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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19553

FusionGeneSummary for LDHA_PLA2G2A

check button Fusion gene summary
Fusion gene informationFusion gene name: LDHA_PLA2G2A
Fusion gene ID: 19553
HgeneTgene
Gene symbol

LDHA

PLA2G2A

Gene ID

3939

5320

Gene namelactate dehydrogenase Aphospholipase A2 group IIA
SynonymsGSD11|HEL-S-133P|LDHM|PIG19MOM1|PLA2|PLA2B|PLA2L|PLA2S|PLAS1|sPLA2
Cytomap

11p15.1

1p36.13

Type of geneprotein-codingprotein-coding
DescriptionL-lactate dehydrogenase A chainLDH muscle subunitLDH-ALDH-Mcell proliferation-inducing gene 19 proteinepididymis secretory sperm binding protein Li 133Plactate dehydrogenase Mproliferation-inducing gene 19renal carcinoma antigen NY-REN-59phospholipase A2, membrane associatedGIIC sPLA2NPS-PLA2group IIA phospholipase A2non-pancreatic secretory phospholipase A2phosphatidylcholine 2-acylhydrolase 2Aphospholipase A2, group IIA (platelets, synovial fluid)
Modification date2018052220180519
UniProtAcc

P00338

P14555

Ensembl transtripts involved in fusion geneENST00000422447, ENST00000430553, 
ENST00000396222, ENST00000227157, 
ENST00000540430, ENST00000379412, 
ENST00000542179, 		ENST00000400520, 
ENST00000496748, ENST00000375111, 
Fusion gene scores* DoF score5 X 5 X 2=506 X 3 X 5=90
# samples 86
** MAII scorelog2(8/50*10)=0.678071905112638
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LDHA [Title/Abstract] AND PLA2G2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLA2G2A

GO:0006644

phospholipid metabolic process

17069818

TgenePLA2G2A

GO:0046473

phosphatidic acid metabolic process

9032461

TgenePLA2G2A

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22837859


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-HC-7744-01ALDHAchr11

18425358

+PLA2G2Achr1

20305372

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000422447ENST00000400520LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000422447ENST00000496748LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000422447ENST00000375111LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000430553ENST00000400520LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000430553ENST00000496748LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000430553ENST00000375111LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
intron-5UTRENST00000396222ENST00000400520LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
intron-5UTRENST00000396222ENST00000496748LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
intron-5UTRENST00000396222ENST00000375111LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000227157ENST00000400520LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000227157ENST00000496748LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000227157ENST00000375111LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000540430ENST00000400520LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000540430ENST00000496748LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000540430ENST00000375111LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000379412ENST00000400520LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000379412ENST00000496748LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000379412ENST00000375111LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000542179ENST00000400520LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000542179ENST00000496748LDHAchr11

18425358

+PLA2G2Achr1

20305372

-
5CDS-5UTRENST00000542179ENST00000375111LDHAchr11

18425358

+PLA2G2Achr1

20305372

-

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FusionProtFeatures for LDHA_PLA2G2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LDHA

P00338

PLA2G2A

P14555

Catalyzes the calcium-dependent hydrolysis of the 2-acylgroups in 3-sn-phosphoglycerides (PubMed:2925633). Thought toparticipate in the regulation of phospholipid metabolism inbiomembranes including eicosanoid biosynthesis. Independent of itscatalytic activity, acts as a ligand for integrins(PubMed:18635536, PubMed:25398877). Binds to and activatesintegrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1(PubMed:18635536, PubMed:25398877). Binds to a site (site 2) whichis distinct from the classical ligand-binding site (site 1) andinduces integrin conformational changes and enhanced ligandbinding to site 1 (PubMed:25398877). Induces cell proliferation inan integrin-dependent manner (PubMed:18635536).{ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:25398877,ECO:0000269|PubMed:2925633}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LDHA_PLA2G2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LDHA_PLA2G2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LDHAKCNJ11, ABCC9, KAT5, KAT2A, HDAC5, PCNA, PSMA3, PCK1, NDRG1, ISG15, TERF1, TINF2, ACD, POT1, CUL3, CUL5, CDK2, CAND1, AKT1, MDH1, LDHB, ECT2, LIG4, PAXIP1, HNF1A, HSP90AA1, HSP90AB1, FN1, VCAM1, ATF2, METTL21B, ITGA4, LDHA, UPF2, XRN1, YWHAQ, FBXO6, BZW1, CNDP2, GNAI3, GSR, BCCIP, CSE1L, DLD, FTO, KYNU, LDHAL6B, NAGK, PAFAH1B3, PDIA3, C11orf58, SMS, TCEA1, PGD, RPS6KA1, SORD, RPA3, RPA2, RPA1, ASB9, STAU1, HUWE1, FUS, MAPK10, CUL7, OBSL1, CCDC8, RNF2, HNRNPA1, UNK, ABAT, ACADM, ADK, ALDH1B1, ALDH2, ALDH4A1, APRT, ARF4, ARF5, CAT, CCT3, CCT6B, CTSD, ENO1, ETFA, FAH, FAHD1, FH, GAA, GSTO1, IDE, ALDOA, ANXA11, ARF1, BROX, CFL1, CFL2, DSTN, HSPA9, NIT2, RAB1A, RAB1B, RAB5C, SOD1, SUCLG2, TKT, WDR1, MIF, NME1-NME2, NME2, PARK7, PDHA1, PEPD, PGK1, PGM1, PKM, PPIA, PPT1, PRCP, PRDX2, PRDX5, PRKCSH, PSMC2, RAB5A, RAB6B, SDHB, SPR, TALDO1, TPI1, UFD1L, NTRK1, CEP290, AHSA1, PPME1, KIF11, CKAP5, ERCC6L, SKI, MCM2, SQSTM1, CDC73, ZNF746, CDH1, LDHC, COX15, DNM1L, SDHA, SOAT1, VDAC1, TRIM25, BRCA1PLA2G2APLA2G1B, DCN, CEP70, BAG6, PLA2G2A, VIM, UCHL5, UCHL3, USP8, USP7, USP5, USP47, USP4, USP28, USP20, USP2, USP15, UCHL1, SENP6, JOSD2, SENP8, KRAS, ALOX12, ITGAV, ITGB3, TGM2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LDHA_PLA2G2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneLDHAP00338DB09118StiripentolL-lactate dehydrogenase A chainsmall moleculeapproved
HgeneLDHAP00338DB02701NicotinamideL-lactate dehydrogenase A chainsmall moleculeapproved|investigational
HgeneLDHAP00338DB11638ArtenimolL-lactate dehydrogenase A chainsmall moleculeapproved|investigational
TgenePLA2G2AP14555DB00328IndomethacinPhospholipase A2, membrane associatedsmall moleculeapproved|investigational
TgenePLA2G2AP14555DB02325Isopropyl AlcoholPhospholipase A2, membrane associatedsmall moleculeapproved|investigational
TgenePLA2G2AP14555DB04786SuraminPhospholipase A2, membrane associatedsmall moleculeapproved|investigational
TgenePLA2G2AP14555DB01381Ginkgo bilobaPhospholipase A2, membrane associatedsmall moleculeapproved|investigational|nutraceutical
TgenePLA2G2AP14555DB00586DiclofenacPhospholipase A2, membrane associatedsmall moleculeapproved|vet_approved

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RelatedDiseases for LDHA_PLA2G2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLDHAC0005586Bipolar Disorder1PSYGENET
HgeneLDHAC0011570Mental Depression1PSYGENET
HgeneLDHAC0027051Myocardial Infarction1CTD_human
HgeneLDHAC0027080Myoglobinuria1CTD_human;HPO
HgeneLDHAC0041696Unipolar Depression1PSYGENET
HgeneLDHAC0525045Mood Disorders1PSYGENET
HgeneLDHAC0878544Cardiomyopathies1CTD_human
HgeneLDHAC1269683Major Depressive Disorder1PSYGENET
TgenePLA2G2AC0005586Bipolar Disorder2PSYGENET
TgenePLA2G2AC0004153Atherosclerosis1CTD_human
TgenePLA2G2AC0011581Depressive disorder1PSYGENET
TgenePLA2G2AC0014175Endometriosis1CTD_human
TgenePLA2G2AC0035126Reperfusion Injury1CTD_human
TgenePLA2G2AC0151744Myocardial Ischemia1CTD_human
TgenePLA2G2AC0349218Recurrent depressive disorder, unspecified1PSYGENET
TgenePLA2G2AC1839839MAJOR AFFECTIVE DISORDER 21PSYGENET