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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19545

FusionGeneSummary for LDB2_LDB2

check button Fusion gene summary
Fusion gene informationFusion gene name: LDB2_LDB2
Fusion gene ID: 19545
HgeneTgene
Gene symbol

LDB2

LDB2

Gene ID

9079

9079

Gene nameLIM domain binding 2LIM domain binding 2
SynonymsCLIM1|LDB-2|LDB1CLIM1|LDB-2|LDB1
Cytomap

4p15.32

4p15.32

Type of geneprotein-codingprotein-coding
DescriptionLIM domain-binding protein 2LIM binding domain 2LIM domain-binding factor CLIM1LIM domain-binding factor-2carboxyl-terminal LIM domain-binding protein 1LIM domain-binding protein 2LIM binding domain 2LIM domain-binding factor CLIM1LIM domain-binding factor-2carboxyl-terminal LIM domain-binding protein 1
Modification date2018052320180523
UniProtAcc

O43679

O43679

Ensembl transtripts involved in fusion geneENST00000515064, ENST00000441778, 
ENST00000304523, ENST00000502640, 
ENST00000503178, ENST00000503829, 
ENST00000515064, ENST00000441778, 
ENST00000304523, ENST00000502640, 
ENST00000503178, ENST00000503829, 
Fusion gene scores* DoF score3 X 3 X 1=95 X 5 X 4=100
# samples 35
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LDB2 [Title/Abstract] AND LDB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK024979LDB2chr4

16876091

-LDB2chr4

16883977

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000515064ENST00000515064LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000515064ENST00000441778LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000515064ENST00000304523LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000515064ENST00000502640LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000515064ENST00000503178LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000515064ENST00000503829LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000441778ENST00000515064LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000441778ENST00000441778LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000441778ENST00000304523LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000441778ENST00000502640LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000441778ENST00000503178LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000441778ENST00000503829LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000304523ENST00000515064LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000304523ENST00000441778LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000304523ENST00000304523LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000304523ENST00000502640LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000304523ENST00000503178LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000304523ENST00000503829LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000502640ENST00000515064LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000502640ENST00000441778LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000502640ENST00000304523LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000502640ENST00000502640LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000502640ENST00000503178LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000502640ENST00000503829LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000503178ENST00000515064LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000503178ENST00000441778LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000503178ENST00000304523LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000503178ENST00000502640LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000503178ENST00000503178LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000503178ENST00000503829LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000503829ENST00000515064LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000503829ENST00000441778LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000503829ENST00000304523LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000503829ENST00000502640LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000503829ENST00000503178LDB2chr4

16876091

-LDB2chr4

16883977

-
intron-intronENST00000503829ENST00000503829LDB2chr4

16876091

-LDB2chr4

16883977

-

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FusionProtFeatures for LDB2_LDB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LDB2

O43679

LDB2

O43679

Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LDB2_LDB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LDB2_LDB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LDB2_LDB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LDB2_LDB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource