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Fusion gene ID: 1964 |
FusionGeneSummary for ANP32E_FAM13A-AS1 |
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Fusion gene information | Fusion gene name: ANP32E_FAM13A-AS1 | Fusion gene ID: 1964 | Hgene | Tgene | Gene symbol | ANP32E | FAM13A-AS1 | Gene ID | 81611 | 285512 |
Gene name | acidic nuclear phosphoprotein 32 family member E | FAM13A antisense RNA 1 | |
Synonyms | LANP-L|LANPL | FAM13A1OS|FAM13AOS|NCRNA00039 | |
Cytomap | 1q21.2 | 4q22.1 | |
Type of gene | protein-coding | ncRNA | |
Description | acidic leucine-rich nuclear phosphoprotein 32 family member ELANP-like proteinacidic (leucine-rich) nuclear phosphoprotein 32 family, member Eleucine-rich acidic nuclear protein like | FAM13A antisense RNA 1 (non-protein coding)FAM13A opposite strand (non-protein coding)FAM13A1 opposite strand (non-protein coding)family with sequence similarity 13, member A1 opposite strand | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | Q9BTT0 | ||
Ensembl transtripts involved in fusion gene | ENST00000314136, ENST00000369119, ENST00000369116, ENST00000436748, ENST00000369114, ENST00000369115, ENST00000533654, | ENST00000500765, ENST00000511543, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 1=4 |
# samples | 3 | 2 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: ANP32E [Title/Abstract] AND FAM13A-AS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ANP32E | GO:0043486 | histone exchange | 24463511 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF367648 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000314136 | ENST00000500765 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
intron-intron | ENST00000314136 | ENST00000511543 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
intron-intron | ENST00000369119 | ENST00000500765 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
intron-intron | ENST00000369119 | ENST00000511543 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
intron-intron | ENST00000369116 | ENST00000500765 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
intron-intron | ENST00000369116 | ENST00000511543 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
intron-intron | ENST00000436748 | ENST00000500765 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
intron-intron | ENST00000436748 | ENST00000511543 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
intron-intron | ENST00000369114 | ENST00000500765 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
intron-intron | ENST00000369114 | ENST00000511543 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
intron-intron | ENST00000369115 | ENST00000500765 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
intron-intron | ENST00000369115 | ENST00000511543 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
intron-intron | ENST00000533654 | ENST00000500765 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
intron-intron | ENST00000533654 | ENST00000511543 | ANP32E | chr1 | 150199076 | - | FAM13A-AS1 | chr4 | 89648632 | - |
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FusionProtFeatures for ANP32E_FAM13A-AS1 |
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Hgene | Tgene |
ANP32E | FAM13A-AS1 |
Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removesH2A.Z/H2AFZ from its normal sites of deposition, especially fromenhancer and insulator regions. Not involved in deposition ofH2A.Z/H2AFZ in the nucleosome. May stabilize the evictedH2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towardsdissociation and the off-chromatin state (PubMed:24463511).Inhibits activity of protein phosphatase 2A (PP2A). Does notinhibit protein phosphatase 1. May play a role in cerebellardevelopment and synaptogenesis. {ECO:0000269|PubMed:24463511}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ANP32E_FAM13A-AS1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ANP32E_FAM13A-AS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANP32E_FAM13A-AS1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANP32E_FAM13A-AS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |