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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19552

FusionGeneSummary for LDHA_MEST

check button Fusion gene summary
Fusion gene informationFusion gene name: LDHA_MEST
Fusion gene ID: 19552
HgeneTgene
Gene symbol

LDHA

MEST

Gene ID

3939

4232

Gene namelactate dehydrogenase Amesoderm specific transcript
SynonymsGSD11|HEL-S-133P|LDHM|PIG19PEG1
Cytomap

11p15.1

7q32.2

Type of geneprotein-codingprotein-coding
DescriptionL-lactate dehydrogenase A chainLDH muscle subunitLDH-ALDH-Mcell proliferation-inducing gene 19 proteinepididymis secretory sperm binding protein Li 133Plactate dehydrogenase Mproliferation-inducing gene 19renal carcinoma antigen NY-REN-59mesoderm-specific transcript homolog proteinpaternally-expressed gene 1 protein
Modification date2018052220180523
UniProtAcc

P00338

Q5EB52

Ensembl transtripts involved in fusion geneENST00000422447, ENST00000430553, 
ENST00000396222, ENST00000227157, 
ENST00000540430, ENST00000379412, 
ENST00000542179, 		ENST00000341441, 
ENST00000378576, ENST00000416162, 
ENST00000393187, ENST00000223215, 
ENST00000437945, ENST00000462132, 
Fusion gene scores* DoF score5 X 5 X 2=503 X 3 X 1=9
# samples 83
** MAII scorelog2(8/50*10)=0.678071905112638
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LDHA [Title/Abstract] AND MEST [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG179712LDHAchr11

18429180

+MESTchr7

130145346

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000422447ENST00000341441LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000422447ENST00000378576LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000422447ENST00000416162LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000422447ENST00000393187LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000422447ENST00000223215LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-intronENST00000422447ENST00000437945LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-intronENST00000422447ENST00000462132LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000430553ENST00000341441LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000430553ENST00000378576LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000430553ENST00000416162LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000430553ENST00000393187LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000430553ENST00000223215LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-intronENST00000430553ENST00000437945LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-intronENST00000430553ENST00000462132LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000396222ENST00000341441LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000396222ENST00000378576LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000396222ENST00000416162LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000396222ENST00000393187LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000396222ENST00000223215LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-intronENST00000396222ENST00000437945LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-intronENST00000396222ENST00000462132LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000227157ENST00000341441LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000227157ENST00000378576LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000227157ENST00000416162LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000227157ENST00000393187LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000227157ENST00000223215LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-intronENST00000227157ENST00000437945LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-intronENST00000227157ENST00000462132LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000540430ENST00000341441LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000540430ENST00000378576LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000540430ENST00000416162LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000540430ENST00000393187LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000540430ENST00000223215LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-intronENST00000540430ENST00000437945LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-intronENST00000540430ENST00000462132LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000379412ENST00000341441LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000379412ENST00000378576LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000379412ENST00000416162LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000379412ENST00000393187LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-3UTRENST00000379412ENST00000223215LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-intronENST00000379412ENST00000437945LDHAchr11

18429180

+MESTchr7

130145346

+
3UTR-intronENST00000379412ENST00000462132LDHAchr11

18429180

+MESTchr7

130145346

+
intron-3UTRENST00000542179ENST00000341441LDHAchr11

18429180

+MESTchr7

130145346

+
intron-3UTRENST00000542179ENST00000378576LDHAchr11

18429180

+MESTchr7

130145346

+
intron-3UTRENST00000542179ENST00000416162LDHAchr11

18429180

+MESTchr7

130145346

+
intron-3UTRENST00000542179ENST00000393187LDHAchr11

18429180

+MESTchr7

130145346

+
intron-3UTRENST00000542179ENST00000223215LDHAchr11

18429180

+MESTchr7

130145346

+
intron-intronENST00000542179ENST00000437945LDHAchr11

18429180

+MESTchr7

130145346

+
intron-intronENST00000542179ENST00000462132LDHAchr11

18429180

+MESTchr7

130145346

+

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FusionProtFeatures for LDHA_MEST


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LDHA

P00338

MEST

Q5EB52


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LDHA_MEST


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LDHA_MEST


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LDHA_MEST


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneLDHAP00338DB09118StiripentolL-lactate dehydrogenase A chainsmall moleculeapproved
HgeneLDHAP00338DB02701NicotinamideL-lactate dehydrogenase A chainsmall moleculeapproved|investigational
HgeneLDHAP00338DB11638ArtenimolL-lactate dehydrogenase A chainsmall moleculeapproved|investigational

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RelatedDiseases for LDHA_MEST


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLDHAC0005586Bipolar Disorder1PSYGENET
HgeneLDHAC0011570Mental Depression1PSYGENET
HgeneLDHAC0027051Myocardial Infarction1CTD_human
HgeneLDHAC0027080Myoglobinuria1CTD_human;HPO
HgeneLDHAC0041696Unipolar Depression1PSYGENET
HgeneLDHAC0525045Mood Disorders1PSYGENET
HgeneLDHAC0878544Cardiomyopathies1CTD_human
HgeneLDHAC1269683Major Depressive Disorder1PSYGENET
TgeneMESTC0043094Weight Gain1CTD_human