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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19658

FusionGeneSummary for LGALS8_WAC

check button Fusion gene summary
Fusion gene informationFusion gene name: LGALS8_WAC
Fusion gene ID: 19658
HgeneTgene
Gene symbol

LGALS8

WAC

Gene ID

3964

51322

Gene namegalectin 8WW domain containing adaptor with coiled-coil
SynonymsGal-8|PCTA-1|PCTA1|Po66-CBPBM-016|DESSH|PRO1741|Wwp4
Cytomap

1q43

10p12.1|10p12.1-p11.2

Type of geneprotein-codingprotein-coding
Descriptiongalectin-8Po66 carbohydrate binding proteingalectin-8glectin, galactoside-binding, soluble, 8po66 carbohydrate-binding proteinprostate carcinoma tumor antigen 1WW domain-containing adapter protein with coiled-coil
Modification date2018051920180519
UniProtAcc

O00214

Q9BTA9

Ensembl transtripts involved in fusion geneENST00000526589, ENST00000527974, 
ENST00000352231, ENST00000341872, 
ENST00000450372, ENST00000366584, 
ENST00000416919, ENST00000323938, 
ENST00000526634, ENST00000525042, 
ENST00000375664, ENST00000375646, 
ENST00000347934, ENST00000354911, 
ENST00000428935, ENST00000532233, 
Fusion gene scores* DoF score5 X 5 X 3=759 X 11 X 3=297
# samples 713
** MAII scorelog2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/297*10)=-1.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LGALS8 [Title/Abstract] AND WAC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLGALS8

GO:1904977

lymphatic endothelial cell migration

19268462


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE082917LGALS8chr1

236714485

-WACchr10

28897201

-
ChiTaRS3.1BE082698LGALS8chr1

236714485

-WACchr10

28897201

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000526589ENST00000375664LGALS8chr1

236714485

-WACchr10

28897201

-
3UTR-3CDSENST00000526589ENST00000375646LGALS8chr1

236714485

-WACchr10

28897201

-
3UTR-3CDSENST00000526589ENST00000347934LGALS8chr1

236714485

-WACchr10

28897201

-
3UTR-3CDSENST00000526589ENST00000354911LGALS8chr1

236714485

-WACchr10

28897201

-
3UTR-3CDSENST00000526589ENST00000428935LGALS8chr1

236714485

-WACchr10

28897201

-
3UTR-intronENST00000526589ENST00000532233LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000527974ENST00000375664LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000527974ENST00000375646LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000527974ENST00000347934LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000527974ENST00000354911LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000527974ENST00000428935LGALS8chr1

236714485

-WACchr10

28897201

-
intron-intronENST00000527974ENST00000532233LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000352231ENST00000375664LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000352231ENST00000375646LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000352231ENST00000347934LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000352231ENST00000354911LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000352231ENST00000428935LGALS8chr1

236714485

-WACchr10

28897201

-
intron-intronENST00000352231ENST00000532233LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000341872ENST00000375664LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000341872ENST00000375646LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000341872ENST00000347934LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000341872ENST00000354911LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000341872ENST00000428935LGALS8chr1

236714485

-WACchr10

28897201

-
intron-intronENST00000341872ENST00000532233LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000450372ENST00000375664LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000450372ENST00000375646LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000450372ENST00000347934LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000450372ENST00000354911LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000450372ENST00000428935LGALS8chr1

236714485

-WACchr10

28897201

-
intron-intronENST00000450372ENST00000532233LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000366584ENST00000375664LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000366584ENST00000375646LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000366584ENST00000347934LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000366584ENST00000354911LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000366584ENST00000428935LGALS8chr1

236714485

-WACchr10

28897201

-
intron-intronENST00000366584ENST00000532233LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000416919ENST00000375664LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000416919ENST00000375646LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000416919ENST00000347934LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000416919ENST00000354911LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000416919ENST00000428935LGALS8chr1

236714485

-WACchr10

28897201

-
intron-intronENST00000416919ENST00000532233LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000323938ENST00000375664LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000323938ENST00000375646LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000323938ENST00000347934LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000323938ENST00000354911LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000323938ENST00000428935LGALS8chr1

236714485

-WACchr10

28897201

-
intron-intronENST00000323938ENST00000532233LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000526634ENST00000375664LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000526634ENST00000375646LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000526634ENST00000347934LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000526634ENST00000354911LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000526634ENST00000428935LGALS8chr1

236714485

-WACchr10

28897201

-
intron-intronENST00000526634ENST00000532233LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000525042ENST00000375664LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000525042ENST00000375646LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000525042ENST00000347934LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000525042ENST00000354911LGALS8chr1

236714485

-WACchr10

28897201

-
intron-3CDSENST00000525042ENST00000428935LGALS8chr1

236714485

-WACchr10

28897201

-
intron-intronENST00000525042ENST00000532233LGALS8chr1

236714485

-WACchr10

28897201

-

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FusionProtFeatures for LGALS8_WAC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LGALS8

O00214

WAC

Q9BTA9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LGALS8_WAC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LGALS8_WAC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LGALS8_WAC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LGALS8_WAC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource