FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1968

FusionGeneSummary for ANTXR1_NCOA3

check button Fusion gene summary
Fusion gene informationFusion gene name: ANTXR1_NCOA3
Fusion gene ID: 1968
HgeneTgene
Gene symbol

ANTXR1

NCOA3

Gene ID

84168

8202

Gene nameANTXR cell adhesion molecule 1nuclear receptor coactivator 3
SynonymsATR|GAPO|TEM8ACTR|AIB-1|AIB1|CAGH16|CTG26|KAT13B|RAC3|SRC-3|SRC3|TNRC14|TNRC16|TRAM-1|bHLHe42|pCIP
Cytomap

2p13.3

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionanthrax toxin receptor 12310008J16Rik2810405N18Riktumor endothelial marker 8nuclear receptor coactivator 3CBP-interacting proteinamplified in breast cancer 1 proteinclass E basic helix-loop-helix protein 42receptor-associated coactivator 3steroid receptor coactivator protein 3thyroid hormone receptor activator molecule 1
Modification date2018052320180523
UniProtAcc

Q9H6X2

Q9Y6Q9

Ensembl transtripts involved in fusion geneENST00000303714, ENST00000409829, 
ENST00000409349, 
ENST00000341724, 
ENST00000372004, ENST00000371998, 
ENST00000371997, ENST00000497292, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 6 X 4=216
# samples 29
** MAII scorelog2(2/8*10)=1.32192809488736log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANTXR1 [Title/Abstract] AND NCOA3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANTXR1

GO:0031532

actin cytoskeleton reorganization

16762926

HgeneANTXR1

GO:0034446

substrate adhesion-dependent cell spreading

16762926

TgeneNCOA3

GO:0045944

positive regulation of transcription by RNA polymerase II

9267036

TgeneNCOA3

GO:0071392

cellular response to estradiol stimulus

15831516


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF839348ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000303714ENST00000341724ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
5CDS-intronENST00000303714ENST00000372004ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
5CDS-intronENST00000303714ENST00000371998ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
5CDS-intronENST00000303714ENST00000371997ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
5CDS-intronENST00000303714ENST00000497292ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
intron-intronENST00000409829ENST00000341724ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
intron-intronENST00000409829ENST00000372004ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
intron-intronENST00000409829ENST00000371998ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
intron-intronENST00000409829ENST00000371997ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
intron-intronENST00000409829ENST00000497292ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
5CDS-intronENST00000409349ENST00000341724ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
5CDS-intronENST00000409349ENST00000372004ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
5CDS-intronENST00000409349ENST00000371998ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
5CDS-intronENST00000409349ENST00000371997ANTXR1chr2

69397409

+NCOA3chr20

46219171

+
5CDS-intronENST00000409349ENST00000497292ANTXR1chr2

69397409

+NCOA3chr20

46219171

+

Top

FusionProtFeatures for ANTXR1_NCOA3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANTXR1

Q9H6X2

NCOA3

Q9Y6Q9

Plays a role in cell attachment and migration. Interactswith extracellular matrix proteins and with the actincytoskeleton. Mediates adhesion of cells to type 1 collagen andgelatin, reorganization of the actin cytoskeleton and promotescell spreading. Plays a role in the angiogenic response ofcultured umbilical vein endothelial cells.{ECO:0000269|PubMed:15777794, ECO:0000269|PubMed:16762926}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ANTXR1_NCOA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ANTXR1_NCOA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ANTXR1_NCOA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ANTXR1_NCOA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNCOA3C0023418leukemia2CTD_human
TgeneNCOA3C0033578Prostatic Neoplasms2CTD_human
TgeneNCOA3C0001418Adenocarcinoma1CTD_human
TgeneNCOA3C0004114Astrocytoma1CTD_human
TgeneNCOA3C0005967Bone neoplasms1CTD_human
TgeneNCOA3C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneNCOA3C0007137Squamous cell carcinoma1CTD_human
TgeneNCOA3C1458155Mammary Neoplasms1CTD_human