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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19578

FusionGeneSummary for LDLRAD4_DLGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: LDLRAD4_DLGAP1
Fusion gene ID: 19578
HgeneTgene
Gene symbol

LDLRAD4

DLGAP1

Gene ID

753

9229

Gene namelow density lipoprotein receptor class A domain containing 4DLG associated protein 1
SynonymsC18orf1DAP-1|DAP-1-ALPHA|DAP-1-BETA|DAP1|DLGAP1A|DLGAP1B|GKAP|SAPAP1
Cytomap

18p11.21

18p11.31

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptor class A domain-containing protein 4clone 22disks large-associated protein 1PSD-95/SAP90 binding protein 1SAP90/PSD-95-associated protein 1discs large homolog associated protein 1guanylate kinase-associated protein
Modification date2018051920180519
UniProtAcc

O15165

O14490

Ensembl transtripts involved in fusion geneENST00000361205, ENST00000399848, 
ENST00000359446, ENST00000587757, 
ENST00000585931, ENST00000586765, 
ENST00000590308, ENST00000592991, 
ENST00000315677, ENST00000581527, 
ENST00000400147, ENST00000400149, 
ENST00000400155, ENST00000400150, 
ENST00000584874, ENST00000534970, 
ENST00000539435, ENST00000581699, 
ENST00000400145, ENST00000515196, 
ENST00000478161, 
Fusion gene scores* DoF score7 X 7 X 3=14714 X 11 X 7=1078
# samples 915
** MAII scorelog2(9/147*10)=-0.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1078*10)=-2.84532277225662
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LDLRAD4 [Title/Abstract] AND DLGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLDLRAD4

GO:0010991

negative regulation of SMAD protein complex assembly

24627487


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCOADTCGA-F4-6461-01ALDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000361205ENST00000315677LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000361205ENST00000581527LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000361205ENST00000400147LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000361205ENST00000400149LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000361205ENST00000400155LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000361205ENST00000400150LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000361205ENST00000584874LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000361205ENST00000534970LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000361205ENST00000539435LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000361205ENST00000581699LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000361205ENST00000400145LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000361205ENST00000515196LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000361205ENST00000478161LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000399848ENST00000315677LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000399848ENST00000581527LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000399848ENST00000400147LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399848ENST00000400149LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399848ENST00000400155LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399848ENST00000400150LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399848ENST00000584874LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399848ENST00000534970LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399848ENST00000539435LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399848ENST00000581699LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399848ENST00000400145LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399848ENST00000515196LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399848ENST00000478161LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000359446ENST00000315677LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000359446ENST00000581527LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000359446ENST00000400147LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000359446ENST00000400149LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000359446ENST00000400155LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000359446ENST00000400150LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000359446ENST00000584874LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000359446ENST00000534970LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000359446ENST00000539435LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000359446ENST00000581699LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000359446ENST00000400145LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000359446ENST00000515196LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000359446ENST00000478161LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000587757ENST00000315677LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000587757ENST00000581527LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000587757ENST00000400147LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000587757ENST00000400149LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000587757ENST00000400155LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000587757ENST00000400150LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000587757ENST00000584874LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000587757ENST00000534970LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000587757ENST00000539435LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000587757ENST00000581699LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000587757ENST00000400145LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000587757ENST00000515196LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000587757ENST00000478161LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000585931ENST00000315677LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000585931ENST00000581527LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000585931ENST00000400147LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000585931ENST00000400149LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000585931ENST00000400155LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000585931ENST00000400150LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000585931ENST00000584874LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000585931ENST00000534970LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000585931ENST00000539435LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000585931ENST00000581699LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000585931ENST00000400145LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000585931ENST00000515196LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000585931ENST00000478161LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000586765ENST00000315677LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000586765ENST00000581527LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
Frame-shiftENST00000586765ENST00000400147LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000586765ENST00000400149LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000586765ENST00000400155LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000586765ENST00000400150LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000586765ENST00000584874LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000586765ENST00000534970LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000586765ENST00000539435LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000586765ENST00000581699LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000586765ENST00000400145LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000586765ENST00000515196LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
5CDS-intronENST00000586765ENST00000478161LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-3CDSENST00000590308ENST00000315677LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-3CDSENST00000590308ENST00000581527LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-3CDSENST00000590308ENST00000400147LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000590308ENST00000400149LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000590308ENST00000400155LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000590308ENST00000400150LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000590308ENST00000584874LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000590308ENST00000534970LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000590308ENST00000539435LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000590308ENST00000581699LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000590308ENST00000400145LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000590308ENST00000515196LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000590308ENST00000478161LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-3CDSENST00000592991ENST00000315677LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-3CDSENST00000592991ENST00000581527LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-3CDSENST00000592991ENST00000400147LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000592991ENST00000400149LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000592991ENST00000400155LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000592991ENST00000400150LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000592991ENST00000584874LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000592991ENST00000534970LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000592991ENST00000539435LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000592991ENST00000581699LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000592991ENST00000400145LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000592991ENST00000515196LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-
intron-intronENST00000592991ENST00000478161LDLRAD4chr18

13621270

+DLGAP1chr18

3582246

-

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FusionProtFeatures for LDLRAD4_DLGAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LDLRAD4

O15165

DLGAP1

O14490


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LDLRAD4_DLGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LDLRAD4_DLGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LDLRAD4RTFDC1, HECW2, HECW1, WWP2, NEDD4, ITCH, NEDD4L, WWP1, TAX1BP1, WWC2, KIDINS220, NCAPD3, UBR3, ARFGEF2, UBR1, VPS18, STXBP4, ACVR2B, ACVR2A, EPN1, MAGI3, DPY19L1, ANKRD13D, ANKRD13A, TOMM40, NCAPH2, DHX38, CMTR1, SMURF1, SMURF2, PLCG1, FLCN, RNF31, CSNK1E, CSNK1D, MAGI1, FGFR1, USP33, CALCOCO2, YAP1, SUFU, SMAD2, SMAD3, RBCK1, CUEDC1, WWOX, UIMC1, USP22, KIAA1033DLGAP1SHANK1, DYNLL2, DYNLL1, MYO5A, DLG2, SHANK2, DLG4, DLG1, DLG3, GRIN2A, CTNNB1, APC, SHANK3, SORBS2, GRB2, ITSN1, ITSN2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LDLRAD4_DLGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LDLRAD4_DLGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDLGAP1C0036341Schizophrenia3PSYGENET