	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 19654

FusionGeneSummary for LGALS8_EDARADD

Fusion gene summary

Fusion gene information	Fusion gene name: LGALS8_EDARADD
	Fusion gene ID: 19654
		Hgene	Tgene
	Gene symbol	LGALS8	EDARADD
	Gene ID	3964	128178
	Gene name	galectin 8	EDAR associated death domain
	Synonyms	Gal-8\|PCTA-1\|PCTA1\|Po66-CBP	ECTD11A\|ECTD11B\|ED3\|EDA3
	Cytomap	1q43	1q42.3-q43
	Type of gene	protein-coding	protein-coding
	Description	galectin-8Po66 carbohydrate binding proteingalectin-8glectin, galactoside-binding, soluble, 8po66 carbohydrate-binding proteinprostate carcinoma tumor antigen 1	ectodysplasin-A receptor-associated adapter proteinEDAR-associated death domain proteincrinkled homologectodysplasia A receptor associated death domain
	Modification date	20180519	20180523
	UniProtAcc	O00214	Q8WWZ3
	Ensembl transtripts involved in fusion gene	ENST00000526589, ENST00000527974, ENST00000352231, ENST00000341872, ENST00000450372, ENST00000366584, ENST00000416919, ENST00000323938, ENST00000526634, ENST00000525042,	ENST00000334232, ENST00000359362,
Fusion gene scores	* DoF score	5 X 5 X 3=75	4 X 3 X 4=48
	# samples	7	5
	** MAII score	log2(7/75*10)=-0.0995356735509144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: LGALS8 [Title/Abstract] AND EDARADD [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LGALS8	GO:1904977	lymphatic endothelial cell migration	19268462

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BLCA	TCGA-DK-AA6P-01A	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
TCGA	RV	BRCA	TCGA-BH-A203-01A	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000526589	ENST00000334232	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
In-frame	ENST00000526589	ENST00000359362	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
Frame-shift	ENST00000527974	ENST00000334232	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
In-frame	ENST00000527974	ENST00000359362	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
Frame-shift	ENST00000352231	ENST00000334232	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
In-frame	ENST00000352231	ENST00000359362	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
Frame-shift	ENST00000341872	ENST00000334232	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
In-frame	ENST00000341872	ENST00000359362	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
Frame-shift	ENST00000450372	ENST00000334232	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
In-frame	ENST00000450372	ENST00000359362	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
Frame-shift	ENST00000366584	ENST00000334232	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
In-frame	ENST00000366584	ENST00000359362	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
Frame-shift	ENST00000416919	ENST00000334232	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
In-frame	ENST00000416919	ENST00000359362	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
Frame-shift	ENST00000323938	ENST00000334232	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
In-frame	ENST00000323938	ENST00000359362	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
Frame-shift	ENST00000526634	ENST00000334232	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
In-frame	ENST00000526634	ENST00000359362	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
Frame-shift	ENST00000525042	ENST00000334232	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
In-frame	ENST00000525042	ENST00000359362	LGALS8	chr1	236708215	+	EDARADD	chr1	236645567	+
5UTR-3CDS	ENST00000526589	ENST00000334232	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
5UTR-3CDS	ENST00000526589	ENST00000359362	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
5UTR-3CDS	ENST00000527974	ENST00000334232	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
5UTR-3CDS	ENST00000527974	ENST00000359362	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
5UTR-3CDS	ENST00000352231	ENST00000334232	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
5UTR-3CDS	ENST00000352231	ENST00000359362	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
intron-3CDS	ENST00000341872	ENST00000334232	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
intron-3CDS	ENST00000341872	ENST00000359362	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
intron-3CDS	ENST00000450372	ENST00000334232	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
intron-3CDS	ENST00000450372	ENST00000359362	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
intron-3CDS	ENST00000366584	ENST00000334232	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
intron-3CDS	ENST00000366584	ENST00000359362	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
intron-3CDS	ENST00000416919	ENST00000334232	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
intron-3CDS	ENST00000416919	ENST00000359362	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
intron-3CDS	ENST00000323938	ENST00000334232	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
intron-3CDS	ENST00000323938	ENST00000359362	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
intron-3CDS	ENST00000526634	ENST00000334232	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
intron-3CDS	ENST00000526634	ENST00000359362	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
intron-3CDS	ENST00000525042	ENST00000334232	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+
intron-3CDS	ENST00000525042	ENST00000359362	LGALS8	chr1	236681584	+	EDARADD	chr1	236645567	+

Top

FusionProtFeatures for LGALS8_EDARADD

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LGALS8 O00214	EDARADD Q8WWZ3
	Adapter protein that interacts with EDAR DEATH domainand couples the receptor to EDA signaling pathway duringmorphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B. {ECO:0000269\|PubMed:11882293}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for LGALS8_EDARADD

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LGALS8_EDARADD

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
LGALS8	CALCOCO2, ITGA3, ITGB1, ITGA4, NDP, CUL1, BARD1, PAN2, EGFR, APEH, TRIM23, TAX1BP1, MID2, COLEC12, PTPRK, RNF13, SV2A, ABCC4, KIAA0319L, ATP2B4, ATP2B2, ATP2B3, PTPRA, SLC30A1, SLC9A6, RRAGC, SLC12A9, SLC12A2, ITGA5, ITGA2, MFAP3, KIAA1549, ALCAM, SLC4A2, PTPRG, ATP6V0A2, ATP6V0A1, C1orf159, NCR3LG1, ITGA1, PODXL, PTPRJ, SPPL2A, FN1, ITGA6, EMB, CD58, SLC12A6, SLC12A4, SLC12A7, CSPG4, NPC1, ACP2, C1orf85, SDCBP, ADCY6, PTGFRN, ADCY9, SLC22A23, SLC4A7, FLT4, CLCN5, CLCN3, ENPP4, LRRC8E, LRRC8A, LRRC8C, LNPEP, TMEM237, DAG1, SORL1, PVRL3, SLC35A5, SLC17A5, MRC2, ANO6, ATP13A3, SLC36A1, SUSD5, ITGA7, HEG1, FGFR1, TMEM63B, CD47, C4A, PVRL1, SLC26A2, RRAGB, SLC38A9, SCARB2, CD276, CLCN7, LAMA4, ATG9A, OSTM1, TRPM4, SDK1, CD63, MCAM, SEZ6L2, TMEM63A, PROCR, SLC1A1, SLC31A1, LRRC4B, ECE1, ABCC1, TRIM5, TRIM6, TRIM17, MEFV, TRIM22, TRIM49	EDARADD	EDAR, TRAF2, TAB2, TRAF6, MAP3K7, SDCBP, UBE2I, SUMO1, RNF111, WDYHV1, EDARADD, SHPRH, SUMO1P1

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for LGALS8_EDARADD

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for LGALS8_EDARADD

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	EDARADD	C3539920	ECTODERMAL DYSPLASIA 11B, HYPOHIDROTIC/HAIR/TOOTH TYPE, AUTOSOMAL RECESSIVE	2	UNIPROT
Tgene	EDARADD	C3541517	ECTODERMAL DYSPLASIA 11A, HYPOHIDROTIC/HAIR/TOOTH TYPE, AUTOSOMAL DOMINANT	2	UNIPROT

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 19654

FusionGeneSummary for LGALS8_EDARADD

FusionProtFeatures for LGALS8_EDARADD

FusionGeneSequence for LGALS8_EDARADD

FusionGenePPI for LGALS8_EDARADD

RelatedDrugs for LGALS8_EDARADD

RelatedDiseases for LGALS8_EDARADD