGCAAGCGGCTGGCTGGCGTGCGCGGGGTGCTGCTTGACATCTCGGGCGTGCTGTACG ACAGCGGCGCGGGCGGCGGCACGGCCATCGCCGGCTCGGTGGAGGCGGTGGCCAGACTGAAGCGTTCCCGGCTGAAGGTGAGGTTCTGCA CCAACGAGTCGCAGAAGTCCCGGGCAGAGCTGGTGGGGCAGCTTCAGAGGCTGGGATTTGACATCTCTGAGCAGGAGGTGACCGCCCCGG CACCAGCTGCCTGCCAGATCCTGAAGGAGCAAGGCCTGCGACCATACCTGCTCATCCATGACGGAGACATGGTCTCAAAGTACCGAGAAC CTTTGATCCATACCTTCCTGAGGGGAGTGAGAGATCCTGATGGTGCTCACAGGGCCAGCAGCTTGGCCAACCTTGGGGAGCTGTGCCAGA GGCTGGACTTTCTGCTGGGCTCCGTGGTCCATGAGGTAACAGCTTGCCTGATTGCTGTGGCCAAAACAGATGGTGAAGTTCAAGTACGCA GAGCTGCCATACATGTGGTTGTGCTGCTGCTTCGGGGACTCAGCCAGAAAGCTACTGAGGTGCTGAGCGCCGTCCTCAAGGATCTCTACC ACCTGCTGAAGCACGTAGTGTGTCTGGAGCCCGATGACGTGGCCAAGCTCCATGCCCAGTTGGCCCTAGAAGAGCTGGATGACATCATGA AAAACTTCCTGTTCCCTCCACAGAAGCTGGAGAAGAAGATCATGGTCCTGCCGTAGACCTGGCTCCAAGGACGTGGAGGAGGCAGGCAGG GCCAGGCACCCAGAGCCGTGCCCAGGTCTTCCAGCAGGTGGCCCTGCTGCCTCTTGAGTGCTGGCAGCATGGCTGACCCTCGGGGTGGTT TTATGGTGCAGGTCACTTGGGTCTTCAGGGTCCCTTCCGAGGGCATGTGTTCAGCACTCCCGCGTTCAGCCTGAGGGGTGTACAGTTAAG AGAAGACAGTTACAGATCTCATTAATCTACATTTTTCACTGTCCTCTAGCATTGAAAGAAGGATGTCTACCTGGTGAAAGTATATTTTAA CATGACTGATGGAATTTCACTAATTGCCCACTCTCTTGGAACTTGAGGAGAAGCGGTTGGCCACCCATATGTCACCTAGCTCTATATTCT TTCAGGCTGAGATTCTTCTTCAGGAAAATGAGGAGCAGAACTGGCCACCCTTGGCTGCTCAAGAGGCATTTCAGAGTAGGAGATGCAGTT GGAGGTGGGGAGGGGAAGGAAATAGTTATCAAATAATGCAAAATGGAATAAAGTTATCTTGGATGGAAAGAACAGGGCTAAATCTGGTCC TCTGGTGTCGAGATGGAAAACTGTGGAGTTGAAGAGGCTCTGATGCCCAGAAAGGACAATCAAGCTGGTTGACTCTTCCAGAGAAGAAGG GTAAGCCCTGTATTTATCCTCCCAGGCCATTCTTCTTCACTCCTGCTGCTGTTTGCAGAGAGTTGCCCTGATTATCAGGAGAAAAGAACC ACGAGCATCCAGAGAGTTTACATCCTGCCTTCTGTCCTCTGCTCCTTCAGAAAGATGAATGCCTAGACAATGGGTTCACACTGAATGCAG GCTGGAAAGAATGCATGCTGGTGGCCTAATGCCAGGGCTGTTGAAACAATTTCAGATATAGCACTGTGGTCTCCACTTTATTTCTTTATA TGTTTTGGCCGCTGCATTTTGATTGCAGCTAAAAGAGATAACAGAAAGGAGATACTGGCTGGCTGCTTCATATTAGCCCTCTCTGTTGTC AACACCTTGATGAGGCCAACCCAGAGATGCTTGATCAGTCCTCAGCTTTGCAGGGCTAGGTACAGAATTTTATCACAGGATTTTATCACG CTCTCTGGGGTGACTAGATCCACAGGAACCAAAACGCAGTTTCCAAAAGCTCGAGTGACTGAAGGATCTATACACAAACATGGCTATTTG CTAGTTAACAACAGGATATTTCTCTCTGGCCAGATCACAGACATGGTTCTGAGTCAGATCTTCCTTGGTGGCATCCCTTTAAAGAGGCCA TCTTATGAACAGGATCACAAGTGAGCTTAGTGAGCAGAGAGTTAGAACAAATCTAGCTAGGTGTGTTTAAGGAATATTTCCATTCAGCTA GTGTAGCTGGATTAATTTCTATTCTCCAAATCAAGGATGTCTAGAAAATGGGCATTGTGGCTTTCAAATCTAAGAAGAATCTCCTTTGGG >In-frame_LHPP_ENST00000392757_chr10_126172895_+_TANGO6_ENST00000261778_chr16_69056731_+_2304nt CGCGGAGCTGAGGAGCAGGGCCGGGCGCCATGGCACCGTGGGGCAAGCGGCTGGCTGGCGTGCGCGGGGTGCTGCTTGACATCTCGGGCG TGCTGTACGACAGCGGCGCGGGCGGCGGCACGGCCATCGCCGGCTCGGTGGAGGCGGTGGCCAGACTGAAGCGTTCCCGGCTGAAGGTGA GGTTCTGCACCAACGAGTCGCAGAAGTCCCGGGCAGAGCTGGTGGGGCAGCTTCAGAGGCTGGGATTTGACATCTCTGAGCAGGAGGTGA