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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19602

FusionGeneSummary for LEKR1_BMP2K

check button Fusion gene summary
Fusion gene informationFusion gene name: LEKR1_BMP2K
Fusion gene ID: 19602
HgeneTgene
Gene symbol

LEKR1

BMP2K

Gene ID

389170

55589

Gene nameleucine, glutamate and lysine rich 1BMP2 inducible kinase
Synonyms-BIKE|HRIHFB2017
Cytomap

3q25.31

4q21.21

Type of geneprotein-codingprotein-coding
Descriptionleucine-, glutamate- and lysine-rich protein 1BMP-2-inducible protein kinase
Modification date2018051920180523
UniProtAcc

Q6ZMV7

Q9NSY1

Ensembl transtripts involved in fusion geneENST00000356539, ENST00000470811, 
ENST00000477399, ENST00000489350, 
ENST00000491763, ENST00000498839, 
ENST00000483177, 
ENST00000335016, 
ENST00000502871, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LEKR1 [Title/Abstract] AND BMP2K [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW836821LEKR1chr3

156677761

-BMP2Kchr4

79828405

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000356539ENST00000335016LEKR1chr3

156677761

-BMP2Kchr4

79828405

+
intron-intronENST00000356539ENST00000502871LEKR1chr3

156677761

-BMP2Kchr4

79828405

+
intron-intronENST00000470811ENST00000335016LEKR1chr3

156677761

-BMP2Kchr4

79828405

+
intron-intronENST00000470811ENST00000502871LEKR1chr3

156677761

-BMP2Kchr4

79828405

+
intron-intronENST00000477399ENST00000335016LEKR1chr3

156677761

-BMP2Kchr4

79828405

+
intron-intronENST00000477399ENST00000502871LEKR1chr3

156677761

-BMP2Kchr4

79828405

+
intron-intronENST00000489350ENST00000335016LEKR1chr3

156677761

-BMP2Kchr4

79828405

+
intron-intronENST00000489350ENST00000502871LEKR1chr3

156677761

-BMP2Kchr4

79828405

+
intron-intronENST00000491763ENST00000335016LEKR1chr3

156677761

-BMP2Kchr4

79828405

+
intron-intronENST00000491763ENST00000502871LEKR1chr3

156677761

-BMP2Kchr4

79828405

+
intron-intronENST00000498839ENST00000335016LEKR1chr3

156677761

-BMP2Kchr4

79828405

+
intron-intronENST00000498839ENST00000502871LEKR1chr3

156677761

-BMP2Kchr4

79828405

+
intron-intronENST00000483177ENST00000335016LEKR1chr3

156677761

-BMP2Kchr4

79828405

+
intron-intronENST00000483177ENST00000502871LEKR1chr3

156677761

-BMP2Kchr4

79828405

+

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FusionProtFeatures for LEKR1_BMP2K


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LEKR1

Q6ZMV7

BMP2K

Q9NSY1

May be involved in osteoblast differentiation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LEKR1_BMP2K


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LEKR1_BMP2K


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LEKR1_BMP2K


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LEKR1_BMP2K


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource