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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 19629

FusionGeneSummary for LEPROT_SGIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: LEPROT_SGIP1
Fusion gene ID: 19629
HgeneTgene
Gene symbol

LEPROT

SGIP1

Gene ID

54741

84251

Gene nameleptin receptor overlapping transcriptSH3 domain GRB2 like endophilin interacting protein 1
SynonymsLEPR|OB-RGRP|OBRGRP|VPS55-
Cytomap

1p31.3

1p31.3

Type of geneprotein-codingprotein-coding
Descriptionleptin receptor gene-related proteinDnaJ (Hsp40) homolog, subfamily C, member 6OB-R gene-related proteinendospaninendospanin-1leptin receptor overlapping transcript proteinSH3-containing GRB2-like protein 3-interacting protein 1endophilin-3-interacting protein
Modification date2018052320180523
UniProtAcc

O15243

Q9BQI5

Ensembl transtripts involved in fusion geneENST00000371065, ENST00000484243, 
ENST00000237247, ENST00000371039, 
ENST00000371035, ENST00000468286, 
ENST00000371036, ENST00000371037, 
ENST00000435165, 
Fusion gene scores* DoF score5 X 5 X 3=755 X 5 X 3=75
# samples 66
** MAII scorelog2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LEPROT [Title/Abstract] AND SGIP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLEPROT

GO:0046426

negative regulation of JAK-STAT cascade

18042720

HgeneLEPROT

GO:0060400

negative regulation of growth hormone receptor signaling pathway

19907080

HgeneLEPROT

GO:2000009

negative regulation of protein localization to cell surface

18042720


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-HC-7737-01ALEPROTchr1

65886423

+SGIP1chr1

67184977

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000371065ENST00000237247LEPROTchr1

65886423

+SGIP1chr1

67184977

+
In-frameENST00000371065ENST00000371039LEPROTchr1

65886423

+SGIP1chr1

67184977

+
In-frameENST00000371065ENST00000371035LEPROTchr1

65886423

+SGIP1chr1

67184977

+
5CDS-intronENST00000371065ENST00000468286LEPROTchr1

65886423

+SGIP1chr1

67184977

+
5CDS-intronENST00000371065ENST00000371036LEPROTchr1

65886423

+SGIP1chr1

67184977

+
5CDS-intronENST00000371065ENST00000371037LEPROTchr1

65886423

+SGIP1chr1

67184977

+
5CDS-intronENST00000371065ENST00000435165LEPROTchr1

65886423

+SGIP1chr1

67184977

+
3UTR-3CDSENST00000484243ENST00000237247LEPROTchr1

65886423

+SGIP1chr1

67184977

+
3UTR-3CDSENST00000484243ENST00000371039LEPROTchr1

65886423

+SGIP1chr1

67184977

+
3UTR-3CDSENST00000484243ENST00000371035LEPROTchr1

65886423

+SGIP1chr1

67184977

+
3UTR-intronENST00000484243ENST00000468286LEPROTchr1

65886423

+SGIP1chr1

67184977

+
3UTR-intronENST00000484243ENST00000371036LEPROTchr1

65886423

+SGIP1chr1

67184977

+
3UTR-intronENST00000484243ENST00000371037LEPROTchr1

65886423

+SGIP1chr1

67184977

+
3UTR-intronENST00000484243ENST00000435165LEPROTchr1

65886423

+SGIP1chr1

67184977

+

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FusionProtFeatures for LEPROT_SGIP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LEPROT

O15243

SGIP1

Q9BQI5

Negatively regulates leptin receptor (LEPR) cell surfaceexpression, and thus decreases response to leptin. Negativelyregulates growth hormone (GH) receptor cell surface expression inliver. May play a role in liver resistance to GH during periods ofreduced nutrient availability. {ECO:0000269|PubMed:18042720,ECO:0000269|PubMed:19907080}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSGIP1chr1:65886423chr1:67184977ENST00000371037+1725559_827543829DomainMHD
TgeneSGIP1chr1:65886423chr1:67184977ENST00000371039+1422559_827346632DomainMHD

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLEPROTchr1:65886423chr1:67184977ENST00000371065+14100_1205132TransmembraneHelical
HgeneLEPROTchr1:65886423chr1:67184977ENST00000371065+1432_525132TransmembraneHelical
HgeneLEPROTchr1:65886423chr1:67184977ENST00000371065+1469_895132TransmembraneHelical
HgeneLEPROTchr1:65886423chr1:67184977ENST00000371065+147_275132TransmembraneHelical
TgeneSGIP1chr1:65886423chr1:67184977ENST00000237247+1927106_112574860Compositional biasPoly-Glu
TgeneSGIP1chr1:65886423chr1:67184977ENST00000237247+1927176_499574860Compositional biasPro-rich
TgeneSGIP1chr1:65886423chr1:67184977ENST00000371037+1725106_112543829Compositional biasPoly-Glu
TgeneSGIP1chr1:65886423chr1:67184977ENST00000371037+1725176_499543829Compositional biasPro-rich
TgeneSGIP1chr1:65886423chr1:67184977ENST00000371039+1422106_112346632Compositional biasPoly-Glu
TgeneSGIP1chr1:65886423chr1:67184977ENST00000371039+1422176_499346632Compositional biasPro-rich
TgeneSGIP1chr1:65886423chr1:67184977ENST00000237247+1927559_827574860DomainMHD


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FusionGeneSequence for LEPROT_SGIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000237247_chr1_67184977_+_291aa
MAGVKGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNP
QLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAV
ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGA

>In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000371039_chr1_67184977_+_291aa
MAGVKGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNP
QLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAV
ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGA

>In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000371035_chr1_67184977_+_291aa
MAGVKGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNP
QLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAV
ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000237247_chr1_67184977_+_873nt
ATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTAACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAA
ACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGTATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATC
ACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACTTTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCC
CAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACCAAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAA
GTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGACATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTG
AACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGACCTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTG
GCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGAGTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAA
CAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAGTCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCT
GAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACAAGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCA

>In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000371039_chr1_67184977_+_873nt
ATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTAACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAA
ACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGTATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATC
ACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACTTTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCC
CAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACCAAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAA
GTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGACATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTG
AACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGACCTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTG
GCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGAGTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAA
CAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAGTCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCT
GAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACAAGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCA

>In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000371035_chr1_67184977_+_873nt
ATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTAACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAA
ACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGTATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATC
ACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACTTTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCC
CAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACCAAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAA
GTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGACATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTG
AACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGACCTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTG
GCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGAGTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAA
CAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAGTCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCT
GAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACAAGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000237247_chr1_67184977_+_2290nt
GTTCTGCACCGGCGGGGGCGGGGCTCTGCGTGGCCGGGGCGGGCTCGGGATCCGCGGGGCGACTCCCGGTCTGGCTTGGGCAGGCTGCCC
GGGCCGTGGCAGGAAGCCGGAAGCAGCCGCGGCCCCAGTTCGGGAGACATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTA
ACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAAACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGT
ATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATCACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACT
TTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCCCAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACC
AAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAAGTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGAC
ATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTGAACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGAC
CTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTGGCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGA
GTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAACAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAG
TCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCTGAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACA
AGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCAGGGTATCGATTTTCACTCATCAAGAAAAGGTTTGCTGCAGGA
AAATACTTGGCAGATAACTAATGAAATCTTATGCAAGGATTTGGAGGATTCATATAATGGAGAACTGATGTATGAGAAACAGATTTTAAT
TTTGGTTTGATGAAAACAAACCAATATCTGCACTTGGGATATATCAGGTGGAAAGTCAATGACTTTCATCTGTGATTTCCCTCACACACT
ACCATGATGACCAGTCCTACAGTATTTACTTCTAGGTGTAATATTGTTAATGGTTTTAAAATGTAATTATTGTATTTGTAAATTGTACTC
TCATTCCAGTAAGGCAGTTAGACACTTGAGTTTTAGCATTTTACCATTCCTGAAATGGATGTAATTTAAACTGTGGTATGTAAATTTAAT
AGTAGTATTGTTGAATGGCACAATGCTTACAGAGGTAGATTGCATTTTGTCAATATATAAAATTTAAATATAATATTGATAGCTGTCATA
AAGGGGGTGCCACATATTAAAGAAACTTAAGTGGAACCAGAAGAAAAAGAAACAAACTTACTTTTCTTCAATGCTTAGTATGTTTTACTC
TAGTGCTAAATAAAAACTCTATCTTCAAATGTTTAGTGGGTTAAATTGAGAAACTATTTCAGAAAAAAATTCTAAGGTTACAGCATATTC
AAAGAAAAGCATTAGTTACCACTTTTTAAAAAGCTTTTTTTTCAAACTGCAAATTTCATAAAAATGCAAACTGTGTAAACAGGGCCTCTT
ATTTTTATAACTTGTGTAAAAAGGGAAAGCAATTCATATTTAAAGTTTAAGTATATTAAATTATAATCAAGAGTAAAGAAGATGTTGAAG
TCTTAACTACTTGCCCCTCTCTACAGTTTCGCAAATGTGGGGATTGCTGAATAATCAGTCAGACTAAAACCAAAATTGTGATTTTAAGAT
TTCAAGACTTTCCGTAGTTGAACTGGTTAAGAATTTTTGCTTAGTTACTCTGAATAGATGATCTTACTCATCCAGTATGGGGGAATGATA
CCTCACGTCTTCCTCTTTACCCACAGGAATCAAAACGCTGAGACTGAGAATTTTAGGGAAAAAAAAGTCCACTGTTTAGATCCAGAAGGA
GAGTTTTAATCATTGTTTATATCATTTGAGAATGAAAAAATAAGCTTCATAAATGAAATTCTATTCACATTACTGTGTAATAAATTTCCT
TTTGGATGATTAGGATTCATTGTATAAAACTGTAAATCTTTGCCATTCTTGGAGAAGCAAAAGGAGAGTTATCAAAAATGTATGTCGTTT

>In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000371039_chr1_67184977_+_3001nt
GTTCTGCACCGGCGGGGGCGGGGCTCTGCGTGGCCGGGGCGGGCTCGGGATCCGCGGGGCGACTCCCGGTCTGGCTTGGGCAGGCTGCCC
GGGCCGTGGCAGGAAGCCGGAAGCAGCCGCGGCCCCAGTTCGGGAGACATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTA
ACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAAACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGT
ATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATCACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACT
TTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCCCAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACC
AAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAAGTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGAC
ATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTGAACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGAC
CTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTGGCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGA
GTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAACAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAG
TCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCTGAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACA
AGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCAGGGTATCGATTTTCACTCATCAAGAAAAGGTTTGCTGCAGGA
AAATACTTGGCAGATAACTAATGAAATCTTATGCAAGGATTTGGAGGATTCATATAATGGAGAACTGATGTATGAGAAACAGATTTTAAT
TTTGGTTTGATGAAAACAAACCAATATCTGCACTTGGGATATATCAGGTGGAAAGTCAATGACTTTCATCTGTGATTTCCCTCACACACT
ACCATGATGACCAGTCCTACAGTATTTACTTCTAGGTGTAATATTGTTAATGGTTTTAAAATGTAATTATTGTATTTGTAAATTGTACTC
TCATTCCAGTAAGGCAGTTAGACACTTGAGTTTTAGCATTTTACCATTCCTGAAATGGATGTAATTTAAACTGTGGTATGTAAATTTAAT
AGTAGTATTGTTGAATGGCACAATGCTTACAGAGGTAGATTGCATTTTGTCAATATATAAAATTTAAATATAATATTGATAGCTGTCATA
AAGGGGGTGCCACATATTAAAGAAACTTAAGTGGAACCAGAAGAAAAAGAAACAAACTTACTTTTCTTCAATGCTTAGTATGTTTTACTC
TAGTGCTAAATAAAAACTCTATCTTCAAATGTTTAGTGGGTTAAATTGAGAAACTATTTCAGAAAAAAATTCTAAGGTTACAGCATATTC
AAAGAAAAGCATTAGTTACCACTTTTTAAAAAGCTTTTTTTTCAAACTGCAAATTTCATAAAAATGCAAACTGTGTAAACAGGGCCTCTT
ATTTTTATAACTTGTGTAAAAAGGGAAAGCAATTCATATTTAAAGTTTAAGTATATTAAATTATAATCAAGAGTAAAGAAGATGTTGAAG
TCTTAACTACTTGCCCCTCTCTACAGTTTCGCAAATGTGGGGATTGCTGAATAATCAGTCAGACTAAAACCAAAATTGTGATTTTAAGAT
TTCAAGACTTTCCGTAGTTGAACTGGTTAAGAATTTTTGCTTAGTTACTCTGAATAGATGATCTTACTCATCCAGTATGGGGGAATGATA
CCTCACGTCTTCCTCTTTACCCACAGGAATCAAAACGCTGAGACTGAGAATTTTAGGGAAAAAAAAGTCCACTGTTTAGATCCAGAAGGA
GAGTTTTAATCATTGTTTATATCATTTGAGAATGAAAAAATAAGCTTCATAAATGAAATTCTATTCACATTACTGTGTAATAAATTTCCT
TTTGGATGATTAGGATTCATTGTATAAAACTGTAAATCTTTGCCATTCTTGGAGAAGCAAAAGGAGAGTTATCAAAAATGTATGTCGTTT
CATCGTTGCAAGGTATAATAAAAACTGTAATTATTCAATCTGGCCCTGCCATATGAACATTTAGAAAGACAAACTTCTTCGGGAGTCTCA
GTTGTAAAACCTTCCCTCATTAATATCTGAAAATGTTAGTCTTCCTTTAAGTCATAGAACTTATTTAAACATAAACCAATTTCTATTACA
GGTTATGCTATTAAATAGCTGTAATTATTAAGTTATTATTTTTATAATTAGTTGTTAAATTTCATTTTACACCCACTCAAATTTAACAAA
GAATCTTTAGCCCCTTTAAATTTTAGAATTAAATTAAATTTTTAAAGTTTTACTTCTAAAATGAGATTGTGACTGGCAATTGTTTATAGT
GAAACTTTTTAAATTAATCTTTGTACTCCTCTATCAGTGCTTGCTACCAAGAGAATGTCCAAAATGATTTGTTTTACCATGGGAAAATTC
TTACTATTCAACAAACTCTCAGTTGGCCCCCTACAGCAGTCTGGTGTTGAAGTTTCTTTGAACGAACTAAATATACTCATTTTATGTAAA
GGTATCCAATTTGATTTTGAAACCAAAATAGAAAATGCAAAATTCTAAATTCCATGAAACATGGAATTTATGACACCAAAATCAATGGAG
AGTAAGCAGCAGCAAACTGAGAATTATCCAGCATATGAATATAACAATGTGTTTTTAAGTAATCAATTCATTTAAAAAATTGAATATTAA

>In-frame_LEPROT_ENST00000371065_chr1_65886423_+_SGIP1_ENST00000371035_chr1_67184977_+_1115nt
GTTCTGCACCGGCGGGGGCGGGGCTCTGCGTGGCCGGGGCGGGCTCGGGATCCGCGGGGCGACTCCCGGTCTGGCTTGGGCAGGCTGCCC
GGGCCGTGGCAGGAAGCCGGAAGCAGCCGCGGCCCCAGTTCGGGAGACATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTA
ACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAAACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGT
ATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATCACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACT
TTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCCCAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACC
AAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAAGTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGAC
ATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTGAACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGAC
CTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTGGCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGA
GTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAACAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAG
TCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCTGAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACA
AGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCAGGGTATCGATTTTCACTCATCAAGAAAAGGTTTGCTGCAGGA
AAATACTTGGCAGATAACTAATGAAATCTTATGCAAGGATTTGGAGGATTCATATAATGGAGAACTGATGTATGAGAAACAGATTTTAAT


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FusionGenePPI for LEPROT_SGIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LEPROTELAVL1SGIP1ITSN1, REPS1, AMPH, APP, EPS15


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSGIP1chr1:65886423chr1:67184977ENST00000237247+1927667_670574860DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST00000237247+1927813_818574860DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST00000371037+1725667_670543829DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST00000371037+1725813_818543829DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST00000371039+1422667_670346632DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST00000371039+1422813_818346632DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST00000237247+1927593_595574860DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST00000371037+1725561_567543829DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST00000371037+1725593_595543829DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST00000371039+1422561_567346632DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST00000371039+1422593_595346632DPF motifs-containing proteins


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSGIP1chr1:65886423chr1:67184977ENST00000237247+1927561_567574860DPF motifs-containing proteins


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LEPROT_SGIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LEPROT_SGIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSGIP1C0001973Alcoholic Intoxication, Chronic2PSYGENET