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Fusion gene ID: 19629 |
FusionGeneSummary for LEPROT_SGIP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LEPROT_SGIP1 | Fusion gene ID: 19629 | Hgene | Tgene | Gene symbol | LEPROT | SGIP1 | Gene ID | 54741 | 84251 |
| Gene name | leptin receptor overlapping transcript | SH3 domain GRB2 like endophilin interacting protein 1 | |
| Synonyms | LEPR|OB-RGRP|OBRGRP|VPS55 | - | |
| Cytomap | 1p31.3 | 1p31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leptin receptor gene-related proteinDnaJ (Hsp40) homolog, subfamily C, member 6OB-R gene-related proteinendospaninendospanin-1leptin receptor overlapping transcript protein | SH3-containing GRB2-like protein 3-interacting protein 1endophilin-3-interacting protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O15243 | Q9BQI5 | |
| Ensembl transtripts involved in fusion gene | ENST00000371065, ENST00000484243, | ENST00000237247, ENST00000371039, ENST00000371035, ENST00000468286, ENST00000371036, ENST00000371037, ENST00000435165, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 5 X 5 X 3=75 |
| # samples | 6 | 6 | |
| ** MAII score | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LEPROT [Title/Abstract] AND SGIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LEPROT | GO:0046426 | negative regulation of JAK-STAT cascade | 18042720 |
| Hgene | LEPROT | GO:0060400 | negative regulation of growth hormone receptor signaling pathway | 19907080 |
| Hgene | LEPROT | GO:2000009 | negative regulation of protein localization to cell surface | 18042720 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-HC-7737-01A | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000371065 | ENST00000237247 | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
| In-frame | ENST00000371065 | ENST00000371039 | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
| In-frame | ENST00000371065 | ENST00000371035 | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
| 5CDS-intron | ENST00000371065 | ENST00000468286 | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
| 5CDS-intron | ENST00000371065 | ENST00000371036 | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
| 5CDS-intron | ENST00000371065 | ENST00000371037 | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
| 5CDS-intron | ENST00000371065 | ENST00000435165 | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
| 3UTR-3CDS | ENST00000484243 | ENST00000237247 | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
| 3UTR-3CDS | ENST00000484243 | ENST00000371039 | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
| 3UTR-3CDS | ENST00000484243 | ENST00000371035 | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
| 3UTR-intron | ENST00000484243 | ENST00000468286 | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
| 3UTR-intron | ENST00000484243 | ENST00000371036 | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
| 3UTR-intron | ENST00000484243 | ENST00000371037 | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
| 3UTR-intron | ENST00000484243 | ENST00000435165 | LEPROT | chr1 | 65886423 | + | SGIP1 | chr1 | 67184977 | + |
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FusionProtFeatures for LEPROT_SGIP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LEPROT | SGIP1 |
| Negatively regulates leptin receptor (LEPR) cell surfaceexpression, and thus decreases response to leptin. Negativelyregulates growth hormone (GH) receptor cell surface expression inliver. May play a role in liver resistance to GH during periods ofreduced nutrient availability. {ECO:0000269|PubMed:18042720,ECO:0000269|PubMed:19907080}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000371037 | + | 17 | 25 | 559_827 | 543 | 829 | Domain | MHD |
| Tgene | >SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000371039 | + | 14 | 22 | 559_827 | 346 | 632 | Domain | MHD |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LEPROT | chr1:65886423 | chr1:67184977 | ENST00000371065 | + | 1 | 4 | 100_120 | 5 | 132 | Transmembrane | Helical |
| Hgene | >LEPROT | chr1:65886423 | chr1:67184977 | ENST00000371065 | + | 1 | 4 | 32_52 | 5 | 132 | Transmembrane | Helical |
| Hgene | >LEPROT | chr1:65886423 | chr1:67184977 | ENST00000371065 | + | 1 | 4 | 69_89 | 5 | 132 | Transmembrane | Helical |
