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Fusion gene ID: 19506 |
FusionGeneSummary for LATS1_NUP43 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LATS1_NUP43 | Fusion gene ID: 19506 | Hgene | Tgene | Gene symbol | LATS1 | NUP43 | Gene ID | 9113 | 348995 |
| Gene name | large tumor suppressor kinase 1 | nucleoporin 43 | |
| Synonyms | WARTS|wts | bA350J20.1|p42 | |
| Cytomap | 6q25.1 | 6q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase LATS1LATS (large tumor suppressor, Drosophila) homolog 1LATS, large tumor suppressor, homolog 1WARTS protein kinaseh-wartslarge tumor suppressor homolog 1 | nucleoporin Nup43nucleoporin 43kDanup107-160 subcomplex subunit Nup43 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | O95835 | Q8NFH3 | |
| Ensembl transtripts involved in fusion gene | ENST00000543571, ENST00000253339, ENST00000542747, ENST00000392273, | ENST00000340413, ENST00000460354, ENST00000367403, ENST00000367404, ENST00000463048, | |
| Fusion gene scores | * DoF score | 1 X 2 X 2=4 | 1 X 2 X 2=4 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: LATS1 [Title/Abstract] AND NUP43 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LATS1 | GO:0000086 | G2/M transition of mitotic cell cycle | 15122335 |
| Hgene | LATS1 | GO:0000819 | sister chromatid segregation | 15122335 |
| Hgene | LATS1 | GO:0006468 | protein phosphorylation | 10518011 |
| Hgene | LATS1 | GO:0030833 | regulation of actin filament polymerization | 15220930 |
| Hgene | LATS1 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 20412773 |
| Hgene | LATS1 | GO:0035329 | hippo signaling | 20412773 |
| Hgene | LATS1 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 9988268 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-61-1917-01A | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| TCGA | LD | READ | TCGA-EI-6884-01A | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000543571 | ENST00000340413 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| Frame-shift | ENST00000543571 | ENST00000460354 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5CDS-3UTR | ENST00000543571 | ENST00000367403 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5CDS-3UTR | ENST00000543571 | ENST00000367404 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5CDS-intron | ENST00000543571 | ENST00000463048 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| Frame-shift | ENST00000253339 | ENST00000340413 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| Frame-shift | ENST00000253339 | ENST00000460354 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5CDS-3UTR | ENST00000253339 | ENST00000367403 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5CDS-3UTR | ENST00000253339 | ENST00000367404 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5CDS-intron | ENST00000253339 | ENST00000463048 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5UTR-3CDS | ENST00000542747 | ENST00000340413 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5UTR-3CDS | ENST00000542747 | ENST00000460354 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5UTR-3UTR | ENST00000542747 | ENST00000367403 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5UTR-3UTR | ENST00000542747 | ENST00000367404 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5UTR-intron | ENST00000542747 | ENST00000463048 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| Frame-shift | ENST00000392273 | ENST00000340413 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| Frame-shift | ENST00000392273 | ENST00000460354 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5CDS-3UTR | ENST00000392273 | ENST00000367403 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5CDS-3UTR | ENST00000392273 | ENST00000367404 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5CDS-intron | ENST00000392273 | ENST00000463048 | LATS1 | chr6 | 150022915 | - | NUP43 | chr6 | 150048334 | - |
| 5UTR-3CDS | ENST00000543571 | ENST00000340413 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| 5UTR-3CDS | ENST00000543571 | ENST00000460354 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| 5UTR-3UTR | ENST00000543571 | ENST00000367403 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| 5UTR-3UTR | ENST00000543571 | ENST00000367404 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| 5UTR-intron | ENST00000543571 | ENST00000463048 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| intron-3CDS | ENST00000253339 | ENST00000340413 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| intron-3CDS | ENST00000253339 | ENST00000460354 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| intron-3UTR | ENST00000253339 | ENST00000367403 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| intron-3UTR | ENST00000253339 | ENST00000367404 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| intron-intron | ENST00000253339 | ENST00000463048 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| intron-3CDS | ENST00000542747 | ENST00000340413 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| intron-3CDS | ENST00000542747 | ENST00000460354 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| intron-3UTR | ENST00000542747 | ENST00000367403 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| intron-3UTR | ENST00000542747 | ENST00000367404 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| intron-intron | ENST00000542747 | ENST00000463048 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| 5UTR-3CDS | ENST00000392273 | ENST00000340413 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| 5UTR-3CDS | ENST00000392273 | ENST00000460354 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| 5UTR-3UTR | ENST00000392273 | ENST00000367403 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| 5UTR-3UTR | ENST00000392273 | ENST00000367404 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
| 5UTR-intron | ENST00000392273 | ENST00000463048 | LATS1 | chr6 | 150038985 | - | NUP43 | chr6 | 150052871 | - |
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FusionProtFeatures for LATS1_NUP43 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LATS1 | NUP43 |
| Negative regulator of YAP1 in the Hippo signalingpathway that plays a pivotal role in organ size control and tumorsuppression by restricting proliferation and promoting apoptosis.The core of this pathway is composed of a kinase cascade whereinSTK3/MST2 and STK4/MST1, in complex with its regulatory proteinSAV1, phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation ofYAP1 by LATS1 inhibits its translocation into the nucleus toregulate cellular genes important for cell proliferation, celldeath, and cell migration. Acts as a tumor suppressor which playsa critical role in maintenance of ploidy through its actions inboth mitotic progression and the G1 tetraploidy checkpoint.Negatively regulates G2/M transition by down-regulating CDK1kinase activity. Involved in the control of p53 expression.Affects cytokinesis by regulating actin polymerization throughnegative modulation of LIMK1. May also play a role in endocrinefunction. Plays a role in mammary gland epithelial cellsdifferentiation, both through the Hippo signaling pathway and theintracellular estrogen receptor signaling pathway by promoting thedegradation of ESR1 (PubMed:28068668).{ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611,ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930,ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127,ECO:0000269|PubMed:28068668}. | Component of the Nup107-160 subcomplex of the nuclearpore complex (NPC). The Nup107-160 subcomplex is required for theassembly of a functional NPC. The Nup107-160 subcomplex is alsorequired for normal kinetochore microtubule attachment, mitoticprogression and chromosome segregation.{ECO:0000269|PubMed:17363900}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LATS1_NUP43 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LATS1_NUP43 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LATS1 | CDK1, ZYX, RAC1, WWC1, ITCH, LATS2, MYC, MAST2, MDM2, STK3, LIMK1, YAP1, RASSF1, SAV1, AURKB, HTRA2, PPP1R13B, MOB1A, MOB1B, MOB3A, MOB3B, MOB3C, MOB4, DCUN1D1, XIAP, RAF1, NPHP4, WWTR1, APP, FOXL2, TAZ, NUAK1, NUAK2, PPP1R11, PPP6R3, ALPP, PPP1R12A, PTEN, PLK1, PPP1CC, EIF4EBP1, AMOT, AMOTL1, ASS1, CEP131, CCP110, CEP152, CEP192, CGN, CNTROB, DNAJC11, INADL, KIAA1549, KIRREL, LIMD1, LZTS2, MAGI1, MPP5, OFD1, PARD3, PKP4, PTPN13, PTPN14, RAB35, SDCCAG3, SEC16A, SIPA1L2, TJP2, HSP90AB1, GOLGA2, KRT31, TRAF1, LDOC1, TFIP11, MOAP1, CEP76, SSX2IP, FSD2, SPERT, NEDD4, WWP1, WWOX, SMURF1, SMURF2, CAV1, PABPN1, MAGI3, NF2, AJUBA, WTIP, CDK2, WWC2, WWC3, NINL, KATNA1, CDC26, PPP1CA, UBE2I, ESR1, TNFAIP8, CUL4A, USP9X | NUP43 | NUP133, NUP107, NUP85, NUP37, NUP160, UBC, ISG15, DDB1, CUL4A, RAB3GAP2, DCTN2, SEH1L, TP53RK, CUL7, SEC13, OSGEP, LAGE3, NUP98, CCT7, CCT6B, TPRKB, KIF5B, KLC2, KLC4, XPA, IFI16, CSMD3, CEP250, GUCY2D, TCP1, POM121, MCM3AP, ZCCHC16, AURKAIP1, TBX4, RPL26L1, SENP1, RANBP2, SENP2, NUP50, NUP153, CCT8, B9D2, KPNB1, SPAST |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LATS1_NUP43 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LATS1_NUP43 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LATS1 | C0004114 | Astrocytoma | 1 | CTD_human |
| Hgene | LATS1 | C0007117 | Basal cell carcinoma | 1 | CTD_human |
| Hgene | LATS1 | C0027660 | Neoplasms, Glandular and Epithelial | 1 | CTD_human |
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