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Fusion gene ID: 19645 |
FusionGeneSummary for LGALS3BP_CLSPN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LGALS3BP_CLSPN | Fusion gene ID: 19645 | Hgene | Tgene | Gene symbol | LGALS3BP | CLSPN | Gene ID | 3959 | 63967 |
| Gene name | galectin 3 binding protein | claspin | |
| Synonyms | 90K|BTBD17B|CyCAP|M2BP|MAC-2-BP|TANGO10B|gp90 | - | |
| Cytomap | 17q25.3 | 1p34.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | galectin-3-binding proteinL3 antigenMAC2BPMac-2-binding proteinbasement membrane autoantigen p105lectin galactoside-binding soluble 3-binding proteinmac-2 BPserum protein 90Ktransport and golgi organization 10 homolog Btumor-associated antigen 90 | claspinclaspin homolog | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q08380 | Q9HAW4 | |
| Ensembl transtripts involved in fusion gene | ENST00000591778, ENST00000262776, ENST00000585407, | ENST00000251195, ENST00000466308, ENST00000373220, ENST00000520551, ENST00000318121, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 4 X 4=80 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LGALS3BP [Title/Abstract] AND CLSPN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CLSPN | GO:0007095 | mitotic G2 DNA damage checkpoint | 18662541 |
| Tgene | CLSPN | GO:0018105 | peptidyl-serine phosphorylation | 16885022 |
| Tgene | CLSPN | GO:0032147 | activation of protein kinase activity | 16885022 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CESC | TCGA-VS-A9UO-01A | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000591778 | ENST00000251195 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| intron-intron | ENST00000591778 | ENST00000466308 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| intron-intron | ENST00000591778 | ENST00000373220 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| intron-intron | ENST00000591778 | ENST00000520551 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| intron-intron | ENST00000591778 | ENST00000318121 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| intron-intron | ENST00000262776 | ENST00000251195 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| intron-intron | ENST00000262776 | ENST00000466308 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| intron-intron | ENST00000262776 | ENST00000373220 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| intron-intron | ENST00000262776 | ENST00000520551 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| intron-intron | ENST00000262776 | ENST00000318121 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| intron-intron | ENST00000585407 | ENST00000251195 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| intron-intron | ENST00000585407 | ENST00000466308 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| intron-intron | ENST00000585407 | ENST00000373220 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| intron-intron | ENST00000585407 | ENST00000520551 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
| intron-intron | ENST00000585407 | ENST00000318121 | LGALS3BP | chr17 | 76967338 | - | CLSPN | chr1 | 36214444 | - |
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FusionProtFeatures for LGALS3BP_CLSPN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LGALS3BP | CLSPN |
| Promotes integrin-mediated cell adhesion. May stimulatehost defense against viruses and tumor cells.{ECO:0000269|PubMed:11146440, ECO:0000269|PubMed:8034587,ECO:0000269|PubMed:9501082}. | Required for checkpoint mediated cell cycle arrest inresponse to inhibition of DNA replication or to DNA damage inducedby both ionizing and UV irradiation. Adapter protein which bindsto BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bindspecifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex(pre-RC). This may indicate a role for this protein as a sensorwhich monitors the integrity of DNA replication forks.{ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610,ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314,ECO:0000269|PubMed:15707391}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LGALS3BP_CLSPN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LGALS3BP_CLSPN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LGALS3BP | PHB2, LGALS3, LGALS1, H2AFX, HDAC5, FAF2, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, CD9, CD82, CD209, CD248, FBXO6, SYNCRIP, HSP90AA1, NOS2, SOX2, ATP4A, XRN1, DROSHA, SELE, CEP250, ACTB, BAG2, PRRC2C, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8, CEP55, CRTC2, TUBB, HSPA1A, ENAH, TRAP1, RPL23, MOGS, GIGYF2, HNRNPU, HSP90AB1, HSPA5, HSPA8, HSPD1, IRS4, TUBGCP3, MAGED2, RAVER1, RPL38, RPS4X, TCP1, TUBA1A, TUBA1C, TUBB4B, XRN2, CUL7, OBSL1, CCDC8, SIGLEC9, LGALS3BP, SIGLEC5, SIGLEC10, SIGLEC6, SIGLEC7, SIGLEC11, NTRK1, ITGB1, ITGA5, ITGAV, ITGA6, PPME1, CAD, LAMB3, TUBG1, DYNLL1, PRPF4, SCAF11, VAPA, TUBGCP2, NCAPD3, TMEM63B, UGGT1, NEDD1, MZT1, NRD1, SURF4, RAE1, SEP15, MVP, PRSS21, MYCBP2, ZC3H3, GANAB, MYOF, NME7, TMEM161A, NKRF, VCPIP1, CEP290, SPRYD3, TUBGCP6, FBXO45, MZT2A, FOXA3, FOXG1, MCM2, ERBB3, GRB2, SHC1, UBASH3B, HECTD4, DNAJC13, HELZ2, GNE, C10orf2, TUBGCP4, FN1, TUBGCP5, FMR1, KIF7, BCKDK, FXR1, PHKB, MZT2B, ACACA, TRIM27, NEURL4, FXR2, HERC2, POLE, TRAPPC9, MIOS, PPHLN1, GPHN, TRAPPC10, LENG8, FAM120A, USP54, N4BP2L2, RGPD8, TYK2, FAM83H, UBE2A, BRCA1 | CLSPN | BRCA1, CHEK1, ATR, RAD9A, USP7, PCNA, TIMELESS, USP28, BTRC, FBXW11, PLK1, MSH6, PMS2, LTA, RAD17, CDC7, CDK9, FZR1, CDC20, HERC2, CASP7, USP29, CEP250, GINS3, XPO1, GJB2, MPP1, MYH7, LTN1, USP20 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LGALS3BP_CLSPN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LGALS3BP_CLSPN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LGALS3BP | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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