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Fusion gene ID: 1968 |
FusionGeneSummary for ANTXR1_NCOA3 |
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Fusion gene information | Fusion gene name: ANTXR1_NCOA3 | Fusion gene ID: 1968 | Hgene | Tgene | Gene symbol | ANTXR1 | NCOA3 | Gene ID | 84168 | 8202 |
Gene name | ANTXR cell adhesion molecule 1 | nuclear receptor coactivator 3 | |
Synonyms | ATR|GAPO|TEM8 | ACTR|AIB-1|AIB1|CAGH16|CTG26|KAT13B|RAC3|SRC-3|SRC3|TNRC14|TNRC16|TRAM-1|bHLHe42|pCIP | |
Cytomap | 2p13.3 | 20q13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | anthrax toxin receptor 12310008J16Rik2810405N18Riktumor endothelial marker 8 | nuclear receptor coactivator 3CBP-interacting proteinamplified in breast cancer 1 proteinclass E basic helix-loop-helix protein 42receptor-associated coactivator 3steroid receptor coactivator protein 3thyroid hormone receptor activator molecule 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9H6X2 | Q9Y6Q9 | |
Ensembl transtripts involved in fusion gene | ENST00000303714, ENST00000409829, ENST00000409349, | ENST00000341724, ENST00000372004, ENST00000371998, ENST00000371997, ENST00000497292, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 9 X 6 X 4=216 |
# samples | 2 | 9 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ANTXR1 [Title/Abstract] AND NCOA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ANTXR1 | GO:0031532 | actin cytoskeleton reorganization | 16762926 |
Hgene | ANTXR1 | GO:0034446 | substrate adhesion-dependent cell spreading | 16762926 |
Tgene | NCOA3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9267036 |
Tgene | NCOA3 | GO:0071392 | cellular response to estradiol stimulus | 15831516 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF839348 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000303714 | ENST00000341724 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
5CDS-intron | ENST00000303714 | ENST00000372004 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
5CDS-intron | ENST00000303714 | ENST00000371998 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
5CDS-intron | ENST00000303714 | ENST00000371997 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
5CDS-intron | ENST00000303714 | ENST00000497292 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
intron-intron | ENST00000409829 | ENST00000341724 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
intron-intron | ENST00000409829 | ENST00000372004 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
intron-intron | ENST00000409829 | ENST00000371998 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
intron-intron | ENST00000409829 | ENST00000371997 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
intron-intron | ENST00000409829 | ENST00000497292 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
5CDS-intron | ENST00000409349 | ENST00000341724 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
5CDS-intron | ENST00000409349 | ENST00000372004 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
5CDS-intron | ENST00000409349 | ENST00000371998 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
5CDS-intron | ENST00000409349 | ENST00000371997 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
5CDS-intron | ENST00000409349 | ENST00000497292 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
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FusionProtFeatures for ANTXR1_NCOA3 |
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Hgene | Tgene |
ANTXR1 | NCOA3 |
Plays a role in cell attachment and migration. Interactswith extracellular matrix proteins and with the actincytoskeleton. Mediates adhesion of cells to type 1 collagen andgelatin, reorganization of the actin cytoskeleton and promotescell spreading. Plays a role in the angiogenic response ofcultured umbilical vein endothelial cells.{ECO:0000269|PubMed:15777794, ECO:0000269|PubMed:16762926}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ANTXR1_NCOA3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ANTXR1_NCOA3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANTXR1_NCOA3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANTXR1_NCOA3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | NCOA3 | C0023418 | leukemia | 2 | CTD_human |
Tgene | NCOA3 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Tgene | NCOA3 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Tgene | NCOA3 | C0004114 | Astrocytoma | 1 | CTD_human |
Tgene | NCOA3 | C0005967 | Bone neoplasms | 1 | CTD_human |
Tgene | NCOA3 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Tgene | NCOA3 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Tgene | NCOA3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |