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Fusion gene ID: 19523 |
FusionGeneSummary for LCN1_LYZ |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LCN1_LYZ | Fusion gene ID: 19523 | Hgene | Tgene | Gene symbol | LCN1 | LYZ | Gene ID | 3933 | 4069 |
| Gene name | lipocalin 1 | lysozyme | |
| Synonyms | PMFA|TLC|TP|VEGP | LYZF1|LZM | |
| Cytomap | 9q34.3 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lipocalin-1VEG proteinVon Ebner gland proteinprotein migrating faster than albumintear prealbumin | lysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P31025 | P61626 | |
| Ensembl transtripts involved in fusion gene | ENST00000263598, ENST00000371781, | ENST00000261267, ENST00000549690, ENST00000548839, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 26 X 11 X 9=2574 |
| # samples | 3 | 30 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(30/2574*10)=-3.10097764772482 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LCN1 [Title/Abstract] AND LYZ [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LYZ | GO:0031640 | killing of cells of other organism | 9727055 |
| Tgene | LYZ | GO:0042742 | defense response to bacterium | 21093056 |
| Tgene | LYZ | GO:0050830 | defense response to Gram-positive bacterium | 21093056 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CK429413 | LCN1 | chr9 | 138414015 | + | LYZ | chr12 | 69746005 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000263598 | ENST00000261267 | LCN1 | chr9 | 138414015 | + | LYZ | chr12 | 69746005 | + |
| 5CDS-intron | ENST00000263598 | ENST00000549690 | LCN1 | chr9 | 138414015 | + | LYZ | chr12 | 69746005 | + |
| 5CDS-intron | ENST00000263598 | ENST00000548839 | LCN1 | chr9 | 138414015 | + | LYZ | chr12 | 69746005 | + |
| Frame-shift | ENST00000371781 | ENST00000261267 | LCN1 | chr9 | 138414015 | + | LYZ | chr12 | 69746005 | + |
| 5CDS-intron | ENST00000371781 | ENST00000549690 | LCN1 | chr9 | 138414015 | + | LYZ | chr12 | 69746005 | + |
| 5CDS-intron | ENST00000371781 | ENST00000548839 | LCN1 | chr9 | 138414015 | + | LYZ | chr12 | 69746005 | + |
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FusionProtFeatures for LCN1_LYZ |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LCN1 | LYZ |
| Could play a role in taste reception. Could be necessaryfor the concentration and delivery of sapid molecules in thegustatory system. Can bind various ligands, with chemicalstructures ranging from lipids and retinoids to the macrocyclicantibiotic rifampicin and even to microbial siderophores. Exhibitsan extremely wide ligand pocket. | Lysozymes have primarily a bacteriolytic function; thosein tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LCN1_LYZ |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LCN1_LYZ |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LCN1_LYZ |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | LCN1 | P31025 | DB00755 | Tretinoin | Lipocalin-1 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for LCN1_LYZ |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | LYZ | C0268389 | Amyloidosis, familial visceral | 1 | CTD_human;UNIPROT |
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