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Fusion gene ID: 19579 |
FusionGeneSummary for LDLRAD4_FAM177A1 |
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Fusion gene information | Fusion gene name: LDLRAD4_FAM177A1 | Fusion gene ID: 19579 | Hgene | Tgene | Gene symbol | LDLRAD4 | FAM177A1 | Gene ID | 753 | 283635 |
Gene name | low density lipoprotein receptor class A domain containing 4 | family with sequence similarity 177 member A1 | |
Synonyms | C18orf1 | C14orf24 | |
Cytomap | 18p11.21 | 14q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | low-density lipoprotein receptor class A domain-containing protein 4clone 22 | protein FAM177A1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O15165 | Q8N128 | |
Ensembl transtripts involved in fusion gene | ENST00000361205, ENST00000399848, ENST00000359446, ENST00000587757, ENST00000585931, ENST00000586765, ENST00000590308, ENST00000592991, | ENST00000396472, ENST00000382406, ENST00000280987, ENST00000554052, | |
Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 7 X 7 X 4=196 |
# samples | 9 | 9 | |
** MAII score | log2(9/147*10)=-0.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/196*10)=-1.12285674778553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LDLRAD4 [Title/Abstract] AND FAM177A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LDLRAD4 | GO:0010991 | negative regulation of SMAD protein complex assembly | 24627487 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BC040538 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000361205 | ENST00000396472 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000361205 | ENST00000382406 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000361205 | ENST00000280987 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000361205 | ENST00000554052 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000399848 | ENST00000396472 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000399848 | ENST00000382406 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000399848 | ENST00000280987 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000399848 | ENST00000554052 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000359446 | ENST00000396472 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000359446 | ENST00000382406 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000359446 | ENST00000280987 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000359446 | ENST00000554052 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000587757 | ENST00000396472 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000587757 | ENST00000382406 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000587757 | ENST00000280987 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000587757 | ENST00000554052 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000585931 | ENST00000396472 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000585931 | ENST00000382406 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000585931 | ENST00000280987 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000585931 | ENST00000554052 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000586765 | ENST00000396472 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000586765 | ENST00000382406 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000586765 | ENST00000280987 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000586765 | ENST00000554052 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000590308 | ENST00000396472 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000590308 | ENST00000382406 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000590308 | ENST00000280987 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000590308 | ENST00000554052 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000592991 | ENST00000396472 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000592991 | ENST00000382406 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-3UTR | ENST00000592991 | ENST00000280987 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
intron-intron | ENST00000592991 | ENST00000554052 | LDLRAD4 | chr18 | 13329979 | + | FAM177A1 | chr14 | 35551705 | + |
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FusionProtFeatures for LDLRAD4_FAM177A1 |
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Hgene | Tgene |
LDLRAD4 | FAM177A1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LDLRAD4_FAM177A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LDLRAD4_FAM177A1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LDLRAD4_FAM177A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LDLRAD4_FAM177A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |