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Fusion gene ID: 1967 |
FusionGeneSummary for ANTXR1_APLF |
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Fusion gene information | Fusion gene name: ANTXR1_APLF | Fusion gene ID: 1967 | Hgene | Tgene | Gene symbol | ANTXR1 | APLF | Gene ID | 84168 | 200558 |
Gene name | ANTXR cell adhesion molecule 1 | aprataxin and PNKP like factor | |
Synonyms | ATR|GAPO|TEM8 | APFL|C2orf13|PALF|Xip1|ZCCHH1 | |
Cytomap | 2p13.3 | 2p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | anthrax toxin receptor 12310008J16Rik2810405N18Riktumor endothelial marker 8 | aprataxin and PNK-like factorPNK and APTX-like FHA domain-containing proteinPNK and APTX-like FHA proteinXRCC1-interacting protein 1aprataxin- and PNK-like factorapurinic-apyrimidinic endonuclease APLFzinc finger, CX5CX6HX5H motif containing 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9H6X2 | Q8IW19 | |
Ensembl transtripts involved in fusion gene | ENST00000303714, ENST00000409829, ENST00000409349, | ENST00000471727, ENST00000303795, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 3=27 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ANTXR1 [Title/Abstract] AND APLF [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ANTXR1 | GO:0031532 | actin cytoskeleton reorganization | 16762926 |
Hgene | ANTXR1 | GO:0034446 | substrate adhesion-dependent cell spreading | 16762926 |
Tgene | APLF | GO:0006974 | cellular response to DNA damage stimulus | 17396150 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | OV | TCGA-24-1469-01A | ANTXR1 | chr2 | 69298919 | + | APLF | chr2 | 68804952 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000303714 | ENST00000471727 | ANTXR1 | chr2 | 69298919 | + | APLF | chr2 | 68804952 | + |
5CDS-3UTR | ENST00000303714 | ENST00000303795 | ANTXR1 | chr2 | 69298919 | + | APLF | chr2 | 68804952 | + |
5CDS-3UTR | ENST00000409829 | ENST00000471727 | ANTXR1 | chr2 | 69298919 | + | APLF | chr2 | 68804952 | + |
5CDS-3UTR | ENST00000409829 | ENST00000303795 | ANTXR1 | chr2 | 69298919 | + | APLF | chr2 | 68804952 | + |
5CDS-3UTR | ENST00000409349 | ENST00000471727 | ANTXR1 | chr2 | 69298919 | + | APLF | chr2 | 68804952 | + |
5CDS-3UTR | ENST00000409349 | ENST00000303795 | ANTXR1 | chr2 | 69298919 | + | APLF | chr2 | 68804952 | + |
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FusionProtFeatures for ANTXR1_APLF |
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Hgene | Tgene |
ANTXR1 | APLF |
Plays a role in cell attachment and migration. Interactswith extracellular matrix proteins and with the actincytoskeleton. Mediates adhesion of cells to type 1 collagen andgelatin, reorganization of the actin cytoskeleton and promotescell spreading. Plays a role in the angiogenic response ofcultured umbilical vein endothelial cells.{ECO:0000269|PubMed:15777794, ECO:0000269|PubMed:16762926}. | Nuclease involved in single-strand and double-strand DNAbreak repair. Recruited to sites of DNA damage through interactionwith poly(ADP-ribose), a polymeric post-translational modificationsynthesized transiently at sites of chromosomal damage toaccelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities invitro. Also able to introduce nicks at hydroxyuracil and othertypes of pyrimidine base damage. {ECO:0000269|PubMed:17353262,ECO:0000269|PubMed:17396150}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ANTXR1_APLF |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ANTXR1_APLF |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ANTXR1 | ELAVL1, SPACA1, TUBB3, RSAD1, CA11, ZNF146, POTEF, TUBB8, HSPA5, KANK2, RICTOR, LRP11, PDIA5, TUBA4A, TUBA1A, PC, DNAJC12, OBSL1, RPL23, H6PD, KIRREL, GALNT7, WFS1, PCYOX1, CNTNAP3, FOXF2, TUBB4A, DMXL2, MAP2K7, ETV3, MANEA, ERF, TRMT44, PAM16, GDF11, SAMD1, WNT5A, SLAMF1, PRMT2, FLNA, GJB2, MYH9, SYN1, KLF8, MYO19, B4GALNT4, OCLN, IL13RA2, FCGRT, PMEL, TMEM30A, UBC, TRIM25 | APLF | CHD1L, HIST3H3, PARP1, LIG4, XRCC5, APP, FBXO25, GMCL1, POLB, H2AFY2, H2AFY, SUPT16H, XRCC1, LIG3, PARP2, XRCC6, HLTF, HIST1H2BJ, HIST1H2AG, HIST2H2AB, XRCC4, XPC, CETN2, TDP1, TOP1, SSRP1, ZG16B, HIST2H3PS2, CST4, HIST1H2BA, HIST2H2AC, MSH3, CST1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANTXR1_APLF |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANTXR1_APLF |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |