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Fusion gene ID: 19651 |
FusionGeneSummary for LGALS3_SOCS4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LGALS3_SOCS4 | Fusion gene ID: 19651 | Hgene | Tgene | Gene symbol | LGALS3 | SOCS4 | Gene ID | 3958 | 122809 |
| Gene name | galectin 3 | suppressor of cytokine signaling 4 | |
| Synonyms | CBP35|GAL3|GALBP|GALIG|L31|LGALS2|MAC2 | SOCS7 | |
| Cytomap | 14q22.3 | 14q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | galectin-335 kDa lectinIgE-binding proteinMAC-2 antigenadvanced glycation end-product receptor 3carbohydrate-binding protein 35galactose-specific lectin 3laminin-binding proteinlectin L-29lectin, galactoside-binding, soluble, 3 | suppressor of cytokine signaling 4SH2 domain containing SOCS box proteinSOCS-4SOCS-7suppressor of cytokine signaling 7 | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | P17931 | Q8WXH5 | |
| Ensembl transtripts involved in fusion gene | ENST00000254301, ENST00000553755, ENST00000554715, | ENST00000395472, ENST00000555846, ENST00000553735, ENST00000339298, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: LGALS3 [Title/Abstract] AND SOCS4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LGALS3 | GO:0002548 | monocyte chemotaxis | 10925302 |
| Hgene | LGALS3 | GO:0030593 | neutrophil chemotaxis | 10925302 |
| Hgene | LGALS3 | GO:0045806 | negative regulation of endocytosis | 19706535 |
| Hgene | LGALS3 | GO:0048245 | eosinophil chemotaxis | 10925302 |
| Hgene | LGALS3 | GO:0048246 | macrophage chemotaxis | 10925302 |
| Hgene | LGALS3 | GO:0050918 | positive chemotaxis | 10925302 |
| Hgene | LGALS3 | GO:0070232 | regulation of T cell apoptotic process | 8692888 |
| Hgene | LGALS3 | GO:0071674 | mononuclear cell migration | 10925302 |
| Hgene | LGALS3 | GO:0071677 | positive regulation of mononuclear cell migration | 10925302 |
| Hgene | LGALS3 | GO:0090280 | positive regulation of calcium ion import | 10925302 |
| Hgene | LGALS3 | GO:2001200 | positive regulation of dendritic cell differentiation | 16116184 |
| Hgene | LGALS3 | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 22761016 |
| Tgene | SOCS4 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity | 15590694 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | READ | TCGA-AG-3731-01A | LGALS3 | chr14 | 55609467 | + | SOCS4 | chr14 | 55515514 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000254301 | ENST00000395472 | LGALS3 | chr14 | 55609467 | + | SOCS4 | chr14 | 55515514 | + |
| 5CDS-intron | ENST00000254301 | ENST00000555846 | LGALS3 | chr14 | 55609467 | + | SOCS4 | chr14 | 55515514 | + |
| 5CDS-intron | ENST00000254301 | ENST00000553735 | LGALS3 | chr14 | 55609467 | + | SOCS4 | chr14 | 55515514 | + |
| 5CDS-3UTR | ENST00000254301 | ENST00000339298 | LGALS3 | chr14 | 55609467 | + | SOCS4 | chr14 | 55515514 | + |
| 5CDS-3UTR | ENST00000553755 | ENST00000395472 | LGALS3 | chr14 | 55609467 | + | SOCS4 | chr14 | 55515514 | + |
| 5CDS-intron | ENST00000553755 | ENST00000555846 | LGALS3 | chr14 | 55609467 | + | SOCS4 | chr14 | 55515514 | + |
| 5CDS-intron | ENST00000553755 | ENST00000553735 | LGALS3 | chr14 | 55609467 | + | SOCS4 | chr14 | 55515514 | + |
| 5CDS-3UTR | ENST00000553755 | ENST00000339298 | LGALS3 | chr14 | 55609467 | + | SOCS4 | chr14 | 55515514 | + |
| 5CDS-3UTR | ENST00000554715 | ENST00000395472 | LGALS3 | chr14 | 55609467 | + | SOCS4 | chr14 | 55515514 | + |
| 5CDS-intron | ENST00000554715 | ENST00000555846 | LGALS3 | chr14 | 55609467 | + | SOCS4 | chr14 | 55515514 | + |
| 5CDS-intron | ENST00000554715 | ENST00000553735 | LGALS3 | chr14 | 55609467 | + | SOCS4 | chr14 | 55515514 | + |
| 5CDS-3UTR | ENST00000554715 | ENST00000339298 | LGALS3 | chr14 | 55609467 | + | SOCS4 | chr14 | 55515514 | + |
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FusionProtFeatures for LGALS3_SOCS4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LGALS3 | SOCS4 |
| Galactose-specific lectin which binds IgE. May mediatewith the alpha-3, beta-1 integrin the stimulation by CSPG4 ofendothelial cells migration. Together with DMBT1, required forterminal differentiation of columnar epithelial cells during earlyembryogenesis (By similarity). In the nucleus: acts as a pre-mRNAsplicing factor. Involved in acute inflammatory responsesincluding neutrophil activation and adhesion, chemoattraction ofmonocytes macrophages, opsonization of apoptotic neutrophils, andactivation of mast cells. {ECO:0000250,ECO:0000269|PubMed:15181153, ECO:0000269|PubMed:19594635,ECO:0000269|PubMed:19616076}. | SOCS family proteins form part of a classical negativefeedback system that regulates cytokine signal transduction.Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex whichmediates the ubiquitination and subsequent proteasomal degradationof target proteins. Inhibits EGF signaling by mediating thedegradation of the Tyr-phosphorylated EGF receptor/EGFR.{ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:17997974}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LGALS3_SOCS4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LGALS3_SOCS4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LGALS3 | GEMIN4, LGALS1, FCGR2A, ELN, LGALS3BP, C1GALT1C1, EGFR, MYOC, GTF2I, ACTA1, APP, CLNS1A, IGBP1, SLC25A5, AGPS, BARD1, PAXIP1, CFTR, SQSTM1, RAB7A, LAMP1, MAP1LC3A, GOLGA2, LGALS3, PPIG, SS18L1, PRR13, TEX35, COASY, COLEC12, LAMB1, ABCC4, KIAA0319L, ATP2B4, SLC9A6, LAMA4, RRAGC, SLC12A2, ABCB1, ITGA2, PTPRZ1, MFAP3, NID2, ALCAM, SLC4A2, CD109, SLC4A7, SLC15A4, ADCY9, CAPN1, ITGA1, PODXL, SCARA3, PTPRJ, SDK1, SDK2, KIAA1549, FN1, CD58, SLC12A6, SLC12A4, SLC12A7, ADCY6, SLC30A1, FLT4, ENPP4, LAMA1, LNPEP, PTPN11, SLC17A5, MRC2, SLC7A2, ADCY3, CSPG4, HEG1, PTPRK, ATP13A3, RRAGB, SLC38A9, NPTN, MPZL1, EMB, PTGFRN, TMEM179B, ATG9A, OSTM1, CD63, TMEM63A, SLC26A2, CLCN3, ACP2, RTN4RL2, ELMOD1, GPR35, GPR55, LGALS9, RAB11B, LGALS9C, CD68, GPR52, P2RY12, SERINC2, LPAR1, PYHIN1, SLC46A3, BRCA1, ATP1A1, BSG, CADM1, CCT3, ITGB1, LAMC1, SLC3A2, AHCY, CKAP4, DDOST, GLB1, HSP90AB1, IPO5, KPNB1, MYL6, RPL35, RPS20, LAMP2, MYH10, NAP1L1, VIM, ATP5C1, HRNR, MCCC1, PDHX, ACTA2, CDC5L, MCCC2, MYL12B, PARP1, PRPF19, RPL7A, SLC1A3, SLC1A5, TMPO, ECE1, NCSTN, PCCA, RPL12, SERPINH1, COX17, CRIP1, CRYZ, DBI, PEBP1, PLIN3, SOD1, SPR, TMSB10, MYO1E, PCBP2, TXN, MAPK3, RNF167, TMEM182, HTR2C, SERINC1, IPPK, TSPAN2, FBXL4, SYPL1, CACNG5, MFSD4, FCF1, IL31RA, LPAR2, PTPRO, TRIM5, TRIM6, TRIM17, MEFV, TRIM22, TRIM23, TRIM49, TRIM16, CYLD, FOXA1, MCPH1 | SOCS4 | EGFR, CUL5, NR4A1, VWF, SPRY1, MDFIC, TCEB2, TCEB1, GRB2, PIK3R3, PPAPDC2, LDHAL6B, LECT1, MPP5, PINK1, RBP7, TNK2, FRS3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LGALS3_SOCS4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LGALS3_SOCS4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LGALS3 | C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_human |
| Hgene | LGALS3 | C0000786 | Spontaneous abortion | 1 | CTD_human |
| Hgene | LGALS3 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Hgene | LGALS3 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Hgene | LGALS3 | C0025202 | melanoma | 1 | CTD_human |
| Hgene | LGALS3 | C0027540 | Necrosis | 1 | CTD_human |
| Hgene | LGALS3 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | LGALS3 | C0027697 | Nephritis | 1 | CTD_human |
| Hgene | LGALS3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Hgene | LGALS3 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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