| Hgene | >LEPROT | chr1:65886423 | chr1:67184977 | ENST00000371065 | + | 1 | 4 | 7_27 | 5 | 132 | Transmembrane | Helical |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000237247 | + | 19 | 27 | 106_112 | 574 | 860 | Compositional bias | Poly-Glu |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000237247 | + | 19 | 27 | 176_499 | 574 | 860 | Compositional bias | Pro-rich |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000371037 | + | 17 | 25 | 106_112 | 543 | 829 | Compositional bias | Poly-Glu |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000371037 | + | 17 | 25 | 176_499 | 543 | 829 | Compositional bias | Pro-rich |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000371039 | + | 14 | 22 | 106_112 | 346 | 632 | Compositional bias | Poly-Glu |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000371039 | + | 14 | 22 | 176_499 | 346 | 632 | Compositional bias | Pro-rich |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000237247 | + | 19 | 27 | 559_827 | 574 | 860 | Domain | MHD |
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FusionGeneSequence for LEPROT_SGIP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000237247_chr1_67184977_+_291aa MAGVKGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNP QLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAV ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGA >In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000371039_chr1_67184977_+_291aa MAGVKGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNP QLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAV ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGA >In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000371035_chr1_67184977_+_291aa MAGVKGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNP QLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAV ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000237247_chr1_67184977_+_873nt ATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTAACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAA ACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGTATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATC ACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACTTTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCC CAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACCAAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAA GTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGACATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTG AACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGACCTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTG GCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGAGTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAA CAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAGTCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCT GAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACAAGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCA >In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000371039_chr1_67184977_+_873nt ATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTAACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAA ACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGTATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATC ACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACTTTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCC CAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACCAAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAA GTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGACATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTG AACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGACCTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTG GCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGAGTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAA CAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAGTCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCT GAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACAAGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCA >In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000371035_chr1_67184977_+_873nt ATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTAACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAA ACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGTATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATC ACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACTTTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCC CAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACCAAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAA GTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGACATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTG AACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGACCTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTG GCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGAGTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAA CAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAGTCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCT GAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACAAGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000237247_chr1_67184977_+_2290nt GTTCTGCACCGGCGGGGGCGGGGCTCTGCGTGGCCGGGGCGGGCTCGGGATCCGCGGGGCGACTCCCGGTCTGGCTTGGGCAGGCTGCCC GGGCCGTGGCAGGAAGCCGGAAGCAGCCGCGGCCCCAGTTCGGGAGACATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTA ACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAAACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGT ATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATCACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACT TTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCCCAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACC AAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAAGTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGAC ATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTGAACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGAC CTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTGGCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGA GTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAACAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAG TCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCTGAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACA AGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCAGGGTATCGATTTTCACTCATCAAGAAAAGGTTTGCTGCAGGA AAATACTTGGCAGATAACTAATGAAATCTTATGCAAGGATTTGGAGGATTCATATAATGGAGAACTGATGTATGAGAAACAGATTTTAAT TTTGGTTTGATGAAAACAAACCAATATCTGCACTTGGGATATATCAGGTGGAAAGTCAATGACTTTCATCTGTGATTTCCCTCACACACT ACCATGATGACCAGTCCTACAGTATTTACTTCTAGGTGTAATATTGTTAATGGTTTTAAAATGTAATTATTGTATTTGTAAATTGTACTC TCATTCCAGTAAGGCAGTTAGACACTTGAGTTTTAGCATTTTACCATTCCTGAAATGGATGTAATTTAAACTGTGGTATGTAAATTTAAT AGTAGTATTGTTGAATGGCACAATGCTTACAGAGGTAGATTGCATTTTGTCAATATATAAAATTTAAATATAATATTGATAGCTGTCATA AAGGGGGTGCCACATATTAAAGAAACTTAAGTGGAACCAGAAGAAAAAGAAACAAACTTACTTTTCTTCAATGCTTAGTATGTTTTACTC TAGTGCTAAATAAAAACTCTATCTTCAAATGTTTAGTGGGTTAAATTGAGAAACTATTTCAGAAAAAAATTCTAAGGTTACAGCATATTC AAAGAAAAGCATTAGTTACCACTTTTTAAAAAGCTTTTTTTTCAAACTGCAAATTTCATAAAAATGCAAACTGTGTAAACAGGGCCTCTT ATTTTTATAACTTGTGTAAAAAGGGAAAGCAATTCATATTTAAAGTTTAAGTATATTAAATTATAATCAAGAGTAAAGAAGATGTTGAAG TCTTAACTACTTGCCCCTCTCTACAGTTTCGCAAATGTGGGGATTGCTGAATAATCAGTCAGACTAAAACCAAAATTGTGATTTTAAGAT TTCAAGACTTTCCGTAGTTGAACTGGTTAAGAATTTTTGCTTAGTTACTCTGAATAGATGATCTTACTCATCCAGTATGGGGGAATGATA CCTCACGTCTTCCTCTTTACCCACAGGAATCAAAACGCTGAGACTGAGAATTTTAGGGAAAAAAAAGTCCACTGTTTAGATCCAGAAGGA GAGTTTTAATCATTGTTTATATCATTTGAGAATGAAAAAATAAGCTTCATAAATGAAATTCTATTCACATTACTGTGTAATAAATTTCCT TTTGGATGATTAGGATTCATTGTATAAAACTGTAAATCTTTGCCATTCTTGGAGAAGCAAAAGGAGAGTTATCAAAAATGTATGTCGTTT >In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000371039_chr1_67184977_+_3001nt GTTCTGCACCGGCGGGGGCGGGGCTCTGCGTGGCCGGGGCGGGCTCGGGATCCGCGGGGCGACTCCCGGTCTGGCTTGGGCAGGCTGCCC GGGCCGTGGCAGGAAGCCGGAAGCAGCCGCGGCCCCAGTTCGGGAGACATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTA ACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAAACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGT ATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATCACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACT TTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCCCAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACC AAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAAGTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGAC ATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTGAACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGAC CTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTGGCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGA GTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAACAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAG TCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCTGAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACA AGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCAGGGTATCGATTTTCACTCATCAAGAAAAGGTTTGCTGCAGGA AAATACTTGGCAGATAACTAATGAAATCTTATGCAAGGATTTGGAGGATTCATATAATGGAGAACTGATGTATGAGAAACAGATTTTAAT TTTGGTTTGATGAAAACAAACCAATATCTGCACTTGGGATATATCAGGTGGAAAGTCAATGACTTTCATCTGTGATTTCCCTCACACACT ACCATGATGACCAGTCCTACAGTATTTACTTCTAGGTGTAATATTGTTAATGGTTTTAAAATGTAATTATTGTATTTGTAAATTGTACTC TCATTCCAGTAAGGCAGTTAGACACTTGAGTTTTAGCATTTTACCATTCCTGAAATGGATGTAATTTAAACTGTGGTATGTAAATTTAAT AGTAGTATTGTTGAATGGCACAATGCTTACAGAGGTAGATTGCATTTTGTCAATATATAAAATTTAAATATAATATTGATAGCTGTCATA AAGGGGGTGCCACATATTAAAGAAACTTAAGTGGAACCAGAAGAAAAAGAAACAAACTTACTTTTCTTCAATGCTTAGTATGTTTTACTC TAGTGCTAAATAAAAACTCTATCTTCAAATGTTTAGTGGGTTAAATTGAGAAACTATTTCAGAAAAAAATTCTAAGGTTACAGCATATTC AAAGAAAAGCATTAGTTACCACTTTTTAAAAAGCTTTTTTTTCAAACTGCAAATTTCATAAAAATGCAAACTGTGTAAACAGGGCCTCTT ATTTTTATAACTTGTGTAAAAAGGGAAAGCAATTCATATTTAAAGTTTAAGTATATTAAATTATAATCAAGAGTAAAGAAGATGTTGAAG TCTTAACTACTTGCCCCTCTCTACAGTTTCGCAAATGTGGGGATTGCTGAATAATCAGTCAGACTAAAACCAAAATTGTGATTTTAAGAT TTCAAGACTTTCCGTAGTTGAACTGGTTAAGAATTTTTGCTTAGTTACTCTGAATAGATGATCTTACTCATCCAGTATGGGGGAATGATA CCTCACGTCTTCCTCTTTACCCACAGGAATCAAAACGCTGAGACTGAGAATTTTAGGGAAAAAAAAGTCCACTGTTTAGATCCAGAAGGA GAGTTTTAATCATTGTTTATATCATTTGAGAATGAAAAAATAAGCTTCATAAATGAAATTCTATTCACATTACTGTGTAATAAATTTCCT TTTGGATGATTAGGATTCATTGTATAAAACTGTAAATCTTTGCCATTCTTGGAGAAGCAAAAGGAGAGTTATCAAAAATGTATGTCGTTT CATCGTTGCAAGGTATAATAAAAACTGTAATTATTCAATCTGGCCCTGCCATATGAACATTTAGAAAGACAAACTTCTTCGGGAGTCTCA GTTGTAAAACCTTCCCTCATTAATATCTGAAAATGTTAGTCTTCCTTTAAGTCATAGAACTTATTTAAACATAAACCAATTTCTATTACA GGTTATGCTATTAAATAGCTGTAATTATTAAGTTATTATTTTTATAATTAGTTGTTAAATTTCATTTTACACCCACTCAAATTTAACAAA GAATCTTTAGCCCCTTTAAATTTTAGAATTAAATTAAATTTTTAAAGTTTTACTTCTAAAATGAGATTGTGACTGGCAATTGTTTATAGT GAAACTTTTTAAATTAATCTTTGTACTCCTCTATCAGTGCTTGCTACCAAGAGAATGTCCAAAATGATTTGTTTTACCATGGGAAAATTC TTACTATTCAACAAACTCTCAGTTGGCCCCCTACAGCAGTCTGGTGTTGAAGTTTCTTTGAACGAACTAAATATACTCATTTTATGTAAA GGTATCCAATTTGATTTTGAAACCAAAATAGAAAATGCAAAATTCTAAATTCCATGAAACATGGAATTTATGACACCAAAATCAATGGAG AGTAAGCAGCAGCAAACTGAGAATTATCCAGCATATGAATATAACAATGTGTTTTTAAGTAATCAATTCATTTAAAAAATTGAATATTAA >In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000371035_chr1_67184977_+_1115nt GTTCTGCACCGGCGGGGGCGGGGCTCTGCGTGGCCGGGGCGGGCTCGGGATCCGCGGGGCGACTCCCGGTCTGGCTTGGGCAGGCTGCCC GGGCCGTGGCAGGAAGCCGGAAGCAGCCGCGGCCCCAGTTCGGGAGACATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTA ACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAAACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGT ATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATCACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACT TTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCCCAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACC AAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAAGTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGAC ATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTGAACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGAC CTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTGGCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGA GTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAACAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAG TCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCTGAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACA AGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCAGGGTATCGATTTTCACTCATCAAGAAAAGGTTTGCTGCAGGA AAATACTTGGCAGATAACTAATGAAATCTTATGCAAGGATTTGGAGGATTCATATAATGGAGAACTGATGTATGAGAAACAGATTTTAAT |
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FusionGenePPI for LEPROT_SGIP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LEPROT | ELAVL1 | SGIP1 | ITSN1, REPS1, AMPH, APP, EPS15 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000237247 | + | 19 | 27 | 667_670 | 574 | 860 | DPF motifs-containing proteins |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000237247 | + | 19 | 27 | 813_818 | 574 | 860 | DPF motifs-containing proteins |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000371037 | + | 17 | 25 | 667_670 | 543 | 829 | DPF motifs-containing proteins |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000371037 | + | 17 | 25 | 813_818 | 543 | 829 | DPF motifs-containing proteins |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000371039 | + | 14 | 22 | 667_670 | 346 | 632 | DPF motifs-containing proteins |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000371039 | + | 14 | 22 | 813_818 | 346 | 632 | DPF motifs-containing proteins |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000237247 | + | 19 | 27 | 593_595 | 574 | 860 | DPF motifs-containing proteins |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000371037 | + | 17 | 25 | 561_567 | 543 | 829 | DPF motifs-containing proteins |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000371037 | + | 17 | 25 | 593_595 | 543 | 829 | DPF motifs-containing proteins |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000371039 | + | 14 | 22 | 561_567 | 346 | 632 | DPF motifs-containing proteins |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000371039 | + | 14 | 22 | 593_595 | 346 | 632 | DPF motifs-containing proteins |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | SGIP1 | chr1:65886423 | chr1:67184977 | ENST00000237247 | + | 19 | 27 | 561_567 | 574 | 860 | DPF motifs-containing proteins |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LEPROT_SGIP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LEPROT_SGIP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SGIP1 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
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