	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 19656

FusionGeneSummary for LGALS8_RHBG

Fusion gene summary

Fusion gene information	Fusion gene name: LGALS8_RHBG
	Fusion gene ID: 19656
		Hgene	Tgene
	Gene symbol	LGALS8	RHBG
	Gene ID	3964	57127
	Gene name	galectin 8	Rh family B glycoprotein (gene/pseudogene)
	Synonyms	Gal-8\|PCTA-1\|PCTA1\|Po66-CBP	SLC42A2
	Cytomap	1q43	1q22
	Type of gene	protein-coding	protein-coding
	Description	galectin-8Po66 carbohydrate binding proteingalectin-8glectin, galactoside-binding, soluble, 8po66 carbohydrate-binding proteinprostate carcinoma tumor antigen 1	ammonium transporter Rh type BRh family, B glycoproteinRhesus blood group, B glycoprotein
	Modification date	20180519	20180523
	UniProtAcc	O00214	Q9H310
	Ensembl transtripts involved in fusion gene	ENST00000526589, ENST00000527974, ENST00000352231, ENST00000341872, ENST00000450372, ENST00000366584, ENST00000416919, ENST00000323938, ENST00000526634, ENST00000525042,	ENST00000537040, ENST00000451864, ENST00000400992, ENST00000368246, ENST00000255013, ENST00000368249, ENST00000494874,
Fusion gene scores	* DoF score	5 X 5 X 3=75	5 X 4 X 5=100
	# samples	7	6
	** MAII score	log2(7/75*10)=-0.0995356735509144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LGALS8 [Title/Abstract] AND RHBG [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LGALS8	GO:1904977	lymphatic endothelial cell migration	19268462
Tgene	RHBG	GO:0015696	ammonium transport	15929723\|18032481\|18635543
Tgene	RHBG	GO:0070634	transepithelial ammonium transport	18032481

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BLCA	TCGA-FD-A3B4-01A	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000526589	ENST00000537040	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000526589	ENST00000451864	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000526589	ENST00000400992	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000526589	ENST00000368246	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000526589	ENST00000255013	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000526589	ENST00000368249	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000526589	ENST00000494874	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000527974	ENST00000537040	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000527974	ENST00000451864	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000527974	ENST00000400992	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000527974	ENST00000368246	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000527974	ENST00000255013	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000527974	ENST00000368249	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000527974	ENST00000494874	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000352231	ENST00000537040	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000352231	ENST00000451864	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000352231	ENST00000400992	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000352231	ENST00000368246	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000352231	ENST00000255013	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000352231	ENST00000368249	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000352231	ENST00000494874	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000341872	ENST00000537040	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000341872	ENST00000451864	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000341872	ENST00000400992	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000341872	ENST00000368246	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000341872	ENST00000255013	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000341872	ENST00000368249	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000341872	ENST00000494874	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000450372	ENST00000537040	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000450372	ENST00000451864	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000450372	ENST00000400992	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000450372	ENST00000368246	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000450372	ENST00000255013	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000450372	ENST00000368249	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000450372	ENST00000494874	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000366584	ENST00000537040	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000366584	ENST00000451864	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000366584	ENST00000400992	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000366584	ENST00000368246	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000366584	ENST00000255013	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000366584	ENST00000368249	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000366584	ENST00000494874	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000416919	ENST00000537040	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000416919	ENST00000451864	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000416919	ENST00000400992	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000416919	ENST00000368246	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000416919	ENST00000255013	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000416919	ENST00000368249	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000416919	ENST00000494874	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000323938	ENST00000537040	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000323938	ENST00000451864	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000323938	ENST00000400992	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000323938	ENST00000368246	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000323938	ENST00000255013	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000323938	ENST00000368249	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000323938	ENST00000494874	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000526634	ENST00000537040	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000526634	ENST00000451864	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000526634	ENST00000400992	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000526634	ENST00000368246	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000526634	ENST00000255013	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000526634	ENST00000368249	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000526634	ENST00000494874	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000525042	ENST00000537040	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000525042	ENST00000451864	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000525042	ENST00000400992	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000525042	ENST00000368246	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-5UTR	ENST00000525042	ENST00000255013	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000525042	ENST00000368249	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+
5CDS-intron	ENST00000525042	ENST00000494874	LGALS8	chr1	236689415	+	RHBG	chr1	156344398	+

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FusionProtFeatures for LGALS8_RHBG

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LGALS8 O00214	RHBG Q9H310
	Functions as a specific ammonium transporter.{ECO:0000269\|PubMed:15284342, ECO:0000269\|PubMed:15929723}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for LGALS8_RHBG

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LGALS8_RHBG

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
LGALS8	CALCOCO2, ITGA3, ITGB1, ITGA4, NDP, CUL1, BARD1, PAN2, EGFR, APEH, TRIM23, TAX1BP1, MID2, COLEC12, PTPRK, RNF13, SV2A, ABCC4, KIAA0319L, ATP2B4, ATP2B2, ATP2B3, PTPRA, SLC30A1, SLC9A6, RRAGC, SLC12A9, SLC12A2, ITGA5, ITGA2, MFAP3, KIAA1549, ALCAM, SLC4A2, PTPRG, ATP6V0A2, ATP6V0A1, C1orf159, NCR3LG1, ITGA1, PODXL, PTPRJ, SPPL2A, FN1, ITGA6, EMB, CD58, SLC12A6, SLC12A4, SLC12A7, CSPG4, NPC1, ACP2, C1orf85, SDCBP, ADCY6, PTGFRN, ADCY9, SLC22A23, SLC4A7, FLT4, CLCN5, CLCN3, ENPP4, LRRC8E, LRRC8A, LRRC8C, LNPEP, TMEM237, DAG1, SORL1, PVRL3, SLC35A5, SLC17A5, MRC2, ANO6, ATP13A3, SLC36A1, SUSD5, ITGA7, HEG1, FGFR1, TMEM63B, CD47, C4A, PVRL1, SLC26A2, RRAGB, SLC38A9, SCARB2, CD276, CLCN7, LAMA4, ATG9A, OSTM1, TRPM4, SDK1, CD63, MCAM, SEZ6L2, TMEM63A, PROCR, SLC1A1, SLC31A1, LRRC4B, ECE1, ABCC1, TRIM5, TRIM6, TRIM17, MEFV, TRIM22, TRIM49	RHBG	SH2B1

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for LGALS8_RHBG

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for LGALS8_RHBG

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 19656

FusionGeneSummary for LGALS8_RHBG

FusionProtFeatures for LGALS8_RHBG

FusionGeneSequence for LGALS8_RHBG

FusionGenePPI for LGALS8_RHBG

RelatedDrugs for LGALS8_RHBG

RelatedDiseases for LGALS8_RHBG