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Fusion gene ID: 19632 |
FusionGeneSummary for LETM1_MXD4 |
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Fusion gene information | Fusion gene name: LETM1_MXD4 | Fusion gene ID: 19632 | Hgene | Tgene | Gene symbol | LETM1 | MXD4 | Gene ID | 3954 | 10608 |
Gene name | leucine zipper and EF-hand containing transmembrane protein 1 | MAX dimerization protein 4 | |
Synonyms | SLC55A1 | MAD4|MST149|MSTP149|bHLHc12 | |
Cytomap | 4p16.3 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | mitochondrial proton/calcium exchanger proteinLETM1 and EF-hand domain-containing protein 1, mitochondrialMdm38 homologleucine zipper-EF-hand containing transmembrane protein 1 | max dimerization protein 4Mad4 homologclass C basic helix-loop-helix protein 12max dimerizer 4max-associated protein 4max-interacting transcriptional repressor MAD4 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O95202 | Q14582 | |
Ensembl transtripts involved in fusion gene | ENST00000302787, ENST00000512189, | ENST00000337190, ENST00000515378, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 3 X 3 X 2=18 |
# samples | 6 | 3 | |
** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: LETM1 [Title/Abstract] AND MXD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LETM1 | GO:0006851 | mitochondrial calcium ion transmembrane transport | 19797662 |
Hgene | LETM1 | GO:0051560 | mitochondrial calcium ion homeostasis | 19797662 |
Hgene | LETM1 | GO:0099093 | calcium export from the mitochondrion | 19797662 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCEC | TCGA-AJ-A3BF-01A | LETM1 | chr4 | 1838156 | - | MXD4 | chr4 | 2259738 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000302787 | ENST00000337190 | LETM1 | chr4 | 1838156 | - | MXD4 | chr4 | 2259738 | - |
5CDS-5UTR | ENST00000302787 | ENST00000515378 | LETM1 | chr4 | 1838156 | - | MXD4 | chr4 | 2259738 | - |
intron-3CDS | ENST00000512189 | ENST00000337190 | LETM1 | chr4 | 1838156 | - | MXD4 | chr4 | 2259738 | - |
intron-5UTR | ENST00000512189 | ENST00000515378 | LETM1 | chr4 | 1838156 | - | MXD4 | chr4 | 2259738 | - |
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FusionProtFeatures for LETM1_MXD4 |
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Hgene | Tgene |
LETM1 | MXD4 |
Mitochondrial proton/calcium antiporter that mediatesproton-dependent calcium efflux from mitochondrion(PubMed:19797662). Crucial for the maintenance of mitochondrialtubular networks and for the assembly of the supercomplexes of therespiratory chain (PubMed:18628306). Required for the maintenanceof the tubular shape and cristae organization (PubMed:18628306).In contrast to SLC8B1/NCLX, does not constitute the major factorfor mitochondrial calcium extrusion (PubMed:24898248).{ECO:0000269|PubMed:18628306, ECO:0000269|PubMed:19797662,ECO:0000269|PubMed:24898248}. | Transcriptional repressor. Binds with MAX to form asequence-specific DNA-binding protein complex which recognizes thecore sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptionalactivity by competing for MAX and suppresses MYC dependent celltransformation (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LETM1_MXD4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LETM1_MXD4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LETM1 | ICT1, TBK1, ILF3, C12orf57, SYNCRIP, LATS2, PSMA3, CYP1A1, NTRK1, NDUFA4, COQ9, PTPMT1, C15orf48, PPM1A, USP47, SNRNP27, PCDHGB4, HSD3B2, FGB, MRPS11, LYPD4, RNF19B, ATP6V0D1 | MXD4 | TCP10L, MLX, MAX, SMC3, SHBG |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LETM1_MXD4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LETM1_MXD4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LETM1 | C0026827 | Muscle hypotonia | 1 | CTD_human;HPO |
Hgene | LETM1 | C0036572 | Seizures | 1 | CTD_human;HPO |
Hgene | LETM1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | LETM1 | C1956097 | Wolf-Hirschhorn Syndrome | 1 | CTD_human;ORPHANET |
Hgene | LETM1 | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | LETM1 | C3714756 | Intellectual Disability | 1 | CTD_human |