FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 19592

FusionGeneSummary for LDLR_LRPAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: LDLR_LRPAP1
Fusion gene ID: 19592
HgeneTgene
Gene symbol

LDLR

LRPAP1

Gene ID

3949

4043

Gene namelow density lipoprotein receptorLDL receptor related protein associated protein 1
SynonymsFH|FHC|LDLCQ2A2MRAP|A2RAP|HBP44|MRAP|MYP23|RAP|alpha-2-MRAP
Cytomap

19p13.2

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptorLDL receptorlow-density lipoprotein receptor class A domain-containing protein 3alpha-2-macroglobulin receptor-associated protein39 kDa receptor-associated proteinlow density lipoprotein receptor-related protein associated protein 1low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associa
Modification date2018052020180522
UniProtAcc

P01130

P30533

Ensembl transtripts involved in fusion geneENST00000558518, ENST00000557933, 
ENST00000455727, ENST00000535915, 
ENST00000545707, ENST00000558013, 
ENST00000560628, 		ENST00000500728, 
ENST00000296325, 
Fusion gene scores* DoF score14 X 9 X 11=13862 X 2 X 2=8
# samples 172
** MAII scorelog2(17/1386*10)=-3.02732060599951
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: LDLR [Title/Abstract] AND LRPAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLRPAP1

GO:0010916

negative regulation of very-low-density lipoprotein particle clearance

8083232

TgeneLRPAP1

GO:0032091

negative regulation of protein binding

8083232

TgeneLRPAP1

GO:0048259

regulation of receptor-mediated endocytosis

7774585


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-04-1348-01ALDLRchr19

11200291

+LRPAP1chr4

3514763

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000558518ENST00000500728LDLRchr19

11200291

+LRPAP1chr4

3514763

-
5CDS-5UTRENST00000558518ENST00000296325LDLRchr19

11200291

+LRPAP1chr4

3514763

-
In-frameENST00000557933ENST00000500728LDLRchr19

11200291

+LRPAP1chr4

3514763

-
5CDS-5UTRENST00000557933ENST00000296325LDLRchr19

11200291

+LRPAP1chr4

3514763

-
In-frameENST00000455727ENST00000500728LDLRchr19

11200291

+LRPAP1chr4

3514763

-
5CDS-5UTRENST00000455727ENST00000296325LDLRchr19

11200291

+LRPAP1chr4

3514763

-
In-frameENST00000535915ENST00000500728LDLRchr19

11200291

+LRPAP1chr4

3514763

-
5CDS-5UTRENST00000535915ENST00000296325LDLRchr19

11200291

+LRPAP1chr4

3514763

-
In-frameENST00000545707ENST00000500728LDLRchr19

11200291

+LRPAP1chr4

3514763

-
5CDS-5UTRENST00000545707ENST00000296325LDLRchr19

11200291

+LRPAP1chr4

3514763

-
In-frameENST00000558013ENST00000500728LDLRchr19

11200291

+LRPAP1chr4

3514763

-
5CDS-5UTRENST00000558013ENST00000296325LDLRchr19

11200291

+LRPAP1chr4

3514763

-
intron-3CDSENST00000560628ENST00000500728LDLRchr19

11200291

+LRPAP1chr4

3514763

-
intron-5UTRENST00000560628ENST00000296325LDLRchr19

11200291

+LRPAP1chr4

3514763

-

Top

FusionProtFeatures for LDLR_LRPAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LDLR

P01130

LRPAP1

P30533

Molecular chaperone for LDL receptor-related proteinsthat may regulate their ligand binding activity along thesecretory pathway. {ECO:0000269|PubMed:7774585}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRPAP1chr19:11200291chr4:3514763ENST00000500728-68354_357337358MotifPrevents secretion from ER

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116107_14522693DomainLDL-receptor class A 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116146_18622693DomainLDL-receptor class A 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116195_23322693DomainLDL-receptor class A 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116234_27222693DomainLDL-receptor class A 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+11625_6522693DomainLDL-receptor class A 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116274_31322693DomainLDL-receptor class A 7
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116314_35322693DomainEGF-like 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116354_39322693DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116663_71222693DomainEGF-like 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+11666_10622693DomainLDL-receptor class A 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117107_14522820DomainLDL-receptor class A 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117146_18622820DomainLDL-receptor class A 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117195_23322820DomainLDL-receptor class A 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117234_27222820DomainLDL-receptor class A 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+11725_6522820DomainLDL-receptor class A 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117274_31322820DomainLDL-receptor class A 7
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117314_35322820DomainEGF-like 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117354_39322820DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117663_71222820DomainEGF-like 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+11766_10622820DomainLDL-receptor class A 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116107_14522683DomainLDL-receptor class A 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116146_18622683DomainLDL-receptor class A 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116195_23322683DomainLDL-receptor class A 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116234_27222683DomainLDL-receptor class A 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+11625_6522683DomainLDL-receptor class A 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116274_31322683DomainLDL-receptor class A 7
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116314_35322683DomainEGF-like 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116354_39322683DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116663_71222683DomainEGF-like 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+11666_10622683DomainLDL-receptor class A 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118107_14522859DomainLDL-receptor class A 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118146_18622859DomainLDL-receptor class A 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118195_23322859DomainLDL-receptor class A 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118234_27222859DomainLDL-receptor class A 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+11825_6522859DomainLDL-receptor class A 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118274_31322859DomainLDL-receptor class A 7
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118314_35322859DomainEGF-like 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118354_39322859DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118663_71222859DomainEGF-like 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+11866_10622859DomainLDL-receptor class A 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118107_14522861DomainLDL-receptor class A 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118146_18622861DomainLDL-receptor class A 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118195_23322861DomainLDL-receptor class A 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118234_27222861DomainLDL-receptor class A 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+11825_6522861DomainLDL-receptor class A 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118274_31322861DomainLDL-receptor class A 7
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118314_35322861DomainEGF-like 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118354_39322861DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118663_71222861DomainEGF-like 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+11866_10622861DomainLDL-receptor class A 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116823_82822693MotifNPXY motif
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117823_82822820MotifNPXY motif
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116823_82822683MotifNPXY motif
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118823_82822859MotifNPXY motif
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118823_82822861MotifNPXY motif
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116721_76822693RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116811_86022693RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117721_76822820RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117811_86022820RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116721_76822683RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116811_86022683RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118721_76822859RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118811_86022859RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118721_76822861RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118811_86022861RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116397_43822693RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116439_48522693RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116486_52822693RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116529_57222693RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116573_61522693RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116616_65822693RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117397_43822820RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117439_48522820RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117486_52822820RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117529_57222820RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117573_61522820RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117616_65822820RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116397_43822683RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116439_48522683RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116486_52822683RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116529_57222683RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116573_61522683RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116616_65822683RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118397_43822859RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118439_48522859RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118486_52822859RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118529_57222859RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118573_61522859RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118616_65822859RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118397_43822861RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118439_48522861RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118486_52822861RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118529_57222861RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118573_61522861RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118616_65822861RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+11622_78822693Topological domainExtracellular
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+11722_78822820Topological domainExtracellular
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+11622_78822683Topological domainExtracellular
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+11822_78822859Topological domainExtracellular
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+11822_78822861Topological domainExtracellular
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116789_81022693TransmembraneHelical
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117789_81022820TransmembraneHelical
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116789_81022683TransmembraneHelical
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118789_81022859TransmembraneHelical
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118789_81022861TransmembraneHelical
TgeneLRPAP1chr19:11200291chr4:3514763ENST00000500728-68219_310337358Coiled coilOntology_term=ECO:0000255
TgeneLRPAP1chr19:11200291chr4:3514763ENST00000500728-68237_353337358RegionLDL receptor binding


Top

FusionGeneSequence for LDLR_LRPAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_LDLR_ENST00000558518_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_43aa

>In-frame_LDLR_ENST00000557933_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_43aa

>In-frame_LDLR_ENST00000455727_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_43aa

>In-frame_LDLR_ENST00000535915_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_43aa

>In-frame_LDLR_ENST00000545707_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_43aa

>In-frame_LDLR_ENST00000558013_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_43aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_LDLR_ENST00000558518_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_130nt
ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCT

>In-frame_LDLR_ENST00000557933_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_130nt
ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCT

>In-frame_LDLR_ENST00000455727_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_130nt
ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCT

>In-frame_LDLR_ENST00000535915_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_130nt
ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCT

>In-frame_LDLR_ENST00000545707_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_130nt
ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCT

>In-frame_LDLR_ENST00000558013_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_130nt
ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_LDLR_ENST00000558518_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_6915nt
CTCTTGCAGTGAGGTGAAGACATTTGAAAATCACCCCACTGCAAACTCCTCCCCCTGCTAGAAACCTCACATTGAAATGCTGTAAATGAC
GTGGGCCCCGAGTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGC
TGCGAGCATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGC
AGGACCTGTCCGGCAGGATCTCCAGAGCTCGGCACAACGAACTCTGAAGGCATTGGGGAGCCCAGCCCGGCAGGGAAGAGGCCAGCGTGA
AGGACCTGGGCTCTTGGCCGTGGCATTTCCGTGGACAGCCCGCCGTCAGGGTGGCTGGGGCTGGCACGGGTGTCGAGGCAGGAAGGATTG
TTTCTGGTGACTGCAGCCGCTGCCGTCGCGACACAGGGCTTGGTGGTGGTAGCATTTGGGTCTGAGATCGGCCCAGCTCTGACTGAAGGG
GCTTGGCTTCCACTCAGCATCAGCGTGGCAGTCACCACCCCAGTGAGGACCTCGATGTCCAGCTGCTGTCAGGTCTGATAGTCCTCTGCT
AAAACAACACGATTTACATAAAAAATCTTACACATCTGCCACCGGAAATACCATGCACAGAGTCCTTAAAAAATAGAGTGCAGTATTTAA
ACCACCCGCTTGTTGGCTGGTCACTAAGTGTCCTGGTGGCTGGGGCCGGAGCCAGTGCTCTTGAAGGGATCGCGTCATAGCCAGCTTCCC
CTCTGGGCCCTGTGGGTCTTTGCAGCCAACCTCCTTTTCCCGTGAGACGGCCCGGCCTGATTTAAAGCCAAGAGCGCTTGAGTTGAGTTT
GAGGGGAAGATGTGGAGCGTGTGGTTCTGTGGACAGTCAGAGACTGTGGCCTGGGGGCAGCGTCTTTCAACTCTCACCTCTGCAGCTCAG
GGACCTCGGGAGACCTCACCAAACCTGCAGGGCCTCCGTGTCCCTAAGTGTGCTGTGTAAATGCCCCATCTCATGGGGGAGAGACAGCCA
CGGAGGCCTTCCTCTGACCATAGCTGATGGACTGGCGGTTGCTCAGGTCCGGCTCCGAGAATGTTCCTGTGTCTGAGCCTGGAAGAGGCT
CGGGTCTGGCTCCAGGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCT
GAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGG
TTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGT
CCGGCTCTGGGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGGCGTGGTTCCCGTGTCTGAGCCTGGAA
GAGGCTCGGGTCCGGGTCCAGCTCCGAGCGTGGTTCCCGTGTTTGAACCTGGAAGAGGCTCCACCAGGCGTATTGTGTTTTGACTGCAGC
TGGATCTTGGCTTGACTGTTGAGATCTGCCAAACATCCGCTAAGCTATCATTTCTGAGAAAGGTCAAGGCTAGAGGCAGCATGTCGGGAG
TTGGCGCATCAGGGTTGGAAGGGCCCCAGGGTACAGCATGTGGGTGCCTGTTCCTTTGTGGACTTGTGTGTGTGTGGCTGGTGGGGCGGG
GGGTGGATTCTGGTTCTTTTTTTTCCCATTATCCTGAGAGCCTTAAGGTACTCAGTGTGTTGGTGAGACTCAGCCCTGTCATCTAGCAGA
AGTGTGTTCCTTTTCATTGCTGTATAGTATTCCATTGCATGACTGTCCTGTGCTCTGATTTTAATGCACTTTATTGTGGGTGGATATTTG
AGTTGCTTCCTTTCTGGGGTAATAACACTCACTTGGAAATAGCTGTGGTGAACACTCGTGTGGGGGTGGGGGTGGGGGCCAACTCTAGGA
GCACCTAATGGATCTTACGAAGCGTGTTGTCCAAGTATAGAGATGATTCCAAAGTGGTTGGACTGTGTTTCTTTCTCCCAGCTGGGTGGA
AGGAGAACACTAGTGGATTGCTGAGACTTGGTGCTCGGTATTTTTAATTATGGACAGCCTGGCTGGCGTTTTGTGGTGTCTAATTGCGGA
GTAGCGTGTCTTACTGTATAATGGCCTCTTTTGTATGTGGGAGACCATGGTGTTGAGGGGAGGCAGTTACACAAAAAACCCAGATACCGA
GTGTTAGTTCCATGGGTGTGGCTGGTCATGGTGCGCACTCACGAAGGATGTAGGTGATGCCCTCCACTCCGCAGAGCCAGTCCCACAGGG
GTACCCATTCTGACTCCTACCACCGCAGCTCCCTACCTCCCGCCTGCCATGGGTTCCACGTGCATGGCTCTGGGCAGTCTGTGTCTTTGC
GTGCGTCTGTGTATGTCTGCGTGTATCTGCTTACATTCGCTCAGCATCTGAGATTCACCCAGGCTTTTGCGTGGATCAGCGGCAGACTCC
TGATTGCCGCGTGGCGGCCTGTTGTGTGGGTGTGTGCCGCGTGTGTATCCAGTCCCTACTCAGGAGTGTACGTTTCCAGTGTGGGTTGCA
GTCAGGATCCATTTCTCCCTTAACTTTCAGATTATTTGCTGCATAGGCTTTTTTCTCCTAATTTGGCGCCTTTGTCAGAAATCAACTGAC
CTACCTGTGTGGGTCTGTTTCTGTTTGTCCTTACGCTCTTGCCATTGCCACACTTTAGACAAGGTCTTGCTCTGTCCCTCAGGCTGGAGT
GCAGTAGCGTGATCTCAGCTCACTGCACCCTTGACCTCCCATACTCCAGCAATCCCCTCGCCTCAGTCTCCTGAGTAGTAGCTGCGACCA
CAGGCGTGTGTCACCACACCCGGCTGATTTTATTTTTTTTATTTTTATTTTTTTTGTAGAGACGGGGTTTTACTATGTTGCCCAGGCAGG
TCTTGATCTGGGCTCAAGTGATGCTCCTGTCTCAGCCTCCCAAACTACTGGGATTACAGGTTGTAGGTGTGAGCCATGGTGCCCGGCCGC
CACACTGTCTTGGCTACAGTTGGGTTTATAATAAACCCTGAATCGAGGTGATGTGCATTTTCCAACTCTTCTTTTTAAAGATTCTTGTGG
CTGTTTATGTCCTTGGTGTTTCCATATATGTTTTACAATCAGTGTCTCAATTTCTACCAAAAAAACATGCCTTCTGGAATTTCAATAGCA
ATTCCCTTGAACGCATTTTTGAATACCTTTTCTGAATGTCTTGAATACATGTTGGGAAGAATCGGTGTCTTAACAGTCTCCAGTGTCCAC
GCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCT
CAGCAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCCAGTGTCCACGCGTTGACTGCCGTG
TGTGACTCCAGTCGGCGTCTCAGCAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTG
TCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGG
CGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTG
CCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTC
CGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCA
GTCGGCGTCTCAACAGTCTCCGGTGTCCATGCGTTGACTGCCATGTATGACTCCAGGTATTGAGTTCATCTTCAACTTCTCCCAACAATG
AACTGGAGTTTTCTGTGCATGTGTCTGGCATGTTTTCCTTTAGATCTAGTCCTAGGTGTTCGATATGCTATTGAGGACTGTGTATTTTTA
TTTCATTTGTCACCTGTGCGTGGTGCTTTAATCCTGTGCCCTAAACTCCCGCCTTGGCCATGGCGGTGTTTCTGTGGACTCGTGGGGTTT
CCGTGTGCACACGCGTGTCCTCTGTCTGACAGTGGCTTTGCTTCCCCTTGTCAGTCTGTGCCTCGGCTTCTCACTGCACTGGTGAGGTGA
GCCGGCGCTCGCTAATCTTATTCCCAGTCTCGGTGAACATGGGCTCAGTCTCTCCCGGCTCAGTGTTGGGTTTGCACTGGTGCACTTACA
GGCAGAAGAGCTTCCTCATTTGCTGAGGGCTTTTCCTGAATCCGTGTTGAATGTGGTCAGCTGCCTTTCCTGCACCTAGTGAGATGCTCA
TGAGGTCACTTCCTTACCGCATTACTGTAGTGAATTACGCTGACTTTCATATGCCAAGATGACCTGGCATTTCCAGGTAAGTCCCTGTGG
CCATGGTGCATTGGCCTTTTCTCTGCATGGCCAGATGAGATTTGCTCATACCGGGCTAAGGACCTCCTGTGTAGGAATGCTCTTGAGGGA
CACTGGGCTTGGATGTTCATTGTCTTGTCATGTGATGTGTCTGTCATGGTTTGATATTGCATTAAGTGGGCCTCCTGAAACAAGTTCTGC
CATAGTTTGTATAGGATTGGCATTATTTGTTTCATAGAGATGTGATGGGTGAGGCCATCTATGCCTGCCATTTTCTTTTTGCTTAGGTTT
TTCATTAAGAACTTGATTTTTAAAAATAGACATGAGGCCTGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAACGTGG
ATGGATCACCTGAGGTCAGGAGTTTGAGACCAACCTAGTCAACATGGTGAAACCCCGTCTCCATTAAAAATATAAAAATTAGCAGGGTGT
GGTGGTGCATGCCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGTGGAGGTTGCAGTGAGCTGAGA
TCACACCACTGCACTCCAGCCTGGGCAACAGAGCGAGGCTCTGTCTCAAAAAAAAAGACATGAGGCTTTTGGATTTTCTGTTTCTTCCTT
TGTCATTTTTTTAAAGATAGGTTTGTCGCAGAATTTCATCTAAGTTATCAAAACAATTTACATAAATCATTCACAGTATCCTCTGTGCAG
TGATGTCCATTCTCATTCCTGCTCTGGGCCATTTGTGTTTTCTTTTCCCCCTGATCAGACTAGCTAAGAGTTTATCATTTTTACAGATAT
TTTCCCCAAAGAAACCTACTTTTGGGTCCATTGATTTTTTTTTTCTATTGTTTTCTTTTTCATTGACTTTTGCTCTTTTCTTATGAATTT
CCTTTCTTCTACCTATTTTGTGTTCAATTTGCTGTCCTTGTTTTAGGTTCTTTTGATAGAGGCTTAGATCATTGATGAAGAATATGAAAG
AATGGGATAATACAGTTAAAAACTTGGTCTACTTATGCCCATTAGAGAAAACATTCTTAAGCACGCATGGAATCTTTTAAAAATGGACGA
GGTACTAGGACCCAAAGCAAATGTCAGTAATTCGCAGATGATAATGTATAAATATATGATATGTAGGTAAATAATACAAATCACATTCTT
TGGCCAGAGTGCAATTGAGGAGGAAATCAGTAACAAAAAGACAATTAAATCCATTTGATTCTTTTGTTTTCGTTTTGTAGTAACTTGCAC
TTCCCTGGTGCCAGAGGCATGACACCTTTTTGTCTGCTCTTGGCCATTTGGGTGGCGTCTTTGGGAAGGGCCTACTTAATTCTTTTGCCT
ATTTAAAAAACTGGGTCTTGGAAATCTTGTCTTTTTTTTTGAGTCAGGATCTTTCTCGCACAGGCTTGGAGTGCAGTGGTGCGATCATAG
CTCACTGCAACCTCAAACTCCTGGGCTCAAGCGAGCCTCCCACCTCGGTCTTCTGAGTAGCTGGGACTACAGGCATGCATCACTATGCTC
TGCTAATTTAAAGAAAAGGTTTTTTTTATAGAGACTGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCGGAGTCCTGGTCTCAAGTGATTCA
CCTGCCTCCACCTCGCGGAGTGCCAGGATTACAGGTGGCGGGAGCCGCCACACCCAGCCTGGTCTTAGCGTTATTCCCAGGTCTAGGTGT
GAGTCCTTCCTCAGATATGTGTTGTGAATAATTTCCGATCCTCTGGCTTGCTATTTTACTTTCTTAATGGTTATCTTTTGGAAAGCAAAG
GTTTCCAGTTTGATGAAATCTAATTTTTATTTTTTATTTTTCCGTTCTAGTGGTCTTTCTATTTTCTCATCAAATTGAGACTTTGGGGAA
ACTACACAGCAGCAAACCAGGATATATCCTCTTAAAAACAGCTCGAGCCGGCCGGGTGCGGTGGCTCATGCCTGGAATCCCAGCACTTTG
GGAGGTGGAGGTGGGCGGATCACGTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAAAAA
ATTAGCCAGGCATGGTGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCTGGGAGGCAGAGGTTG

>In-frame_LDLR_ENST00000557933_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_6815nt
AGTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATG
GGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCTGTC
CGGCAGGATCTCCAGAGCTCGGCACAACGAACTCTGAAGGCATTGGGGAGCCCAGCCCGGCAGGGAAGAGGCCAGCGTGAAGGACCTGGG
CTCTTGGCCGTGGCATTTCCGTGGACAGCCCGCCGTCAGGGTGGCTGGGGCTGGCACGGGTGTCGAGGCAGGAAGGATTGTTTCTGGTGA
CTGCAGCCGCTGCCGTCGCGACACAGGGCTTGGTGGTGGTAGCATTTGGGTCTGAGATCGGCCCAGCTCTGACTGAAGGGGCTTGGCTTC
CACTCAGCATCAGCGTGGCAGTCACCACCCCAGTGAGGACCTCGATGTCCAGCTGCTGTCAGGTCTGATAGTCCTCTGCTAAAACAACAC
GATTTACATAAAAAATCTTACACATCTGCCACCGGAAATACCATGCACAGAGTCCTTAAAAAATAGAGTGCAGTATTTAAACCACCCGCT
TGTTGGCTGGTCACTAAGTGTCCTGGTGGCTGGGGCCGGAGCCAGTGCTCTTGAAGGGATCGCGTCATAGCCAGCTTCCCCTCTGGGCCC
TGTGGGTCTTTGCAGCCAACCTCCTTTTCCCGTGAGACGGCCCGGCCTGATTTAAAGCCAAGAGCGCTTGAGTTGAGTTTGAGGGGAAGA
TGTGGAGCGTGTGGTTCTGTGGACAGTCAGAGACTGTGGCCTGGGGGCAGCGTCTTTCAACTCTCACCTCTGCAGCTCAGGGACCTCGGG
AGACCTCACCAAACCTGCAGGGCCTCCGTGTCCCTAAGTGTGCTGTGTAAATGCCCCATCTCATGGGGGAGAGACAGCCACGGAGGCCTT
CCTCTGACCATAGCTGATGGACTGGCGGTTGCTCAGGTCCGGCTCCGAGAATGTTCCTGTGTCTGAGCCTGGAAGAGGCTCGGGTCTGGC
TCCAGGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAA
GAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCC
GTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGG
GCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGGCGTGGTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGG
TCCGGGTCCAGCTCCGAGCGTGGTTCCCGTGTTTGAACCTGGAAGAGGCTCCACCAGGCGTATTGTGTTTTGACTGCAGCTGGATCTTGG
CTTGACTGTTGAGATCTGCCAAACATCCGCTAAGCTATCATTTCTGAGAAAGGTCAAGGCTAGAGGCAGCATGTCGGGAGTTGGCGCATC
AGGGTTGGAAGGGCCCCAGGGTACAGCATGTGGGTGCCTGTTCCTTTGTGGACTTGTGTGTGTGTGGCTGGTGGGGCGGGGGGTGGATTC
TGGTTCTTTTTTTTCCCATTATCCTGAGAGCCTTAAGGTACTCAGTGTGTTGGTGAGACTCAGCCCTGTCATCTAGCAGAAGTGTGTTCC
TTTTCATTGCTGTATAGTATTCCATTGCATGACTGTCCTGTGCTCTGATTTTAATGCACTTTATTGTGGGTGGATATTTGAGTTGCTTCC
TTTCTGGGGTAATAACACTCACTTGGAAATAGCTGTGGTGAACACTCGTGTGGGGGTGGGGGTGGGGGCCAACTCTAGGAGCACCTAATG
GATCTTACGAAGCGTGTTGTCCAAGTATAGAGATGATTCCAAAGTGGTTGGACTGTGTTTCTTTCTCCCAGCTGGGTGGAAGGAGAACAC
TAGTGGATTGCTGAGACTTGGTGCTCGGTATTTTTAATTATGGACAGCCTGGCTGGCGTTTTGTGGTGTCTAATTGCGGAGTAGCGTGTC
TTACTGTATAATGGCCTCTTTTGTATGTGGGAGACCATGGTGTTGAGGGGAGGCAGTTACACAAAAAACCCAGATACCGAGTGTTAGTTC
CATGGGTGTGGCTGGTCATGGTGCGCACTCACGAAGGATGTAGGTGATGCCCTCCACTCCGCAGAGCCAGTCCCACAGGGGTACCCATTC
TGACTCCTACCACCGCAGCTCCCTACCTCCCGCCTGCCATGGGTTCCACGTGCATGGCTCTGGGCAGTCTGTGTCTTTGCGTGCGTCTGT
GTATGTCTGCGTGTATCTGCTTACATTCGCTCAGCATCTGAGATTCACCCAGGCTTTTGCGTGGATCAGCGGCAGACTCCTGATTGCCGC
GTGGCGGCCTGTTGTGTGGGTGTGTGCCGCGTGTGTATCCAGTCCCTACTCAGGAGTGTACGTTTCCAGTGTGGGTTGCAGTCAGGATCC
ATTTCTCCCTTAACTTTCAGATTATTTGCTGCATAGGCTTTTTTCTCCTAATTTGGCGCCTTTGTCAGAAATCAACTGACCTACCTGTGT
GGGTCTGTTTCTGTTTGTCCTTACGCTCTTGCCATTGCCACACTTTAGACAAGGTCTTGCTCTGTCCCTCAGGCTGGAGTGCAGTAGCGT
GATCTCAGCTCACTGCACCCTTGACCTCCCATACTCCAGCAATCCCCTCGCCTCAGTCTCCTGAGTAGTAGCTGCGACCACAGGCGTGTG
TCACCACACCCGGCTGATTTTATTTTTTTTATTTTTATTTTTTTTGTAGAGACGGGGTTTTACTATGTTGCCCAGGCAGGTCTTGATCTG
GGCTCAAGTGATGCTCCTGTCTCAGCCTCCCAAACTACTGGGATTACAGGTTGTAGGTGTGAGCCATGGTGCCCGGCCGCCACACTGTCT
TGGCTACAGTTGGGTTTATAATAAACCCTGAATCGAGGTGATGTGCATTTTCCAACTCTTCTTTTTAAAGATTCTTGTGGCTGTTTATGT
CCTTGGTGTTTCCATATATGTTTTACAATCAGTGTCTCAATTTCTACCAAAAAAACATGCCTTCTGGAATTTCAATAGCAATTCCCTTGA
ACGCATTTTTGAATACCTTTTCTGAATGTCTTGAATACATGTTGGGAAGAATCGGTGTCTTAACAGTCTCCAGTGTCCACGCGTTGACTG
CCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTC
CAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCA
GTCGGCGTCTCAGCAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTT
GACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACA
GTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGA
CTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCAC
GCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCT
CAACAGTCTCCGGTGTCCATGCGTTGACTGCCATGTATGACTCCAGGTATTGAGTTCATCTTCAACTTCTCCCAACAATGAACTGGAGTT
TTCTGTGCATGTGTCTGGCATGTTTTCCTTTAGATCTAGTCCTAGGTGTTCGATATGCTATTGAGGACTGTGTATTTTTATTTCATTTGT
CACCTGTGCGTGGTGCTTTAATCCTGTGCCCTAAACTCCCGCCTTGGCCATGGCGGTGTTTCTGTGGACTCGTGGGGTTTCCGTGTGCAC
ACGCGTGTCCTCTGTCTGACAGTGGCTTTGCTTCCCCTTGTCAGTCTGTGCCTCGGCTTCTCACTGCACTGGTGAGGTGAGCCGGCGCTC
GCTAATCTTATTCCCAGTCTCGGTGAACATGGGCTCAGTCTCTCCCGGCTCAGTGTTGGGTTTGCACTGGTGCACTTACAGGCAGAAGAG
CTTCCTCATTTGCTGAGGGCTTTTCCTGAATCCGTGTTGAATGTGGTCAGCTGCCTTTCCTGCACCTAGTGAGATGCTCATGAGGTCACT
TCCTTACCGCATTACTGTAGTGAATTACGCTGACTTTCATATGCCAAGATGACCTGGCATTTCCAGGTAAGTCCCTGTGGCCATGGTGCA
TTGGCCTTTTCTCTGCATGGCCAGATGAGATTTGCTCATACCGGGCTAAGGACCTCCTGTGTAGGAATGCTCTTGAGGGACACTGGGCTT
GGATGTTCATTGTCTTGTCATGTGATGTGTCTGTCATGGTTTGATATTGCATTAAGTGGGCCTCCTGAAACAAGTTCTGCCATAGTTTGT
ATAGGATTGGCATTATTTGTTTCATAGAGATGTGATGGGTGAGGCCATCTATGCCTGCCATTTTCTTTTTGCTTAGGTTTTTCATTAAGA
ACTTGATTTTTAAAAATAGACATGAGGCCTGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAACGTGGATGGATCACC
TGAGGTCAGGAGTTTGAGACCAACCTAGTCAACATGGTGAAACCCCGTCTCCATTAAAAATATAAAAATTAGCAGGGTGTGGTGGTGCAT
GCCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACT
GCACTCCAGCCTGGGCAACAGAGCGAGGCTCTGTCTCAAAAAAAAAGACATGAGGCTTTTGGATTTTCTGTTTCTTCCTTTGTCATTTTT
TTAAAGATAGGTTTGTCGCAGAATTTCATCTAAGTTATCAAAACAATTTACATAAATCATTCACAGTATCCTCTGTGCAGTGATGTCCAT
TCTCATTCCTGCTCTGGGCCATTTGTGTTTTCTTTTCCCCCTGATCAGACTAGCTAAGAGTTTATCATTTTTACAGATATTTTCCCCAAA
GAAACCTACTTTTGGGTCCATTGATTTTTTTTTTCTATTGTTTTCTTTTTCATTGACTTTTGCTCTTTTCTTATGAATTTCCTTTCTTCT
ACCTATTTTGTGTTCAATTTGCTGTCCTTGTTTTAGGTTCTTTTGATAGAGGCTTAGATCATTGATGAAGAATATGAAAGAATGGGATAA
TACAGTTAAAAACTTGGTCTACTTATGCCCATTAGAGAAAACATTCTTAAGCACGCATGGAATCTTTTAAAAATGGACGAGGTACTAGGA
CCCAAAGCAAATGTCAGTAATTCGCAGATGATAATGTATAAATATATGATATGTAGGTAAATAATACAAATCACATTCTTTGGCCAGAGT
GCAATTGAGGAGGAAATCAGTAACAAAAAGACAATTAAATCCATTTGATTCTTTTGTTTTCGTTTTGTAGTAACTTGCACTTCCCTGGTG
CCAGAGGCATGACACCTTTTTGTCTGCTCTTGGCCATTTGGGTGGCGTCTTTGGGAAGGGCCTACTTAATTCTTTTGCCTATTTAAAAAA
CTGGGTCTTGGAAATCTTGTCTTTTTTTTTGAGTCAGGATCTTTCTCGCACAGGCTTGGAGTGCAGTGGTGCGATCATAGCTCACTGCAA
CCTCAAACTCCTGGGCTCAAGCGAGCCTCCCACCTCGGTCTTCTGAGTAGCTGGGACTACAGGCATGCATCACTATGCTCTGCTAATTTA
AAGAAAAGGTTTTTTTTATAGAGACTGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCGGAGTCCTGGTCTCAAGTGATTCACCTGCCTCCA
CCTCGCGGAGTGCCAGGATTACAGGTGGCGGGAGCCGCCACACCCAGCCTGGTCTTAGCGTTATTCCCAGGTCTAGGTGTGAGTCCTTCC
TCAGATATGTGTTGTGAATAATTTCCGATCCTCTGGCTTGCTATTTTACTTTCTTAATGGTTATCTTTTGGAAAGCAAAGGTTTCCAGTT
TGATGAAATCTAATTTTTATTTTTTATTTTTCCGTTCTAGTGGTCTTTCTATTTTCTCATCAAATTGAGACTTTGGGGAAACTACACAGC
AGCAAACCAGGATATATCCTCTTAAAAACAGCTCGAGCCGGCCGGGTGCGGTGGCTCATGCCTGGAATCCCAGCACTTTGGGAGGTGGAG
GTGGGCGGATCACGTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAAAAAATTAGCCAGG
CATGGTGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCG

>In-frame_LDLR_ENST00000455727_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_6814nt
GTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGG
GGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCTGTCC
GGCAGGATCTCCAGAGCTCGGCACAACGAACTCTGAAGGCATTGGGGAGCCCAGCCCGGCAGGGAAGAGGCCAGCGTGAAGGACCTGGGC
TCTTGGCCGTGGCATTTCCGTGGACAGCCCGCCGTCAGGGTGGCTGGGGCTGGCACGGGTGTCGAGGCAGGAAGGATTGTTTCTGGTGAC
TGCAGCCGCTGCCGTCGCGACACAGGGCTTGGTGGTGGTAGCATTTGGGTCTGAGATCGGCCCAGCTCTGACTGAAGGGGCTTGGCTTCC
ACTCAGCATCAGCGTGGCAGTCACCACCCCAGTGAGGACCTCGATGTCCAGCTGCTGTCAGGTCTGATAGTCCTCTGCTAAAACAACACG
ATTTACATAAAAAATCTTACACATCTGCCACCGGAAATACCATGCACAGAGTCCTTAAAAAATAGAGTGCAGTATTTAAACCACCCGCTT
GTTGGCTGGTCACTAAGTGTCCTGGTGGCTGGGGCCGGAGCCAGTGCTCTTGAAGGGATCGCGTCATAGCCAGCTTCCCCTCTGGGCCCT
GTGGGTCTTTGCAGCCAACCTCCTTTTCCCGTGAGACGGCCCGGCCTGATTTAAAGCCAAGAGCGCTTGAGTTGAGTTTGAGGGGAAGAT
GTGGAGCGTGTGGTTCTGTGGACAGTCAGAGACTGTGGCCTGGGGGCAGCGTCTTTCAACTCTCACCTCTGCAGCTCAGGGACCTCGGGA
GACCTCACCAAACCTGCAGGGCCTCCGTGTCCCTAAGTGTGCTGTGTAAATGCCCCATCTCATGGGGGAGAGACAGCCACGGAGGCCTTC
CTCTGACCATAGCTGATGGACTGGCGGTTGCTCAGGTCCGGCTCCGAGAATGTTCCTGTGTCTGAGCCTGGAAGAGGCTCGGGTCTGGCT
CCAGGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAG
AGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCG
TGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGG
CGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGGCGTGGTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGT
CCGGGTCCAGCTCCGAGCGTGGTTCCCGTGTTTGAACCTGGAAGAGGCTCCACCAGGCGTATTGTGTTTTGACTGCAGCTGGATCTTGGC
TTGACTGTTGAGATCTGCCAAACATCCGCTAAGCTATCATTTCTGAGAAAGGTCAAGGCTAGAGGCAGCATGTCGGGAGTTGGCGCATCA
GGGTTGGAAGGGCCCCAGGGTACAGCATGTGGGTGCCTGTTCCTTTGTGGACTTGTGTGTGTGTGGCTGGTGGGGCGGGGGGTGGATTCT
GGTTCTTTTTTTTCCCATTATCCTGAGAGCCTTAAGGTACTCAGTGTGTTGGTGAGACTCAGCCCTGTCATCTAGCAGAAGTGTGTTCCT
TTTCATTGCTGTATAGTATTCCATTGCATGACTGTCCTGTGCTCTGATTTTAATGCACTTTATTGTGGGTGGATATTTGAGTTGCTTCCT
TTCTGGGGTAATAACACTCACTTGGAAATAGCTGTGGTGAACACTCGTGTGGGGGTGGGGGTGGGGGCCAACTCTAGGAGCACCTAATGG
ATCTTACGAAGCGTGTTGTCCAAGTATAGAGATGATTCCAAAGTGGTTGGACTGTGTTTCTTTCTCCCAGCTGGGTGGAAGGAGAACACT
AGTGGATTGCTGAGACTTGGTGCTCGGTATTTTTAATTATGGACAGCCTGGCTGGCGTTTTGTGGTGTCTAATTGCGGAGTAGCGTGTCT
TACTGTATAATGGCCTCTTTTGTATGTGGGAGACCATGGTGTTGAGGGGAGGCAGTTACACAAAAAACCCAGATACCGAGTGTTAGTTCC
ATGGGTGTGGCTGGTCATGGTGCGCACTCACGAAGGATGTAGGTGATGCCCTCCACTCCGCAGAGCCAGTCCCACAGGGGTACCCATTCT
GACTCCTACCACCGCAGCTCCCTACCTCCCGCCTGCCATGGGTTCCACGTGCATGGCTCTGGGCAGTCTGTGTCTTTGCGTGCGTCTGTG
TATGTCTGCGTGTATCTGCTTACATTCGCTCAGCATCTGAGATTCACCCAGGCTTTTGCGTGGATCAGCGGCAGACTCCTGATTGCCGCG
TGGCGGCCTGTTGTGTGGGTGTGTGCCGCGTGTGTATCCAGTCCCTACTCAGGAGTGTACGTTTCCAGTGTGGGTTGCAGTCAGGATCCA
TTTCTCCCTTAACTTTCAGATTATTTGCTGCATAGGCTTTTTTCTCCTAATTTGGCGCCTTTGTCAGAAATCAACTGACCTACCTGTGTG
GGTCTGTTTCTGTTTGTCCTTACGCTCTTGCCATTGCCACACTTTAGACAAGGTCTTGCTCTGTCCCTCAGGCTGGAGTGCAGTAGCGTG
ATCTCAGCTCACTGCACCCTTGACCTCCCATACTCCAGCAATCCCCTCGCCTCAGTCTCCTGAGTAGTAGCTGCGACCACAGGCGTGTGT
CACCACACCCGGCTGATTTTATTTTTTTTATTTTTATTTTTTTTGTAGAGACGGGGTTTTACTATGTTGCCCAGGCAGGTCTTGATCTGG
GCTCAAGTGATGCTCCTGTCTCAGCCTCCCAAACTACTGGGATTACAGGTTGTAGGTGTGAGCCATGGTGCCCGGCCGCCACACTGTCTT
GGCTACAGTTGGGTTTATAATAAACCCTGAATCGAGGTGATGTGCATTTTCCAACTCTTCTTTTTAAAGATTCTTGTGGCTGTTTATGTC
CTTGGTGTTTCCATATATGTTTTACAATCAGTGTCTCAATTTCTACCAAAAAAACATGCCTTCTGGAATTTCAATAGCAATTCCCTTGAA
CGCATTTTTGAATACCTTTTCTGAATGTCTTGAATACATGTTGGGAAGAATCGGTGTCTTAACAGTCTCCAGTGTCCACGCGTTGACTGC
CGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCC
AGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAG
TCGGCGTCTCAGCAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTG
ACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAG
TCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGAC
TCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACG
CGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTC
AACAGTCTCCGGTGTCCATGCGTTGACTGCCATGTATGACTCCAGGTATTGAGTTCATCTTCAACTTCTCCCAACAATGAACTGGAGTTT
TCTGTGCATGTGTCTGGCATGTTTTCCTTTAGATCTAGTCCTAGGTGTTCGATATGCTATTGAGGACTGTGTATTTTTATTTCATTTGTC
ACCTGTGCGTGGTGCTTTAATCCTGTGCCCTAAACTCCCGCCTTGGCCATGGCGGTGTTTCTGTGGACTCGTGGGGTTTCCGTGTGCACA
CGCGTGTCCTCTGTCTGACAGTGGCTTTGCTTCCCCTTGTCAGTCTGTGCCTCGGCTTCTCACTGCACTGGTGAGGTGAGCCGGCGCTCG
CTAATCTTATTCCCAGTCTCGGTGAACATGGGCTCAGTCTCTCCCGGCTCAGTGTTGGGTTTGCACTGGTGCACTTACAGGCAGAAGAGC
TTCCTCATTTGCTGAGGGCTTTTCCTGAATCCGTGTTGAATGTGGTCAGCTGCCTTTCCTGCACCTAGTGAGATGCTCATGAGGTCACTT
CCTTACCGCATTACTGTAGTGAATTACGCTGACTTTCATATGCCAAGATGACCTGGCATTTCCAGGTAAGTCCCTGTGGCCATGGTGCAT
TGGCCTTTTCTCTGCATGGCCAGATGAGATTTGCTCATACCGGGCTAAGGACCTCCTGTGTAGGAATGCTCTTGAGGGACACTGGGCTTG
GATGTTCATTGTCTTGTCATGTGATGTGTCTGTCATGGTTTGATATTGCATTAAGTGGGCCTCCTGAAACAAGTTCTGCCATAGTTTGTA
TAGGATTGGCATTATTTGTTTCATAGAGATGTGATGGGTGAGGCCATCTATGCCTGCCATTTTCTTTTTGCTTAGGTTTTTCATTAAGAA
CTTGATTTTTAAAAATAGACATGAGGCCTGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAACGTGGATGGATCACCT
GAGGTCAGGAGTTTGAGACCAACCTAGTCAACATGGTGAAACCCCGTCTCCATTAAAAATATAAAAATTAGCAGGGTGTGGTGGTGCATG
CCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACTG
CACTCCAGCCTGGGCAACAGAGCGAGGCTCTGTCTCAAAAAAAAAGACATGAGGCTTTTGGATTTTCTGTTTCTTCCTTTGTCATTTTTT
TAAAGATAGGTTTGTCGCAGAATTTCATCTAAGTTATCAAAACAATTTACATAAATCATTCACAGTATCCTCTGTGCAGTGATGTCCATT
CTCATTCCTGCTCTGGGCCATTTGTGTTTTCTTTTCCCCCTGATCAGACTAGCTAAGAGTTTATCATTTTTACAGATATTTTCCCCAAAG
AAACCTACTTTTGGGTCCATTGATTTTTTTTTTCTATTGTTTTCTTTTTCATTGACTTTTGCTCTTTTCTTATGAATTTCCTTTCTTCTA
CCTATTTTGTGTTCAATTTGCTGTCCTTGTTTTAGGTTCTTTTGATAGAGGCTTAGATCATTGATGAAGAATATGAAAGAATGGGATAAT
ACAGTTAAAAACTTGGTCTACTTATGCCCATTAGAGAAAACATTCTTAAGCACGCATGGAATCTTTTAAAAATGGACGAGGTACTAGGAC
CCAAAGCAAATGTCAGTAATTCGCAGATGATAATGTATAAATATATGATATGTAGGTAAATAATACAAATCACATTCTTTGGCCAGAGTG
CAATTGAGGAGGAAATCAGTAACAAAAAGACAATTAAATCCATTTGATTCTTTTGTTTTCGTTTTGTAGTAACTTGCACTTCCCTGGTGC
CAGAGGCATGACACCTTTTTGTCTGCTCTTGGCCATTTGGGTGGCGTCTTTGGGAAGGGCCTACTTAATTCTTTTGCCTATTTAAAAAAC
TGGGTCTTGGAAATCTTGTCTTTTTTTTTGAGTCAGGATCTTTCTCGCACAGGCTTGGAGTGCAGTGGTGCGATCATAGCTCACTGCAAC
CTCAAACTCCTGGGCTCAAGCGAGCCTCCCACCTCGGTCTTCTGAGTAGCTGGGACTACAGGCATGCATCACTATGCTCTGCTAATTTAA
AGAAAAGGTTTTTTTTATAGAGACTGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCGGAGTCCTGGTCTCAAGTGATTCACCTGCCTCCAC
CTCGCGGAGTGCCAGGATTACAGGTGGCGGGAGCCGCCACACCCAGCCTGGTCTTAGCGTTATTCCCAGGTCTAGGTGTGAGTCCTTCCT
CAGATATGTGTTGTGAATAATTTCCGATCCTCTGGCTTGCTATTTTACTTTCTTAATGGTTATCTTTTGGAAAGCAAAGGTTTCCAGTTT
GATGAAATCTAATTTTTATTTTTTATTTTTCCGTTCTAGTGGTCTTTCTATTTTCTCATCAAATTGAGACTTTGGGGAAACTACACAGCA
GCAAACCAGGATATATCCTCTTAAAAACAGCTCGAGCCGGCCGGGTGCGGTGGCTCATGCCTGGAATCCCAGCACTTTGGGAGGTGGAGG
TGGGCGGATCACGTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAAAAAATTAGCCAGGC
ATGGTGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGA

>In-frame_LDLR_ENST00000535915_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_6814nt
GTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGG
GGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCTGTCC
GGCAGGATCTCCAGAGCTCGGCACAACGAACTCTGAAGGCATTGGGGAGCCCAGCCCGGCAGGGAAGAGGCCAGCGTGAAGGACCTGGGC
TCTTGGCCGTGGCATTTCCGTGGACAGCCCGCCGTCAGGGTGGCTGGGGCTGGCACGGGTGTCGAGGCAGGAAGGATTGTTTCTGGTGAC
TGCAGCCGCTGCCGTCGCGACACAGGGCTTGGTGGTGGTAGCATTTGGGTCTGAGATCGGCCCAGCTCTGACTGAAGGGGCTTGGCTTCC
ACTCAGCATCAGCGTGGCAGTCACCACCCCAGTGAGGACCTCGATGTCCAGCTGCTGTCAGGTCTGATAGTCCTCTGCTAAAACAACACG
ATTTACATAAAAAATCTTACACATCTGCCACCGGAAATACCATGCACAGAGTCCTTAAAAAATAGAGTGCAGTATTTAAACCACCCGCTT
GTTGGCTGGTCACTAAGTGTCCTGGTGGCTGGGGCCGGAGCCAGTGCTCTTGAAGGGATCGCGTCATAGCCAGCTTCCCCTCTGGGCCCT
GTGGGTCTTTGCAGCCAACCTCCTTTTCCCGTGAGACGGCCCGGCCTGATTTAAAGCCAAGAGCGCTTGAGTTGAGTTTGAGGGGAAGAT
GTGGAGCGTGTGGTTCTGTGGACAGTCAGAGACTGTGGCCTGGGGGCAGCGTCTTTCAACTCTCACCTCTGCAGCTCAGGGACCTCGGGA
GACCTCACCAAACCTGCAGGGCCTCCGTGTCCCTAAGTGTGCTGTGTAAATGCCCCATCTCATGGGGGAGAGACAGCCACGGAGGCCTTC
CTCTGACCATAGCTGATGGACTGGCGGTTGCTCAGGTCCGGCTCCGAGAATGTTCCTGTGTCTGAGCCTGGAAGAGGCTCGGGTCTGGCT
CCAGGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAG
AGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCG
TGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGG
CGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGGCGTGGTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGT
CCGGGTCCAGCTCCGAGCGTGGTTCCCGTGTTTGAACCTGGAAGAGGCTCCACCAGGCGTATTGTGTTTTGACTGCAGCTGGATCTTGGC
TTGACTGTTGAGATCTGCCAAACATCCGCTAAGCTATCATTTCTGAGAAAGGTCAAGGCTAGAGGCAGCATGTCGGGAGTTGGCGCATCA
GGGTTGGAAGGGCCCCAGGGTACAGCATGTGGGTGCCTGTTCCTTTGTGGACTTGTGTGTGTGTGGCTGGTGGGGCGGGGGGTGGATTCT
GGTTCTTTTTTTTCCCATTATCCTGAGAGCCTTAAGGTACTCAGTGTGTTGGTGAGACTCAGCCCTGTCATCTAGCAGAAGTGTGTTCCT
TTTCATTGCTGTATAGTATTCCATTGCATGACTGTCCTGTGCTCTGATTTTAATGCACTTTATTGTGGGTGGATATTTGAGTTGCTTCCT
TTCTGGGGTAATAACACTCACTTGGAAATAGCTGTGGTGAACACTCGTGTGGGGGTGGGGGTGGGGGCCAACTCTAGGAGCACCTAATGG
ATCTTACGAAGCGTGTTGTCCAAGTATAGAGATGATTCCAAAGTGGTTGGACTGTGTTTCTTTCTCCCAGCTGGGTGGAAGGAGAACACT
AGTGGATTGCTGAGACTTGGTGCTCGGTATTTTTAATTATGGACAGCCTGGCTGGCGTTTTGTGGTGTCTAATTGCGGAGTAGCGTGTCT
TACTGTATAATGGCCTCTTTTGTATGTGGGAGACCATGGTGTTGAGGGGAGGCAGTTACACAAAAAACCCAGATACCGAGTGTTAGTTCC
ATGGGTGTGGCTGGTCATGGTGCGCACTCACGAAGGATGTAGGTGATGCCCTCCACTCCGCAGAGCCAGTCCCACAGGGGTACCCATTCT
GACTCCTACCACCGCAGCTCCCTACCTCCCGCCTGCCATGGGTTCCACGTGCATGGCTCTGGGCAGTCTGTGTCTTTGCGTGCGTCTGTG
TATGTCTGCGTGTATCTGCTTACATTCGCTCAGCATCTGAGATTCACCCAGGCTTTTGCGTGGATCAGCGGCAGACTCCTGATTGCCGCG
TGGCGGCCTGTTGTGTGGGTGTGTGCCGCGTGTGTATCCAGTCCCTACTCAGGAGTGTACGTTTCCAGTGTGGGTTGCAGTCAGGATCCA
TTTCTCCCTTAACTTTCAGATTATTTGCTGCATAGGCTTTTTTCTCCTAATTTGGCGCCTTTGTCAGAAATCAACTGACCTACCTGTGTG
GGTCTGTTTCTGTTTGTCCTTACGCTCTTGCCATTGCCACACTTTAGACAAGGTCTTGCTCTGTCCCTCAGGCTGGAGTGCAGTAGCGTG
ATCTCAGCTCACTGCACCCTTGACCTCCCATACTCCAGCAATCCCCTCGCCTCAGTCTCCTGAGTAGTAGCTGCGACCACAGGCGTGTGT
CACCACACCCGGCTGATTTTATTTTTTTTATTTTTATTTTTTTTGTAGAGACGGGGTTTTACTATGTTGCCCAGGCAGGTCTTGATCTGG
GCTCAAGTGATGCTCCTGTCTCAGCCTCCCAAACTACTGGGATTACAGGTTGTAGGTGTGAGCCATGGTGCCCGGCCGCCACACTGTCTT
GGCTACAGTTGGGTTTATAATAAACCCTGAATCGAGGTGATGTGCATTTTCCAACTCTTCTTTTTAAAGATTCTTGTGGCTGTTTATGTC
CTTGGTGTTTCCATATATGTTTTACAATCAGTGTCTCAATTTCTACCAAAAAAACATGCCTTCTGGAATTTCAATAGCAATTCCCTTGAA
CGCATTTTTGAATACCTTTTCTGAATGTCTTGAATACATGTTGGGAAGAATCGGTGTCTTAACAGTCTCCAGTGTCCACGCGTTGACTGC
CGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCC
AGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAG
TCGGCGTCTCAGCAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTG
ACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAG
TCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGAC
TCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACG
CGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTC
AACAGTCTCCGGTGTCCATGCGTTGACTGCCATGTATGACTCCAGGTATTGAGTTCATCTTCAACTTCTCCCAACAATGAACTGGAGTTT
TCTGTGCATGTGTCTGGCATGTTTTCCTTTAGATCTAGTCCTAGGTGTTCGATATGCTATTGAGGACTGTGTATTTTTATTTCATTTGTC
ACCTGTGCGTGGTGCTTTAATCCTGTGCCCTAAACTCCCGCCTTGGCCATGGCGGTGTTTCTGTGGACTCGTGGGGTTTCCGTGTGCACA
CGCGTGTCCTCTGTCTGACAGTGGCTTTGCTTCCCCTTGTCAGTCTGTGCCTCGGCTTCTCACTGCACTGGTGAGGTGAGCCGGCGCTCG
CTAATCTTATTCCCAGTCTCGGTGAACATGGGCTCAGTCTCTCCCGGCTCAGTGTTGGGTTTGCACTGGTGCACTTACAGGCAGAAGAGC
TTCCTCATTTGCTGAGGGCTTTTCCTGAATCCGTGTTGAATGTGGTCAGCTGCCTTTCCTGCACCTAGTGAGATGCTCATGAGGTCACTT
CCTTACCGCATTACTGTAGTGAATTACGCTGACTTTCATATGCCAAGATGACCTGGCATTTCCAGGTAAGTCCCTGTGGCCATGGTGCAT
TGGCCTTTTCTCTGCATGGCCAGATGAGATTTGCTCATACCGGGCTAAGGACCTCCTGTGTAGGAATGCTCTTGAGGGACACTGGGCTTG
GATGTTCATTGTCTTGTCATGTGATGTGTCTGTCATGGTTTGATATTGCATTAAGTGGGCCTCCTGAAACAAGTTCTGCCATAGTTTGTA
TAGGATTGGCATTATTTGTTTCATAGAGATGTGATGGGTGAGGCCATCTATGCCTGCCATTTTCTTTTTGCTTAGGTTTTTCATTAAGAA
CTTGATTTTTAAAAATAGACATGAGGCCTGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAACGTGGATGGATCACCT
GAGGTCAGGAGTTTGAGACCAACCTAGTCAACATGGTGAAACCCCGTCTCCATTAAAAATATAAAAATTAGCAGGGTGTGGTGGTGCATG
CCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACTG
CACTCCAGCCTGGGCAACAGAGCGAGGCTCTGTCTCAAAAAAAAAGACATGAGGCTTTTGGATTTTCTGTTTCTTCCTTTGTCATTTTTT
TAAAGATAGGTTTGTCGCAGAATTTCATCTAAGTTATCAAAACAATTTACATAAATCATTCACAGTATCCTCTGTGCAGTGATGTCCATT
CTCATTCCTGCTCTGGGCCATTTGTGTTTTCTTTTCCCCCTGATCAGACTAGCTAAGAGTTTATCATTTTTACAGATATTTTCCCCAAAG
AAACCTACTTTTGGGTCCATTGATTTTTTTTTTCTATTGTTTTCTTTTTCATTGACTTTTGCTCTTTTCTTATGAATTTCCTTTCTTCTA
CCTATTTTGTGTTCAATTTGCTGTCCTTGTTTTAGGTTCTTTTGATAGAGGCTTAGATCATTGATGAAGAATATGAAAGAATGGGATAAT
ACAGTTAAAAACTTGGTCTACTTATGCCCATTAGAGAAAACATTCTTAAGCACGCATGGAATCTTTTAAAAATGGACGAGGTACTAGGAC
CCAAAGCAAATGTCAGTAATTCGCAGATGATAATGTATAAATATATGATATGTAGGTAAATAATACAAATCACATTCTTTGGCCAGAGTG
CAATTGAGGAGGAAATCAGTAACAAAAAGACAATTAAATCCATTTGATTCTTTTGTTTTCGTTTTGTAGTAACTTGCACTTCCCTGGTGC
CAGAGGCATGACACCTTTTTGTCTGCTCTTGGCCATTTGGGTGGCGTCTTTGGGAAGGGCCTACTTAATTCTTTTGCCTATTTAAAAAAC
TGGGTCTTGGAAATCTTGTCTTTTTTTTTGAGTCAGGATCTTTCTCGCACAGGCTTGGAGTGCAGTGGTGCGATCATAGCTCACTGCAAC
CTCAAACTCCTGGGCTCAAGCGAGCCTCCCACCTCGGTCTTCTGAGTAGCTGGGACTACAGGCATGCATCACTATGCTCTGCTAATTTAA
AGAAAAGGTTTTTTTTATAGAGACTGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCGGAGTCCTGGTCTCAAGTGATTCACCTGCCTCCAC
CTCGCGGAGTGCCAGGATTACAGGTGGCGGGAGCCGCCACACCCAGCCTGGTCTTAGCGTTATTCCCAGGTCTAGGTGTGAGTCCTTCCT
CAGATATGTGTTGTGAATAATTTCCGATCCTCTGGCTTGCTATTTTACTTTCTTAATGGTTATCTTTTGGAAAGCAAAGGTTTCCAGTTT
GATGAAATCTAATTTTTATTTTTTATTTTTCCGTTCTAGTGGTCTTTCTATTTTCTCATCAAATTGAGACTTTGGGGAAACTACACAGCA
GCAAACCAGGATATATCCTCTTAAAAACAGCTCGAGCCGGCCGGGTGCGGTGGCTCATGCCTGGAATCCCAGCACTTTGGGAGGTGGAGG
TGGGCGGATCACGTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAAAAAATTAGCCAGGC
ATGGTGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGA

>In-frame_LDLR_ENST00000545707_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_6814nt
GTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGG
GGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCTGTCC
GGCAGGATCTCCAGAGCTCGGCACAACGAACTCTGAAGGCATTGGGGAGCCCAGCCCGGCAGGGAAGAGGCCAGCGTGAAGGACCTGGGC
TCTTGGCCGTGGCATTTCCGTGGACAGCCCGCCGTCAGGGTGGCTGGGGCTGGCACGGGTGTCGAGGCAGGAAGGATTGTTTCTGGTGAC
TGCAGCCGCTGCCGTCGCGACACAGGGCTTGGTGGTGGTAGCATTTGGGTCTGAGATCGGCCCAGCTCTGACTGAAGGGGCTTGGCTTCC
ACTCAGCATCAGCGTGGCAGTCACCACCCCAGTGAGGACCTCGATGTCCAGCTGCTGTCAGGTCTGATAGTCCTCTGCTAAAACAACACG
ATTTACATAAAAAATCTTACACATCTGCCACCGGAAATACCATGCACAGAGTCCTTAAAAAATAGAGTGCAGTATTTAAACCACCCGCTT
GTTGGCTGGTCACTAAGTGTCCTGGTGGCTGGGGCCGGAGCCAGTGCTCTTGAAGGGATCGCGTCATAGCCAGCTTCCCCTCTGGGCCCT
GTGGGTCTTTGCAGCCAACCTCCTTTTCCCGTGAGACGGCCCGGCCTGATTTAAAGCCAAGAGCGCTTGAGTTGAGTTTGAGGGGAAGAT
GTGGAGCGTGTGGTTCTGTGGACAGTCAGAGACTGTGGCCTGGGGGCAGCGTCTTTCAACTCTCACCTCTGCAGCTCAGGGACCTCGGGA
GACCTCACCAAACCTGCAGGGCCTCCGTGTCCCTAAGTGTGCTGTGTAAATGCCCCATCTCATGGGGGAGAGACAGCCACGGAGGCCTTC
CTCTGACCATAGCTGATGGACTGGCGGTTGCTCAGGTCCGGCTCCGAGAATGTTCCTGTGTCTGAGCCTGGAAGAGGCTCGGGTCTGGCT
CCAGGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAG
AGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCG
TGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGG
CGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGGCGTGGTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGT
CCGGGTCCAGCTCCGAGCGTGGTTCCCGTGTTTGAACCTGGAAGAGGCTCCACCAGGCGTATTGTGTTTTGACTGCAGCTGGATCTTGGC
TTGACTGTTGAGATCTGCCAAACATCCGCTAAGCTATCATTTCTGAGAAAGGTCAAGGCTAGAGGCAGCATGTCGGGAGTTGGCGCATCA
GGGTTGGAAGGGCCCCAGGGTACAGCATGTGGGTGCCTGTTCCTTTGTGGACTTGTGTGTGTGTGGCTGGTGGGGCGGGGGGTGGATTCT
GGTTCTTTTTTTTCCCATTATCCTGAGAGCCTTAAGGTACTCAGTGTGTTGGTGAGACTCAGCCCTGTCATCTAGCAGAAGTGTGTTCCT
TTTCATTGCTGTATAGTATTCCATTGCATGACTGTCCTGTGCTCTGATTTTAATGCACTTTATTGTGGGTGGATATTTGAGTTGCTTCCT
TTCTGGGGTAATAACACTCACTTGGAAATAGCTGTGGTGAACACTCGTGTGGGGGTGGGGGTGGGGGCCAACTCTAGGAGCACCTAATGG
ATCTTACGAAGCGTGTTGTCCAAGTATAGAGATGATTCCAAAGTGGTTGGACTGTGTTTCTTTCTCCCAGCTGGGTGGAAGGAGAACACT
AGTGGATTGCTGAGACTTGGTGCTCGGTATTTTTAATTATGGACAGCCTGGCTGGCGTTTTGTGGTGTCTAATTGCGGAGTAGCGTGTCT
TACTGTATAATGGCCTCTTTTGTATGTGGGAGACCATGGTGTTGAGGGGAGGCAGTTACACAAAAAACCCAGATACCGAGTGTTAGTTCC
ATGGGTGTGGCTGGTCATGGTGCGCACTCACGAAGGATGTAGGTGATGCCCTCCACTCCGCAGAGCCAGTCCCACAGGGGTACCCATTCT
GACTCCTACCACCGCAGCTCCCTACCTCCCGCCTGCCATGGGTTCCACGTGCATGGCTCTGGGCAGTCTGTGTCTTTGCGTGCGTCTGTG
TATGTCTGCGTGTATCTGCTTACATTCGCTCAGCATCTGAGATTCACCCAGGCTTTTGCGTGGATCAGCGGCAGACTCCTGATTGCCGCG
TGGCGGCCTGTTGTGTGGGTGTGTGCCGCGTGTGTATCCAGTCCCTACTCAGGAGTGTACGTTTCCAGTGTGGGTTGCAGTCAGGATCCA
TTTCTCCCTTAACTTTCAGATTATTTGCTGCATAGGCTTTTTTCTCCTAATTTGGCGCCTTTGTCAGAAATCAACTGACCTACCTGTGTG
GGTCTGTTTCTGTTTGTCCTTACGCTCTTGCCATTGCCACACTTTAGACAAGGTCTTGCTCTGTCCCTCAGGCTGGAGTGCAGTAGCGTG
ATCTCAGCTCACTGCACCCTTGACCTCCCATACTCCAGCAATCCCCTCGCCTCAGTCTCCTGAGTAGTAGCTGCGACCACAGGCGTGTGT
CACCACACCCGGCTGATTTTATTTTTTTTATTTTTATTTTTTTTGTAGAGACGGGGTTTTACTATGTTGCCCAGGCAGGTCTTGATCTGG
GCTCAAGTGATGCTCCTGTCTCAGCCTCCCAAACTACTGGGATTACAGGTTGTAGGTGTGAGCCATGGTGCCCGGCCGCCACACTGTCTT
GGCTACAGTTGGGTTTATAATAAACCCTGAATCGAGGTGATGTGCATTTTCCAACTCTTCTTTTTAAAGATTCTTGTGGCTGTTTATGTC
CTTGGTGTTTCCATATATGTTTTACAATCAGTGTCTCAATTTCTACCAAAAAAACATGCCTTCTGGAATTTCAATAGCAATTCCCTTGAA
CGCATTTTTGAATACCTTTTCTGAATGTCTTGAATACATGTTGGGAAGAATCGGTGTCTTAACAGTCTCCAGTGTCCACGCGTTGACTGC
CGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCC
AGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAG
TCGGCGTCTCAGCAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTG
ACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAG
TCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGAC
TCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACG
CGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTC
AACAGTCTCCGGTGTCCATGCGTTGACTGCCATGTATGACTCCAGGTATTGAGTTCATCTTCAACTTCTCCCAACAATGAACTGGAGTTT
TCTGTGCATGTGTCTGGCATGTTTTCCTTTAGATCTAGTCCTAGGTGTTCGATATGCTATTGAGGACTGTGTATTTTTATTTCATTTGTC
ACCTGTGCGTGGTGCTTTAATCCTGTGCCCTAAACTCCCGCCTTGGCCATGGCGGTGTTTCTGTGGACTCGTGGGGTTTCCGTGTGCACA
CGCGTGTCCTCTGTCTGACAGTGGCTTTGCTTCCCCTTGTCAGTCTGTGCCTCGGCTTCTCACTGCACTGGTGAGGTGAGCCGGCGCTCG
CTAATCTTATTCCCAGTCTCGGTGAACATGGGCTCAGTCTCTCCCGGCTCAGTGTTGGGTTTGCACTGGTGCACTTACAGGCAGAAGAGC
TTCCTCATTTGCTGAGGGCTTTTCCTGAATCCGTGTTGAATGTGGTCAGCTGCCTTTCCTGCACCTAGTGAGATGCTCATGAGGTCACTT
CCTTACCGCATTACTGTAGTGAATTACGCTGACTTTCATATGCCAAGATGACCTGGCATTTCCAGGTAAGTCCCTGTGGCCATGGTGCAT
TGGCCTTTTCTCTGCATGGCCAGATGAGATTTGCTCATACCGGGCTAAGGACCTCCTGTGTAGGAATGCTCTTGAGGGACACTGGGCTTG
GATGTTCATTGTCTTGTCATGTGATGTGTCTGTCATGGTTTGATATTGCATTAAGTGGGCCTCCTGAAACAAGTTCTGCCATAGTTTGTA
TAGGATTGGCATTATTTGTTTCATAGAGATGTGATGGGTGAGGCCATCTATGCCTGCCATTTTCTTTTTGCTTAGGTTTTTCATTAAGAA
CTTGATTTTTAAAAATAGACATGAGGCCTGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAACGTGGATGGATCACCT
GAGGTCAGGAGTTTGAGACCAACCTAGTCAACATGGTGAAACCCCGTCTCCATTAAAAATATAAAAATTAGCAGGGTGTGGTGGTGCATG
CCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACTG
CACTCCAGCCTGGGCAACAGAGCGAGGCTCTGTCTCAAAAAAAAAGACATGAGGCTTTTGGATTTTCTGTTTCTTCCTTTGTCATTTTTT
TAAAGATAGGTTTGTCGCAGAATTTCATCTAAGTTATCAAAACAATTTACATAAATCATTCACAGTATCCTCTGTGCAGTGATGTCCATT
CTCATTCCTGCTCTGGGCCATTTGTGTTTTCTTTTCCCCCTGATCAGACTAGCTAAGAGTTTATCATTTTTACAGATATTTTCCCCAAAG
AAACCTACTTTTGGGTCCATTGATTTTTTTTTTCTATTGTTTTCTTTTTCATTGACTTTTGCTCTTTTCTTATGAATTTCCTTTCTTCTA
CCTATTTTGTGTTCAATTTGCTGTCCTTGTTTTAGGTTCTTTTGATAGAGGCTTAGATCATTGATGAAGAATATGAAAGAATGGGATAAT
ACAGTTAAAAACTTGGTCTACTTATGCCCATTAGAGAAAACATTCTTAAGCACGCATGGAATCTTTTAAAAATGGACGAGGTACTAGGAC
CCAAAGCAAATGTCAGTAATTCGCAGATGATAATGTATAAATATATGATATGTAGGTAAATAATACAAATCACATTCTTTGGCCAGAGTG
CAATTGAGGAGGAAATCAGTAACAAAAAGACAATTAAATCCATTTGATTCTTTTGTTTTCGTTTTGTAGTAACTTGCACTTCCCTGGTGC
CAGAGGCATGACACCTTTTTGTCTGCTCTTGGCCATTTGGGTGGCGTCTTTGGGAAGGGCCTACTTAATTCTTTTGCCTATTTAAAAAAC
TGGGTCTTGGAAATCTTGTCTTTTTTTTTGAGTCAGGATCTTTCTCGCACAGGCTTGGAGTGCAGTGGTGCGATCATAGCTCACTGCAAC
CTCAAACTCCTGGGCTCAAGCGAGCCTCCCACCTCGGTCTTCTGAGTAGCTGGGACTACAGGCATGCATCACTATGCTCTGCTAATTTAA
AGAAAAGGTTTTTTTTATAGAGACTGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCGGAGTCCTGGTCTCAAGTGATTCACCTGCCTCCAC
CTCGCGGAGTGCCAGGATTACAGGTGGCGGGAGCCGCCACACCCAGCCTGGTCTTAGCGTTATTCCCAGGTCTAGGTGTGAGTCCTTCCT
CAGATATGTGTTGTGAATAATTTCCGATCCTCTGGCTTGCTATTTTACTTTCTTAATGGTTATCTTTTGGAAAGCAAAGGTTTCCAGTTT
GATGAAATCTAATTTTTATTTTTTATTTTTCCGTTCTAGTGGTCTTTCTATTTTCTCATCAAATTGAGACTTTGGGGAAACTACACAGCA
GCAAACCAGGATATATCCTCTTAAAAACAGCTCGAGCCGGCCGGGTGCGGTGGCTCATGCCTGGAATCCCAGCACTTTGGGAGGTGGAGG
TGGGCGGATCACGTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAAAAAATTAGCCAGGC
ATGGTGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGA

>In-frame_LDLR_ENST00000558013_chr19_11200291_+_LRPAP1_ENST00000500728_chr4_3514763_-_6799nt
GCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGGGGCCCTGGGGCTGGA
AATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCTGTCCGGCAGGATCTCCAGA
GCTCGGCACAACGAACTCTGAAGGCATTGGGGAGCCCAGCCCGGCAGGGAAGAGGCCAGCGTGAAGGACCTGGGCTCTTGGCCGTGGCAT
TTCCGTGGACAGCCCGCCGTCAGGGTGGCTGGGGCTGGCACGGGTGTCGAGGCAGGAAGGATTGTTTCTGGTGACTGCAGCCGCTGCCGT
CGCGACACAGGGCTTGGTGGTGGTAGCATTTGGGTCTGAGATCGGCCCAGCTCTGACTGAAGGGGCTTGGCTTCCACTCAGCATCAGCGT
GGCAGTCACCACCCCAGTGAGGACCTCGATGTCCAGCTGCTGTCAGGTCTGATAGTCCTCTGCTAAAACAACACGATTTACATAAAAAAT
CTTACACATCTGCCACCGGAAATACCATGCACAGAGTCCTTAAAAAATAGAGTGCAGTATTTAAACCACCCGCTTGTTGGCTGGTCACTA
AGTGTCCTGGTGGCTGGGGCCGGAGCCAGTGCTCTTGAAGGGATCGCGTCATAGCCAGCTTCCCCTCTGGGCCCTGTGGGTCTTTGCAGC
CAACCTCCTTTTCCCGTGAGACGGCCCGGCCTGATTTAAAGCCAAGAGCGCTTGAGTTGAGTTTGAGGGGAAGATGTGGAGCGTGTGGTT
CTGTGGACAGTCAGAGACTGTGGCCTGGGGGCAGCGTCTTTCAACTCTCACCTCTGCAGCTCAGGGACCTCGGGAGACCTCACCAAACCT
GCAGGGCCTCCGTGTCCCTAAGTGTGCTGTGTAAATGCCCCATCTCATGGGGGAGAGACAGCCACGGAGGCCTTCCTCTGACCATAGCTG
ATGGACTGGCGGTTGCTCAGGTCCGGCTCCGAGAATGTTCCTGTGTCTGAGCCTGGAAGAGGCTCGGGTCTGGCTCCAGGCGTGGTTCCC
TTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGC
TCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAA
GAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGGCGTGGTTCCCTTCCC
GTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGGCGTGGTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGGTCCAGCTCCG
AGCGTGGTTCCCGTGTTTGAACCTGGAAGAGGCTCCACCAGGCGTATTGTGTTTTGACTGCAGCTGGATCTTGGCTTGACTGTTGAGATC
TGCCAAACATCCGCTAAGCTATCATTTCTGAGAAAGGTCAAGGCTAGAGGCAGCATGTCGGGAGTTGGCGCATCAGGGTTGGAAGGGCCC
CAGGGTACAGCATGTGGGTGCCTGTTCCTTTGTGGACTTGTGTGTGTGTGGCTGGTGGGGCGGGGGGTGGATTCTGGTTCTTTTTTTTCC
CATTATCCTGAGAGCCTTAAGGTACTCAGTGTGTTGGTGAGACTCAGCCCTGTCATCTAGCAGAAGTGTGTTCCTTTTCATTGCTGTATA
GTATTCCATTGCATGACTGTCCTGTGCTCTGATTTTAATGCACTTTATTGTGGGTGGATATTTGAGTTGCTTCCTTTCTGGGGTAATAAC
ACTCACTTGGAAATAGCTGTGGTGAACACTCGTGTGGGGGTGGGGGTGGGGGCCAACTCTAGGAGCACCTAATGGATCTTACGAAGCGTG
TTGTCCAAGTATAGAGATGATTCCAAAGTGGTTGGACTGTGTTTCTTTCTCCCAGCTGGGTGGAAGGAGAACACTAGTGGATTGCTGAGA
CTTGGTGCTCGGTATTTTTAATTATGGACAGCCTGGCTGGCGTTTTGTGGTGTCTAATTGCGGAGTAGCGTGTCTTACTGTATAATGGCC
TCTTTTGTATGTGGGAGACCATGGTGTTGAGGGGAGGCAGTTACACAAAAAACCCAGATACCGAGTGTTAGTTCCATGGGTGTGGCTGGT
CATGGTGCGCACTCACGAAGGATGTAGGTGATGCCCTCCACTCCGCAGAGCCAGTCCCACAGGGGTACCCATTCTGACTCCTACCACCGC
AGCTCCCTACCTCCCGCCTGCCATGGGTTCCACGTGCATGGCTCTGGGCAGTCTGTGTCTTTGCGTGCGTCTGTGTATGTCTGCGTGTAT
CTGCTTACATTCGCTCAGCATCTGAGATTCACCCAGGCTTTTGCGTGGATCAGCGGCAGACTCCTGATTGCCGCGTGGCGGCCTGTTGTG
TGGGTGTGTGCCGCGTGTGTATCCAGTCCCTACTCAGGAGTGTACGTTTCCAGTGTGGGTTGCAGTCAGGATCCATTTCTCCCTTAACTT
TCAGATTATTTGCTGCATAGGCTTTTTTCTCCTAATTTGGCGCCTTTGTCAGAAATCAACTGACCTACCTGTGTGGGTCTGTTTCTGTTT
GTCCTTACGCTCTTGCCATTGCCACACTTTAGACAAGGTCTTGCTCTGTCCCTCAGGCTGGAGTGCAGTAGCGTGATCTCAGCTCACTGC
ACCCTTGACCTCCCATACTCCAGCAATCCCCTCGCCTCAGTCTCCTGAGTAGTAGCTGCGACCACAGGCGTGTGTCACCACACCCGGCTG
ATTTTATTTTTTTTATTTTTATTTTTTTTGTAGAGACGGGGTTTTACTATGTTGCCCAGGCAGGTCTTGATCTGGGCTCAAGTGATGCTC
CTGTCTCAGCCTCCCAAACTACTGGGATTACAGGTTGTAGGTGTGAGCCATGGTGCCCGGCCGCCACACTGTCTTGGCTACAGTTGGGTT
TATAATAAACCCTGAATCGAGGTGATGTGCATTTTCCAACTCTTCTTTTTAAAGATTCTTGTGGCTGTTTATGTCCTTGGTGTTTCCATA
TATGTTTTACAATCAGTGTCTCAATTTCTACCAAAAAAACATGCCTTCTGGAATTTCAATAGCAATTCCCTTGAACGCATTTTTGAATAC
CTTTTCTGAATGTCTTGAATACATGTTGGGAAGAATCGGTGTCTTAACAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAG
TCGGCGTCTCAACAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCCAGTGTCCACGCGTTG
ACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAG
TCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGAC
TCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACG
CGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTC
AACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGT
GTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGT
CCATGCGTTGACTGCCATGTATGACTCCAGGTATTGAGTTCATCTTCAACTTCTCCCAACAATGAACTGGAGTTTTCTGTGCATGTGTCT
GGCATGTTTTCCTTTAGATCTAGTCCTAGGTGTTCGATATGCTATTGAGGACTGTGTATTTTTATTTCATTTGTCACCTGTGCGTGGTGC
TTTAATCCTGTGCCCTAAACTCCCGCCTTGGCCATGGCGGTGTTTCTGTGGACTCGTGGGGTTTCCGTGTGCACACGCGTGTCCTCTGTC
TGACAGTGGCTTTGCTTCCCCTTGTCAGTCTGTGCCTCGGCTTCTCACTGCACTGGTGAGGTGAGCCGGCGCTCGCTAATCTTATTCCCA
GTCTCGGTGAACATGGGCTCAGTCTCTCCCGGCTCAGTGTTGGGTTTGCACTGGTGCACTTACAGGCAGAAGAGCTTCCTCATTTGCTGA
GGGCTTTTCCTGAATCCGTGTTGAATGTGGTCAGCTGCCTTTCCTGCACCTAGTGAGATGCTCATGAGGTCACTTCCTTACCGCATTACT
GTAGTGAATTACGCTGACTTTCATATGCCAAGATGACCTGGCATTTCCAGGTAAGTCCCTGTGGCCATGGTGCATTGGCCTTTTCTCTGC
ATGGCCAGATGAGATTTGCTCATACCGGGCTAAGGACCTCCTGTGTAGGAATGCTCTTGAGGGACACTGGGCTTGGATGTTCATTGTCTT
GTCATGTGATGTGTCTGTCATGGTTTGATATTGCATTAAGTGGGCCTCCTGAAACAAGTTCTGCCATAGTTTGTATAGGATTGGCATTAT
TTGTTTCATAGAGATGTGATGGGTGAGGCCATCTATGCCTGCCATTTTCTTTTTGCTTAGGTTTTTCATTAAGAACTTGATTTTTAAAAA
TAGACATGAGGCCTGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAACGTGGATGGATCACCTGAGGTCAGGAGTTTG
AGACCAACCTAGTCAACATGGTGAAACCCCGTCTCCATTAAAAATATAAAAATTAGCAGGGTGTGGTGGTGCATGCCTGTAATCCCAGCT
ACTCTGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACTGCACTCCAGCCTGGGC
AACAGAGCGAGGCTCTGTCTCAAAAAAAAAGACATGAGGCTTTTGGATTTTCTGTTTCTTCCTTTGTCATTTTTTTAAAGATAGGTTTGT
CGCAGAATTTCATCTAAGTTATCAAAACAATTTACATAAATCATTCACAGTATCCTCTGTGCAGTGATGTCCATTCTCATTCCTGCTCTG
GGCCATTTGTGTTTTCTTTTCCCCCTGATCAGACTAGCTAAGAGTTTATCATTTTTACAGATATTTTCCCCAAAGAAACCTACTTTTGGG
TCCATTGATTTTTTTTTTCTATTGTTTTCTTTTTCATTGACTTTTGCTCTTTTCTTATGAATTTCCTTTCTTCTACCTATTTTGTGTTCA
ATTTGCTGTCCTTGTTTTAGGTTCTTTTGATAGAGGCTTAGATCATTGATGAAGAATATGAAAGAATGGGATAATACAGTTAAAAACTTG
GTCTACTTATGCCCATTAGAGAAAACATTCTTAAGCACGCATGGAATCTTTTAAAAATGGACGAGGTACTAGGACCCAAAGCAAATGTCA
GTAATTCGCAGATGATAATGTATAAATATATGATATGTAGGTAAATAATACAAATCACATTCTTTGGCCAGAGTGCAATTGAGGAGGAAA
TCAGTAACAAAAAGACAATTAAATCCATTTGATTCTTTTGTTTTCGTTTTGTAGTAACTTGCACTTCCCTGGTGCCAGAGGCATGACACC
TTTTTGTCTGCTCTTGGCCATTTGGGTGGCGTCTTTGGGAAGGGCCTACTTAATTCTTTTGCCTATTTAAAAAACTGGGTCTTGGAAATC
TTGTCTTTTTTTTTGAGTCAGGATCTTTCTCGCACAGGCTTGGAGTGCAGTGGTGCGATCATAGCTCACTGCAACCTCAAACTCCTGGGC
TCAAGCGAGCCTCCCACCTCGGTCTTCTGAGTAGCTGGGACTACAGGCATGCATCACTATGCTCTGCTAATTTAAAGAAAAGGTTTTTTT
TATAGAGACTGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCGGAGTCCTGGTCTCAAGTGATTCACCTGCCTCCACCTCGCGGAGTGCCAG
GATTACAGGTGGCGGGAGCCGCCACACCCAGCCTGGTCTTAGCGTTATTCCCAGGTCTAGGTGTGAGTCCTTCCTCAGATATGTGTTGTG
AATAATTTCCGATCCTCTGGCTTGCTATTTTACTTTCTTAATGGTTATCTTTTGGAAAGCAAAGGTTTCCAGTTTGATGAAATCTAATTT
TTATTTTTTATTTTTCCGTTCTAGTGGTCTTTCTATTTTCTCATCAAATTGAGACTTTGGGGAAACTACACAGCAGCAAACCAGGATATA
TCCTCTTAAAAACAGCTCGAGCCGGCCGGGTGCGGTGGCTCATGCCTGGAATCCCAGCACTTTGGGAGGTGGAGGTGGGCGGATCACGTG
AGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAAAAAATTAGCCAGGCATGGTGGCAGGCACC
TGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCGCCATTGCA


Top

FusionGenePPI for LDLR_LRPAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LDLRDAB1, PF4, CD36, DAB2, AP1M2, LDLRAP1, LRPAP1, SNX17, HSPA5, MYLIP, HSP90B1, PDIA4, CANX, PDIA3, CREBBP, MAP4, PCSK9, GINM1, B3GNT2, ZFP41, PRG2, CBR3, USP2, FAM19A3, FCGRT, ZNF408, PRG3, DLK2, TYW3, MGAT4C, DEFA1, UST, EGFL6, WNT7ALRPAP1LRP8, VLDLR, POLA2, RTN4, RAF1, RALGDS, SORL1, EIF4EBP1, MTOR, LRP2, LRP1, SORT1, LDLR, RANBP2, ETV7, TCTN3, TCTN1, LRP1B, LRP4, ROCK2, LCOR, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LDLR_LRPAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneLDLRP01130DB00707Porfimer sodiumLow-density lipoprotein receptorsmall moleculeapproved|investigational

Top

RelatedDiseases for LDLR_LRPAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLDLRC0745103Hyperlipoproteinemia Type IIa32CTD_human;ORPHANET;UNIPROT
HgeneLDLRC0020445Hypercholesterolemia, Familial6CTD_human;HPO
HgeneLDLRC0004153Atherosclerosis4CTD_human
HgeneLDLRC0020443Hypercholesterolemia4CTD_human;HPO
HgeneLDLRC0400966Non-alcoholic Fatty Liver Disease3CTD_human
HgeneLDLRC0020473Hyperlipidemia2CTD_human;HPO
HgeneLDLRC1956346Coronary Artery Disease2CTD_human
HgeneLDLRC0010068Coronary heart disease1CTD_human
HgeneLDLRC0015695Fatty Liver1CTD_human
HgeneLDLRC0020507Hyperplasia1CTD_human
HgeneLDLRC0028754Obesity1CTD_human
HgeneLDLRC0034362Q Fever1CTD_human
HgeneLDLRC0085762Alcohol abuse1PSYGENET
HgeneLDLRC0242339Dyslipidemias1CTD_human
HgeneLDLRC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human