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Fusion gene ID: 19588 |
FusionGeneSummary for LDLR_CALR |
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Fusion gene information | Fusion gene name: LDLR_CALR | Fusion gene ID: 19588 | Hgene | Tgene | Gene symbol | LDLR | CALR | Gene ID | 3949 | 811 |
Gene name | low density lipoprotein receptor | calreticulin | |
Synonyms | FH|FHC|LDLCQ2 | CRT|HEL-S-99n|RO|SSA|cC1qR | |
Cytomap | 19p13.2 | 19p13.13 | |
Type of gene | protein-coding | protein-coding | |
Description | low-density lipoprotein receptorLDL receptorlow-density lipoprotein receptor class A domain-containing protein 3 | calreticulinCRP55ERp60HACBPSicca syndrome antigen A (autoantigen Ro; calreticulin)calregulinendoplasmic reticulum resident protein 60epididymis secretory sperm binding protein Li 99ngrp60 | |
Modification date | 20180520 | 20180527 | |
UniProtAcc | P01130 | P27797 | |
Ensembl transtripts involved in fusion gene | ENST00000558518, ENST00000557933, ENST00000455727, ENST00000535915, ENST00000545707, ENST00000558013, ENST00000560628, | ENST00000316448, | |
Fusion gene scores | * DoF score | 14 X 9 X 11=1386 | 12 X 15 X 3=540 |
# samples | 17 | 18 | |
** MAII score | log2(17/1386*10)=-3.02732060599951 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/540*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LDLR [Title/Abstract] AND CALR [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CALR | GO:0000122 | negative regulation of transcription by RNA polymerase II | 8107809 |
Tgene | CALR | GO:0006611 | protein export from nucleus | 11149926 |
Tgene | CALR | GO:0017148 | negative regulation of translation | 14726956 |
Tgene | CALR | GO:0033144 | negative regulation of intracellular steroid hormone receptor signaling pathway | 8107809 |
Tgene | CALR | GO:0034504 | protein localization to nucleus | 15998798 |
Tgene | CALR | GO:0045665 | negative regulation of neuron differentiation | 8107809 |
Tgene | CALR | GO:0045892 | negative regulation of transcription, DNA-templated | 8107809 |
Tgene | CALR | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway | 8107809 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | CESC | TCGA-VS-A8Q9-01A | LDLR | chr19 | 11227674 | + | CALR | chr19 | 13049948 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000558518 | ENST00000316448 | LDLR | chr19 | 11227674 | + | CALR | chr19 | 13049948 | + |
Frame-shift | ENST00000557933 | ENST00000316448 | LDLR | chr19 | 11227674 | + | CALR | chr19 | 13049948 | + |
Frame-shift | ENST00000455727 | ENST00000316448 | LDLR | chr19 | 11227674 | + | CALR | chr19 | 13049948 | + |
Frame-shift | ENST00000535915 | ENST00000316448 | LDLR | chr19 | 11227674 | + | CALR | chr19 | 13049948 | + |
Frame-shift | ENST00000545707 | ENST00000316448 | LDLR | chr19 | 11227674 | + | CALR | chr19 | 13049948 | + |
Frame-shift | ENST00000558013 | ENST00000316448 | LDLR | chr19 | 11227674 | + | CALR | chr19 | 13049948 | + |
intron-3CDS | ENST00000560628 | ENST00000316448 | LDLR | chr19 | 11227674 | + | CALR | chr19 | 13049948 | + |
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FusionProtFeatures for LDLR_CALR |
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Hgene | Tgene |
LDLR | CALR |
Calcium-binding chaperone that promotes folding,oligomeric assembly and quality control in the endoplasmicreticulum (ER) via the calreticulin/calnexin cycle. This lectininteracts transiently with almost all of the monoglucosylatedglycoproteins that are synthesized in the ER. Interacts with theDNA-binding domain of NR3C1 and mediates its nuclear export.Involved in maternal gene expression regulation. May participatein oocyte maturation via the regulation of calcium homeostasis (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:11149926,ECO:0000269|PubMed:7876246}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LDLR_CALR |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LDLR_CALR |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LDLR | DAB1, PF4, CD36, DAB2, AP1M2, LDLRAP1, LRPAP1, SNX17, HSPA5, MYLIP, HSP90B1, PDIA4, CANX, PDIA3, CREBBP, MAP4, PCSK9, GINM1, B3GNT2, ZFP41, PRG2, CBR3, USP2, FAM19A3, FCGRT, ZNF408, PRG3, DLK2, TYW3, MGAT4C, DEFA1, UST, EGFL6, WNT7A | CALR | CD40, ELF3, EPB41, LRP1, PLAT, MBL2, PDIA3, CANX, PRF1, FGB, APP, CD1D, APOB, TAPBP, VWF, AR, F5, NR3C1, TF, SLC6A4, NKX2-1, SLC2A1, H2AFX, PSMA3, LRIF1, SMARCB1, MAPK6, TAP1, ELAVL1, SIRT7, CDK2, GRK5, KCNH2, PRKCSH, GANAB, KRT17, HSP90B1, P4HB, HLA-E, LPL, ATF2, MTNR1A, ITGA3, HLA-A, CALR, CLN5, SOX2, SLC27A2, UPF2, PARK2, AARSD1, ACTR2, ANP32B, ARPC1B, ARPC3, ARPC1A, ARPC5, EEF2K, LPP, RPA3, SH3GLB1, NSUN2, PFDN5, PRKACA, RPA1, SH3GL1, THG1L, TPD52L2, LGR4, HUWE1, CUL7, SUZ12, RNF2, EGFR, INHA, NTM, HSPB1, ATP5B, CALU, EEF2, ENO1, ENO2, ENO3, EZR, HNRNPU, HSP90AB1, MATR3, MSN, PTGES3, RCN1, RDX, TKT, TPT1, VCP, WDR1, YWHAE, MAPRE3, NACA2, PCNA, NTRK1, KRAS, TSHR, PLP1, EWSR1, TCTN3, CNTRL, TCTN1, PPME1, F8, B2M, UBE3A, MCM2, RNY3, RNY1, RNY4, TRIM21, U2AF2, CDC73, HYPK, PTPRN, ACP5, DUSP13, SFRP4, WNT7A, CHI3L1, BMP4, PTPN22, PTPRO, TCTN2, EDEM3, HLA-B, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LDLR_CALR |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | LDLR | P01130 | DB00707 | Porfimer sodium | Low-density lipoprotein receptor | small molecule | approved|investigational |
Tgene | CALR | P27797 | DB00031 | Tenecteplase | Calreticulin | biotech | approved |
Tgene | CALR | P27797 | DB11093 | Calcium Citrate | Calreticulin | small molecule | approved |
Tgene | CALR | P27797 | DB11348 | Calcium Phosphate | Calreticulin | small molecule | approved |
Tgene | CALR | P27797 | DB00025 | Antihemophilic factor, human recombinant | Calreticulin | biotech | approved|investigational |
Tgene | CALR | P27797 | DB01065 | Melatonin | Calreticulin | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for LDLR_CALR |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LDLR | C0745103 | Hyperlipoproteinemia Type IIa | 32 | CTD_human;ORPHANET;UNIPROT |
Hgene | LDLR | C0020445 | Hypercholesterolemia, Familial | 6 | CTD_human;HPO |
Hgene | LDLR | C0004153 | Atherosclerosis | 4 | CTD_human |
Hgene | LDLR | C0020443 | Hypercholesterolemia | 4 | CTD_human;HPO |
Hgene | LDLR | C0400966 | Non-alcoholic Fatty Liver Disease | 3 | CTD_human |
Hgene | LDLR | C0020473 | Hyperlipidemia | 2 | CTD_human;HPO |
Hgene | LDLR | C1956346 | Coronary Artery Disease | 2 | CTD_human |
Hgene | LDLR | C0010068 | Coronary heart disease | 1 | CTD_human |
Hgene | LDLR | C0015695 | Fatty Liver | 1 | CTD_human |
Hgene | LDLR | C0020507 | Hyperplasia | 1 | CTD_human |
Hgene | LDLR | C0028754 | Obesity | 1 | CTD_human |
Hgene | LDLR | C0034362 | Q Fever | 1 | CTD_human |
Hgene | LDLR | C0085762 | Alcohol abuse | 1 | PSYGENET |
Hgene | LDLR | C0242339 | Dyslipidemias | 1 | CTD_human |
Hgene | LDLR | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
Tgene | CALR | C0033975 | Psychotic Disorders | 2 | PSYGENET |
Tgene | CALR | C0036337 | Schizoaffective Disorder | 2 | PSYGENET |
Tgene | CALR | C0349204 | Nonorganic psychosis | 2 | PSYGENET |
Tgene | CALR | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | CALR | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | CALR | C0025205 | Melanoma, Experimental | 1 | CTD_human |
Tgene | CALR | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | CALR | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | CALR | C0033937 | Psychoses, Drug | 1 | PSYGENET |
Tgene | CALR | C0036349 | Paranoid Schizophrenia | 1 | PSYGENET |
Tgene | CALR | C0036939 | Shared Paranoid Disorder | 1 | PSYGENET |
Tgene | CALR | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | CALR | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |