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Fusion gene ID: 19539 |
FusionGeneSummary for LCP1_SLC4A10 |
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Fusion gene information | Fusion gene name: LCP1_SLC4A10 | Fusion gene ID: 19539 | Hgene | Tgene | Gene symbol | LCP1 | SLC4A10 | Gene ID | 9878 | 57282 |
Gene name | TOX high mobility group box family member 4 | solute carrier family 4 member 10 | |
Synonyms | C14orf92|KIAA0737|LCP1|MIG7 | NBCn2|NCBE | |
Cytomap | 14q11.2 | 2q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | TOX high mobility group box family member 4epidermal Langerhans cell protein LCP1migration-inducing protein 7 | sodium-driven chloride bicarbonate exchangersolute carrier family 4, sodium bicarbonate cotransporter-like, member 10solute carrier family 4, sodium bicarbonate transporter, member 10 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P13796 | Q6U841 | |
Ensembl transtripts involved in fusion gene | ENST00000398576, ENST00000323076, ENST00000435666, ENST00000460190, | ENST00000375514, ENST00000415876, ENST00000535165, ENST00000493021, ENST00000272716, ENST00000446997, ENST00000421911, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 4 X 4 X 3=48 |
# samples | 4 | 4 | |
** MAII score | log2(4/9*10)=2.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LCP1 [Title/Abstract] AND SLC4A10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG392690 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000398576 | ENST00000375514 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000398576 | ENST00000415876 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000398576 | ENST00000535165 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000398576 | ENST00000493021 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000398576 | ENST00000272716 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000398576 | ENST00000446997 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000398576 | ENST00000421911 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000323076 | ENST00000375514 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000323076 | ENST00000415876 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000323076 | ENST00000535165 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000323076 | ENST00000493021 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000323076 | ENST00000272716 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000323076 | ENST00000446997 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000323076 | ENST00000421911 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000435666 | ENST00000375514 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000435666 | ENST00000415876 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000435666 | ENST00000535165 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000435666 | ENST00000493021 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000435666 | ENST00000272716 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000435666 | ENST00000446997 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000435666 | ENST00000421911 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000460190 | ENST00000375514 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000460190 | ENST00000415876 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000460190 | ENST00000535165 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000460190 | ENST00000493021 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000460190 | ENST00000272716 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000460190 | ENST00000446997 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
intron-intron | ENST00000460190 | ENST00000421911 | LCP1 | chr13 | 46717436 | - | SLC4A10 | chr2 | 162661287 | + |
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FusionProtFeatures for LCP1_SLC4A10 |
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Hgene | Tgene |
LCP1 | SLC4A10 |
Actin-binding protein (PubMed:16636079, PubMed:17294403,PubMed:28493397). Plays a role in the activation of T-cells inresponse to costimulation through TCR/CD3 and CD2 or CD28(PubMed:17294403). Modulates the cell surface expression ofIL2RA/CD25 and CD69 (PubMed:17294403).{ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403,ECO:0000269|PubMed:28493397}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LCP1_SLC4A10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LCP1_SLC4A10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LCP1_SLC4A10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LCP1_SLC4A10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LCP1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | LCP1 | C0040336 | Tobacco Use Disorder | 1 | CTD_human |
Tgene | SLC4A10 | C0009241 | Cognition Disorders | 1 | CTD_human |
Tgene | SLC4A10 | C0014544 | Epilepsy | 1 | CTD_human |
Tgene | SLC4A10 | C0085541 | Epilepsy, Frontal Lobe | 1 | CTD_human |
Tgene | SLC4A10 | C0151740 | Intracranial Hypertension | 1 | CTD_human |
Tgene | SLC4A10 | C3714756 | Intellectual Disability | 1 | CTD_human |