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Fusion gene ID: 19606 |
FusionGeneSummary for LEMD3_LYZ |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LEMD3_LYZ | Fusion gene ID: 19606 | Hgene | Tgene | Gene symbol | LEMD3 | LYZ | Gene ID | 23592 | 4069 |
| Gene name | LEM domain containing 3 | lysozyme | |
| Synonyms | MAN1 | LYZF1|LZM | |
| Cytomap | 12q14.3 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inner nuclear membrane protein Man1LEM domain-containing protein 3LEMD3/MKX fusionintegral inner nuclear membrane protein | lysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y2U8 | P61626 | |
| Ensembl transtripts involved in fusion gene | ENST00000308330, ENST00000541171, | ENST00000261267, ENST00000549690, ENST00000548839, | |
| Fusion gene scores | * DoF score | 7 X 5 X 4=140 | 26 X 11 X 9=2574 |
| # samples | 8 | 30 | |
| ** MAII score | log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(30/2574*10)=-3.10097764772482 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LEMD3 [Title/Abstract] AND LYZ [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LEMD3 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 15647271 |
| Hgene | LEMD3 | GO:0030514 | negative regulation of BMP signaling pathway | 15647271 |
| Hgene | LEMD3 | GO:0032926 | negative regulation of activin receptor signaling pathway | 15647271 |
| Tgene | LYZ | GO:0031640 | killing of cells of other organism | 9727055 |
| Tgene | LYZ | GO:0042742 | defense response to bacterium | 21093056 |
| Tgene | LYZ | GO:0050830 | defense response to Gram-positive bacterium | 21093056 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AN-A0AM-01A | LEMD3 | chr12 | 65564898 | + | LYZ | chr12 | 69743888 | + |
| TCGA | RV | SARC | TCGA-DX-A6BE-01A | LEMD3 | chr12 | 65564898 | + | LYZ | chr12 | 69743888 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000308330 | ENST00000261267 | LEMD3 | chr12 | 65564898 | + | LYZ | chr12 | 69743888 | + |
| In-frame | ENST00000308330 | ENST00000549690 | LEMD3 | chr12 | 65564898 | + | LYZ | chr12 | 69743888 | + |
| Frame-shift | ENST00000308330 | ENST00000548839 | LEMD3 | chr12 | 65564898 | + | LYZ | chr12 | 69743888 | + |
| intron-3CDS | ENST00000541171 | ENST00000261267 | LEMD3 | chr12 | 65564898 | + | LYZ | chr12 | 69743888 | + |
| intron-3CDS | ENST00000541171 | ENST00000549690 | LEMD3 | chr12 | 65564898 | + | LYZ | chr12 | 69743888 | + |
| intron-3CDS | ENST00000541171 | ENST00000548839 | LEMD3 | chr12 | 65564898 | + | LYZ | chr12 | 69743888 | + |
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FusionProtFeatures for LEMD3_LYZ |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LEMD3 | LYZ |
| Can function as a specific repressor of TGF-beta,activin, and BMP signaling through its interaction with the R-SMADproteins. Antagonizes TGF-beta-induced cell proliferation arrest.{ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. | Lysozymes have primarily a bacteriolytic function; thosein tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 155_158 | 507 | 912 | Compositional bias | Note=Poly-Gly |
| Hgene | LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 265_268 | 507 | 912 | Compositional bias | Note=Poly-Asp |
| Hgene | LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 312_315 | 507 | 912 | Compositional bias | Note=Poly-Gly |
| Hgene | LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 322_325 | 507 | 912 | Compositional bias | Note=Poly-Ala |
| Hgene | LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 337_340 | 507 | 912 | Compositional bias | Note=Poly-Ala |
| Hgene | LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 65_70 | 507 | 912 | Compositional bias | Note=Poly-Asn |
| Hgene | LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 72_87 | 507 | 912 | Compositional bias | Note=Ala-rich |
| Hgene | LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 82_87 | 507 | 912 | Compositional bias | Note=Poly-Ala |
| Hgene | LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 6_50 | 507 | 912 | Domain | LEM |
| Hgene | LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 475_495 | 507 | 912 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 635_640 | 507 | 912 | Compositional bias | Note=Poly-Leu |
| Hgene | >LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 659_662 | 507 | 912 | Compositional bias | Note=Poly-Glu |
| Hgene | >LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 707_726 | 507 | 912 | DNA binding | . |
| Hgene | >LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 628_648 | 507 | 912 | Transmembrane | Helical |
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FusionGeneSequence for LEMD3_LYZ |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LEMD3_ENST00000308330_chr12_65564898_+_LYZ_ENST00000261267_chr12_69743888_+_611aa MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSRMCLAKWESGYNTRATNYNAGDRSTDYGIFQIN >In-frame_LEMD3_ENST00000308330_chr12_65564898_+_LYZ_ENST00000549690_chr12_69743888_+_600aa MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSRMCLAKWESGYNTRATNYNAGDRSTDYGIFQIN >In-frame_LEMD3_ENST00000308330_chr12_65564898_+_LYZ_ENST00000261267_chr12_69743888_+_611aa MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSRMCLAKWESGYNTRATNYNAGDRSTDYGIFQIN >In-frame_LEMD3_ENST00000308330_chr12_65564898_+_LYZ_ENST00000549690_chr12_69743888_+_600aa MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSRMCLAKWESGYNTRATNYNAGDRSTDYGIFQIN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LEMD3_ENST00000308330_chr12_65564898_+_LYZ_ENST00000261267_chr12_69743888_+_1833nt ATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCCGCCGTTACGGCCTGTCTCCCGGACCA GTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGCAACAGCACCGGTCAGGGGGCCGCGGC AACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAGCGGCGGCGGCGGCCGCGGGGATGGGG GTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGGCCTCTGGCCCAGAGAGCCTCCTGGGA GGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGGACGAGTCGGACGTGGAGGCCAGTCCC CGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAGCGCCGCCGGCGCCCCTGGCCGCCAGC GAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGCCGGCGGGCCCCGAGCTGCAGACCCCG CCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACCCGGAGACCGAGGAGCCGCTCTGGGCG AGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAGAGGAAGAGGACGACGACGACGTGGCC TCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTAAGCCTCTCCCCCCGCTGACTGCTAAA TCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGGCGGCGGCTGCCGGGAGTCTAGACAGG AGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCAGCCCCGTTCCTAGATACCGTGTTAAC GCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGTCAACAGGCTCCCTTCTGAAAACCAAT AATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTCCCAGTGCGGCGGTGGCCGCCTCTAGT TCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACAACAAACCGAAGCTTTCCGAACCCGAA GAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACTACTTGTCGATGTTTCTCTTAACTGCT GCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTGAGGATGGAGAACTCAGCAGGATGTGT TTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAAT AGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGCTTTGCTGCAAGATAACATCGCT GATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGAT >In-frame_LEMD3_ENST00000308330_chr12_65564898_+_LYZ_ENST00000549690_chr12_69743888_+_1800nt ATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCCGCCGTTACGGCCTGTCTCCCGGACCA GTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGCAACAGCACCGGTCAGGGGGCCGCGGC AACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAGCGGCGGCGGCGGCCGCGGGGATGGGG GTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGGCCTCTGGCCCAGAGAGCCTCCTGGGA GGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGGACGAGTCGGACGTGGAGGCCAGTCCC CGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAGCGCCGCCGGCGCCCCTGGCCGCCAGC GAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGCCGGCGGGCCCCGAGCTGCAGACCCCG CCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACCCGGAGACCGAGGAGCCGCTCTGGGCG AGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAGAGGAAGAGGACGACGACGACGTGGCC TCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTAAGCCTCTCCCCCCGCTGACTGCTAAA TCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGGCGGCGGCTGCCGGGAGTCTAGACAGG AGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCAGCCCCGTTCCTAGATACCGTGTTAAC GCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGTCAACAGGCTCCCTTCTGAAAACCAAT AATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTCCCAGTGCGGCGGTGGCCGCCTCTAGT TCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACAACAAACCGAAGCTTTCCGAACCCGAA GAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACTACTTGTCGATGTTTCTCTTAACTGCT GCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTGAGGATGGAGAACTCAGCAGGATGTGT TTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAAT AGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGGGTGGCATGGAGAAATCGTTGTC AAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAA >In-frame_LEMD3_ENST00000308330_chr12_65564898_+_LYZ_ENST00000261267_chr12_69743888_+_1833nt ATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCCGCCGTTACGGCCTGTCTCCCGGACCA GTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGCAACAGCACCGGTCAGGGGGCCGCGGC AACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAGCGGCGGCGGCGGCCGCGGGGATGGGG GTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGGCCTCTGGCCCAGAGAGCCTCCTGGGA GGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGGACGAGTCGGACGTGGAGGCCAGTCCC CGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAGCGCCGCCGGCGCCCCTGGCCGCCAGC GAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGCCGGCGGGCCCCGAGCTGCAGACCCCG CCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACCCGGAGACCGAGGAGCCGCTCTGGGCG AGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAGAGGAAGAGGACGACGACGACGTGGCC TCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTAAGCCTCTCCCCCCGCTGACTGCTAAA TCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGGCGGCGGCTGCCGGGAGTCTAGACAGG AGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCAGCCCCGTTCCTAGATACCGTGTTAAC GCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGTCAACAGGCTCCCTTCTGAAAACCAAT AATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTCCCAGTGCGGCGGTGGCCGCCTCTAGT TCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACAACAAACCGAAGCTTTCCGAACCCGAA GAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACTACTTGTCGATGTTTCTCTTAACTGCT GCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTGAGGATGGAGAACTCAGCAGGATGTGT TTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAAT AGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGCTTTGCTGCAAGATAACATCGCT GATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGAT >In-frame_LEMD3_ENST00000308330_chr12_65564898_+_LYZ_ENST00000549690_chr12_69743888_+_1800nt ATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCCGCCGTTACGGCCTGTCTCCCGGACCA GTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGCAACAGCACCGGTCAGGGGGCCGCGGC AACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAGCGGCGGCGGCGGCCGCGGGGATGGGG GTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGGCCTCTGGCCCAGAGAGCCTCCTGGGA GGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGGACGAGTCGGACGTGGAGGCCAGTCCC CGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAGCGCCGCCGGCGCCCCTGGCCGCCAGC GAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGCCGGCGGGCCCCGAGCTGCAGACCCCG CCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACCCGGAGACCGAGGAGCCGCTCTGGGCG AGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAGAGGAAGAGGACGACGACGACGTGGCC TCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTAAGCCTCTCCCCCCGCTGACTGCTAAA TCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGGCGGCGGCTGCCGGGAGTCTAGACAGG AGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCAGCCCCGTTCCTAGATACCGTGTTAAC GCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGTCAACAGGCTCCCTTCTGAAAACCAAT AATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTCCCAGTGCGGCGGTGGCCGCCTCTAGT TCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACAACAAACCGAAGCTTTCCGAACCCGAA GAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACTACTTGTCGATGTTTCTCTTAACTGCT GCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTGAGGATGGAGAACTCAGCAGGATGTGT TTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAAT AGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGGGTGGCATGGAGAAATCGTTGTC AAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LEMD3_ENST00000308330_chr12_65564898_+_LYZ_ENST00000261267_chr12_69743888_+_2874nt AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG AGGATGGAGAACTCAGCAGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCA CTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCA GTGCTTTGCTGCAAGATAACATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGGGTGGCAT GGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTG TCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGG AGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATA GAACTAATACTGGTGAAAATTTACCTAAAACCTTGGTTATCAAATACATCTCCAGTACATTCCGTTCTTTTTTTTTTTGAGACAGTCTCG CTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCT CCCGAGTAGCTGGGATTACGGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAG GATGGTCTCGATCTCCTGACCTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCACA TTCAGTTCTTATCAAAGAAATAACCCAGACTTAATCTTGAATGATACGATTATGCCCAATATTAAGTAAAAAATATAAGAAAAGGTTATC TTAAATAGATCTTAGGCAAAATACCAGCTGATGAAGGCATCTGATGCCTTCATCTGTTCAGTCATCTCCAAAAACAGTAAAAATAACCAC TTTTTGTTGGGCAATATGAAATTTTTAAAGGAGTAGAATACCAAATGATAGAAACAGACTGCCTGAATTGAGAATTTTGATTTCTTAAAG TGTGTTTCTTTCTAAATTGCTGTTCCTTAATTTGATTAATTTAATTCATGTATTATGATTAAATCTGAGGCAGATGAGCTTACAAGTATT >In-frame_LEMD3_ENST00000308330_chr12_65564898_+_LYZ_ENST00000549690_chr12_69743888_+_2056nt AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG AGGATGGAGAACTCAGCAGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCA CTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCA GTGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTC AGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTT ACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCA >In-frame_LEMD3_ENST00000308330_chr12_65564898_+_LYZ_ENST00000261267_chr12_69743888_+_2874nt AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG AGGATGGAGAACTCAGCAGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCA CTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCA GTGCTTTGCTGCAAGATAACATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGGGTGGCAT GGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTG TCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGG AGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATA GAACTAATACTGGTGAAAATTTACCTAAAACCTTGGTTATCAAATACATCTCCAGTACATTCCGTTCTTTTTTTTTTTGAGACAGTCTCG CTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCT CCCGAGTAGCTGGGATTACGGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAG GATGGTCTCGATCTCCTGACCTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCACA TTCAGTTCTTATCAAAGAAATAACCCAGACTTAATCTTGAATGATACGATTATGCCCAATATTAAGTAAAAAATATAAGAAAAGGTTATC TTAAATAGATCTTAGGCAAAATACCAGCTGATGAAGGCATCTGATGCCTTCATCTGTTCAGTCATCTCCAAAAACAGTAAAAATAACCAC TTTTTGTTGGGCAATATGAAATTTTTAAAGGAGTAGAATACCAAATGATAGAAACAGACTGCCTGAATTGAGAATTTTGATTTCTTAAAG TGTGTTTCTTTCTAAATTGCTGTTCCTTAATTTGATTAATTTAATTCATGTATTATGATTAAATCTGAGGCAGATGAGCTTACAAGTATT >In-frame_LEMD3_ENST00000308330_chr12_65564898_+_LYZ_ENST00000549690_chr12_69743888_+_2056nt AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG AGGATGGAGAACTCAGCAGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCA CTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCA GTGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTC AGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTT ACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCA |
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FusionGenePPI for LEMD3_LYZ |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LEMD3 | SMAD2, SMAD3, CDV3, DUT, SMAD9, SMAD1, LMNA, PYCARD, SPINT2, SRPRB, NRG1, SLAMF7, TMEM171, TEX29, SYNE4, VSIG2, B3GAT3, SGCA, WBP1, LPAR1, HTR3C, NTRK1, NUP160, NUP35, HIST1H2BG, B9D2, TCTN2, TCTN3, TMEM17, TMEM216, NANOG, POU5F1, CTDNEP1, AOC2, KIAA1467, MME, IPPK, ZNRF4, TRHDE, LAMP1, CDHR5, SYT12, CD44, PCDHGB1, LRRC32, PCDHGB4, TRIM25, G3BP1 | LYZ | KHK, LRRK1, NME2, LTF, PARP11, USP1, USP25, CUL4B, CDK2, COPS6, CLU, GRK5, CRK, SMAD6, STAU1, AURKA, CEP57, NEDD1, TP53, FUS, RPS6KB2, NTRK1, MCM2, CRYAB, DDX31, FRMD1, HBM, SNX27, WWOX, CYLD, CDK1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | LEMD3 | chr12:65564898 | chr12:69743888 | ENST00000308330 | + | 1 | 13 | 699_911 | 507 | 912 | SMAD1%2C SMAD2%2C SMAD3 and SMAD5 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LEMD3_LYZ |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LEMD3_LYZ |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | LYZ | C0268389 | Amyloidosis, familial visceral | 1 | CTD_human;UNIPROT |
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