FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 19579

FusionGeneSummary for LDLRAD4_FAM177A1

check button Fusion gene summary
Fusion gene informationFusion gene name: LDLRAD4_FAM177A1
Fusion gene ID: 19579
HgeneTgene
Gene symbol

LDLRAD4

FAM177A1

Gene ID

753

283635

Gene namelow density lipoprotein receptor class A domain containing 4family with sequence similarity 177 member A1
SynonymsC18orf1C14orf24
Cytomap

18p11.21

14q13.2

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptor class A domain-containing protein 4clone 22protein FAM177A1
Modification date2018051920180519
UniProtAcc

O15165

Q8N128

Ensembl transtripts involved in fusion geneENST00000361205, ENST00000399848, 
ENST00000359446, ENST00000587757, 
ENST00000585931, ENST00000586765, 
ENST00000590308, ENST00000592991, 
ENST00000396472, ENST00000382406, 
ENST00000280987, ENST00000554052, 
Fusion gene scores* DoF score7 X 7 X 3=1477 X 7 X 4=196
# samples 99
** MAII scorelog2(9/147*10)=-0.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/196*10)=-1.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LDLRAD4 [Title/Abstract] AND FAM177A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLDLRAD4

GO:0010991

negative regulation of SMAD protein complex assembly

24627487


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC040538LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000361205ENST00000396472LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000361205ENST00000382406LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000361205ENST00000280987LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000361205ENST00000554052LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000399848ENST00000396472LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000399848ENST00000382406LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000399848ENST00000280987LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000399848ENST00000554052LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000359446ENST00000396472LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000359446ENST00000382406LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000359446ENST00000280987LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000359446ENST00000554052LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000587757ENST00000396472LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000587757ENST00000382406LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000587757ENST00000280987LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000587757ENST00000554052LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000585931ENST00000396472LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000585931ENST00000382406LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000585931ENST00000280987LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000585931ENST00000554052LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000586765ENST00000396472LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000586765ENST00000382406LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000586765ENST00000280987LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000586765ENST00000554052LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000590308ENST00000396472LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000590308ENST00000382406LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000590308ENST00000280987LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000590308ENST00000554052LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000592991ENST00000396472LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000592991ENST00000382406LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-3UTRENST00000592991ENST00000280987LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+
intron-intronENST00000592991ENST00000554052LDLRAD4chr18

13329979

+FAM177A1chr14

35551705

+

Top

FusionProtFeatures for LDLRAD4_FAM177A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LDLRAD4

O15165

FAM177A1

Q8N128


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for LDLRAD4_FAM177A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LDLRAD4_FAM177A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LDLRAD4_FAM177A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for LDLRAD4_FAM177A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource