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Fusion gene ID: 19544 |
FusionGeneSummary for LDB2_ATL2 |
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Fusion gene information | Fusion gene name: LDB2_ATL2 | Fusion gene ID: 19544 | Hgene | Tgene | Gene symbol | LDB2 | ATL2 | Gene ID | 9079 | 64225 |
Gene name | LIM domain binding 2 | atlastin GTPase 2 | |
Synonyms | CLIM1|LDB-2|LDB1 | ARL3IP2|ARL6IP2|aip-2|atlastin2 | |
Cytomap | 4p15.32 | 2p22.2-p22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | LIM domain-binding protein 2LIM binding domain 2LIM domain-binding factor CLIM1LIM domain-binding factor-2carboxyl-terminal LIM domain-binding protein 1 | atlastin-2ADP-ribosylation factor-like protein 6-interacting protein 2ARL-6-interacting protein 2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O43679 | Q8NHH9 | |
Ensembl transtripts involved in fusion gene | ENST00000515064, ENST00000441778, ENST00000304523, ENST00000502640, ENST00000503178, ENST00000503829, | ENST00000378954, ENST00000406122, ENST00000402054, ENST00000539122, ENST00000332337, ENST00000419554, ENST00000452935, ENST00000546051, ENST00000486927, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 3 X 4 X 2=24 |
# samples | 3 | 4 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: LDB2 [Title/Abstract] AND ATL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ATL2 | GO:0051260 | protein homooligomerization | 18270207 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | R06104 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000515064 | ENST00000378954 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000515064 | ENST00000406122 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000515064 | ENST00000402054 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000515064 | ENST00000539122 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000515064 | ENST00000332337 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000515064 | ENST00000419554 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000515064 | ENST00000452935 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000515064 | ENST00000546051 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000515064 | ENST00000486927 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000441778 | ENST00000378954 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000441778 | ENST00000406122 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000441778 | ENST00000402054 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000441778 | ENST00000539122 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000441778 | ENST00000332337 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000441778 | ENST00000419554 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000441778 | ENST00000452935 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000441778 | ENST00000546051 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000441778 | ENST00000486927 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000304523 | ENST00000378954 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000304523 | ENST00000406122 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000304523 | ENST00000402054 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000304523 | ENST00000539122 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000304523 | ENST00000332337 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000304523 | ENST00000419554 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000304523 | ENST00000452935 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000304523 | ENST00000546051 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000304523 | ENST00000486927 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000502640 | ENST00000378954 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000502640 | ENST00000406122 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000502640 | ENST00000402054 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000502640 | ENST00000539122 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000502640 | ENST00000332337 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000502640 | ENST00000419554 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000502640 | ENST00000452935 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000502640 | ENST00000546051 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000502640 | ENST00000486927 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503178 | ENST00000378954 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503178 | ENST00000406122 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503178 | ENST00000402054 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503178 | ENST00000539122 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503178 | ENST00000332337 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503178 | ENST00000419554 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503178 | ENST00000452935 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503178 | ENST00000546051 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503178 | ENST00000486927 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503829 | ENST00000378954 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503829 | ENST00000406122 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503829 | ENST00000402054 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503829 | ENST00000539122 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503829 | ENST00000332337 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503829 | ENST00000419554 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503829 | ENST00000452935 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503829 | ENST00000546051 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
intron-intron | ENST00000503829 | ENST00000486927 | LDB2 | chr4 | 16823309 | - | ATL2 | chr2 | 38591939 | - |
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FusionProtFeatures for LDB2_ATL2 |
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Hgene | Tgene |
LDB2 | ATL2 |
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. | GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmicreticulum membranes. Functions in endoplasmic reticulum tubularnetwork biogenesis (PubMed:18270207, PubMed:19665976,PubMed:27619977). {ECO:0000269|PubMed:18270207,ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:27619977}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LDB2_ATL2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LDB2_ATL2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LDB2_ATL2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LDB2_ATL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |