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Fusion gene ID: 19507 |
FusionGeneSummary for LATS2_MYLK |
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Fusion gene information | Fusion gene name: LATS2_MYLK | Fusion gene ID: 19507 | Hgene | Tgene | Gene symbol | LATS2 | MYLK | Gene ID | 26524 | 4638 |
Gene name | large tumor suppressor kinase 2 | myosin light chain kinase | |
Synonyms | KPM | AAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MSTP083|MYLK1|smMLCK | |
Cytomap | 13q12.11 | 3q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase LATS2LATS (large tumor suppressor, Drosophila) homolog 2LATS, large tumor suppressor, homolog 2kinase phosphorylated during mitosis proteinlarge tumor suppressor homolog 2serine/threonine kinase KPMserine/threonine-pr | myosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokin | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NRM7 | Q15746 | |
Ensembl transtripts involved in fusion gene | ENST00000382592, ENST00000542899, ENST00000472754, | ENST00000360772, ENST00000359169, ENST00000360304, ENST00000418370, ENST00000578202, ENST00000354792, ENST00000346322, ENST00000583087, ENST00000475616, ENST00000510775, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 9 X 10 X 3=270 |
# samples | 3 | 12 | |
** MAII score | log2(3/8*10)=1.90689059560852 | log2(12/270*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LATS2 [Title/Abstract] AND MYLK [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LATS2 | GO:0000082 | G1/S transition of mitotic cell cycle | 12853976 |
Hgene | LATS2 | GO:0006468 | protein phosphorylation | 10871863 |
Hgene | LATS2 | GO:0009755 | hormone-mediated signaling pathway | 15131260 |
Hgene | LATS2 | GO:0035329 | hippo signaling | 20412773 |
Hgene | LATS2 | GO:0035556 | intracellular signal transduction | 10871863 |
Hgene | LATS2 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 12853976 |
Tgene | MYLK | GO:0030335 | positive regulation of cell migration | 19826488 |
Tgene | MYLK | GO:0051928 | positive regulation of calcium ion transport | 16284075 |
Tgene | MYLK | GO:0071476 | cellular hypotonic response | 11976941 |
Tgene | MYLK | GO:0090303 | positive regulation of wound healing | 15825080 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-K1-A42X-02A | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
TCGA | RV | SARC | TCGA-K1-A42X-01A | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000382592 | ENST00000360772 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
5UTR-3CDS | ENST00000382592 | ENST00000359169 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
5UTR-3CDS | ENST00000382592 | ENST00000360304 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
5UTR-intron | ENST00000382592 | ENST00000418370 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
5UTR-intron | ENST00000382592 | ENST00000578202 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
5UTR-intron | ENST00000382592 | ENST00000354792 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
5UTR-intron | ENST00000382592 | ENST00000346322 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
5UTR-intron | ENST00000382592 | ENST00000583087 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
5UTR-intron | ENST00000382592 | ENST00000475616 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
5UTR-5UTR | ENST00000382592 | ENST00000510775 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-3CDS | ENST00000542899 | ENST00000360772 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-3CDS | ENST00000542899 | ENST00000359169 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-3CDS | ENST00000542899 | ENST00000360304 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-intron | ENST00000542899 | ENST00000418370 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-intron | ENST00000542899 | ENST00000578202 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-intron | ENST00000542899 | ENST00000354792 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-intron | ENST00000542899 | ENST00000346322 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-intron | ENST00000542899 | ENST00000583087 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-intron | ENST00000542899 | ENST00000475616 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-5UTR | ENST00000542899 | ENST00000510775 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-3CDS | ENST00000472754 | ENST00000360772 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-3CDS | ENST00000472754 | ENST00000359169 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-3CDS | ENST00000472754 | ENST00000360304 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-intron | ENST00000472754 | ENST00000418370 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-intron | ENST00000472754 | ENST00000578202 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-intron | ENST00000472754 | ENST00000354792 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-intron | ENST00000472754 | ENST00000346322 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-intron | ENST00000472754 | ENST00000583087 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-intron | ENST00000472754 | ENST00000475616 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
intron-5UTR | ENST00000472754 | ENST00000510775 | LATS2 | chr13 | 21635485 | - | MYLK | chr3 | 123386034 | - |
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FusionProtFeatures for LATS2_MYLK |
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Hgene | Tgene |
LATS2 | MYLK |
Negative regulator of YAP1 in the Hippo signalingpathway that plays a pivotal role in organ size control and tumorsuppression by restricting proliferation and promoting apoptosis.The core of this pathway is composed of a kinase cascade whereinSTK3/MST2 and STK4/MST1, in complex with its regulatory proteinSAV1, phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation ofYAP1 by LATS2 inhibits its translocation into the nucleus toregulate cellular genes important for cell proliferation, celldeath, and cell migration. Acts as a tumor suppressor which playsa critical role in centrosome duplication, maintenance of mitoticfidelity and genomic stability. Negatively regulates G1/Stransition by down-regulating cyclin E/CDK2 kinase activity.Negative regulator of the androgen receptor. Phosphorylates SNAI1in the nucleus leading to its nuclear retention and stabilization,which enhances its epithelial-mesenchymal transition and tumorcell invasion/migration activities. This tumor-promoting activityis independent of its effects upon YAP1 or WWTR1/TAZ.{ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976,ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288,ECO:0000269|PubMed:21952048}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LATS2_MYLK |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LATS2_MYLK |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LATS2 | WWC1, LATS1, ELAVL1, YAP1, AR, AURKB, AURKA, PPP1R13B, MOB1A, MOB1B, MOB3A, MOB3B, MOB3C, MOB4, CHEK1, CHEK2, YWHAG, STK3, MDM2, SNAI1, AMOTL2, HIST2H2BE, HRAS, AJUBA, DYRK1A, CDK2, ALDH18A1, ALMS1, AMOT, AMOTL1, ANAPC1, ANAPC5, APC, CEP131, BAG2, BAG5, CCDC77, CCDC85C, CCDC88C, CCP110, CENPJ, CEP192, CEP72, CEP85, CEP89, CGN, CNTROB, CPVL, CSPP1, CTNNB1, CUL7, CYLD, DCAF7, DNAJA3, EIF4ENIF1, ERC1, AMER1, FBXL16, FUBP3, GIGYF1, GRIP1, IFFO1, INADL, KIAA0368, KIAA1462, KIAA1549, KIAA1671, CEP295, LATS2, LETM1, LIMD1, LIN7C, LNX2, LONP1, LZTS2, MAGI1, MIA3, MIPOL1, MLLT4, MPDZ, MPHOSPH9, MPP5, NCKAP5L, NIN, NINL, NME7, NOTCH1, NOTCH2, NUP160, OFD1, PAK4, PARD3, PCM1, PDZD11, PHLDB2, PKP4, PLEKHA1, PLEKHA5, PLEKHA7, PLEKHG1, PLOD1, PNMA2, PPFIA1, PPFIBP1, PPP2R1A, PPP2R2A, PTPN13, PTPN14, RADIL, RASAL2, RBM15, RCN2, SDCCAG3, SEC16A, SIPA1L1, SIPA1L2, SIPA1L3, SKP1, SKP2, SORBS1, SPICE1, SSX2IP, STK4, STXBP4, TANC2, TBK1, TBKBP1, TCHP, TJP1, TJP2, TNRC6B, TP53BP2, TRIM27, TRIM37, TUBB2A, TUBB6, USP54, USP9X, UTRN, YWHAH, SAV1, HSP90AB1, TAZ, ABL1, CDKN1A, NF2, WTIP, WWC2, WWC3, CEP128, RASSF1, SIAH1, SKI, WWTR1, KIF23, NEDD4, IKBKB, ZYX, SIAH2, EZH2, SUZ12 | MYLK | PRKG2, CALM1, CTTN, PAK1, MLC1, SRC, ALK, MYC, TP53, GOPC, HSPB1, MYH9, PPP1CB, ANLN, MYO19 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LATS2_MYLK |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LATS2_MYLK |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LATS2 | C0004114 | Astrocytoma | 1 | CTD_human |
Tgene | MYLK | C0027626 | Neoplasm Invasiveness | 2 | CTD_human |
Tgene | MYLK | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
Tgene | MYLK | C0017178 | Gastrointestinal Diseases | 1 | CTD_human |
Tgene | MYLK | C0017601 | Glaucoma | 1 | CTD_human |
Tgene | MYLK | C0017638 | Glioma | 1 | CTD_human |
Tgene | MYLK | C0020443 | Hypercholesterolemia | 1 | CTD_human |
Tgene | MYLK | C0020517 | Hypersensitivity | 1 | CTD_human |
Tgene | MYLK | C0032285 | Pneumonia | 1 | CTD_human |
Tgene | MYLK | C0042373 | Vascular Diseases | 1 | CTD_human |
Tgene | MYLK | C0242488 | Acute Lung Injury | 1 | CTD_human |
Tgene | MYLK | C1527311 | Brain Edema | 1 | CTD_human |
Tgene | MYLK | C3151077 | AORTIC ANEURYSM, FAMILIAL THORACIC 7 | 1 | UNIPROT |