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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19507

FusionGeneSummary for LATS2_MYLK

check button Fusion gene summary
Fusion gene informationFusion gene name: LATS2_MYLK
Fusion gene ID: 19507
HgeneTgene
Gene symbol

LATS2

MYLK

Gene ID

26524

4638

Gene namelarge tumor suppressor kinase 2myosin light chain kinase
SynonymsKPMAAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MSTP083|MYLK1|smMLCK
Cytomap

13q12.11

3q21.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase LATS2LATS (large tumor suppressor, Drosophila) homolog 2LATS, large tumor suppressor, homolog 2kinase phosphorylated during mitosis proteinlarge tumor suppressor homolog 2serine/threonine kinase KPMserine/threonine-prmyosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokin
Modification date2018052320180523
UniProtAcc

Q9NRM7

Q15746

Ensembl transtripts involved in fusion geneENST00000382592, ENST00000542899, 
ENST00000472754, 
ENST00000360772, 
ENST00000359169, ENST00000360304, 
ENST00000418370, ENST00000578202, 
ENST00000354792, ENST00000346322, 
ENST00000583087, ENST00000475616, 
ENST00000510775, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 10 X 3=270
# samples 312
** MAII scorelog2(3/8*10)=1.90689059560852log2(12/270*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LATS2 [Title/Abstract] AND MYLK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLATS2

GO:0000082

G1/S transition of mitotic cell cycle

12853976

HgeneLATS2

GO:0006468

protein phosphorylation

10871863

HgeneLATS2

GO:0009755

hormone-mediated signaling pathway

15131260

HgeneLATS2

GO:0035329

hippo signaling

20412773

HgeneLATS2

GO:0035556

intracellular signal transduction

10871863

HgeneLATS2

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

12853976

TgeneMYLK

GO:0030335

positive regulation of cell migration

19826488

TgeneMYLK

GO:0051928

positive regulation of calcium ion transport

16284075

TgeneMYLK

GO:0071476

cellular hypotonic response

11976941

TgeneMYLK

GO:0090303

positive regulation of wound healing

15825080


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-K1-A42X-02ALATS2chr13

21635485

-MYLKchr3

123386034

-
TCGARVSARCTCGA-K1-A42X-01ALATS2chr13

21635485

-MYLKchr3

123386034

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000382592ENST00000360772LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-3CDSENST00000382592ENST00000359169LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-3CDSENST00000382592ENST00000360304LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000418370LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000578202LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000354792LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000346322LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000583087LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000475616LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-5UTRENST00000382592ENST00000510775LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000360772LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000359169LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000360304LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000418370LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000578202LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000354792LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000346322LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000583087LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000475616LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-5UTRENST00000542899ENST00000510775LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000472754ENST00000360772LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000472754ENST00000359169LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000472754ENST00000360304LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000418370LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000578202LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000354792LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000346322LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000583087LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000475616LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-5UTRENST00000472754ENST00000510775LATS2chr13

21635485

-MYLKchr3

123386034

-

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FusionProtFeatures for LATS2_MYLK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LATS2

Q9NRM7

MYLK

Q15746

Negative regulator of YAP1 in the Hippo signalingpathway that plays a pivotal role in organ size control and tumorsuppression by restricting proliferation and promoting apoptosis.The core of this pathway is composed of a kinase cascade whereinSTK3/MST2 and STK4/MST1, in complex with its regulatory proteinSAV1, phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation ofYAP1 by LATS2 inhibits its translocation into the nucleus toregulate cellular genes important for cell proliferation, celldeath, and cell migration. Acts as a tumor suppressor which playsa critical role in centrosome duplication, maintenance of mitoticfidelity and genomic stability. Negatively regulates G1/Stransition by down-regulating cyclin E/CDK2 kinase activity.Negative regulator of the androgen receptor. Phosphorylates SNAI1in the nucleus leading to its nuclear retention and stabilization,which enhances its epithelial-mesenchymal transition and tumorcell invasion/migration activities. This tumor-promoting activityis independent of its effects upon YAP1 or WWTR1/TAZ.{ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976,ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288,ECO:0000269|PubMed:21952048}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LATS2_MYLK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LATS2_MYLK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LATS2WWC1, LATS1, ELAVL1, YAP1, AR, AURKB, AURKA, PPP1R13B, MOB1A, MOB1B, MOB3A, MOB3B, MOB3C, MOB4, CHEK1, CHEK2, YWHAG, STK3, MDM2, SNAI1, AMOTL2, HIST2H2BE, HRAS, AJUBA, DYRK1A, CDK2, ALDH18A1, ALMS1, AMOT, AMOTL1, ANAPC1, ANAPC5, APC, CEP131, BAG2, BAG5, CCDC77, CCDC85C, CCDC88C, CCP110, CENPJ, CEP192, CEP72, CEP85, CEP89, CGN, CNTROB, CPVL, CSPP1, CTNNB1, CUL7, CYLD, DCAF7, DNAJA3, EIF4ENIF1, ERC1, AMER1, FBXL16, FUBP3, GIGYF1, GRIP1, IFFO1, INADL, KIAA0368, KIAA1462, KIAA1549, KIAA1671, CEP295, LATS2, LETM1, LIMD1, LIN7C, LNX2, LONP1, LZTS2, MAGI1, MIA3, MIPOL1, MLLT4, MPDZ, MPHOSPH9, MPP5, NCKAP5L, NIN, NINL, NME7, NOTCH1, NOTCH2, NUP160, OFD1, PAK4, PARD3, PCM1, PDZD11, PHLDB2, PKP4, PLEKHA1, PLEKHA5, PLEKHA7, PLEKHG1, PLOD1, PNMA2, PPFIA1, PPFIBP1, PPP2R1A, PPP2R2A, PTPN13, PTPN14, RADIL, RASAL2, RBM15, RCN2, SDCCAG3, SEC16A, SIPA1L1, SIPA1L2, SIPA1L3, SKP1, SKP2, SORBS1, SPICE1, SSX2IP, STK4, STXBP4, TANC2, TBK1, TBKBP1, TCHP, TJP1, TJP2, TNRC6B, TP53BP2, TRIM27, TRIM37, TUBB2A, TUBB6, USP54, USP9X, UTRN, YWHAH, SAV1, HSP90AB1, TAZ, ABL1, CDKN1A, NF2, WTIP, WWC2, WWC3, CEP128, RASSF1, SIAH1, SKI, WWTR1, KIF23, NEDD4, IKBKB, ZYX, SIAH2, EZH2, SUZ12MYLKPRKG2, CALM1, CTTN, PAK1, MLC1, SRC, ALK, MYC, TP53, GOPC, HSPB1, MYH9, PPP1CB, ANLN, MYO19


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LATS2_MYLK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LATS2_MYLK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLATS2C0004114Astrocytoma1CTD_human
TgeneMYLKC0027626Neoplasm Invasiveness2CTD_human
TgeneMYLKC0027627Neoplasm Metastasis2CTD_human
TgeneMYLKC0017178Gastrointestinal Diseases1CTD_human
TgeneMYLKC0017601Glaucoma1CTD_human
TgeneMYLKC0017638Glioma1CTD_human
TgeneMYLKC0020443Hypercholesterolemia1CTD_human
TgeneMYLKC0020517Hypersensitivity1CTD_human
TgeneMYLKC0032285Pneumonia1CTD_human
TgeneMYLKC0042373Vascular Diseases1CTD_human
TgeneMYLKC0242488Acute Lung Injury1CTD_human
TgeneMYLKC1527311Brain Edema1CTD_human
TgeneMYLKC3151077AORTIC ANEURYSM, FAMILIAL THORACIC 71UNIPROT