CCGCCCCGGCACCAGCTGCCTGCCAGATCCTGAAGGAGCAAGGCCTGCGACCATACCTGCTCATCCATGACGGAGACATGGTCTCAAAGT ACCGAGAACCTTTGATCCATACCTTCCTGAGGGGAGTGAGAGATCCTGATGGTGCTCACAGGGCCAGCAGCTTGGCCAACCTTGGGGAGC TGTGCCAGAGGCTGGACTTTCTGCTGGGCTCCGTGGTCCATGAGGTAACAGCTTGCCTGATTGCTGTGGCCAAAACAGATGGTGAAGTTC AAGTACGCAGAGCTGCCATACATGTGGTTGTGCTGCTGCTTCGGGGACTCAGCCAGAAAGCTACTGAGGTGCTGAGCGCCGTCCTCAAGG ATCTCTACCACCTGCTGAAGCACGTAGTGTGTCTGGAGCCCGATGACGTGGCCAAGCTCCATGCCCAGTTGGCCCTAGAAGAGCTGGATG ACATCATGAAAAACTTCCTGTTCCCTCCACAGAAGCTGGAGAAGAAGATCATGGTCCTGCCGTAGACCTGGCTCCAAGGACGTGGAGGAG GCAGGCAGGGCCAGGCACCCAGAGCCGTGCCCAGGTCTTCCAGCAGGTGGCCCTGCTGCCTCTTGAGTGCTGGCAGCATGGCTGACCCTC GGGGTGGTTTTATGGTGCAGGTCACTTGGGTCTTCAGGGTCCCTTCCGAGGGCATGTGTTCAGCACTCCCGCGTTCAGCCTGAGGGGTGT ACAGTTAAGAGAAGACAGTTACAGATCTCATTAATCTACATTTTTCACTGTCCTCTAGCATTGAAAGAAGGATGTCTACCTGGTGAAAGT ATATTTTAACATGACTGATGGAATTTCACTAATTGCCCACTCTCTTGGAACTTGAGGAGAAGCGGTTGGCCACCCATATGTCACCTAGCT CTATATTCTTTCAGGCTGAGATTCTTCTTCAGGAAAATGAGGAGCAGAACTGGCCACCCTTGGCTGCTCAAGAGGCATTTCAGAGTAGGA GATGCAGTTGGAGGTGGGGAGGGGAAGGAAATAGTTATCAAATAATGCAAAATGGAATAAAGTTATCTTGGATGGAAAGAACAGGGCTAA ATCTGGTCCTCTGGTGTCGAGATGGAAAACTGTGGAGTTGAAGAGGCTCTGATGCCCAGAAAGGACAATCAAGCTGGTTGACTCTTCCAG AGAAGAAGGGTAAGCCCTGTATTTATCCTCCCAGGCCATTCTTCTTCACTCCTGCTGCTGTTTGCAGAGAGTTGCCCTGATTATCAGGAG AAAAGAACCACGAGCATCCAGAGAGTTTACATCCTGCCTTCTGTCCTCTGCTCCTTCAGAAAGATGAATGCCTAGACAATGGGTTCACAC TGAATGCAGGCTGGAAAGAATGCATGCTGGTGGCCTAATGCCAGGGCTGTTGAAACAATTTCAGATATAGCACTGTGGTCTCCACTTTAT TTCTTTATATGTTTTGGCCGCTGCATTTTGATTGCAGCTAAAAGAGATAACAGAAAGGAGATACTGGCTGGCTGCTTCATATTAGCCCTC TCTGTTGTCAACACCTTGATGAGGCCAACCCAGAGATGCTTGATCAGTCCTCAGCTTTGCAGGGCTAGGTACAGAATTTTATCACAGGAT TTTATCACGCTCTCTGGGGTGACTAGATCCACAGGAACCAAAACGCAGTTTCCAAAAGCTCGAGTGACTGAAGGATCTATACACAAACAT GGCTATTTGCTAGTTAACAACAGGATATTTCTCTCTGGCCAGATCACAGACATGGTTCTGAGTCAGATCTTCCTTGGTGGCATCCCTTTA AAGAGGCCATCTTATGAACAGGATCACAAGTGAGCTTAGTGAGCAGAGAGTTAGAACAAATCTAGCTAGGTGTGTTTAAGGAATATTTCC ATTCAGCTAGTGTAGCTGGATTAATTTCTATTCTCCAAATCAAGGATGTCTAGAAAATGGGCATTGTGGCTTTCAAATCTAAGAAGAATC |
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FusionGenePPI for LHPP_TANGO6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LHPP | HDHD2, GDPGP1 | TANGO6 | MACF1, UBE2S, CAPZA2, P4HA2, MTNR1B, ZNHIT2, RPAP3, RUVBL1, RUVBL2, URI1, WDR92 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LHPP_TANGO6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LHPP_TANGO6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LHPP | C0041696 | Unipolar Depression | 2 | PSYGENET |
| Hgene | LHPP | C1269683 | Major Depressive Disorder | 2 | PSYGENET |
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